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ABLASE SIGNED

Advanced Bioderived and Biocompatible Lasers

Total Cost €

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EC-Contrib. €

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Partnership

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 ABLASE project word cloud

Explore the words cloud of the ABLASE project. It provides you a very rough idea of what is the project "ABLASE" about.

photonics    unmatched    gfp    organisms    monitoring    biocompatible    modern    transform    nobel    found    imaging    bioengineered    schemes    resonators    biomolecules    time    opening    poorly    inter    proteins    erc    microscopy    successful    unprecedented    detection    bio    team    intrinsically    dense    pioneering    mechanical    genetically    intracellular    laser    2008    biological    occurring    cell    demonstrated    probes    truly    molecules    completely    wavelength    coherent    genetic    stimulated    rely    science    synergies    phenomena    physical    inspire    brightly    structure    pressure    chemistry    multiplexing    combined    entirely    shared    feedback    sensing    species    external    engineering    emission    edge    lasers    optical    lasing    prize    coupling    source    first    stand    living    emitters    programmed    disciplinary    alone    host    create    ways    naturally    single    bridging    synthetic    fluorescent    few    bulky    competitive    microscopic    impractical    green    nano    discovery    fluorescence    led    exclusive    material    nature    evolutionarily    attract    light    vivo    biolaser    protein   

Project "ABLASE" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS 

Organization address
address: NORTH STREET 66 COLLEGE GATE
city: ST ANDREWS
postcode: KY16 9AJ
website: www.st-andrews.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙499˙875 €
 EC max contribution 1˙499˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS UK (ST ANDREWS) coordinator 1˙499˙875.00

Map

 Project objective

Naturally occurring optical phenomena attract great attention and transform our ability to study biological processes, with “the discovery and development of the green fluorescent protein (GFP)” (Nobel Prize in Chemistry 2008) being a particularly successful example. Although found only in very few species in nature, most organisms can be genetically programmed to produce the brightly fluorescent GFP molecules. Combined with modern fluorescence detection schemes, this has led to entirely new ways of monitoring biological processes. The applicant now demonstrated a biological laser – a completely novel, living source of coherent light based on a single biological cell bioengineered to produce GFP. Such a laser is intrinsically biocompatible, thus offering unique properties not shared by any existing laser. However, the physical processes involved in lasing from GFP remain poorly understood and so far biological lasers rely on bulky, impractical external resonators for optical feedback. Within this project, the applicant and his team will develop for the first time an understanding of stimulated emission in GFP and related proteins and create an unprecedented stand-alone single-cell biolaser based on intracellular optical feedback. These lasers will be deployed as microscopic and biocompatible imaging probes, thus opening in vivo microscopy to dense wavelength-multiplexing and enabling unmatched sensing of biomolecules and mechanical pressure. The evolutionarily evolved nano-structure of GFP will also enable novel ways of studying strong light-matter coupling and will bio-inspire advances of synthetic emitters. The proposed project is inter-disciplinary by its very nature, bridging photonics, genetic engineering and material science. The applicant’s previous pioneering work and synergies with work on other lasers developed at the applicant’s host institution provide an exclusive competitive edge. ERC support would transform this into a truly novel field of research.

