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PULTAR

Delivery of PULmonary Therapeutics through TARgetted Delivery using Phononics

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PULTAR project word cloud

Explore the words cloud of the PULTAR project. It provides you a very rough idea of what is the project "PULTAR" about.

nebulisation    disease    closely    shown    innovation    cells    lung    rna    therapy    patients    outcomes    gene    according    generally    aerosols    limitations    mu    380b    worldwide    tissue    ultrasonic    strand    substantial    enhanced    amount    transits    team    vascular    droplet    inhalation    suffer    arterial    sizes    treatment    dalys    precise    aerosol    reduce    nebuliser    routes    diseases    quality    data    barriers    delivered    people    difficult    lungs    respiratory    3m    clinical    asthma    235    proprietary    regions    epithelium    fibrosis    million    monodisperse    genes    accepted    drug    appealing    selective    chronic    medicine    50m    again    deaths    anatomical    64m    therapies    forms    create    healthcare    model    pulmonary    market    gt    obstructive    types    efficacy    improves    mouse    therapeutic    extremely    similarly    medicines    wisdom    biologics    prototype    cystic    hypertension    industry    droplets    commercial    treating    start   

Project "PULTAR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 149˙791 €
 EC max contribution 149˙791 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2016-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 149˙791.00

Map

 Project objective

According to the WHO 235 million people suffer from asthma and 64M people have chronic obstructive pulmonary disease, leading to 3M deaths per year worldwide. The cost of treating patients with all forms of lung disease is ~ €380B p.a., leading to the loss of >50M DALYS. Generally, patients with such respiratory diseases are treated by inhalation of medicines within aerosols, where the therapy (including medicine or biologics used in gene therapy) can be targeted directly to the lung. The accepted wisdom is that such pulmonary delivery requires aerosol droplet sizes of between 1 and 5 μm. We have now shown that by using a new ultrasonic technology, we can create monodisperse aerosol droplets, which could be used for therapeutic delivery of medicines, genes and RNA to specific regions in the lungs. In one strand of the work we aim to demonstrate that this precise nebulisation technology improves the efficacy of treatment through enhanced drug uptake. In a second strand, we will demonstrate selective targeting of different tissue types in the lungs. For example, the epithelium in cystic fibrosis patients is currently extremely difficult to access leading to limitations in the amount and quality of data obtained for pre-clinical and clinical gene therapies. Similarly, targeting vascular cells is an appealing treatment for patients with pulmonary arterial hypertension, although, again, effective delivery necessitates that the therapeutic system transits defined and substantial anatomical barriers. The overall aim is to demonstrate that this new technology can define routes to new therapies, improve clinical outcomes and reduce healthcare costs. To achieve this we will develop a prototype nebuliser based upon proprietary technology and show that different medicines and gene therapies can be delivered effectively to the lungs of a model mouse. We will also start to build a commercial team and work closely with industry to deliver impact and innovation to the market.

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The information about "PULTAR" are provided by the European Opendata Portal: CORDIS opendata.

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