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Micro-GIFT SIGNED

Microrobotic Gamete/Zygote IntraFallopian Transfer

Total Cost €

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EC-Contrib. €

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Partnership

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 Micro-GIFT project word cloud

Explore the words cloud of the Micro-GIFT project. It provides you a very rough idea of what is the project "Micro-GIFT" about.

microbiosensors    sperm    anaesthesia    close    macroscopic    surgical    molecular    invasive    mice    worldwide    ivf    cellular    introduce    11    embryo    microbots    seek    embryonic    clinical    gametes    appropriate    rates    times    clinic    age    issue    quality    body    multifunctional    deeper    preparation    significantly    synchronization    imaging    32    seems    100    release    vivo    gift    ing    contribution    drug    injury    economic    reproductive    zygote    microtechnologies    social    risk    zift    implying    tube    manipulation    95    removal    infertility    critical    variety    insights    untethered    pi    model    tools    smart    optimal    intracytoplasmic    ntrafallopian    size    involve    procedure    microrobots    repeated    fallopian    physiological    icsi    transport    materials    injection    female    environment    contributed    17    overcome    ectopic    vitro    severe    gamete    fertilization    transfer    techniques    micro    endometrial    natural    create    assisted    implantation    population    pregnancies    invasively    zygotes    stage   

Project "Micro-GIFT" data sheet

The following table provides information about the project.

Coordinator
LEIBNIZ-INSTITUT FUER FESTKOERPER- UND WERKSTOFFFORSCHUNG DRESDEN E.V. 

Organization address
address: HELMHOLTZSTRASSE 20
city: DRESDEN
postcode: 1069
website: www.ifw-dresden.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙967 €
 EC max contribution 1˙499˙967 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIBNIZ-INSTITUT FUER FESTKOERPER- UND WERKSTOFFFORSCHUNG DRESDEN E.V. DE (DRESDEN) coordinator 1˙499˙967.00

Map

 Project objective

Infertility is a worldwide problem affecting ~11% of the reproductive-age population. Severe cases are currently treated by in vitro fertilization (IVF) and intracytoplasmic injection techniques (ICSI) with high fertilization rates (~95%). However, embryo transfer is still the critical stage with only 32% of the cases resulting in clinical pregnancies. Moreover, the implantation rates per embryo remain very low (~17%) and often the procedure needs to be repeated several times with no success implying a high economic and social cost. Among the different methods used to overcome this issue, gamete or zygote ntrafallopian transfer (GIFT or ZIFT) seems more promising offering appropriate physiological environment for zygote/embryo development at an optimal synchronization between embryonic and endometrial preparation. However, these methods are invasive and involve surgical procedures and anaesthesia to introduce macroscopic imaging and manipulation tools into the female body, increasing the risk of injury and ectopic pregnancies. The goal of Micro-GIFT is to seek for novel approaches to non-invasively transport and release high-quality gametes/zygotes in the fallopian tube in vivo (mice model). For that multifunctional untethered microrobots (~100 µm size) will be developed making use of smart materials and advanced microtechnologies. However, there are major challenges that need to be overcome to bring this technology close to the clinic, such as the in vivo imaging and control of such microrobots, and their removal after use. The project will also provide deeper insights on the contribution of the fallopian tube on the natural embryo development and implantation, being crucial to create more natural procedures with high success rates. The PI has contributed significantly to the field of sperm-based microbots for assisted fertilization and targeted drug delivery as well as developed a variety of novel microbiosensors for molecular and cellular analysis.

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The information about "MICRO-GIFT" are provided by the European Opendata Portal: CORDIS opendata.

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