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MIMIC SIGNED

Mimicking organs on chips for high throughput drug screening and basic research

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

MIMIC project word cloud

Explore the words cloud of the MIMIC project. It provides you a very rough idea of what is the project "MIMIC" about.

disc interdisciplinary communication skills modern prototypes business models interface organ doctorate emulation combines translational modular techniques replace basic resolution summer ethical micropatterning confocal validate international stage suited engineering super healthy considerations cell disease animal genome screening industry crispr possibility health chip skill drug lithography train urge corresponding stages patient ideally plan cultures closer toxicity eid 2d tests curriculum 3d cells competitions creativity conferences search efficiency chips engineered suitability agenda editing scientific edge demand training human tissue mimic alternatives workshops soft entrepreneurship cutting organs throughput microfluidics vitro industrial pharmaceutical transferable technologies microscopy conventional schools spinning biology

Project "MIMIC" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF SHEFFIELD Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN website: www.shef.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙057˙324 €
EC max contribution	1˙057˙324 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-EID
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF SHEFFIELD THE UNIVERSITY OF SHEFFIELD Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN website: www.shef.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SHEFFIELD)	coordinator	546˙575.00
2	GALAPAGOS BV GALAPAGOS BV Organization address address: DARWINWEG 24 city: LEIDEN postcode: 2333CR website: www.biofocusdpi.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	255˙374.00
3	MIMETAS BV MIMETAS BV Organization address address: JH Oortweg 19 city: Leiden postcode: 2333CH website: www.mimetas.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Leiden)	participant	255˙374.00
4	Biotechnology Yes Biotechnology Yes Organization address address: UNIVERSITY PARK city: NOTTINGHAM postcode: NG7 2RD website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NOTTINGHAM)	partner	0.00
5	INSTITUT CURIE INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	partner	0.00

Map

Project objective

MIMIC is an interdisciplinary European Industrial Doctorate at the interface of cell biology, engineering and drug development. MIMIC aims to develop and improve novel “organs on chips” technology. This technology combines modern cell biology with microfluidics and chip-based techniques with the goal to mimic organ functionality. There is a high demand by the pharmaceutical industry for more reliable tissue models to test drug toxicity and drug efficiency at early stages of drug development. Early reliable drug testing will have a major impact on drug development costs and human health. Furthermore, ethical considerations urge for the search for alternatives to replace animal tests in drug development and basic research. Organs on chips are a new exciting possibility to closer mimic human organ functionality in vitro than conventional 2D or 3D cell cultures. Organs on chips allow both, the emulation of healthy organs as well as the emulation of specific disease conditions using corresponding engineered or patient derived human cells. Moreover, organs on chips are ideally suited for high-throughput drug screening. The EID-MIMIC will develop novel organs on chips prototypes, and validate their suitability for end-users for high throughput drug screening or basic research. MIMIC will train early stage researchers in cutting edge technologies, like novel chip based technologies e.g. cell micropatterning, soft-lithography and microfluidics technology, as well as state of the art microscopy like super resolution- and confocal spinning disc microscopy and modern genome editing techniques like CRISPR-technology. In addition, MIMIC has developed a 3 year modular curriculum including workshops on creativity and business skills, summer schools, business plan competitions and international conferences with a specific agenda of transferable skill training elements highly relevant for scientific communication, translational research and, in particular, entrepreneurship.

Deliverables

List of deliverables.
MIMIC Jobs advertised	Websites, patent fillings, videos etc.	2019-05-31 18:14:56
Outreach activity I	Other	2019-05-31 18:14:59
Fellow own workshop/meeting	Other	2019-05-31 18:15:00
MIMIC Facebook/Twitter account	Websites, patent fillings, videos etc.	2019-05-31 18:15:00
Fellow project videos	Websites, patent fillings, videos etc.	2019-05-31 18:14:57
MIMIC-Website/Flyer	Websites, patent fillings, videos etc.	2019-05-31 18:14:57

Take a look to the deliverables list in detail: detailed list of MIMIC deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Claudia Beaurivage, Elena Naumovska, Yee Chang, Edo Elstak, Arnaud Nicolas, Heidi Wouters, Guido van Moolenbroek, HenriÃ«tte Lanz, Sebastiaan Trietsch, Jos Joore, Paul Vulto, Richard Janssen, Kai Erdmann, Jan Stallen, Dorota Kurek Development of a Gut-on-a-Chip Model for High Throughput Disease Modeling and Drug Discovery published pages: 5661, ISSN: 1422-0067, DOI: 10.3390/ijms20225661	International Journal of Molecular Sciences 20/22	2020-02-20

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The information about "MIMIC" are provided by the European Opendata Portal: CORDIS opendata.