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YOUNGatHEART

YOUNGatHEART: CARDIAC REJUVENATION BY EPIGENETIC REMODELLING

Total Cost €

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EC-Contrib. €

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Partnership

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 YOUNGatHEART project word cloud

Explore the words cloud of the YOUNGatHEART project. It provides you a very rough idea of what is the project "YOUNGatHEART" about.

rejuvenation    clinical    cvd    unexplored    regulating    feasible    sum    setting    circulation    contributor    puts    cardiomyopathic    linked    remodeling    disease    transplantation    mouse    final    healthy    aging    imaging    breakthrough    cardiac    epigenetic    cardiomyopathy    pairing    breaking    hearts    induces    systematic    interventions    discovered    1a    suggest    patients    inadequate    systemic    poses    inherited    contributes    molecular    functional    2b    transcriptomic    fronts    healthcare    orchestrated    tackle    aged    decipher    regulation    parabiotic    heart    diagnosed    deregulation    proteomic    dilated    anti    landscape    deletion    species    integrating    data    regulator    epigenome    parabiosis    mice    2a    basis    adult    significantly    unveil    risk    critical    regression    unprecedented    indication    model    transplanted    adulthood    hallmark    dysfunction    1b    ground    bmi1    samples    cardiovascular    reversed    dcm    progress    therapeutic    screenings    youngatheart    decode    performance    idea    pioneering    discoveries    despite   

Project "YOUNGatHEART" data sheet

The following table provides information about the project.

Coordinator
CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) 

Organization address
address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029
website: www.cnic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙861˙910 €
 EC max contribution 1˙861˙910 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) ES (MADRID) coordinator 1˙861˙910.00

Map

 Project objective

Aging poses the largest risk for cardiovascular disease (CVD) and is orchestrated, to some extent, by epigenetic changes. Despite the significant progress on many fronts in the cardiovascular field, non-inherited epigenetic regulation in cardiac aging and CVD remains unexplored. Dilated Cardiomyopathy (DCM) is a major contributor to healthcare costs and it is the leading indication for heart transplantation. We have recently discovered that adult cardiac-specific deletion of epigenetic regulator Bmi1 in mice induces DCM and heart failure. These unprecedented data support the idea that inadequate epigenetic regulation in adulthood is critical in CVD. In addition, our studies with parabiotic pairing of healthy and DCM-diagnosed mice show that the circulation of a healthy mouse significantly improve the cardiac performance of mouse with DCM. These ground-breaking discoveries suggest that DCM regression, or cardiac rejuvenation, is feasible in terms of epigenetic states. Therefore, YOUNGatHEART will unveil significant breakthrough on (1) how non-inherited epigenetic deregulation induces DCM and (2) how epigenetic remodeling reversed this process. For that, our challenges are: 1A. To decipher how aged-linked cardiac dysfunction contributes to CVD by identifying the epigenetic landscape regulating cardiac aging among species; 1B. To decode how epigenetic deregulation induces DCM by integrating clinical data and samples from DCM-transplanted patients with imaging, transcriptomic, proteomic, and functional approaches from DCM model; and, 2A. To identified systemic factors with anti-cardiomyopathic effects by systematic proteomic screenings after parabiosis and epigenome of the DCM hearts. In sum, YOUNGatHEART puts forward an ambitious but feasible and pioneering program to tackle the epigenetic hallmark in cardiac aging with the final aim (2B) of setting the molecular basis for future therapeutic interventions in CVD.

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The information about "YOUNGATHEART" are provided by the European Opendata Portal: CORDIS opendata.

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