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Neuro-UTR SIGNED

Mechanism and functional impact of ultra-long 3’ UTRs in the Drosophila nervous system

Total Cost €

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EC-Contrib. €

0

Partnership

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 Neuro-UTR project word cloud

Explore the words cloud of the Neuro-UTR project. It provides you a very rough idea of what is the project "Neuro-UTR" about.

mechanisms    mrnas    neurons    nervous    animal    protein    destination    molecular    link    understand    communication    create    underlying    imaging    genomics    journey    diseases    synthesis    alternative    gene    lengthening    co    region    framework    nucleus    synaptic    ing    elav    hundreds    genes    utrs    deregulation    ultra    regulation    neuronal    humans    memory    aging    initiation    cell    avenue    site    plays    unknown    mechanistic    extended    mrna    follow    promoter    discovered    nascent    mediated    central    flies    health    model    employing    hypothesise    causes    govern    neurological    genetics    promoters    drosophila    biogenesis    rna    synapse    plasticity    drastic    extension    striking    functional    disease    occurs    utr    regulatory    function    impacts    first    proteomics    unpublished    biochemistry    untranslated    binding    association    employ    transcriptional    integrate    give    effector    transcription    recruitment   

Project "Neuro-UTR" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙497˙500 €
 EC max contribution 1˙497˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙497˙500.00

Map

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 Project objective

Neurons employ cell-specific gene regulatory mechanisms. One particularly striking process is the recently discovered, drastic lengthening of the 3’ untranslated region (3’ UTR) of hundreds of genes, which occurs in neurons from flies to humans. The function of the resulting ultra-long 3’ UTRs is unknown. RNA deregulation plays a central role in neurological diseases; to understand underlying causes, it is essential to study regulatory processes and define the function of these novel 3’ UTRs. In Drosophila, the neuronal RNA-binding protein ELAV is the main effector of nervous system specific 3’ UTR extension. ELAV’s association with the promoter region of its target genes is required for synthesis of alternative, ultra-long 3’ UTRs. The mechanistic framework of this novel and exciting link between transcription initiation and alternative 3’ end processing is not understood yet. We hypothesise that mRNAs carrying ultra-long 3’ UTRs create an important communication avenue between transcription regulation and synaptic function. In this proposal, we will study the regulation of ELAV-mediated 3’ UTR extension in a Drosophila model. First, we will provide mechanistic insight into the co-transcriptional processes that give rise to ultra-long 3’ UTRs. Employing genomics, proteomics and biochemistry, we will study the recruitment of ELAV at gene promoters and to nascent mRNA. Second, we will follow the journey of extended mRNAs from their site of synthesis to their destination using imaging, proteomics, and functional genetics. Finally, based on our unpublished results that 3’ UTR plasticity impacts neuronal function, we will analyse the role of ultra-long 3’ UTRs in memory, aging and disease. Our study will integrate the molecular mechanisms that govern biogenesis and function of ultra-long 3’ UTRs, from nucleus to synapse, in an animal model. The results of this research will create a major impact on our understanding of neuronal gene regulation in health and disease.

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