mtFOIE GRAS SIGNED
mitoFOIE GRAS: Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease
Total Cost €
0EC-Contrib. €
0Partnership
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Project "mtFOIE GRAS" data sheet
The following table provides information about the project.
| Coordinator |
CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
Organization address contact info |
| Coordinator Country | Portugal [PT] |
| Project website | http://www.projectrisefoiegras.eu/ |
| Total cost | 454˙500 € |
| EC max contribution | 454˙500 € (100%) |
| Programme |
1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge) |
| Code Call | H2020-MSCA-RISE-2016 |
| Funding Scheme | MSCA-RISE |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-06-01 to 2021-05-31 |
Partnership
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Project objective
'Non-Alcoholic Fatty Liver Disease (NAFLD), including its more pathologic consequence, non-alcoholic steatohepatitis (NASH), is believed to be the most common chronic liver disease worldwide, affecting between 6 to 37% of the population. NAFLD is a so called ‘silent killer’, as clinical symptoms only surface at late stages of the disease, when it is no longer treatable: untreated, NAFLD/NASH can lead to cirrhosis and hepatocellular carcinoma, culminating in liver failure. Currently the best method of diagnosing and staging the disease is liver biopsy, a costly, invasive and somewhat risky procedure, not to mention unfit for routine assessment. Besides, no therapeutic consensus exists for NAFLD/NASH treatment. mtFOIE GRAS (Foie Gras being French for 'fat liver') proposes to address the pressing need for non-invasive, accurate, rapid assessment of NAFLD/NASH stages, before and after intervention, through the development of biomarkers and innovative tools to follow mitochondrial (mt) dysfunction, a central mediator of fatty liver disease pathogenesis. This promising R&D strategy will also bring new knowledge about the disease mechanisms and improved understanding of the pathogenic process and disease drivers. To that end, mtFOIE GRAS envisages a training-through-work plan that brings together an intersectoral, multidisciplinary team of researchers and technicians experts in their fields, from basic to translational research, clinical practice, technology commercialization and public advocacy. Together with several PhD students, the team will share expertises and work synergistically along the value creation chain to address the unmet medical need of more informative NAFLD assessment. In the process, mtFOIE GRAS will endow the involved staff with excellent scientific knowledge and transferable skills while building and strengthening intersectoral cooperation among partners, thus contributing to EU RD&I excellence.'
Deliverables
| Pinpointed putative novel biomarkers and advanced methodologies. | Documents, reports | 2019-10-28 17:53:19 |
| Project Website and social media | Websites, patent fillings, videos etc. | 2019-07-18 21:32:54 |
Take a look to the deliverables list in detail: detailed list of mtFOIE GRAS deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Nádia Duarte, Inês Coelho, Denys Holovanchuk, Joana Inês Almeida, Carlos Penha-Gonçalves, Maria Paula Macedo Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells published pages: 1080-1094, ISSN: 2471-254X, DOI: 10.1002/hep4.1225 |
Hepatology Communications 2/9 | 2019-07-18 |
| 2019 |
Ignazio Grattagliano, Liliana P. Montezinho, Paulo J. Oliveira, Gema Frühbeck, Javier Gómez-Ambrosi, Fabrizio Montecucco, Federico Carbone, Mariusz R. Wieckowski, David Q.-H. Wang, Piero Portincasa Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease published pages: 34-45, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2018.11.020 |
Biochemical Pharmacology 160 | 2019-07-18 |
| 2018 |
Inês C.M. Simões, Adriana Fontes, Paolo Pinton, Hans Zischka, Mariusz R. Wieckowski Mitochondria in non-alcoholic fatty liver disease published pages: 93-99, ISSN: 1357-2725, DOI: 10.1016/j.biocel.2017.12.019 |
The International Journal of Biochemistry & Cell Biology 95 | 2019-07-18 |
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