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NanoCytox SIGNED

Development of Novel Analytical Methods to assess Nanoparticle cytotoxicity

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NanoCytox" data sheet

The following table provides information about the project.

Coordinator
BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG 

Organization address
address: Unter den Eichen 87
city: BERLIN
postcode: 12205
website: www.bam.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.researchgate.net/project/Development-of-Novel-Analytical-Methods-to-Assess-Nanoparticle-Cytotoxicity
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2017-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG DE (BERLIN) coordinator 159˙460.00

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 Project objective

Nanoparticles , NPs, are being used to produce novel materials with unique physico-chemical properties with many applications in fields such as medicine, energy and electronics, consumer goods, among others. Some studies have revealed that the same specific properties that make NPs so unique could also be responsible for potential harmful effects on the environment and human health. Currently, the assessment of their impact is hampered by limited analytical capabilities to detect them in complex natural matrices. New sensitive and selective analytical methods must be developed and validated in order to elucidate their toxicological effects prior to increasing and promoting the NPs production. Herein, new analytical methodologies based on inductively coupled plasma mass spectrometry (ICP-MS) are proposed to evaluate the toxicity of metallic NPs in cells, one of the most powerful and attractive model systems for toxicological assays. The proposed methodology consists on the use of laser ablation (LA) coupled to ICP-MS for spatially resolved bioimaging of the distribution of NPs in single cells upon different NPs incubation experiments; furthermore, a micro-droplet generator (µDG) for sample introduction of single cells into a sector field ICP-MS will be employed to improve the NPs detection sensitivity. The expected results will give essential insights into nanoparticle/cell interactions and will have implications for the development of analytical methods based on applications of nano-particles for medical diagnostics and therapeutics.

 Publications

year authors and title journal last update
List of publications.
2017 Erik Guehrs, Michael Schneider, Christian M. Günther, Piet Hessing, Karen Heitz, Doreen Wittke, Ana López-Serrano Oliver, Norbert Jakubowski, Johanna Plendl, Stefan Eisebitt, Andrea Haase
Quantification of silver nanoparticle uptake and distribution within individual human macrophages by FIB/SEM slice and view
published pages: , ISSN: 1477-3155, DOI: 10.1186/s12951-017-0255-8
Journal of Nanobiotechnology 15/1 2019-06-13
2018 S. Meyer, A. López-Serrano, H. Mitze, N. Jakubowski, T. Schwerdtle
Single-cell analysis by ICP-MS/MS as a fast tool for cellular bioavailability studies of arsenite
published pages: 73-76, ISSN: 1756-5901, DOI: 10.1039/C7MT00285H
Metallomics 10/1 2019-06-13
2018 Ana López-Serrano, Sabine Baumgart, Wolfram Bremser, Sabine Flemig, Doreen Wittke, Andreas Gruetzkau, Andreas Luch, Andrea Haase, Norbert Jakubowski
Quantification of silver nanoparticles up-taken by single cells using inductively coupled plasma mass spectrometry in the single cell measurement mode
published pages: , ISSN: 0267-9477, DOI: 10.1039/C7JA00395A
Journal of Analytical Atomic Spectrometry 2019-06-13

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