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Why is Transparent Hypocotyl Mutant showed reduced phototropic response?

Total Cost €


EC-Contrib. €






 THyM project word cloud

Explore the words cloud of the THyM project. It provides you a very rough idea of what is the project "THyM" about.

visualize    trigger    insights    establishment    localization    regarding    protein    tissue    phototropin    cellular    wall    transporter    gradients    transported    defect    hypocotyls    transparent    downstream    conservation    phenotype    subcellular    characterization    eye    light    hypotheses    function    initiated    showed    testable    underlies    environment    plant    gene    asymmetric    orthologous    hypocotyl    primary    optimize    phototropism    expression    fankhauser    components    perceiving    shares    staining    drosophila    levels    proteins    favorable    transporters    gradient    fiber    abc    plants    pigment    techniques    phenotypic    substance    functional    mutant    understand    transport    wild    microscopy    atp    activated    confocal    pattern    cassette    optic    insect    atabc    precursor    first    stem    brasicca    organ    mutants    reorient    signaling    photo    microscopic    defective    play    biochemical    vision    photosynthesis    lab    gfp    tagged    receptors    family    binding    auxin    homology    blue    stimulated    rapa    photosensory    vital    cell   

Project "THyM" data sheet

The following table provides information about the project.


Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
postcode: 1015

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 203˙149.00


 Project objective

Plants can reorient their growth towards a favorable light environment to optimize photosynthesis in a process called phototropism. This process is initiated by the phototropin blue light receptors, perceiving light gradients to trigger downstream signaling leading to the asymmetric distribution of auxin across the photo-stimulated stem. The Fankhauser lab showed that AtABC, an ABC (ATP-binding cassette) transporter family protein is important for phototropism. AtABC shares homology with Drosophila transporters, which are involved in eye pigment precursor transport and play a vital role in insect vision. In addition to reduced phototropism, Atabc mutants have transparent hypocotyls. The primary objective of this project is to understand the function of AtABC in phototropism and to test whether this transporter is required for light gradient establishment across the hypocotyl. First, I will characterize the Atabc mutant at the tissue, cellular and subcellular levels (e.g. staining for cell wall components) to determine what defect underlies the transparent hypocotyl phenotype. Using several approaches including confocal microscopy to visualize light-activated proteins and fiber-optic techniques, I will measure the light gradient across the hypocotyl of wild type and Atabc mutants. I will characterize phototropin signaling using biochemical and microscopic approaches to determine at which signaling step AtABC is required. To characterize AtABC, I will determine its expression pattern and subcellular localization using GFP-tagged AtABC. Together with the phenotypic characterization of the mutant, this will provide testable hypotheses regarding the substance(s) transported by AtABC. Finally, to determine the functional conservation of AtABC in other plants, I will characterize Brasicca rapa mutants defective in the orthologous gene. The functional characterization of AtABC may provide key insights into light gradient establishment in a plant photosensory organ.

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The information about "THYM" are provided by the European Opendata Portal: CORDIS opendata.

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