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MIMIC SIGNED

Mimicking organs on chips for high throughput drug screening and basic research

Total Cost €

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EC-Contrib. €

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Partnership

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 MIMIC project word cloud

Explore the words cloud of the MIMIC project. It provides you a very rough idea of what is the project "MIMIC" about.

disc    interdisciplinary    communication    skills    modern    prototypes    business    models    interface    organ    doctorate    emulation    combines    translational    modular    techniques    replace    basic    resolution    summer    ethical    micropatterning    confocal    validate    international    stage    suited    engineering    super    healthy    considerations    cell    disease    animal    genome    screening    industry    crispr    possibility    health    chip    skill    drug    lithography    train    urge    corresponding    stages    patient    ideally    plan    cultures    closer    toxicity    eid    2d    tests    curriculum    3d    cells    competitions    creativity    conferences    search    efficiency    chips    engineered    suitability    agenda    editing    scientific    edge    demand    training    human    tissue    mimic    alternatives    workshops    soft    entrepreneurship    cutting    organs    throughput    microfluidics    vitro    industrial    pharmaceutical    transferable    technologies    microscopy    conventional    schools    spinning    biology   

Project "MIMIC" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF SHEFFIELD 

Organization address
address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN
website: www.shef.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙057˙324 €
 EC max contribution 1˙057˙324 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-EID
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) coordinator 546˙575.00
2    GALAPAGOS BV NL (LEIDEN) participant 255˙374.00
3    MIMETAS BV NL (Leiden) participant 255˙374.00
4    Biotechnology Yes UK (NOTTINGHAM) partner 0.00
5    INSTITUT CURIE FR (PARIS) partner 0.00

Map

 Project objective

MIMIC is an interdisciplinary European Industrial Doctorate at the interface of cell biology, engineering and drug development. MIMIC aims to develop and improve novel “organs on chips” technology. This technology combines modern cell biology with microfluidics and chip-based techniques with the goal to mimic organ functionality. There is a high demand by the pharmaceutical industry for more reliable tissue models to test drug toxicity and drug efficiency at early stages of drug development. Early reliable drug testing will have a major impact on drug development costs and human health. Furthermore, ethical considerations urge for the search for alternatives to replace animal tests in drug development and basic research. Organs on chips are a new exciting possibility to closer mimic human organ functionality in vitro than conventional 2D or 3D cell cultures. Organs on chips allow both, the emulation of healthy organs as well as the emulation of specific disease conditions using corresponding engineered or patient derived human cells. Moreover, organs on chips are ideally suited for high-throughput drug screening. The EID-MIMIC will develop novel organs on chips prototypes, and validate their suitability for end-users for high throughput drug screening or basic research. MIMIC will train early stage researchers in cutting edge technologies, like novel chip based technologies e.g. cell micropatterning, soft-lithography and microfluidics technology, as well as state of the art microscopy like super resolution- and confocal spinning disc microscopy and modern genome editing techniques like CRISPR-technology. In addition, MIMIC has developed a 3 year modular curriculum including workshops on creativity and business skills, summer schools, business plan competitions and international conferences with a specific agenda of transferable skill training elements highly relevant for scientific communication, translational research and, in particular, entrepreneurship.

 Deliverables

List of deliverables.
MIMIC Jobs advertised Websites, patent fillings, videos etc. 2019-05-31 18:14:56
Outreach activity I Other 2019-05-31 18:14:59
Fellow own workshop/meeting Other 2019-05-31 18:15:00
MIMIC Facebook/Twitter account Websites, patent fillings, videos etc. 2019-05-31 18:15:00
Fellow project videos Websites, patent fillings, videos etc. 2019-05-31 18:14:57
MIMIC-Website/Flyer Websites, patent fillings, videos etc. 2019-05-31 18:14:57

Take a look to the deliverables list in detail:  detailed list of MIMIC deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Claudia Beaurivage, Elena Naumovska, Yee Chang, Edo Elstak, Arnaud Nicolas, Heidi Wouters, Guido van Moolenbroek, Henriëtte Lanz, Sebastiaan Trietsch, Jos Joore, Paul Vulto, Richard Janssen, Kai Erdmann, Jan Stallen, Dorota Kurek
Development of a Gut-on-a-Chip Model for High Throughput Disease Modeling and Drug Discovery
published pages: 5661, ISSN: 1422-0067, DOI: 10.3390/ijms20225661
International Journal of Molecular Sciences 20/22 2020-02-20

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The information about "MIMIC" are provided by the European Opendata Portal: CORDIS opendata.

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