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DesignerPores SIGNED

Understanding and Designing Novel NanoPores

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EC-Contrib. €

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Project "DesignerPores" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://people.bss.phy.cam.ac.uk/
 Total cost 1˙936˙431 €
 EC max contribution 1˙936˙431 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙936˙431.00

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 Project objective

Translocation of ions and molecules is ubiquitous in biology and technology. Despite the tremendous amount of technical development, biological systems are still much more sophisticated in exerting exquisite control over active and passive translocation through nanopores in membranes than their existing synthetic mimics. This proposal aims to build novel designer nanopores that can match naturally evolved systems. For this we have to control all three stages of translocation: 1) diffusion and entry into, 2) diffusion in, and 3) exit from the nanopore. To gain fundamental insight into the translocation process we will employ microfluidic channels combined with holographic optical tweezers. Results from the microscale model system will be directly translated to nanoscale pores built with DNA origami nanotechnology. Our microfluidic experiments will automatically track diffusing spherical and non-spherical particles in artificial channels. Facilitated membrane transport will be mimicked by holographic optical tweezers providing full control over the translocation process. We will clarify how translocation depends on particle-particle, particle-channel, and particle-channel-entrance interactions. The generic principles discovered on the microscale will guide the design of artificial nanopores made by DNA origami self-assembly. Our DNA origami based designer nanopores will lead to a novel class of transporters for molecules, ions, and water through solid-state and lipid membranes. The project will generate a quantitative understanding of membrane transport processes, test existing theoretical models with unprecedented experimental control, and introduce a novel approach to design active and passive nanopores built from DNA.

