Explore the words cloud of the BIOMENDELIAN project. It provides you a very rough idea of what is the project "BIOMENDELIAN" about.
The following table provides information about the project.
|Coordinator Country||Sweden [SE]|
|Total cost||2˙000˙000 €|
|EC max contribution||2˙000˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-09-01 to 2020-08-31|
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Cardiovascular disease (CVD), type 2 diabetes (T2D) and obesity, collectively referred to as cardiometabolic disease, together with cancer are the major morbidities and causes of death. With few exceptions, research on cardiometabolic disease and cancer is funded, studied and clinically applied separately without fully taking advantage of knowledge on common pathways and treatment targets through interdisciplinary synergies. The purpose of this proposal is to reveal causal factors connecting and disconnecting cardiometabolic diseases and cancer, and to understand interactions between gut microbiota, host diet and genetic susceptibility in a comprehensive prospective cohort study design to subsequently allow design of intervention strategies to guide more personalized disease prevention.
1. We investigate causality between genetic risk factors for cardiometabolic disease associated traits and future incidence of T2D, CVD, cancer (total/breast/colon/prostate) and mortality (total, CVD- and cancer mortality), searching for causal factors in a prospective cohort with >15 y follow-up (N>30,000, incident cases N=3550, 4713, 5975, 6115 for T2D, CVD, cancer, mortality) 2. For the first time in a large population (N=6000), we investigate how gut and oral microbiome are regulated by dietary factors, gut satiety peptides and host genetics, and how such connections relate to cardiometabolic disease associated traits and cancer 3. We investigate the role of diet and gene-diet interactions of importance for cardiometabolic disease and cancer 4. We perform genotype, biomarker and gut microbiota based diet intervention studies.
This inter-disciplinary project contributes to biological understanding of basic disease mechanisms and takes steps towards better possibilities to prevent and treat individuals at high risk for cardiometabolic disease, cancer and death.
|year||authors and title||journal||last update|
Ulrika Ericson, Louise Brunkwall, Joana Alves Dias, Isabel Drake, Sophie Hellstrand, Bo Gullberg, Emily Sonestedt, Peter M. Nilsson, Elisabet WirfÃ¤lt, Marju Orho-Melander
Food patterns in relation to weight change and incidence of type 2 diabetes, coronary events and stroke in the MalmÃ¶ Diet and Cancer cohort
published pages: , ISSN: 1436-6207, DOI: 10.1007/s00394-018-1727-9
|European Journal of Nutrition||2019-06-07|
Ulrika Ericson, George Hindy, Isabel Drake, Christina-Alexandra Schulz, Louise Brunkwall, Sophie Hellstrand, Peter Almgren, Marju Orho-Melander
Dietary and genetic risk scores and incidence of type 2 diabetes
published pages: , ISSN: 1555-8932, DOI: 10.1186/s12263-018-0599-1
|Genes & Nutrition 13/1||2019-06-07|
Filip Ottosson, Louise Brunkwall, Ulrika Ericson, Peter M Nilsson, Peter Almgren, CÃ©line Fernandez, Olle Melander, Marju Orho-Melander
Connection Between BMI-Related Plasma Metabolite Profile and Gut Microbiota
published pages: 1491-1501, ISSN: 0021-972X, DOI: 10.1210/jc.2017-02114
|The Journal of Clinical Endocrinology & Metabolism 103/4||2019-06-07|
Christina-Alexandra Schulz, Margaretha Persson, Anders Christensson, George Hindy, Peter Almgren, Peter M. Nilsson, Olle Melander, Gunnar EngstrÃ¶m, Marju Orho-Melander
Soluble Urokinase-type Plasminogen Activator Receptor (suPAR) and Impaired Kidney Function in the Population-based MalmÃ¶ Diet and Cancer Study
published pages: 239-247, ISSN: 2468-0249, DOI: 10.1016/j.ekir.2016.11.004
|Kidney International Reports 2/2||2019-06-07|
Jing Li, Jun Song, Yekaterina Y. Zaytseva, Yajuan Liu, Piotr Rychahou, Kai Jiang, Marlene E. Starr, Ji Tae Kim, Jennifer W. Harris, Frederique B. Yiannikouris, Wendy S. Katz, Peter M. Nilsson, Marju Orho-Melander, Jing Chen, Haining Zhu, Timothy Fahrenholz, Richard M. Higashi, Tianyan Gao, Andrew J. Morris, Lisa A. Cassis, Teresa W. -M. Fan, Heidi L. Weiss, Paul R. Dobner, Olle Melander, Jianhang Jia, B. Mark Evers
An obligatory role for neurotensin in high-fat-diet-induced obesity
published pages: 411-415, ISSN: 0028-0836, DOI: 10.1038/nature17662
Marju Orho-Melander, George Hindy, Signe Borgquist, Christina-Alexandra Schulz, Jonas Manjer, Olle Melander, Tanja Stocks
Blood lipid genetic scores, the HMGCR gene and cancer risk: a Mendelian randomization study
published pages: 495-505, ISSN: 0300-5771, DOI: 10.1093/ije/dyx237
|International Journal of Epidemiology 47/2||2019-06-07|
Louise Brunkwall, Marju Orho-Melander
The gut microbiome as a target for prevention and treatment of hyperglycaemia in type 2 diabetes: from current human evidence to future possibilities
published pages: 943-951, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4278-3
Isabel Drake, George Hindy, Ulrika Ericson, Marju Orho-Melander
A prospective study of dietary and supplemental zinc intake and risk of type 2 diabetes depending on genetic variation in SLC30A8
published pages: , ISSN: 1555-8932, DOI: 10.1186/s12263-017-0586-y
|Genes & Nutrition 12/1||2019-06-07|
Christina-Alexandra Schulz, Anders Christensson, Ulrika Ericson, Peter Almgren, George Hindy, Peter M. Nilsson, Joachim Struck, Andreas Bergmann, Olle Melander, Marju Orho-Melander
High Level of Fasting Plasma Proenkephalin-A Predicts Deterioration of Kidney Function and Incidence of CKD
published pages: 291-303, ISSN: 1046-6673, DOI: 10.1681/ASN.2015101177
|Journal of the American Society of Nephrology 28/1||2019-06-07|
George Hindy, Gunnar EngstrÃ¶m, Susanna C. Larsson, Matthew Traylor, Hugh S. Markus, Olle Melander, Marju Orho-Melander
Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes
published pages: 820-827, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.117.019653
Isabel Drake, Bo Gullberg, Emily Sonestedt, Tanja Stocks, Anders Bjartell, Elisabet WirfÃ¤lt, Peter WallstrÃ¶m, Marju Orho-Melander
Type 2 diabetes, adiposity and cancer morbidity and mortality risk taking into account competing risk of noncancer deaths in a prospective cohort setting
published pages: 1170-1180, ISSN: 0020-7136, DOI: 10.1002/ijc.30824
|International Journal of Cancer 141/6||2019-06-07|
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