Explore the words cloud of the PERSYST project. It provides you a very rough idea of what is the project "PERSYST" about.
The following table provides information about the project.
HUMANITAS MIRASOLE SPA
|Coordinator Country||Italy [IT]|
|Total cost||1˙500˙000 €|
|EC max contribution||1˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-09-01 to 2021-05-31|
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|1||HUMANITAS MIRASOLE SPA||IT (ROZZANO (MI))||coordinator||1˙500˙000.00|
Defining the molecular mechanisms governing memory T cell differentiation and homeostasis is of pivotal importance to generate durable and protective T cell responses against infections and cancers. Considerable knowledge in this regard has been acquired in mouse models but is still limited about human T cells. In particular, some mechanisms are assumed to occur in humans but were never formally demonstrated. We showed that memory T cells adoptively-transferred with bone marrow transplantation failed to persist in recipient hosts in the absence of antigen. By contrast, self/tumor-specific naïve T cells rapidly acquired T memory stem cell (TSCM) attributes and subsequently reconstituted the memory T cell pool by homeostatic differentiation. Current models indicate human TSCM cells as superior to conventional memory T cells in regards to effector potential and persistence capacity. Genome-wide expression analysis identified candidate TSCM cell-specific transcriptional regulators that were shown to inhibit senescence, promote self-renewal and regulate somatic differentiation. In this project, by using single cell technologies, primary human samples and in vivo humanized models, we will define the molecular mechanisms at the basis of memory T cell formation and maintenance in humans. We will initially define the antigenic requirement for the long-term persistence of memory T cells by following the fate of adoptively-transferred T cells. As the field remains unexplored, we will investigate the acquisition of memory attributes by self/tumor-specific T cells on multiple functional levels. The gene products specifically expressed by self-renewing TSCM cells will be finally tested for their capability to arrest T cell differentiation and generate long-lived memory T cells with enhanced stem cell-like properties. Our results will impact multiple physiological and pathological situations involving T cell-mediated immune responses.
|year||authors and title||journal||last update|
Gabriele De Simone, Emilia M. C. Mazza, Antonino Cassotta, Alexey N. Davydov, Mirela Kuka, Veronica Zanon, Federica De Paoli, Eloise Scamardella, Maria Metsger, Alessandra Roberto, Karolina Pilipow, Federico S. Colombo, Elena Tenedini, Enrico Tagliafico, Luca Gattinoni, Domenico Mavilio, Clelia Peano, David A. Price, Satya P. Singh, Joshua M. Farber, Valentina Serra, Francesco Cucca, Francesco Fer
CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential
published pages: , ISSN: 0022-1767, DOI:
|Journal of Immunology||2020-04-15|
Kared H, Tan SW, Lau MC, Chevrier M, Tan C, How W, Wong G, Strickland M, Malleret B, Amoah A, Pilipow K, Zanon V, Govern NM, Lum J, Chen JM, Lee B, Florian MC, Geiger H, Ginhoux F, Ruiz-Mateos E, Fulop T, Rajasuriar R, Kamarulzaman A, Ng TP, Lugli E, Larbi A.
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
published pages: , ISSN: 2041-1723, DOI:
Veronica Zanon, Karolina Pilipow, Eloise Scamardella, Federica De Paoli, Gabriele De Simone, David A. Price, Amaia Martinez Usatorre, Pedro Romero, Domenico Mavilio, Alessandra Roberto, Enrico Lugli
Curtailed T-cell activation curbs effector differentiation and generates CD8 + T cells with a naturally-occurring memory stem cell phenotype
published pages: 1468-1476, ISSN: 0014-2980, DOI: 10.1002/eji.201646732
|European Journal of Immunology 47/9||2020-02-26|
Karolina Pilipow, Eloise Scamardella, Simone Puccio, Sanjivan Gautam, Federica De Paoli, Emilia M.C. Mazza, Gabriele De Simone, Sara Polletti, Marta Buccilli, Veronica Zanon, Pietro Di Lucia, Matteo Iannacone, Luca Gattinoni, Enrico Lugli
Antioxidant metabolism regulates CD8+ T memory stem cell formation and antitumor immunity
published pages: , ISSN: 2379-3708, DOI:
Emilia Maria Cristina Mazza, Jolanda Brummelman, Giorgia Alvisi, Alessandra Roberto, Federica De Paoli, Veronica Zanon, Federico Colombo, Mario Roederer, Enrico Lugli
Background fluorescence and spreading error are major contributors of variability in highâ€dimensional flow cytometry data visualization by tâ€distributed stochastic neighboring embedding
published pages: , ISSN: 1552-4930, DOI:
|Cytometry Part A||2020-02-26|
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