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Micro-GIFT SIGNED

Microrobotic Gamete/Zygote IntraFallopian Transfer

Total Cost €

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EC-Contrib. €

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Partnership

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 Micro-GIFT project word cloud

Explore the words cloud of the Micro-GIFT project. It provides you a very rough idea of what is the project "Micro-GIFT" about.

social    surgical    drug    anaesthesia    economic    body    untethered    involve    reproductive    synchronization    introduce    contribution    model    close    materials    pi    age    vitro    embryo    icsi    tube    severe    transfer    environment    appropriate    vivo    multifunctional    critical    32    variety    imaging    cellular    invasive    clinical    100    microtechnologies    preparation    population    tools    issue    mice    natural    implantation    removal    embryonic    times    molecular    insights    manipulation    overcome    risk    release    physiological    micro    transport    microrobots    worldwide    smart    implying    seek    gamete    zift    invasively    quality    procedure    fertilization    macroscopic    intracytoplasmic    significantly    clinic    ntrafallopian    injection    seems    fallopian    techniques    stage    contributed    ivf    female    zygote    create    size    optimal    assisted    ing    deeper    ectopic    pregnancies    repeated    endometrial    sperm    injury    95    17    zygotes    rates    microbots    microbiosensors    gift    11    gametes    infertility   

Project "Micro-GIFT" data sheet

The following table provides information about the project.

Coordinator
LEIBNIZ-INSTITUT FUER FESTKOERPER- UND WERKSTOFFFORSCHUNG DRESDEN E.V. 

Organization address
address: HELMHOLTZSTRASSE 20
city: DRESDEN
postcode: 1069
website: www.ifw-dresden.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙967 €
 EC max contribution 1˙499˙967 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIBNIZ-INSTITUT FUER FESTKOERPER- UND WERKSTOFFFORSCHUNG DRESDEN E.V. DE (DRESDEN) coordinator 1˙499˙967.00

Map

 Project objective

Infertility is a worldwide problem affecting ~11% of the reproductive-age population. Severe cases are currently treated by in vitro fertilization (IVF) and intracytoplasmic injection techniques (ICSI) with high fertilization rates (~95%). However, embryo transfer is still the critical stage with only 32% of the cases resulting in clinical pregnancies. Moreover, the implantation rates per embryo remain very low (~17%) and often the procedure needs to be repeated several times with no success implying a high economic and social cost. Among the different methods used to overcome this issue, gamete or zygote ntrafallopian transfer (GIFT or ZIFT) seems more promising offering appropriate physiological environment for zygote/embryo development at an optimal synchronization between embryonic and endometrial preparation. However, these methods are invasive and involve surgical procedures and anaesthesia to introduce macroscopic imaging and manipulation tools into the female body, increasing the risk of injury and ectopic pregnancies. The goal of Micro-GIFT is to seek for novel approaches to non-invasively transport and release high-quality gametes/zygotes in the fallopian tube in vivo (mice model). For that multifunctional untethered microrobots (~100 µm size) will be developed making use of smart materials and advanced microtechnologies. However, there are major challenges that need to be overcome to bring this technology close to the clinic, such as the in vivo imaging and control of such microrobots, and their removal after use. The project will also provide deeper insights on the contribution of the fallopian tube on the natural embryo development and implantation, being crucial to create more natural procedures with high success rates. The PI has contributed significantly to the field of sperm-based microbots for assisted fertilization and targeted drug delivery as well as developed a variety of novel microbiosensors for molecular and cellular analysis.

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The information about "MICRO-GIFT" are provided by the European Opendata Portal: CORDIS opendata.

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