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Neuro-UTR SIGNED

Mechanism and functional impact of ultra-long 3’ UTRs in the Drosophila nervous system

Total Cost €

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EC-Contrib. €

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Partnership

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 Neuro-UTR project word cloud

Explore the words cloud of the Neuro-UTR project. It provides you a very rough idea of what is the project "Neuro-UTR" about.

association    unpublished    synapse    mediated    first    alternative    proteomics    co    underlying    utr    memory    framework    functional    nascent    regulatory    diseases    deregulation    avenue    plasticity    function    central    plays    recruitment    mrna    biogenesis    elav    destination    integrate    effector    disease    drosophila    govern    link    flies    genes    employing    transcription    lengthening    discovered    neurons    imaging    nervous    promoters    gene    ing    biochemistry    genomics    molecular    untranslated    extended    causes    health    neurological    humans    regulation    impacts    communication    genetics    unknown    mechanisms    create    promoter    binding    protein    model    extension    journey    site    ultra    neuronal    follow    animal    synaptic    striking    occurs    employ    aging    cell    nucleus    transcriptional    rna    drastic    region    understand    initiation    mechanistic    mrnas    synthesis    hypothesise    give    hundreds    utrs   

Project "Neuro-UTR" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙497˙500 €
 EC max contribution 1˙497˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙497˙500.00

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 Project objective

Neurons employ cell-specific gene regulatory mechanisms. One particularly striking process is the recently discovered, drastic lengthening of the 3’ untranslated region (3’ UTR) of hundreds of genes, which occurs in neurons from flies to humans. The function of the resulting ultra-long 3’ UTRs is unknown. RNA deregulation plays a central role in neurological diseases; to understand underlying causes, it is essential to study regulatory processes and define the function of these novel 3’ UTRs. In Drosophila, the neuronal RNA-binding protein ELAV is the main effector of nervous system specific 3’ UTR extension. ELAV’s association with the promoter region of its target genes is required for synthesis of alternative, ultra-long 3’ UTRs. The mechanistic framework of this novel and exciting link between transcription initiation and alternative 3’ end processing is not understood yet. We hypothesise that mRNAs carrying ultra-long 3’ UTRs create an important communication avenue between transcription regulation and synaptic function. In this proposal, we will study the regulation of ELAV-mediated 3’ UTR extension in a Drosophila model. First, we will provide mechanistic insight into the co-transcriptional processes that give rise to ultra-long 3’ UTRs. Employing genomics, proteomics and biochemistry, we will study the recruitment of ELAV at gene promoters and to nascent mRNA. Second, we will follow the journey of extended mRNAs from their site of synthesis to their destination using imaging, proteomics, and functional genetics. Finally, based on our unpublished results that 3’ UTR plasticity impacts neuronal function, we will analyse the role of ultra-long 3’ UTRs in memory, aging and disease. Our study will integrate the molecular mechanisms that govern biogenesis and function of ultra-long 3’ UTRs, from nucleus to synapse, in an animal model. The results of this research will create a major impact on our understanding of neuronal gene regulation in health and disease.

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The information about "NEURO-UTR" are provided by the European Opendata Portal: CORDIS opendata.

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