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Evolutionary Neurogenomics

The impact of recent retrotransposon invasions on the evolution of human neural gene expression

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Evolutionary Neurogenomics project word cloud

Explore the words cloud of the Evolutionary Neurogenomics project. It provides you a very rough idea of what is the project "Evolutionary Neurogenomics" about.

evolutionary    thousands    expression    genome    modules    sensitive    showed    source    exploration    retrotransposons    dutch    intimately    neural    activated    professional    methylation    regulatory    dna    krab    neuron    disorders    retrotransposon    clues    health    disease    cell    curie    mobile    human    types    genomes    reactivated    silenced    patterns    zinc    odowska    insertions    opportunity    evolution    neurodevelopmental    correlated    retrovirus    finger    primate    cancer    networks    recruitment    attack    gene    fellowship    suggesting    differentiation    marie    genomic    goals    aberrantly    kznf    integrate    hold    stem    validate    classes    re    functionally    throughout    proteins    astonishing    suggest    assay    50    sk    extra    neurological    neuronal    mechanism    group    training    cortical    me    opens    previously    waves    novelties    genes    locations    restricted    individual    diseases    invasions    unknown   

Project "Evolutionary Neurogenomics" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: SPUI 21
city: AMSTERDAM
postcode: 1012WX
website: www.uva.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.frankjacobslab.com
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 177˙598.00

Map

 Project objective

Throughout evolution, primate genomes have been under attack by different classes of retrotransposons, retrovirus-derived mobile DNA elements. As a result, an astonishing ~50% of the human genome is derived from many types of retrotransposons. I previously showed that primate-specific retrotransposon invasions are restricted by primate-specific KRAB zinc finger proteins. These findings suggest that through recruitment to thousands of new genomic locations, KRAB zinc finger proteins have become intimately integrated into pre-existing gene regulatory pathways. Retrotransposons are an important source for evolutionary novelties, but the impact of thousands of human-specific retrotransposon-KZNF regulatory modules on the evolution of human gene expression patterns is unknown. There is increasing evidence that retrotransposons become reactivated during neural differentiation, suggesting that neuronal gene-regulatory networks may be extra sensitive to retrotransposon insertions. Furthermore, new retrotransposon insertions may hold clues to the mechanism of human disease: Even when retrotransposons are efficiently silenced in health, they may become aberrantly activated by changes in DNA methylation observed in neurological diseases and cancer. Using a previously established human and non-human primate stem cell cortical neuron differentiation assay, I will identify, validate and functionally test neurodevelopmental genes that have come under the control of retrotransposons. This will address the impact of recent waves of retrotransposon insertions on the evolution of human neural gene expression patterns and opens up the exploration of how new retrotransposon insertions may be correlated to human neurological disorders. The Marie Skłodowska-Curie individual fellowship will provide the opportunity to establish my research group in Europe and re-integrate in Dutch and EU networks, as well as allow me to achieve my professional development training goals.

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The information about "EVOLUTIONARY NEUROGENOMICS" are provided by the European Opendata Portal: CORDIS opendata.

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