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BIOMENDELIAN SIGNED

Linking Cardiometabolic Disease and Cancer in the Level of Genetics, Circulating Biomarkers, Microbiota and Environmental Risk Factors

Total Cost €

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EC-Contrib. €

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Partnership

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Project "BIOMENDELIAN" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 2˙000˙000.00

Map

 Project objective

Cardiovascular disease (CVD), type 2 diabetes (T2D) and obesity, collectively referred to as cardiometabolic disease, together with cancer are the major morbidities and causes of death. With few exceptions, research on cardiometabolic disease and cancer is funded, studied and clinically applied separately without fully taking advantage of knowledge on common pathways and treatment targets through interdisciplinary synergies. The purpose of this proposal is to reveal causal factors connecting and disconnecting cardiometabolic diseases and cancer, and to understand interactions between gut microbiota, host diet and genetic susceptibility in a comprehensive prospective cohort study design to subsequently allow design of intervention strategies to guide more personalized disease prevention.

1. We investigate causality between genetic risk factors for cardiometabolic disease associated traits and future incidence of T2D, CVD, cancer (total/breast/colon/prostate) and mortality (total, CVD- and cancer mortality), searching for causal factors in a prospective cohort with >15 y follow-up (N>30,000, incident cases N=3550, 4713, 5975, 6115 for T2D, CVD, cancer, mortality) 2. For the first time in a large population (N=6000), we investigate how gut and oral microbiome are regulated by dietary factors, gut satiety peptides and host genetics, and how such connections relate to cardiometabolic disease associated traits and cancer 3. We investigate the role of diet and gene-diet interactions of importance for cardiometabolic disease and cancer 4. We perform genotype, biomarker and gut microbiota based diet intervention studies.

This inter-disciplinary project contributes to biological understanding of basic disease mechanisms and takes steps towards better possibilities to prevent and treat individuals at high risk for cardiometabolic disease, cancer and death.

 Publications

year authors and title journal last update
List of publications.
2018 Ulrika Ericson, Louise Brunkwall, Joana Alves Dias, Isabel Drake, Sophie Hellstrand, Bo Gullberg, Emily Sonestedt, Peter M. Nilsson, Elisabet Wirfält, Marju Orho-Melander
Food patterns in relation to weight change and incidence of type 2 diabetes, coronary events and stroke in the Malmö Diet and Cancer cohort
published pages: , ISSN: 1436-6207, DOI: 10.1007/s00394-018-1727-9
European Journal of Nutrition 2019-06-07
2018 Ulrika Ericson, George Hindy, Isabel Drake, Christina-Alexandra Schulz, Louise Brunkwall, Sophie Hellstrand, Peter Almgren, Marju Orho-Melander
Dietary and genetic risk scores and incidence of type 2 diabetes
published pages: , ISSN: 1555-8932, DOI: 10.1186/s12263-018-0599-1
Genes & Nutrition 13/1 2019-06-07
2018 Filip Ottosson, Louise Brunkwall, Ulrika Ericson, Peter M Nilsson, Peter Almgren, Céline Fernandez, Olle Melander, Marju Orho-Melander
Connection Between BMI-Related Plasma Metabolite Profile and Gut Microbiota
published pages: 1491-1501, ISSN: 0021-972X, DOI: 10.1210/jc.2017-02114
The Journal of Clinical Endocrinology & Metabolism 103/4 2019-06-07
2017 Christina-Alexandra Schulz, Margaretha Persson, Anders Christensson, George Hindy, Peter Almgren, Peter M. Nilsson, Olle Melander, Gunnar Engström, Marju Orho-Melander
Soluble Urokinase-type Plasminogen Activator Receptor (suPAR) and Impaired Kidney Function in the Population-based Malmö Diet and Cancer Study
published pages: 239-247, ISSN: 2468-0249, DOI: 10.1016/j.ekir.2016.11.004
Kidney International Reports 2/2 2019-06-07
2016 Jing Li, Jun Song, Yekaterina Y. Zaytseva, Yajuan Liu, Piotr Rychahou, Kai Jiang, Marlene E. Starr, Ji Tae Kim, Jennifer W. Harris, Frederique B. Yiannikouris, Wendy S. Katz, Peter M. Nilsson, Marju Orho-Melander, Jing Chen, Haining Zhu, Timothy Fahrenholz, Richard M. Higashi, Tianyan Gao, Andrew J. Morris, Lisa A. Cassis, Teresa W. -M. Fan, Heidi L. Weiss, Paul R. Dobner, Olle Melander, Jianhang Jia, B. Mark Evers
An obligatory role for neurotensin in high-fat-diet-induced obesity
published pages: 411-415, ISSN: 0028-0836, DOI: 10.1038/nature17662
Nature 533/7603 2019-06-07
2017 Marju Orho-Melander, George Hindy, Signe Borgquist, Christina-Alexandra Schulz, Jonas Manjer, Olle Melander, Tanja Stocks
Blood lipid genetic scores, the HMGCR gene and cancer risk: a Mendelian randomization study
published pages: 495-505, ISSN: 0300-5771, DOI: 10.1093/ije/dyx237
International Journal of Epidemiology 47/2 2019-06-07
2017 Louise Brunkwall, Marju Orho-Melander
The gut microbiome as a target for prevention and treatment of hyperglycaemia in type 2 diabetes: from current human evidence to future possibilities
published pages: 943-951, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4278-3
Diabetologia 60/6 2019-06-07
2017 Isabel Drake, George Hindy, Ulrika Ericson, Marju Orho-Melander
A prospective study of dietary and supplemental zinc intake and risk of type 2 diabetes depending on genetic variation in SLC30A8
published pages: , ISSN: 1555-8932, DOI: 10.1186/s12263-017-0586-y
Genes & Nutrition 12/1 2019-06-07
2016 Christina-Alexandra Schulz, Anders Christensson, Ulrika Ericson, Peter Almgren, George Hindy, Peter M. Nilsson, Joachim Struck, Andreas Bergmann, Olle Melander, Marju Orho-Melander
High Level of Fasting Plasma Proenkephalin-A Predicts Deterioration of Kidney Function and Incidence of CKD
published pages: 291-303, ISSN: 1046-6673, DOI: 10.1681/ASN.2015101177
Journal of the American Society of Nephrology 28/1 2019-06-07
2018 George Hindy, Gunnar Engström, Susanna C. Larsson, Matthew Traylor, Hugh S. Markus, Olle Melander, Marju Orho-Melander
Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes
published pages: 820-827, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.117.019653
Stroke 49/4 2019-06-07
2017 Isabel Drake, Bo Gullberg, Emily Sonestedt, Tanja Stocks, Anders Bjartell, Elisabet Wirfält, Peter Wallström, Marju Orho-Melander
Type 2 diabetes, adiposity and cancer morbidity and mortality risk taking into account competing risk of noncancer deaths in a prospective cohort setting
published pages: 1170-1180, ISSN: 0020-7136, DOI: 10.1002/ijc.30824
International Journal of Cancer 141/6 2019-06-07

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