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YOUNGatHEART

YOUNGatHEART: CARDIAC REJUVENATION BY EPIGENETIC REMODELLING

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EC-Contrib. €

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Partnership

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 YOUNGatHEART project word cloud

Explore the words cloud of the YOUNGatHEART project. It provides you a very rough idea of what is the project "YOUNGatHEART" about.

adulthood    youngatheart    discoveries    hearts    data    performance    basis    therapeutic    despite    regulating    unveil    poses    bmi1    parabiosis    molecular    contributes    inherited    cardiomyopathic    induces    rejuvenation    aged    cardiomyopathy    cvd    aging    transplanted    landscape    remodeling    contributor    feasible    species    patients    systemic    ground    pairing    samples    fronts    healthy    heart    healthcare    unprecedented    transplantation    2b    setting    clinical    screenings    proteomic    decipher    sum    unexplored    inadequate    indication    final    orchestrated    critical    risk    discovered    hallmark    linked    mice    dilated    cardiovascular    regulator    cardiac    reversed    deregulation    significantly    parabiotic    puts    model    transcriptomic    breaking    dcm    epigenetic    dysfunction    1a    tackle    epigenome    suggest    pioneering    interventions    mouse    breakthrough    1b    functional    decode    systematic    integrating    regulation    adult    2a    diagnosed    anti    idea    imaging    progress    disease    circulation    regression    deletion   

Project "YOUNGatHEART" data sheet

The following table provides information about the project.

Coordinator
CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) 

Organization address
address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029
website: www.cnic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙861˙910 €
 EC max contribution 1˙861˙910 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) ES (MADRID) coordinator 1˙861˙910.00

Map

 Project objective

Aging poses the largest risk for cardiovascular disease (CVD) and is orchestrated, to some extent, by epigenetic changes. Despite the significant progress on many fronts in the cardiovascular field, non-inherited epigenetic regulation in cardiac aging and CVD remains unexplored. Dilated Cardiomyopathy (DCM) is a major contributor to healthcare costs and it is the leading indication for heart transplantation. We have recently discovered that adult cardiac-specific deletion of epigenetic regulator Bmi1 in mice induces DCM and heart failure. These unprecedented data support the idea that inadequate epigenetic regulation in adulthood is critical in CVD. In addition, our studies with parabiotic pairing of healthy and DCM-diagnosed mice show that the circulation of a healthy mouse significantly improve the cardiac performance of mouse with DCM. These ground-breaking discoveries suggest that DCM regression, or cardiac rejuvenation, is feasible in terms of epigenetic states. Therefore, YOUNGatHEART will unveil significant breakthrough on (1) how non-inherited epigenetic deregulation induces DCM and (2) how epigenetic remodeling reversed this process. For that, our challenges are: 1A. To decipher how aged-linked cardiac dysfunction contributes to CVD by identifying the epigenetic landscape regulating cardiac aging among species; 1B. To decode how epigenetic deregulation induces DCM by integrating clinical data and samples from DCM-transplanted patients with imaging, transcriptomic, proteomic, and functional approaches from DCM model; and, 2A. To identified systemic factors with anti-cardiomyopathic effects by systematic proteomic screenings after parabiosis and epigenome of the DCM hearts. In sum, YOUNGatHEART puts forward an ambitious but feasible and pioneering program to tackle the epigenetic hallmark in cardiac aging with the final aim (2B) of setting the molecular basis for future therapeutic interventions in CVD.

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The information about "YOUNGATHEART" are provided by the European Opendata Portal: CORDIS opendata.

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