 Publications

year authors and title journal last update
List of publications.
2018 Alasdair H. Fikouras, Marcel Schubert, Markus Karl, Jothi D. Kumar, Simon J. Powis, Andrea Di Falco, Malte C. Gather
Non-obstructive intracellular nanolasers
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07248-0
Nature Communications 9/1 2020-02-05
2017 Laura Tropf, Christof P. Dietrich, Stefanie Herbst, Alexander L. Kanibolotsky, Peter J. Skabara, Frank Würthner, Ifor D. W. Samuel, Malte C. Gather, Sven Höfling
Influence of optical material properties on strong coupling in organic semiconductor based microcavities
published pages: 153302, ISSN: 0003-6951, DOI: 10.1063/1.4978646
Applied Physics Letters 110/15 2020-01-24
2017 M Karl, C P Dietrich, M Schubert, I D W Samuel, G A Turnbull, M C Gather
Single cell induced optical confinement in biological lasers
published pages: 84005, ISSN: 0022-3727, DOI: 10.1088/1361-6463/aa5367
Journal of Physics D: Applied Physics 50/8 2020-01-24
2018 Martin Held, Arko Graf, Yuriy Zakharko, Pengning Chao, Laura Tropf, Malte C. Gather, Jana Zaumseil
Ultrastrong Coupling of Electrically Pumped Near-Infrared Exciton-Polaritons in High Mobility Polymers
published pages: 1700962, ISSN: 2195-1071, DOI: 10.1002/adom.201700962
Advanced Optical Materials 6/3 2020-01-24
2017 Nils M. Kronenberg, Philipp Liehm, Anja Steude, Johanna A. Knipper, Jessica G. Borger, Giuliano Scarcelli, Kristian Franze, Simon J. Powis, Malte C. Gather
Long-term imaging of cellular forces with high precision by elastic resonator interference stress microscopy
published pages: 864-872, ISSN: 1465-7392, DOI: 10.1038/ncb3561
Nature Cell Biology 19/7 2020-01-24
2017 Arko Graf, Martin Held, Yuriy Zakharko, Laura Tropf, Malte C. Gather, Jana Zaumseil
Electrical pumping and tuning of exciton-polaritons in carbon nanotube microcavities
published pages: 911-917, ISSN: 1476-1122, DOI: 10.1038/nmat4940
Nature Materials 16/9 2020-01-24
2018 Markus Karl, James M. E. Glackin, Marcel Schubert, Nils M. Kronenberg, Graham A. Turnbull, Ifor D. W. Samuel, Malte C. Gather
Flexible and ultra-lightweight polymer membrane lasers
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03874-w
Nature Communications 9/1 2020-01-24
2017 Christof P. Dietrich, Markus Karl, Jürgen Ohmer, Utz Fischer, Malte C. Gather, Sven Höfling
Molding Photonic Boxes into Fluorescent Emitters by Direct Laser Writing
published pages: 1605236, ISSN: 0935-9648, DOI: 10.1002/adma.201605236
Advanced Materials 29/16 2020-01-24
2018 Laura Tropf, Malte C. Gather
Investigating the Onset of the Strong Coupling Regime by Fine-Tuning the Rabi Splitting in Multilayer Organic Microcavities
published pages: 1800203, ISSN: 2195-1071, DOI: 10.1002/adom.201800203
Advanced Optical Materials 2020-01-24
2018 Kathryn E. Haley, Nils M. Kronenberg, Philipp Liehm, Mustafa Elshani, Cameron Bell, David J. Harrison, Malte C. Gather, Paul A. Reynolds
Podocyte injury elicits loss and recovery of cellular forces
published pages: eaap8030, ISSN: 2375-2548, DOI: 10.1126/sciadv.aap8030
Science Advances 4/6 2020-01-24
2018 Arko Graf, Caroline Murawski, Yuriy Zakharko, Jana Zaumseil, Malte C. Gather
Infrared Organic Light-Emitting Diodes with Carbon Nanotube Emitters
published pages: 1706711, ISSN: 0935-9648, DOI: 10.1002/adma.201706711
Advanced Materials 30/12 2020-01-24
2016 C. P. Dietrich, A. Steude, L. Tropf, M. Schubert, N. M. Kronenberg, K. Ostermann, S. Ho fling, M. C. Gather
An exciton-polariton laser based on biologically produced fluorescent protein
published pages: e1600666-e160066, ISSN: 2375-2548, DOI: 10.1126/sciadv.1600666
Science Advances 2/8 2020-01-24
2016 Arko Graf, Laura Tropf, Yuriy Zakharko, Jana Zaumseil, Malte C. Gather
Near-infrared exciton-polaritons in strongly coupled single-walled carbon nanotube microcavities
published pages: 13078, ISSN: 2041-1723, DOI: 10.1038/ncomms13078
Nature Communications 7 2020-01-24
2015 Matjaž Humar, Malte C. Gather, Seok-Hyun Yun
Cellular dye lasers: lasing thresholds and sensing in a planar resonator
published pages: 27865, ISSN: 1094-4087, DOI: 10.1364/OE.23.027865
Optics Express 23/21 2020-01-24
2017 Christof P. Dietrich, Anja Steude, Marcel Schubert, Jürgen Ohmer, Utz Fischer, Sven Höfling, Malte C. Gather
Strong Coupling in Fully Tunable Microcavities Filled with Biologically Produced Fluorescent Proteins
published pages: 1600659, ISSN: 2195-1071, DOI: 10.1002/adom.201600659
Advanced Optical Materials 5/1 2020-01-24
2016 Markus Karl, Guy L. Whitworth, Marcel Schubert, Christof P. Dietrich, Ifor D. W. Samuel, Graham A. Turnbull, Malte C. Gather
Optofluidic distributed feedback lasers with evanescent pumping: Reduced threshold and angular dispersion analysis
published pages: 261101, ISSN: 0003-6951, DOI: 10.1063/1.4954650
Applied Physics Letters 108/26 2020-01-24
2017 Marcel Schubert, Klara Volckaert, Markus Karl, Andrew Morton, Philipp Liehm, Gareth B. Miles, Simon J. Powis, Malte C. Gather
Lasing in Live Mitotic and Non-Phagocytic Cells by Efficient Delivery of Microresonators
published pages: 40877, ISSN: 2045-2322, DOI: 10.1038/srep40877
Scientific Reports 7 2020-01-24

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