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Endoscopic Comprehensive Optical Multimodal Molecular Intelligent Imaging

Total Cost €


EC-Contrib. €






Project "ENCOMOLE-2i" data sheet

The following table provides information about the project.


Organization address
city: LUBECK
postcode: 23562

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙998˙530 €
 EC max contribution 1˙998˙530 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET zu LUEBECK DE (LUBECK) coordinator 1˙998˙530.00


 Project objective

Optical imaging has exceptional potential for medical diagnosis, because it can provide high spatial resolution and molecular contrast. However, for in vivo imaging in humans, the poor penetration of only a few millimetres is a major obstacle. Optical endoscopes solve this problem, but currently most of them only perform non-advanced, classical white light imaging. Also, the speed of current devices is not sufficient to comprehensively scan entire organs at microscopic resolution. Hence, medical imaging is still dominated by non-optical techniques like X-ray, ultrasound and magnetic resonance imaging. The objective of ENCOMOLE-2i is to push the performance of advanced optical in vivo imaging techniques to cross the application threshold for clinical research and practice. An endoscopic multi-modal molecular imaging platform will be developed with unprecedented capabilities for the diagnosis of disease. The hardware technology development includes three novel imaging modalities. Optical coherence tomography with line rates of several Megahertz will be used for comprehensive structural imaging over large areas. Time encoded stimulated Raman sensing, supported by a new type of two photon microscopy, will be used for guided and referenced molecular imaging. Combining these techniques into one system and interfacing it with a newly developed endoscope will generate great synergy. Moreover, the unique synchronization capabilities of these modalities enable a radically new strategy for more efficient data acquisition: The concept of adaptive “Intelligent Imaging”. The goal is to develop a universal endoscopy platform which can then be specifically tailored to the individual application. In the project the focus is on gastrointestinal imaging. The synergy between technological and algorithmic advances in ENCOMOLE-2i will break ground for more optical in vivo imaging in clinical research and routine, which can finally lead to improved diagnosis of many types of disease.


