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JointPrinting SIGNED

3D Printing of Cell Laden Biomimetic Materials and Biomolecules for Joint Regeneration

Total Cost €

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EC-Contrib. €

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Partnership

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 JointPrinting project word cloud

Explore the words cloud of the JointPrinting project. It provides you a very rough idea of what is the project "JointPrinting" about.

generate    vascular    shelf    vision    therapeutic    immediately    cell    prior    realise    load    hospitals    treat    nearly    inductivity    fulfil    treating    solution    printed    implant    osteoarthritis    osteochondral    cartilage    laden    implantation    create    articular    stem    population    mesenchymal    disease    mechanical    biomaterial    located    construct    structural    composite    vascularization    chondro    vivo    oa    joint    degenerative    transformative    realised    finite    spatial    print    regeneration    worldwide    polymeric    endothelial    scaled    diseases    10    interpenetrating    matrix    form    bioprinted    components    bearing    free    truly    off    regenerate    diseased    chondrogenic    immobilizing    bone    incorporation    biological    joints    implants    integrating    patient    successful    3d    bioprinting    vitro    serious    function    greatest    hydrogel    maturation    extracellular    first    medicine    network    optimal    accelerated    biomimetic    efficacious    envisions    orthopaedic    defect    constructs    gradients    accurate    scaffold    enhanced    therapy    region    anatomically    realising    basis    bony   

Project "JointPrinting" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 1˙999˙700 €
 EC max contribution 1˙999˙700 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 1˙999˙700.00

Map

 Project objective

Osteoarthritis (OA) is a serious disease of the joints affecting nearly 10% of the population worldwide. Realising an efficacious therapeutic solution for treating OA remains one of the greatest challenges in the field of orthopaedic medicine. This proposal envisions a future where 3D bioprinting systems located in hospitals will provide ‘off-the-shelf’, patient-specific biological implants to treat diseases such as OA. To realise this vision, this project will use 3D bioprinting to generate anatomically accurate, biomimetic constructs that can be used to regenerate both the cartilage and bone in a diseased joint. The first aim of this proposal is to print a mesenchymal stem cell laden biomaterial that is both immediately load bearing and can facilitate the regeneration of articular cartilage in vivo, such that the bioprinted construct will not require in vitro maturation prior to implantation. Mechanical function will be realised by integrating an interpenetrating network hydrogel into a 3D printed polymeric scaffold, while chondro-inductivity will be enhanced by the spatially-defined incorporation of cartilage extracellular matrix components and chondrogenic growth factors into the bioprinted construct. The second aim of the proposal is to use 3D bioprinting to create a cell-free, composite construct to facilitate regeneration of the bony region of a large osteochondral defect, where vascularization will be accelerated by immobilizing spatial gradients of vascular endothelial growth factor into the implant. The third aim of the proposal is to scale-up the proposed 3D bioprinted construct to enable whole joint regeneration. Finite element modelling will be used determine the optimal structural characteristics of the scaled-up implant for it to fulfil its required mechanical function. If successful, such an implant would form the basis of a truly transformative therapy for treating degenerative joint disease.

 Publications

year authors and title journal last update
List of publications.
2019 Swetha Rathan, Léa Dejob, Rossana Schipani, Benjamin Haffner, Matthias E. Möbius, Daniel J. Kelly
Fiber Reinforced Cartilage ECM Functionalized Bioinks for Functional Cartilage Tissue Engineering
published pages: 1801501, ISSN: 2192-2640, DOI: 10.1002/adhm.201801501
Advanced Healthcare Materials 8/7 2020-03-13
2020 Rossana Schipani, David R. Nolan, Caitrίona Lally, Daniel J. Kelly
Integrating finite element modelling and 3D printing to engineer biomimetic polymeric scaffolds for tissue engineering
published pages: 174-189, ISSN: 0300-8207, DOI: 10.1080/03008207.2019.1656720
Connective Tissue Research 61/2 2020-03-13
2019 FE Freeman, DC Browe, J Nulty, S Von Euw, WL Grayson, DJ Kelly
Biofabrication of multiscale bone extracellular matrix scaffolds for bone tissue engineering
published pages: 168-187, ISSN: 1473-2262, DOI: 10.22203/ecm.v038a12
European Cells and Materials 38 2020-03-13
2018 Andrew C. Daly, Pierluca Pitacco, Jessica Nulty, Gráinne M. Cunniffe, Daniel J. Kelly
3D printed microchannel networks to direct vascularisation during endochondral bone repair
published pages: 34-46, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.01.057
Biomaterials 162 2019-05-31
2017 Andrew C. Daly, Fiona E. Freeman, Tomas Gonzalez-Fernandez, Susan E. Critchley, Jessica Nulty, Daniel J. Kelly
3D Bioprinting for Cartilage and Osteochondral Tissue Engineering
published pages: 1700298, ISSN: 2192-2640, DOI: 10.1002/adhm.201700298
Advanced Healthcare Materials 6/22 2019-05-31

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The information about "JOINTPRINTING" are provided by the European Opendata Portal: CORDIS opendata.

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