Explore the words cloud of the NANOPDICS project. It provides you a very rough idea of what is the project "NANOPDICS" about.
The following table provides information about the project.
UNIVERSIDAD DE LA LAGUNA
|Coordinator Country||Spain [ES]|
|Total cost||1˙999˙742 €|
|EC max contribution||1˙999˙742 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-09-01 to 2020-08-31|
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|1||UNIVERSIDAD DE LA LAGUNA||ES (LA LAGUNA TENERIFE)||coordinator||1˙999˙742.00|
In neurons, sites of Ca2 influx and Ca2 sensors are located within 20-50 nm, in subcellular “Ca2 nanodomains”. Such tight coupling is crucial for the functional properties of synapses and neuronal excitability. Two key players act together in nanodomains, coupling Ca2 signal to membrane potential: the voltage-dependent Ca2 channels (VDCC) and the large conductance Ca2 and voltage-gated K channels (BK). BK channels are characterized by synergistic activation by Ca2 and membrane depolarization, but the complex molecular mechanism underlying channel function is not adequately understood. Information about the pore region, voltage sensing domain or isolated intracellular domains has been obtained separately using electrophysiology, biochemistry and crystallography. Nevertheless, the specialized behavior of this channel must be studied in the whole protein complex at the membrane in order to determine the complete range of structures and movements critical to its in vivo function. Using a combination of genetics, electrophysiology and spectroscopy, our group has measured for the first time the structural rearrangements accompanying whole BK channel activation at the membrane. From this unique position, our first goal is to fully determine the real time structural dynamics underlying the molecular coupling of Ca2, voltage and activation of BK channels in the membrane environment, its regulation by accessory subunits and channel effectors. BK subcellular localization and role in Ca2 nanodomains make these channels perfect candidates as reporters of local changes in [Ca2] restricted to specific nanodomains close to the neuronal membrane. In our laboratory we have created fluorescent variants of the channel that report BK activity induced by Ca2 binding, or Ca2 binding and voltage. Our second aim in this proposal is to optimize and deploy this novel optoelectrical reporters to study physiologically relevant Ca2-induced processes both in cellular and animal mode
|year||authors and title||journal||last update|
Aravind S. Kshatri, Alberto Gonzalez-Hernandez, Teresa Giraldez
Physiological Roles and Therapeutic Potential of Ca2+ Activated Potassium Channels in the Nervous System
published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2018.00258
|Frontiers in Molecular Neuroscience 11||2020-04-15|
Pablo Miranda, Miguel Holmgren, Teresa Giraldez
Voltage-dependent dynamics of the BK channel cytosolic gating ring are coupled to the membrane-embedded voltage sensor
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.40664
A. Kshatri1,2, A. Cerrada1,2, R. Gimeno1,2, D. BartolomÃ©-MartÃn1,2, P. Rojas3 and T. Giraldez
Differential regulation of BK channels by fragile X mental retardation protein
published pages: , ISSN: , DOI:
|The Journal of General Physiology||2020-04-15|
Elva Martin-Batista, Laura E. Maglio, Natalia Armas-Capote, Guadalberto Hernandez, Diego Alvarez de la Rosa, Teresa Giraldez
Neuronal kinase SGK1.1 protects against brain damage after status epilepticus
published pages: , ISSN: , DOI:
Natalia Armas-Capote, Laura E Maglio, Leonel PÃ©rez-Atencio, Elva Martin-Batista, Antonio Reboreda, Juan A Barios, Guadalberto Hernandez, Diego Alvarez de la Rosa, JosÃ© Antonio Lamas, Luis C Barrio, Teresa Giraldez
SGK1.1 Reduces Kainic Acid-Induced Seizure Severity and Leads to Rapid Termination of Seizures
published pages: , ISSN: 1047-3211, DOI: 10.1093/cercor/bhz302
Aravind S. Kshatri, Alberto J. Gonzalez-Hernandez, Teresa Giraldez
Functional validation of Ca 2+ -binding residues from the crystal structure of the BK ion channel
published pages: 943-952, ISSN: 0005-2736, DOI: 10.1016/j.bbamem.2017.09.023
|Biochimica et Biophysica Acta (BBA) - Biomembranes 1860/4||2019-06-07|
Teresa Giraldez, Brad S. Rothberg
Understanding the conformational motions of RCK gating rings
published pages: 431-441, ISSN: 0022-1295, DOI: 10.1085/jgp.201611726
|The Journal of General Physiology 149/4||2019-06-07|
Pablo Miranda, Teresa Giraldez, Miguel Holmgren
Interactions of divalent cations with calcium binding sites of BK channels reveal independent motions within the gating ring
published pages: 14055-14060, ISSN: 0027-8424, DOI: 10.1073/pnas.1611415113
|Proceedings of the National Academy of Sciences 113/49||2019-06-07|
The GoSlo family of BK channel activators: A no-go for Î³ subunits?
published pages: 1-2, ISSN: 1933-6950, DOI: 10.1080/19336950.2016.1263136
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