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YOUNGatHEART

YOUNGatHEART: CARDIAC REJUVENATION BY EPIGENETIC REMODELLING

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EC-Contrib. €

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Partnership

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 YOUNGatHEART project word cloud

Explore the words cloud of the YOUNGatHEART project. It provides you a very rough idea of what is the project "YOUNGatHEART" about.

cardiac    systemic    performance    anti    cardiomyopathy    contributor    idea    bmi1    samples    1b    hallmark    inherited    decode    puts    epigenetic    regression    1a    proteomic    youngatheart    aging    circulation    poses    induces    feasible    rejuvenation    decipher    breaking    deregulation    systematic    aged    healthcare    significantly    interventions    regulator    breakthrough    integrating    screenings    ground    deletion    imaging    parabiosis    unexplored    fronts    cvd    epigenome    unprecedented    dysfunction    indication    pairing    inadequate    unveil    therapeutic    discoveries    transcriptomic    adult    basis    contributes    transplanted    risk    disease    cardiomyopathic    parabiotic    setting    orchestrated    functional    linked    landscape    transplantation    dcm    cardiovascular    progress    molecular    healthy    reversed    discovered    adulthood    mice    heart    tackle    data    patients    regulating    remodeling    2a    hearts    species    despite    regulation    2b    pioneering    final    mouse    dilated    clinical    suggest    diagnosed    model    sum    critical   

Project "YOUNGatHEART" data sheet

The following table provides information about the project.

Coordinator
CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) 

Organization address
address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029
website: www.cnic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙861˙910 €
 EC max contribution 1˙861˙910 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) ES (MADRID) coordinator 1˙861˙910.00

Map

 Project objective

Aging poses the largest risk for cardiovascular disease (CVD) and is orchestrated, to some extent, by epigenetic changes. Despite the significant progress on many fronts in the cardiovascular field, non-inherited epigenetic regulation in cardiac aging and CVD remains unexplored. Dilated Cardiomyopathy (DCM) is a major contributor to healthcare costs and it is the leading indication for heart transplantation. We have recently discovered that adult cardiac-specific deletion of epigenetic regulator Bmi1 in mice induces DCM and heart failure. These unprecedented data support the idea that inadequate epigenetic regulation in adulthood is critical in CVD. In addition, our studies with parabiotic pairing of healthy and DCM-diagnosed mice show that the circulation of a healthy mouse significantly improve the cardiac performance of mouse with DCM. These ground-breaking discoveries suggest that DCM regression, or cardiac rejuvenation, is feasible in terms of epigenetic states. Therefore, YOUNGatHEART will unveil significant breakthrough on (1) how non-inherited epigenetic deregulation induces DCM and (2) how epigenetic remodeling reversed this process. For that, our challenges are: 1A. To decipher how aged-linked cardiac dysfunction contributes to CVD by identifying the epigenetic landscape regulating cardiac aging among species; 1B. To decode how epigenetic deregulation induces DCM by integrating clinical data and samples from DCM-transplanted patients with imaging, transcriptomic, proteomic, and functional approaches from DCM model; and, 2A. To identified systemic factors with anti-cardiomyopathic effects by systematic proteomic screenings after parabiosis and epigenome of the DCM hearts. In sum, YOUNGatHEART puts forward an ambitious but feasible and pioneering program to tackle the epigenetic hallmark in cardiac aging with the final aim (2B) of setting the molecular basis for future therapeutic interventions in CVD.

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The information about "YOUNGATHEART" are provided by the European Opendata Portal: CORDIS opendata.

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