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Micro-GIFT SIGNED

Microrobotic Gamete/Zygote IntraFallopian Transfer

Total Cost €

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EC-Contrib. €

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Partnership

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 Micro-GIFT project word cloud

Explore the words cloud of the Micro-GIFT project. It provides you a very rough idea of what is the project "Micro-GIFT" about.

untethered    invasively    clinic    critical    appropriate    repeated    preparation    95    seems    social    assisted    icsi    cellular    17    reproductive    removal    issue    stage    100    sperm    11    micro    synchronization    tube    smart    ivf    microrobots    injection    pregnancies    fallopian    implying    techniques    microbiosensors    macroscopic    surgical    materials    ntrafallopian    body    involve    close    microtechnologies    transfer    infertility    pi    worldwide    32    tools    transport    contributed    seek    environment    manipulation    contribution    zygote    overcome    optimal    release    insights    severe    implantation    zift    vivo    embryonic    gift    injury    gamete    imaging    age    physiological    population    gametes    model    create    invasive    variety    female    zygotes    introduce    drug    clinical    ing    microbots    significantly    times    deeper    mice    risk    embryo    intracytoplasmic    vitro    natural    anaesthesia    quality    size    procedure    endometrial    fertilization    multifunctional    molecular    rates    economic    ectopic   

Project "Micro-GIFT" data sheet

The following table provides information about the project.

Coordinator
LEIBNIZ-INSTITUT FUER FESTKOERPER- UND WERKSTOFFFORSCHUNG DRESDEN E.V. 

Organization address
address: HELMHOLTZSTRASSE 20
city: DRESDEN
postcode: 1069
website: www.ifw-dresden.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙967 €
 EC max contribution 1˙499˙967 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIBNIZ-INSTITUT FUER FESTKOERPER- UND WERKSTOFFFORSCHUNG DRESDEN E.V. DE (DRESDEN) coordinator 1˙499˙967.00

Map

 Project objective

Infertility is a worldwide problem affecting ~11% of the reproductive-age population. Severe cases are currently treated by in vitro fertilization (IVF) and intracytoplasmic injection techniques (ICSI) with high fertilization rates (~95%). However, embryo transfer is still the critical stage with only 32% of the cases resulting in clinical pregnancies. Moreover, the implantation rates per embryo remain very low (~17%) and often the procedure needs to be repeated several times with no success implying a high economic and social cost. Among the different methods used to overcome this issue, gamete or zygote ntrafallopian transfer (GIFT or ZIFT) seems more promising offering appropriate physiological environment for zygote/embryo development at an optimal synchronization between embryonic and endometrial preparation. However, these methods are invasive and involve surgical procedures and anaesthesia to introduce macroscopic imaging and manipulation tools into the female body, increasing the risk of injury and ectopic pregnancies. The goal of Micro-GIFT is to seek for novel approaches to non-invasively transport and release high-quality gametes/zygotes in the fallopian tube in vivo (mice model). For that multifunctional untethered microrobots (~100 µm size) will be developed making use of smart materials and advanced microtechnologies. However, there are major challenges that need to be overcome to bring this technology close to the clinic, such as the in vivo imaging and control of such microrobots, and their removal after use. The project will also provide deeper insights on the contribution of the fallopian tube on the natural embryo development and implantation, being crucial to create more natural procedures with high success rates. The PI has contributed significantly to the field of sperm-based microbots for assisted fertilization and targeted drug delivery as well as developed a variety of novel microbiosensors for molecular and cellular analysis.

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The information about "MICRO-GIFT" are provided by the European Opendata Portal: CORDIS opendata.

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