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Evolutionary Neurogenomics

The impact of recent retrotransposon invasions on the evolution of human neural gene expression

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Evolutionary Neurogenomics project word cloud

Explore the words cloud of the Evolutionary Neurogenomics project. It provides you a very rough idea of what is the project "Evolutionary Neurogenomics" about.

neuron    functionally    locations    neuronal    kznf    differentiation    clues    mobile    opens    neurological    patterns    cortical    curie    evolutionary    retrovirus    invasions    me    neural    unknown    recruitment    methylation    regulatory    diseases    modules    retrotransposon    group    zinc    classes    50    types    suggest    intimately    extra    previously    opportunity    silenced    validate    goals    proteins    gene    health    training    correlated    stem    source    activated    genes    marie    cell    expression    fellowship    disease    hold    finger    genomic    genome    exploration    networks    integrate    thousands    neurodevelopmental    astonishing    suggesting    disorders    mechanism    odowska    primate    retrotransposons    genomes    krab    novelties    professional    throughout    human    dna    sensitive    individual    reactivated    cancer    aberrantly    assay    evolution    restricted    showed    sk    attack    waves    dutch    re    insertions   

Project "Evolutionary Neurogenomics" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: SPUI 21
city: AMSTERDAM
postcode: 1012WX
website: www.uva.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.frankjacobslab.com
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 177˙598.00

Map

 Project objective

Throughout evolution, primate genomes have been under attack by different classes of retrotransposons, retrovirus-derived mobile DNA elements. As a result, an astonishing ~50% of the human genome is derived from many types of retrotransposons. I previously showed that primate-specific retrotransposon invasions are restricted by primate-specific KRAB zinc finger proteins. These findings suggest that through recruitment to thousands of new genomic locations, KRAB zinc finger proteins have become intimately integrated into pre-existing gene regulatory pathways. Retrotransposons are an important source for evolutionary novelties, but the impact of thousands of human-specific retrotransposon-KZNF regulatory modules on the evolution of human gene expression patterns is unknown. There is increasing evidence that retrotransposons become reactivated during neural differentiation, suggesting that neuronal gene-regulatory networks may be extra sensitive to retrotransposon insertions. Furthermore, new retrotransposon insertions may hold clues to the mechanism of human disease: Even when retrotransposons are efficiently silenced in health, they may become aberrantly activated by changes in DNA methylation observed in neurological diseases and cancer. Using a previously established human and non-human primate stem cell cortical neuron differentiation assay, I will identify, validate and functionally test neurodevelopmental genes that have come under the control of retrotransposons. This will address the impact of recent waves of retrotransposon insertions on the evolution of human neural gene expression patterns and opens up the exploration of how new retrotransposon insertions may be correlated to human neurological disorders. The Marie Skłodowska-Curie individual fellowship will provide the opportunity to establish my research group in Europe and re-integrate in Dutch and EU networks, as well as allow me to achieve my professional development training goals.

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The information about "EVOLUTIONARY NEUROGENOMICS" are provided by the European Opendata Portal: CORDIS opendata.

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