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YOUNGatHEART

YOUNGatHEART: CARDIAC REJUVENATION BY EPIGENETIC REMODELLING

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EC-Contrib. €

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Partnership

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 YOUNGatHEART project word cloud

Explore the words cloud of the YOUNGatHEART project. It provides you a very rough idea of what is the project "YOUNGatHEART" about.

screenings    regulator    inadequate    transplanted    hearts    mouse    breakthrough    molecular    cardiac    sum    remodeling    transcriptomic    decipher    proteomic    aging    contributor    inherited    contributes    unexplored    1b    induces    heart    feasible    dysfunction    unveil    cardiomyopathic    tackle    youngatheart    landscape    integrating    suggest    regulating    model    clinical    fronts    transplantation    functional    imaging    systemic    bmi1    breaking    epigenetic    mice    regression    rejuvenation    reversed    basis    unprecedented    aged    risk    final    idea    hallmark    disease    species    cardiomyopathy    anti    epigenome    adulthood    interventions    decode    dilated    linked    performance    diagnosed    patients    poses    data    pairing    healthy    healthcare    discovered    circulation    pioneering    adult    indication    1a    cardiovascular    puts    orchestrated    cvd    samples    deregulation    progress    parabiosis    therapeutic    significantly    despite    2b    deletion    parabiotic    regulation    setting    critical    systematic    discoveries    2a    ground    dcm   

Project "YOUNGatHEART" data sheet

The following table provides information about the project.

Coordinator
CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) 

Organization address
address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029
website: www.cnic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙861˙910 €
 EC max contribution 1˙861˙910 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) ES (MADRID) coordinator 1˙861˙910.00

Map

 Project objective

Aging poses the largest risk for cardiovascular disease (CVD) and is orchestrated, to some extent, by epigenetic changes. Despite the significant progress on many fronts in the cardiovascular field, non-inherited epigenetic regulation in cardiac aging and CVD remains unexplored. Dilated Cardiomyopathy (DCM) is a major contributor to healthcare costs and it is the leading indication for heart transplantation. We have recently discovered that adult cardiac-specific deletion of epigenetic regulator Bmi1 in mice induces DCM and heart failure. These unprecedented data support the idea that inadequate epigenetic regulation in adulthood is critical in CVD. In addition, our studies with parabiotic pairing of healthy and DCM-diagnosed mice show that the circulation of a healthy mouse significantly improve the cardiac performance of mouse with DCM. These ground-breaking discoveries suggest that DCM regression, or cardiac rejuvenation, is feasible in terms of epigenetic states. Therefore, YOUNGatHEART will unveil significant breakthrough on (1) how non-inherited epigenetic deregulation induces DCM and (2) how epigenetic remodeling reversed this process. For that, our challenges are: 1A. To decipher how aged-linked cardiac dysfunction contributes to CVD by identifying the epigenetic landscape regulating cardiac aging among species; 1B. To decode how epigenetic deregulation induces DCM by integrating clinical data and samples from DCM-transplanted patients with imaging, transcriptomic, proteomic, and functional approaches from DCM model; and, 2A. To identified systemic factors with anti-cardiomyopathic effects by systematic proteomic screenings after parabiosis and epigenome of the DCM hearts. In sum, YOUNGatHEART puts forward an ambitious but feasible and pioneering program to tackle the epigenetic hallmark in cardiac aging with the final aim (2B) of setting the molecular basis for future therapeutic interventions in CVD.

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The information about "YOUNGATHEART" are provided by the European Opendata Portal: CORDIS opendata.

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