year authors and title journal last update
List of publications.
2017 Tianshi Wang, Tom Pfeiffer, Min Wu, Wolfgang Wieser, Gaetano Amenta, Wolfgang Draxinger, Antonius F. W. van der Steen, Robert Huber, Gijs van Soest
Thermo-elastic optical coherence tomography
published pages: 3466, ISSN: 0146-9592, DOI: 10.1364/ol.42.003466
Optics Letters 42/17 2020-02-21
2017 Matthias Eibl, Sebastian Karpf, Hubertus Hakert, Daniel Weng, Robert Huber
Two-photon-excited fluorescence (TPEF) and fluorescence lifetime imaging (FLIM) with sub-nanosecond pulses and a high analog bandwidth signal detection
published pages: 100691F, ISSN: , DOI: 10.1117/12.2250831
Multiphoton Microscopy in the Biomedical Sciences XVII 2020-02-21
2017 Christian Jirauschek, Robert Huber
Efficient simulation of the swept-waveform polarization dynamics in fiber spools and Fourier domain mode-locked (FDML) lasers
published pages: 1135, ISSN: 0740-3224, DOI: 10.1364/JOSAB.34.001135
Journal of the Optical Society of America B 34/6 2020-02-21
2016 Sebastian Karpf, Matthias Eibl, Benjamin Sauer, Fred Reinholz, Gereon Hüttmann, Robert Huber
Two-photon microscopy using fiber-based nanosecond excitation
published pages: 2432, ISSN: 2156-7085, DOI: 10.1364/BOE.7.002432
Biomedical Optics Express 7/7 2020-02-21
2018 Hinnerk Schulz-Hildebrandt, Tom Pfeiffer, Tim Eixmann, Sabrina Lohmann, Martin Ahrens, Joshua Rehra, Wolfgang Draxinger, Peter König, Robert Huber, Gereon Hüttmann
High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography
published pages: 4386, ISSN: 0146-9592, DOI: 10.1364/ol.43.004386
Optics Letters 43/18 2020-02-21
2016 Tom Pfeiffer, Wolfgang Wieser, Thomas Klein, Markus Petermann, Jan-Phillip Kolb, Matthias Eibl, Robert Huber
Flexible A-scan rate MHz OCT: computational downscaling by coherent averaging
published pages: 96970S, ISSN: , DOI: 10.1117/12.2214788
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX 2020-02-21
2017 Cuiping Yao, Florian Rudnitzki, Gereon Hüttmann, Zhenxi Zhang, Ramtin Rahmanzadeh
Important factors for cell-membrane permeabilization by gold nanoparticles activated by nanosecond-laser irradiation
published pages: 5659-5672, ISSN: 1178-2013, DOI: 10.2147/IJN.S140620
International Journal of Nanomedicine Volume 12 2020-02-21
2017 Thomas Klein, Robert Huber
High-speed OCT light sources and systems [Invited]
published pages: 828, ISSN: 2156-7085, DOI: 10.1364/BOE.8.000828
Biomedical Optics Express 8/2 2020-02-21
2017 Tianshi Wang, Tom Pfeiffer, Min Wu, Wolfgang Wieser, Wolfgang Draxinger, Antonius F. W. van der Steen, Robert Huber, Gijs van Soest
Short pulse laser induced thermo-elastic deformation imaging
published pages: 100620C, ISSN: , DOI: 10.1117/12.2251502
Optical Interactions with Tissue and Cells XXVIII 2020-02-21
2017 Matthias Eibl, Sebastian Karpf, Daniel Weng, Hubertus Hakert, Tom Pfeiffer, Jan Philip Kolb, Robert Huber
Single pulse two photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate
published pages: 3132, ISSN: 2156-7085, DOI: 10.1364/BOE.8.003132
Biomedical Optics Express 8/7 2020-02-21
2017 Sebastian Karpf, Matthias Eibl, Wolfgang Wieser, Thomas Klein, Robert Huber
Shot-Noise Limited Time-Encoded Raman Spectroscopy
published pages: 1-6, ISSN: 2314-4920, DOI: 10.1155/2017/9253475
Journal of Spectroscopy 2017 2020-02-21
2017 Matthias Eibl, Sebastian Karpf, Hubertus Hakert, Daniel Weng, Torben Blömker, Robert Huber
Pulse-to-pulse wavelength switching of diode based fiber laser for multi-color multi-photon imaging
published pages: 100831C, ISSN: , DOI: 10.1117/12.2251965
Fiber Lasers XIV: Technology and Systems 2020-02-21
2016 Robert Huber, Lars Dworak, Jacques E. Moser, Michael Grätzel, Josef Wachtveitl
Beyond Vibrationally Mediated Electron Transfer: Coherent Phenomena Induced by Ultrafast Charge Separation
published pages: 8534-8539, ISSN: 1932-7447, DOI: 10.1021/acs.jpcc.6b02012
The Journal of Physical Chemistry C 120/16 2020-02-21
2016 Jan Philip Kolb, Thomas Klein, Matthias Eibl, Tom Pfeiffer, Wolfgang Wieser, Robert Huber
Megahertz FDML laser with up to 143nm sweep range for ultrahigh resolution OCT at 1050nm
published pages: 969703, ISSN: , DOI: 10.1117/12.2214758
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX 2020-02-21
2017 Tom Pfeiffer, Wolfgang Draxinger, Wolfgang Wieser, Thomas Klein, Markus Petermann, Robert Huber
Analysis of FDML lasers with meter range coherence
published pages: 100531T, ISSN: , DOI: 10.1117/12.2254792
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI 2020-02-21
2017 Max-Heinrich Laves, Andreas Schoob, Lüder A. Kahrs, Tom Pfeiffer, Robert Huber, Tobias Ortmaier
Feature tracking for automated volume of interest stabilization on 4D-OCT images
published pages: 101350W, ISSN: , DOI: 10.1117/12.2255090
Medical Imaging 2017: Image-Guided Procedures, Robotic Interventions, and Modeling 2020-02-21
2016 Tianshi Wang, Tom Pfeiffer, Evelyn Regar, Wolfgang Wieser, Heleen van Beusekom, Charles T. Lancee, Geert Springeling, Ilona Krabbendam-Peters, Antonius F.W. van der Steen, Robert Huber, Gijs van Soest
Heartbeat OCT and Motion-Free 3D In Vivo Coronary Artery Microscopy
published pages: 622-623, ISSN: 1936-878X, DOI: 10.1016/j.jcmg.2015.08.010
JACC: Cardiovascular Imaging 9/5 2020-02-21

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