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Why is Transparent Hypocotyl Mutant showed reduced phototropic response?

Total Cost €


EC-Contrib. €






 THyM project word cloud

Explore the words cloud of the THyM project. It provides you a very rough idea of what is the project "THyM" about.

mutants    family    initiated    regarding    photo    wall    abc    wild    staining    defect    homology    light    orthologous    vision    activated    insect    binding    eye    transparent    downstream    phototropin    expression    function    localization    pigment    signaling    vital    cell    mutant    play    receptors    testable    gene    defective    auxin    organ    first    hypotheses    gradient    characterization    confocal    environment    underlies    shares    gradients    primary    drosophila    optic    asymmetric    blue    trigger    establishment    biochemical    optimize    hypocotyls    visualize    microscopy    phenotypic    microscopic    atp    transport    tissue    rapa    levels    photosensory    stem    phenotype    functional    substance    hypocotyl    transported    protein    reorient    phototropism    showed    components    conservation    plants    brasicca    techniques    tagged    cassette    insights    plant    fankhauser    understand    transporters    cellular    pattern    favorable    transporter    gfp    atabc    photosynthesis    proteins    lab    perceiving    precursor    subcellular    fiber    stimulated   

Project "THyM" data sheet

The following table provides information about the project.


Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
postcode: 1015

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 203˙149.00


 Project objective

Plants can reorient their growth towards a favorable light environment to optimize photosynthesis in a process called phototropism. This process is initiated by the phototropin blue light receptors, perceiving light gradients to trigger downstream signaling leading to the asymmetric distribution of auxin across the photo-stimulated stem. The Fankhauser lab showed that AtABC, an ABC (ATP-binding cassette) transporter family protein is important for phototropism. AtABC shares homology with Drosophila transporters, which are involved in eye pigment precursor transport and play a vital role in insect vision. In addition to reduced phototropism, Atabc mutants have transparent hypocotyls. The primary objective of this project is to understand the function of AtABC in phototropism and to test whether this transporter is required for light gradient establishment across the hypocotyl. First, I will characterize the Atabc mutant at the tissue, cellular and subcellular levels (e.g. staining for cell wall components) to determine what defect underlies the transparent hypocotyl phenotype. Using several approaches including confocal microscopy to visualize light-activated proteins and fiber-optic techniques, I will measure the light gradient across the hypocotyl of wild type and Atabc mutants. I will characterize phototropin signaling using biochemical and microscopic approaches to determine at which signaling step AtABC is required. To characterize AtABC, I will determine its expression pattern and subcellular localization using GFP-tagged AtABC. Together with the phenotypic characterization of the mutant, this will provide testable hypotheses regarding the substance(s) transported by AtABC. Finally, to determine the functional conservation of AtABC in other plants, I will characterize Brasicca rapa mutants defective in the orthologous gene. The functional characterization of AtABC may provide key insights into light gradient establishment in a plant photosensory organ.

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The information about "THYM" are provided by the European Opendata Portal: CORDIS opendata.

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