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Micro-GIFT SIGNED

Microrobotic Gamete/Zygote IntraFallopian Transfer

Total Cost €

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EC-Contrib. €

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Partnership

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 Micro-GIFT project word cloud

Explore the words cloud of the Micro-GIFT project. It provides you a very rough idea of what is the project "Micro-GIFT" about.

economic    overcome    procedure    transfer    microbots    seems    multifunctional    zygotes    vitro    injury    natural    issue    mice    microbiosensors    techniques    population    molecular    implying    contributed    macroscopic    icsi    gametes    significantly    size    close    stage    100    invasive    optimal    physiological    appropriate    transport    rates    95    reproductive    smart    model    times    infertility    sperm    implantation    ectopic    drug    anaesthesia    zygote    injection    fertilization    clinical    synchronization    introduce    age    cellular    critical    variety    assisted    ivf    ing    removal    worldwide    tube    preparation    deeper    female    gamete    clinic    11    contribution    tools    risk    release    seek    vivo    microtechnologies    microrobots    gift    ntrafallopian    involve    embryonic    micro    32    imaging    surgical    zift    pregnancies    create    manipulation    repeated    insights    endometrial    quality    untethered    environment    17    fallopian    intracytoplasmic    body    social    invasively    severe    materials    pi    embryo   

Project "Micro-GIFT" data sheet

The following table provides information about the project.

Coordinator
LEIBNIZ-INSTITUT FUER FESTKOERPER- UND WERKSTOFFFORSCHUNG DRESDEN E.V. 

Organization address
address: HELMHOLTZSTRASSE 20
city: DRESDEN
postcode: 1069
website: www.ifw-dresden.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙967 €
 EC max contribution 1˙499˙967 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIBNIZ-INSTITUT FUER FESTKOERPER- UND WERKSTOFFFORSCHUNG DRESDEN E.V. DE (DRESDEN) coordinator 1˙499˙967.00

Map

 Project objective

Infertility is a worldwide problem affecting ~11% of the reproductive-age population. Severe cases are currently treated by in vitro fertilization (IVF) and intracytoplasmic injection techniques (ICSI) with high fertilization rates (~95%). However, embryo transfer is still the critical stage with only 32% of the cases resulting in clinical pregnancies. Moreover, the implantation rates per embryo remain very low (~17%) and often the procedure needs to be repeated several times with no success implying a high economic and social cost. Among the different methods used to overcome this issue, gamete or zygote ntrafallopian transfer (GIFT or ZIFT) seems more promising offering appropriate physiological environment for zygote/embryo development at an optimal synchronization between embryonic and endometrial preparation. However, these methods are invasive and involve surgical procedures and anaesthesia to introduce macroscopic imaging and manipulation tools into the female body, increasing the risk of injury and ectopic pregnancies. The goal of Micro-GIFT is to seek for novel approaches to non-invasively transport and release high-quality gametes/zygotes in the fallopian tube in vivo (mice model). For that multifunctional untethered microrobots (~100 µm size) will be developed making use of smart materials and advanced microtechnologies. However, there are major challenges that need to be overcome to bring this technology close to the clinic, such as the in vivo imaging and control of such microrobots, and their removal after use. The project will also provide deeper insights on the contribution of the fallopian tube on the natural embryo development and implantation, being crucial to create more natural procedures with high success rates. The PI has contributed significantly to the field of sperm-based microbots for assisted fertilization and targeted drug delivery as well as developed a variety of novel microbiosensors for molecular and cellular analysis.

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The information about "MICRO-GIFT" are provided by the European Opendata Portal: CORDIS opendata.

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