Opendata, web and dolomites

Evolutionary Neurogenomics

The impact of recent retrotransposon invasions on the evolution of human neural gene expression

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Evolutionary Neurogenomics project word cloud

Explore the words cloud of the Evolutionary Neurogenomics project. It provides you a very rough idea of what is the project "Evolutionary Neurogenomics" about.

fellowship    invasions    disorders    thousands    intimately    neurological    neurodevelopmental    patterns    aberrantly    assay    retrotransposons    sk    me    disease    re    finger    restricted    source    mobile    recruitment    genomes    marie    attack    evolution    locations    astonishing    50    health    networks    integrate    retrotransposon    odowska    hold    neuron    mechanism    dutch    neuronal    opens    zinc    goals    differentiation    sensitive    genomic    opportunity    genome    validate    professional    activated    retrovirus    cancer    types    methylation    exploration    kznf    cell    stem    gene    functionally    expression    diseases    unknown    previously    regulatory    showed    correlated    silenced    evolutionary    krab    reactivated    modules    curie    primate    proteins    waves    clues    genes    suggesting    extra    group    classes    suggest    novelties    throughout    training    insertions    dna    individual    human    neural    cortical   

Project "Evolutionary Neurogenomics" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: SPUI 21
city: AMSTERDAM
postcode: 1012WX
website: www.uva.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.frankjacobslab.com
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 177˙598.00

Map

 Project objective

Throughout evolution, primate genomes have been under attack by different classes of retrotransposons, retrovirus-derived mobile DNA elements. As a result, an astonishing ~50% of the human genome is derived from many types of retrotransposons. I previously showed that primate-specific retrotransposon invasions are restricted by primate-specific KRAB zinc finger proteins. These findings suggest that through recruitment to thousands of new genomic locations, KRAB zinc finger proteins have become intimately integrated into pre-existing gene regulatory pathways. Retrotransposons are an important source for evolutionary novelties, but the impact of thousands of human-specific retrotransposon-KZNF regulatory modules on the evolution of human gene expression patterns is unknown. There is increasing evidence that retrotransposons become reactivated during neural differentiation, suggesting that neuronal gene-regulatory networks may be extra sensitive to retrotransposon insertions. Furthermore, new retrotransposon insertions may hold clues to the mechanism of human disease: Even when retrotransposons are efficiently silenced in health, they may become aberrantly activated by changes in DNA methylation observed in neurological diseases and cancer. Using a previously established human and non-human primate stem cell cortical neuron differentiation assay, I will identify, validate and functionally test neurodevelopmental genes that have come under the control of retrotransposons. This will address the impact of recent waves of retrotransposon insertions on the evolution of human neural gene expression patterns and opens up the exploration of how new retrotransposon insertions may be correlated to human neurological disorders. The Marie Skłodowska-Curie individual fellowship will provide the opportunity to establish my research group in Europe and re-integrate in Dutch and EU networks, as well as allow me to achieve my professional development training goals.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EVOLUTIONARY NEUROGENOMICS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EVOLUTIONARY NEUROGENOMICS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CORRELATION (2020)

Characterization and prediction of service-level traffic for future sliced mobile network

Read More  

Photonic Radar (2019)

Implementation of Long Reach Hybrid Photonic Radar System and convergence over FSO and PON Networks

Read More  

ASIQS (2019)

Antiferromagnetic spintronics investigated by quantum sensing techniques

Read More