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YOUNGatHEART

YOUNGatHEART: CARDIAC REJUVENATION BY EPIGENETIC REMODELLING

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EC-Contrib. €

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Partnership

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 YOUNGatHEART project word cloud

Explore the words cloud of the YOUNGatHEART project. It provides you a very rough idea of what is the project "YOUNGatHEART" about.

transplantation    mice    regression    imaging    molecular    clinical    basis    diagnosed    regulating    pairing    sum    setting    proteomic    transcriptomic    contributes    inherited    unprecedented    pioneering    parabiosis    indication    functional    integrating    final    deregulation    dilated    cvd    transplanted    heart    anti    progress    cardiac    epigenome    unveil    dysfunction    discoveries    systematic    rejuvenation    significantly    idea    hallmark    reversed    mouse    puts    linked    cardiomyopathy    hearts    regulation    ground    bmi1    discovered    data    systemic    1b    remodeling    breakthrough    healthy    patients    fronts    risk    poses    aging    decode    parabiotic    suggest    2a    adult    samples    cardiovascular    critical    decipher    tackle    feasible    contributor    breaking    screenings    youngatheart    unexplored    model    landscape    epigenetic    aged    inadequate    1a    orchestrated    disease    adulthood    despite    2b    species    circulation    deletion    dcm    regulator    induces    performance    therapeutic    cardiomyopathic    interventions    healthcare   

Project "YOUNGatHEART" data sheet

The following table provides information about the project.

Coordinator
CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) 

Organization address
address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029
website: www.cnic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙861˙910 €
 EC max contribution 1˙861˙910 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) ES (MADRID) coordinator 1˙861˙910.00

Map

 Project objective

Aging poses the largest risk for cardiovascular disease (CVD) and is orchestrated, to some extent, by epigenetic changes. Despite the significant progress on many fronts in the cardiovascular field, non-inherited epigenetic regulation in cardiac aging and CVD remains unexplored. Dilated Cardiomyopathy (DCM) is a major contributor to healthcare costs and it is the leading indication for heart transplantation. We have recently discovered that adult cardiac-specific deletion of epigenetic regulator Bmi1 in mice induces DCM and heart failure. These unprecedented data support the idea that inadequate epigenetic regulation in adulthood is critical in CVD. In addition, our studies with parabiotic pairing of healthy and DCM-diagnosed mice show that the circulation of a healthy mouse significantly improve the cardiac performance of mouse with DCM. These ground-breaking discoveries suggest that DCM regression, or cardiac rejuvenation, is feasible in terms of epigenetic states. Therefore, YOUNGatHEART will unveil significant breakthrough on (1) how non-inherited epigenetic deregulation induces DCM and (2) how epigenetic remodeling reversed this process. For that, our challenges are: 1A. To decipher how aged-linked cardiac dysfunction contributes to CVD by identifying the epigenetic landscape regulating cardiac aging among species; 1B. To decode how epigenetic deregulation induces DCM by integrating clinical data and samples from DCM-transplanted patients with imaging, transcriptomic, proteomic, and functional approaches from DCM model; and, 2A. To identified systemic factors with anti-cardiomyopathic effects by systematic proteomic screenings after parabiosis and epigenome of the DCM hearts. In sum, YOUNGatHEART puts forward an ambitious but feasible and pioneering program to tackle the epigenetic hallmark in cardiac aging with the final aim (2B) of setting the molecular basis for future therapeutic interventions in CVD.

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The information about "YOUNGATHEART" are provided by the European Opendata Portal: CORDIS opendata.

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