JointPrinting SIGNED
3D Printing of Cell Laden Biomimetic Materials and Biomolecules for Joint Regeneration
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0JointPrinting project word cloud
Explore the words cloud of the JointPrinting project. It provides you a very rough idea of what is the project "JointPrinting" about.
Project "JointPrinting" data sheet
The following table provides information about the project.
| Coordinator |
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Organization address contact info |
| Coordinator Country | Ireland [IE] |
| Total cost | 1˙999˙700 € |
| EC max contribution | 1˙999˙700 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-09-01 to 2020-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN | IE (DUBLIN) | coordinator | 1˙999˙700.00 |
Map
Project objective
Osteoarthritis (OA) is a serious disease of the joints affecting nearly 10% of the population worldwide. Realising an efficacious therapeutic solution for treating OA remains one of the greatest challenges in the field of orthopaedic medicine. This proposal envisions a future where 3D bioprinting systems located in hospitals will provide ‘off-the-shelf’, patient-specific biological implants to treat diseases such as OA. To realise this vision, this project will use 3D bioprinting to generate anatomically accurate, biomimetic constructs that can be used to regenerate both the cartilage and bone in a diseased joint. The first aim of this proposal is to print a mesenchymal stem cell laden biomaterial that is both immediately load bearing and can facilitate the regeneration of articular cartilage in vivo, such that the bioprinted construct will not require in vitro maturation prior to implantation. Mechanical function will be realised by integrating an interpenetrating network hydrogel into a 3D printed polymeric scaffold, while chondro-inductivity will be enhanced by the spatially-defined incorporation of cartilage extracellular matrix components and chondrogenic growth factors into the bioprinted construct. The second aim of the proposal is to use 3D bioprinting to create a cell-free, composite construct to facilitate regeneration of the bony region of a large osteochondral defect, where vascularization will be accelerated by immobilizing spatial gradients of vascular endothelial growth factor into the implant. The third aim of the proposal is to scale-up the proposed 3D bioprinted construct to enable whole joint regeneration. Finite element modelling will be used determine the optimal structural characteristics of the scaled-up implant for it to fulfil its required mechanical function. If successful, such an implant would form the basis of a truly transformative therapy for treating degenerative joint disease.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Swetha Rathan, Léa Dejob, Rossana Schipani, Benjamin Haffner, Matthias E. Möbius, Daniel J. Kelly Fiber Reinforced Cartilage ECM Functionalized Bioinks for Functional Cartilage Tissue Engineering published pages: 1801501, ISSN: 2192-2640, DOI: 10.1002/adhm.201801501 |
Advanced Healthcare Materials 8/7 | 2020-03-13 |
| 2020 |
Rossana Schipani, David R. Nolan, Caitrίona Lally, Daniel J. Kelly Integrating finite element modelling and 3D printing to engineer biomimetic polymeric scaffolds for tissue engineering published pages: 174-189, ISSN: 0300-8207, DOI: 10.1080/03008207.2019.1656720 |
Connective Tissue Research 61/2 | 2020-03-13 |
| 2019 |
FE Freeman, DC Browe, J Nulty, S Von Euw, WL Grayson, DJ Kelly Biofabrication of multiscale bone extracellular matrix scaffolds for bone tissue engineering published pages: 168-187, ISSN: 1473-2262, DOI: 10.22203/ecm.v038a12 |
European Cells and Materials 38 | 2020-03-13 |
| 2018 |
Andrew C. Daly, Pierluca Pitacco, Jessica Nulty, Gráinne M. Cunniffe, Daniel J. Kelly 3D printed microchannel networks to direct vascularisation during endochondral bone repair published pages: 34-46, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.01.057 |
Biomaterials 162 | 2019-05-31 |
| 2017 |
Andrew C. Daly, Fiona E. Freeman, Tomas Gonzalez-Fernandez, Susan E. Critchley, Jessica Nulty, Daniel J. Kelly 3D Bioprinting for Cartilage and Osteochondral Tissue Engineering published pages: 1700298, ISSN: 2192-2640, DOI: 10.1002/adhm.201700298 |
Advanced Healthcare Materials 6/22 | 2019-05-31 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "JOINTPRINTING" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "JOINTPRINTING" are provided by the European Opendata Portal: CORDIS opendata.