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Neuronal MRI

Neuronal MRI: Harnessing chemical exchange between N-Acetylaspartate and water for functional imaging of neural activity

Total Cost €

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EC-Contrib. €

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 Neuronal MRI project word cloud

Explore the words cloud of the Neuronal MRI project. It provides you a very rough idea of what is the project "Neuronal MRI" about.

reached    data    sizes    dynamics    cest    resonance    hitherto    posit    arduous    hence    impart    neurons    report    multiplexing    swellings    combining    relies    auditory    sensitive    selective    extraordinarily    harnessing    physics    diffusion    truly    cell    mri    restricted    firing    function    impactful    successful    modality    compressed    enhancement    frameworks    sensing    full    pave    interdisciplinary    difficult    sequences    methodology    fmri    specificity    circuit    transfer    consists    noninvasive    latest    imaging    saturation    timescale    subtle    reflect    disciplines    neuronal    surrogate    fast    coverage    health    chemistry    borrowing    confined    arising    disease    vivo    engineering    probe    chemical    ultra    model    interpret    naa    neural    exchange    summary    reconstruction    nonspecific    functional    sense    hemodynamic    downfield    population    ms    calls    validation    implementing    techniques    nmri    experiments    unexplored    rigorous    marker    metabolite    effort    cellular    brain    acetylaspartate    imparting    direct    solely   

Project "Neuronal MRI" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD 

Organization address
address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD
city: LISBOA
postcode: 1400-038
website: http://fchampalimaud.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website https://shemeshlab.org/research/
 Total cost 148˙635 €
 EC max contribution 148˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2019-08-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD PT (LISBOA) coordinator 148˙635.00

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 Project objective

Functional MRI (fMRI) is currently the leading noninvasive modality to assess brain function in vivo. However, it relies on a surrogate marker for neural activity –the hemodynamic responses following activity– which makes fMRI nonspecific and difficult to interpret. Here, we propose to advance the state-of-the-art by developing and evaluating a methodology we term neuronal fMRI (nMRI) which would enable a direct measurement of neuronal activity and its fast dynamics. Achieving this arduous goal calls for a truly interdisciplinary effort, borrowing concepts from Chemistry (Chemical Exchange Saturation Transfer (CEST) of a neuronal-selective metabolite to impart specificity, restricted diffusion to probe cell sizes), Physics and Engineering (advanced MRI and reconstruction methods). Our general approach consists of a development-validation-application design, thus our main objectives are: 1. Harnessing the hitherto unexplored downfield resonance of N-Acetylaspartate (NAA) –a metabolite confined solely to neurons– in CEST MRI experiments, thus imparting specificity towards the neuronal population; combining this specificity enhancement with diffusion MRI sequences that are extraordinarily sensitive to cellular sizes, and hence are able to sense subtle cell-swellings arising upon neuronal firing. This new method, which we term neuronal-MRI (nMRI) will thus report on neuronal swellings, and as such reflect activity directly. 2. Implementing ultra-fast imaging techniques based on data multiplexing and the latest compressed sensing frameworks to nMRI, such that the 50 ms timescale can be reached with full brain coverage. This will allow the measurement of fast neuronal activity dynamics in the brain. 3. Applying nMRI to study the auditory circuit as a model system in-vivo. In summary, we posit that nMRI –upon successful implementation and rigorous testing– will be highly impactful in many disciplines, and pave the way to study the neuronal population in health and disease.

 Publications

year authors and title journal last update
List of publications.
2018 Guilherme Blazquez Freches, Cristina Chavarrias, Noam Shemesh
BOLD-fMRI in the mouse auditory pathway
published pages: 265-277, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.10.027
NeuroImage 165 2020-02-25

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