Explore the words cloud of the MtbTransReg project. It provides you a very rough idea of what is the project "MtbTransReg" about.
The following table provides information about the project.
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
|Coordinator Country||United Kingdom [UK]|
|Total cost||1˙495˙625 €|
|EC max contribution||1˙495˙625 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-06-01 to 2021-05-31|
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|1||LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER||UK (LONDON)||coordinator||1˙495˙625.00|
Mycobacterium tuberculosis causes human tuberculosis but can also persist for decades as an asymptomatic latent infection. The mechanisms underlying persistence are poorly understood, and the emergence of drug-resistant tuberculosis makes the development of effective new treatments an urgent challenge. Understanding the ability of M. tuberculosis to switch between replicating and non-replicating states during infection and disease is central to the search for improved treatments. The number of copies of a protein produced by a cell is generally viewed as being determined by the number of mRNA transcripts, but recent findings suggest that ‘specialised ribosomes’ can modify proteome profiles by preferential translation of particular mRNA subsets, particularly in response to stress. mRNA molecules contain specific signals that optimise their interaction with ribosomes; known as leader sequences, these include the Shine-Dalgarno (SD) sequence required for canonical translation initiation in bacteria. I recently demonstrated that M. tuberculosis expresses an unexpected number of leaderless mRNA transcripts that lack the SD sequence. In Escherichia coli, only a few leaderless transcripts have been described and they are selectively translated by specialised ribosomes. I propose to test the hypothesis that differential translation of mRNA subsets contributes to M. tuberculosis persistence and drug susceptibility. I will investigate the importance of selective translation of leaderless and SD mRNAs in the context of adaptation to stress and drug resistance in M. tuberculosis, using cutting-edge experimental techniques combined with bioinformatic analyses. The proposed project addresses the fundamental systems biology challenge of establishing quantitative correlations between transcriptome and proteome data, and beyond contributing to the rational design of novel treatments to cure tuberculosis, could help to re-shape classical paradigms of bacterial gene regulation.
|year||authors and title||journal||last update|
Dimitrios Evangelopoulos, Gareth A. Prosser, Angela Rodgers, Belinda M. Dagg, Bhagwati Khatri, Mei Mei Ho, Maximiliano G. Gutierrez, Teresa Cortes, Luiz Pedro S. de Carvalho
Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12074-z
|Nature Communications 10/1||2020-02-04|
Ãlvaro Chiner-Oms, Michael Berney, Christine Boinett, Fernando GonzÃ¡lez-Candelas, Douglas B. Young, Sebastien Gagneux, William R. Jacobs, Julian Parkhill, Teresa Cortes, IÃ±aki Comas
Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11948-6
|Nature Communications 10/1||2020-01-24|
Elizabeth B Sawyer, Anna D Grabowska, Teresa Cortes
Translational regulation in mycobacteria and its implications for pathogenicity
published pages: 6950-6961, ISSN: 0305-1048, DOI: 10.1093/nar/gky574
|Nucleic Acids Research 46/14||2020-01-24|
Teresa Cortes, Olga T. Schubert, Amir Banaei-Esfahani, Ben C. Collins, Ruedi Aebersold, Douglas B. Young
Delayed effects of transcriptional responses in Mycobacterium tuberculosis exposed to nitric oxide suggest other mechanisms involved in survival
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-08306-1
|Scientific Reports 7/1||2020-01-24|
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The information about "MTBTRANSREG" are provided by the European Opendata Portal: CORDIS opendata.