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Mechanism and functional impact of ultra-long 3’ UTRs in the Drosophila nervous system

Total Cost €


EC-Contrib. €






 Neuro-UTR project word cloud

Explore the words cloud of the Neuro-UTR project. It provides you a very rough idea of what is the project "Neuro-UTR" about.

create    mechanistic    mrnas    recruitment    employ    understand    untranslated    health    memory    disease    elav    give    proteomics    genes    mechanisms    ultra    causes    hundreds    aging    utrs    extension    striking    transcriptional    biochemistry    drosophila    employing    alternative    regulatory    animal    promoter    gene    cell    underlying    journey    link    binding    neurological    occurs    drastic    destination    promoters    transcription    unpublished    association    genetics    synapse    framework    nascent    humans    mediated    co    ing    plays    functional    communication    first    molecular    govern    flies    utr    neuronal    protein    hypothesise    deregulation    function    regulation    unknown    mrna    diseases    synthesis    nucleus    avenue    genomics    effector    impacts    imaging    site    nervous    plasticity    synaptic    follow    integrate    biogenesis    discovered    rna    lengthening    neurons    extended    central    initiation    region    model   

Project "Neuro-UTR" data sheet

The following table provides information about the project.


Organization address
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙497˙500 €
 EC max contribution 1˙497˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Neurons employ cell-specific gene regulatory mechanisms. One particularly striking process is the recently discovered, drastic lengthening of the 3’ untranslated region (3’ UTR) of hundreds of genes, which occurs in neurons from flies to humans. The function of the resulting ultra-long 3’ UTRs is unknown. RNA deregulation plays a central role in neurological diseases; to understand underlying causes, it is essential to study regulatory processes and define the function of these novel 3’ UTRs. In Drosophila, the neuronal RNA-binding protein ELAV is the main effector of nervous system specific 3’ UTR extension. ELAV’s association with the promoter region of its target genes is required for synthesis of alternative, ultra-long 3’ UTRs. The mechanistic framework of this novel and exciting link between transcription initiation and alternative 3’ end processing is not understood yet. We hypothesise that mRNAs carrying ultra-long 3’ UTRs create an important communication avenue between transcription regulation and synaptic function. In this proposal, we will study the regulation of ELAV-mediated 3’ UTR extension in a Drosophila model. First, we will provide mechanistic insight into the co-transcriptional processes that give rise to ultra-long 3’ UTRs. Employing genomics, proteomics and biochemistry, we will study the recruitment of ELAV at gene promoters and to nascent mRNA. Second, we will follow the journey of extended mRNAs from their site of synthesis to their destination using imaging, proteomics, and functional genetics. Finally, based on our unpublished results that 3’ UTR plasticity impacts neuronal function, we will analyse the role of ultra-long 3’ UTRs in memory, aging and disease. Our study will integrate the molecular mechanisms that govern biogenesis and function of ultra-long 3’ UTRs, from nucleus to synapse, in an animal model. The results of this research will create a major impact on our understanding of neuronal gene regulation in health and disease.

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lastchecktime (2021-01-24 12:58:11) correctly updated