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Neuro-UTR SIGNED

Mechanism and functional impact of ultra-long 3’ UTRs in the Drosophila nervous system

Total Cost €

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EC-Contrib. €

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Partnership

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 Neuro-UTR project word cloud

Explore the words cloud of the Neuro-UTR project. It provides you a very rough idea of what is the project "Neuro-UTR" about.

transcription    utr    framework    memory    animal    ultra    create    integrate    lengthening    employ    promoter    biochemistry    mediated    association    nucleus    drosophila    understand    nervous    nascent    disease    biogenesis    protein    functional    proteomics    genes    plays    drastic    promoters    destination    transcriptional    striking    regulatory    follow    alternative    region    hypothesise    mrnas    model    synaptic    humans    elav    communication    link    hundreds    neuronal    mrna    untranslated    plasticity    genetics    genomics    imaging    central    first    aging    occurs    cell    causes    binding    flies    avenue    initiation    utrs    diseases    give    regulation    unpublished    govern    unknown    impacts    deregulation    site    rna    molecular    function    synthesis    extended    co    neurological    mechanistic    recruitment    discovered    effector    neurons    ing    underlying    synapse    gene    journey    employing    health    extension    mechanisms   

Project "Neuro-UTR" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙497˙500 €
 EC max contribution 1˙497˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙497˙500.00

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 Project objective

Neurons employ cell-specific gene regulatory mechanisms. One particularly striking process is the recently discovered, drastic lengthening of the 3’ untranslated region (3’ UTR) of hundreds of genes, which occurs in neurons from flies to humans. The function of the resulting ultra-long 3’ UTRs is unknown. RNA deregulation plays a central role in neurological diseases; to understand underlying causes, it is essential to study regulatory processes and define the function of these novel 3’ UTRs. In Drosophila, the neuronal RNA-binding protein ELAV is the main effector of nervous system specific 3’ UTR extension. ELAV’s association with the promoter region of its target genes is required for synthesis of alternative, ultra-long 3’ UTRs. The mechanistic framework of this novel and exciting link between transcription initiation and alternative 3’ end processing is not understood yet. We hypothesise that mRNAs carrying ultra-long 3’ UTRs create an important communication avenue between transcription regulation and synaptic function. In this proposal, we will study the regulation of ELAV-mediated 3’ UTR extension in a Drosophila model. First, we will provide mechanistic insight into the co-transcriptional processes that give rise to ultra-long 3’ UTRs. Employing genomics, proteomics and biochemistry, we will study the recruitment of ELAV at gene promoters and to nascent mRNA. Second, we will follow the journey of extended mRNAs from their site of synthesis to their destination using imaging, proteomics, and functional genetics. Finally, based on our unpublished results that 3’ UTR plasticity impacts neuronal function, we will analyse the role of ultra-long 3’ UTRs in memory, aging and disease. Our study will integrate the molecular mechanisms that govern biogenesis and function of ultra-long 3’ UTRs, from nucleus to synapse, in an animal model. The results of this research will create a major impact on our understanding of neuronal gene regulation in health and disease.

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The information about "NEURO-UTR" are provided by the European Opendata Portal: CORDIS opendata.

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