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Small RNA regulation of the body plan and epigenome in Arabidopsis embryos

Total Cost €


EC-Contrib. €






Project "sRNA-EMB" data sheet

The following table provides information about the project.


Organization address
address: DR BOHR GASSE 3
city: WIEN
postcode: 1030

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website
 Total cost 1˙499˙988 €
 EC max contribution 1˙499˙988 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Small RNAs are short non-coding RNAs that regulate gene expression in plants and animals. Although small RNAs are essential for proper differentiation and epigenome regulation, little is known regarding their embryonic functions, especially in plants. Arabidopsis thaliana is a leading system to study the regulatory roles of small RNAs because of the abundance of genetic, genomic and epigenomic resources. Moreover, Arabidopsis embryos undergo invariant division patterns and rapidly differentiate to generate the most basic plant cell-types arranged in correct positions. Early Arabidopsis embryos are therefore morphologically simple structures composed of diverse cell types making them ideal for determining the influence of small RNAs on fundamental cellular differentiation and reprogramming events. The objectives of the proposed research are designed to assess the regulatory roles of small RNAs in establishing both the basic body plan and epigenome in plant embryos. We will utilize modified next-generation sequencing technologies to identify small RNAs present in developing embryos. Because we will generate these RNA profiles from a mixture of cell-types, we will also use a fluorescent protein-based approach to quantify specific miRNA repressive activities in individual cell-types. To determine the functions of individual miRNA/target interactions during embryogenesis, we will identify miRNAs required for embryo development and use genome-wide approaches to study specific miRNA/target interactions in greater detail. Lastly, we will use a fusion of genetic and genomic methods to determine how small RNAs influence the nascent epigenome during early embryogenesis.


year authors and title journal last update
List of publications.
2018 Michael A. Schon, Max J. Kellner, Alexandra Plotnikova, Falko Hofmann, Michael D. Nodine
NanoPARE: parallel analysis of RNA 5′ ends from low-input RNA
published pages: 1931-1942, ISSN: 1088-9051, DOI: 10.1101/gr.239202.118
Genome Research 28/12 2020-03-20
2019 Falko Hofmann, Michael A. Schon, Michael D. Nodine
The embryonic transcriptome of Arabidopsis thaliana
published pages: 77-91, ISSN: 2194-7953, DOI: 10.1007/s00497-018-00357-2
Plant Reproduction 32/1 2020-03-20
2019 Alexandra Plotnikova, Max J. Kellner, Michael A. Schon, Magdalena Mosiolek, Michael D. Nodine
MicroRNA Dynamics and Functions During Arabidopsis Embryogenesis
published pages: 2929-2946, ISSN: 1040-4651, DOI: 10.1105/tpc.19.00395
The Plant Cell 31/12 2020-03-20
2017 Stefan Lutzmayer, Balaji Enugutti, Michael D. Nodine
Novel small RNA spike-in oligonucleotides enable absolute normalization of small RNA-Seq data
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-06174-3
Scientific Reports 7/1 2020-03-20
2017 Michael A. Schon, Michael D. Nodine
Widespread Contamination of Arabidopsis Embryo and Endosperm Transcriptome Data Sets
published pages: 608-617, ISSN: 1040-4651, DOI: 10.1105/tpc.16.00845
The Plant Cell 29/4 2020-03-20

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