 Publications

year authors and title journal last update
List of publications.
2019 Jinglin Kong, Jinbo Zhu, Kaikai Chen, Ulrich F. Keyser
Specific Biosensing Using DNA Aptamers and Nanopores
published pages: 1807555, ISSN: 1616-301X, DOI: 10.1002/adfm.201807555
Advanced Functional Materials 29/3 2020-04-14
2020 Mustafa Caglar, Inese Silkina, Bertram T. Brown, Alice L. Thorneywork, Oliver J. Burton, Vitaliy Babenko, Stephen Matthew Gilbert, Alex Zettl, Stephan Hofmann, Ulrich F. Keyser
Tunable Anion-Selective Transport through Monolayer Graphene and Hexagonal Boron Nitride
published pages: , ISSN: 1936-0851, DOI: 10.1021/acsnano.9b08168
ACS Nano 2020-04-14
2019 Alexander Ohmann, Kerstin Göpfrich, Himanshu Joshi, Rebecca F Thompson, Diana Sobota, Neil A Ranson, Aleksei Aksimentiev, Ulrich F Keyser
Controlling aggregation of cholesterol-modified DNA nanostructures
published pages: 11441-11451, ISSN: 0305-1048, DOI: 10.1093/nar/gkz914
Nucleic Acids Research 47/21 2020-04-14
2019 Kaikai Chen, Jinglin Kong, Jinbo Zhu, Niklas Ermann, Paul Predki, Ulrich F. Keyser
Digital Data Storage Using DNA Nanostructures and Solid-State Nanopores
published pages: 1210-1215, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b04715
Nano Letters 19/2 2020-04-14
2019 Filip Bošković, Jinbo Zhu, Kaikai Chen, Ulrich F. Keyser
Monitoring G-Quadruplex Formation with DNA Carriers and Solid-State Nanopores
published pages: 7996-8001, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.9b03184
Nano Letters 19/11 2020-04-14
2019 K. Al Nahas, J. Cama, M. Schaich, K. Hammond, S. Deshpande, C. Dekker, M. G. Ryadnov, U. F. Keyser
A microfluidic platform for the characterisation of membrane active antimicrobials
published pages: 837-844, ISSN: 1473-0197, DOI: 10.1039/c8lc00932e
Lab on a Chip 19/5 2020-04-14
2019 Nicole E. Weckman, Niklas Ermann, Richard Gutierrez, Kaikai Chen, James Graham, Ran Tivony, Andrew Heron, Ulrich F. Keyser
Multiplexed DNA Identification Using Site Specific dCas9 Barcodes and Nanopore Sensing
published pages: 2065-2072, ISSN: 2379-3694, DOI: 10.1021/acssensors.9b00686
ACS Sensors 4/8 2020-04-14
2019 Michael Schaich, Jehangir Cama, Kareem Al Nahas, Diana Sobota, Hannah Sleath, Kevin Jahnke, Siddharth Deshpande, Cees Dekker, Ulrich F. Keyser
An Integrated Microfluidic Platform for Quantifying Drug Permeation across Biomimetic Vesicle Membranes
published pages: 2494-2501, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.9b00086
Molecular Pharmaceutics 16/6 2020-04-14
2019 J. Gladrow, M. Ribezzi-Crivellari, F. Ritort, U. F. Keyser
Experimental evidence of symmetry breaking of transition-path times
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07873-9
Nature Communications 10/1 2020-04-14
2019 Jeffrey Mc Hugh, Kurt Andresen, Ulrich F. Keyser
Cation dependent electroosmotic flow in glass nanopores
published pages: 113702, ISSN: 0003-6951, DOI: 10.1063/1.5116760
Applied Physics Letters 115/11 2020-04-14
2017 Kerstin Göpfrich, Chen-Yu Li, Iwona Mames, Satya Prathyusha Bhamidimarri, Maria Ricci, Jejoong Yoo, Adam Mames, Alexander Ohmann, Mathias Winterhalter, Eugen Stulz, Aleksei Aksimentiev, Ulrich F. Keyser
Correction to Ion Channels Made from a Single Membrane-Spanning DNA Duplex
published pages: 4548-4548, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b02430
Nano Letters 17/7 2020-04-14
2017 Kaikai Chen, Matyas Juhasz, Felix Gularek, Elmar Weinhold, Yu Tian, Ulrich F. Keyser, Nicholas A. W. Bell
Ionic Current-Based Mapping of Short Sequence Motifs in Single DNA Molecules Using Solid-State Nanopores
published pages: 5199-5205, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b01009
Nano Letters 17/9 2020-04-14
2017 Nicholas A. W. Bell, Kaikai Chen, Sandip Ghosal, Maria Ricci, Ulrich F. Keyser
Asymmetric dynamics of DNA entering and exiting a strongly confining nanopore
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00423-9
Nature Communications 8/1 2020-04-14
2018 Karolis Misiunas, Niklas Ermann, Ulrich F. Keyser
QuipuNet: Convolutional Neural Network for Single-Molecule Nanopore Sensing
published pages: 4040-4045, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b01709
Nano Letters 18/6 2020-04-14
2018 Hemmig, Elisa A; Fitzgerald, Clare; Maffeo, Christopher; Hecker, Lisa; Ochmann, Sarah E; Aksimentiev, Aleksei; Tinnefeld, Philip; Keyser, Ulrich Felix
Optical Voltage Sensing Using DNA Origami.
published pages: , ISSN: 1936-0851, DOI: 10.17863/CAM.22565
Nano Letters 3 2020-04-14
2017 Walker, MI; Ubych, K; Saraswat, V; Chalklen, EA; Braeuninger-Weimer, P; Caneva, S; Weatherup, RS; Hofmann, S; Keyser, UF
Extrinsic Cation Selectivity of 2D Membranes
published pages: , ISSN: 1936-0851, DOI: 10.17863/CAM.9055
ACS Nano 3 2020-04-14
2016 Kerstin Göpfrich, Chen-Yu Li, Maria Ricci, Satya Prathyusha Bhamidimarri, Jejoong Yoo, Bertalan Gyenes, Alexander Ohmann, Mathias Winterhalter, Aleksei Aksimentiev, Ulrich F. Keyser
Large-Conductance Transmembrane Porin Made from DNA Origami
published pages: , ISSN: 1936-0851, DOI: 10.1021/acsnano.6b03759
ACS Nano 2020-04-14
2016 Nicholas A. W. Bell, Ulrich F. Keyser
Digitally encoded DNA nanostructures for multiplexed, single-molecule protein sensing with nanopores
published pages: 645-651, ISSN: 1748-3387, DOI: 10.1038/nnano.2016.50
Nature Nanotechnology 11/7 2020-04-14
2016 Kerstin Göpfrich, Chen-Yu Li, Iwona Mames, Satya Prathyusha Bhamidimarri, Maria Ricci, Jejoong Yoo, Adam Mames, Alexander Ohmann, Mathias Winterhalter, Eugen Stulz, Aleksei Aksimentiev, Ulrich F. Keyser
Ion Channels Made from a Single Membrane-Spanning DNA Duplex
published pages: 4665-4669, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.6b02039
Nano Letters 16/7 2020-04-14

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