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MOvE-ECG SIGNED

Moving from genome wide association to elucidating causal mechanisms of electrocardiographic traits

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MOvE-ECG" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS GRONINGEN 

Organization address
address: HANZEPLEIN 1
city: GRONINGEN
postcode: 9713 GZ
website: www.umcg.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 196˙380 €
 EC max contribution 196˙380 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-GF
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) coordinator 196˙380.00
2    THE GENERAL HOSPITAL CORPORATION US (BOSTON MA) partner 0.00

Map

 Project objective

Understanding how genes and genetic variants influence heart function is of major importance, not only from a basic science viewpoint, but also as a foundation for future innovation in medicine and health-care. In this proposal, Dr. Niek Verweij aims to identify novel genes and mechanisms underlying heart growth. This will be done in collaboration with the top-scientist Dr. Chris Newton-Cheh (Harvard/Massachusetts General Hospital, Broad Institute of Harvard and MIT) and Dr. Laurie Boyer (MIT). As heart growth accompanies many forms of heart disease, this project will focus on the QRS-complex (of the electrocardiogram) in population based studies as this reflects electrically active cardiac mass. We will search for novel low-frequency genetic variants associated with the QRS-complex within the CHARGE consortium and within a Dutch population using dedicated reference panels. Loci will be interrogated through the use of published and unpublished in silico big-data sets to further prioritize variants and regions for experimental follow-up aimed at elucidating biological mechanisms. This project will bridge the gap between population based genetic association studies (with Dr. Newton-Cheh) to functional biology (with Dr. Laurie Boyer). This proposal will provide novel insights into cardiomyocyte functioning and provide novel avenues to study heart disease vulnerability and design innovative treatment.

 Publications

year authors and title journal last update
List of publications.
2018 Niek Verweij, Yordi J. van de Vegte, Pim van der Harst
Genetic study links components of the autonomous nervous system to heart-rate profile during exercise
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03395-6
Nature Communications 9/1 2019-06-18
2018 Yordi J. van de Vegte, Pim van der Harst, Niek Verweij
Heart Rate Recovery 10 Seconds After Cessation of Exercise Predicts Death
published pages: e008341, ISSN: 2047-9980, DOI: 10.1161/JAHA.117.008341
Journal of the American Heart Association 7/8 2019-06-18
2018 Pim van der Harst, Niek Verweij
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery DiseaseNovelty and Significance
published pages: 433-443, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.117.312086
Circulation Research 122/3 2019-06-18
2016 Niek Verweij, Irene Mateo Leach, Aaron Isaacs, Dan E. Arking, Joshua C. Bis, Tune H. Pers, Marten E. Van Den Berg, Leo-Pekka Lyytikäinen, Phil Barnett, Xinchen Wang, Elsayed Z. Soliman, Cornelia M. Van Duijn, Mika Kähönen, Dirk J. Van Veldhuisen, Jan A. Kors, Olli T. Raitakari, Claudia T. Silva, Terho Lehtimäki, Hans L. Hillege, Joel N. Hirschhorn, Laurie A. Boyer, Wiek H. Van Gilst, Alvaro Alonso, Nona Sotoodehnia, Mark Eijgelsheim, Rudolf A. De Boer, Paul I. W. De Bakker, Lude Franke, Pim Van Der Harst
Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram
published pages: 2093-2103, ISSN: 0964-6906, DOI: 10.1093/hmg/ddw058
Human Molecular Genetics 25/10 2019-06-18
2016 Ruben N Eppinga, Yanick Hagemeijer, Stephen Burgess, David A Hinds, Kari Stefansson, Daniel F Gudbjartsson, Dirk J van Veldhuisen, Patricia B Munroe, Niek Verweij, Pim van der Harst
Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality
published pages: 1557-1563, ISSN: 1061-4036, DOI: 10.1038/ng.3708
Nature Genetics 48/12 2019-06-18
2015 G. Kosova, N. Verweij, P. van der Harst, C. Newton-Cheh, on behalf of the CHARGE Consortium EX-EKG working group.
Meta-analysis of exome chip variants identifies rare and common variants associated with electrocardiographic left ventricular mass
published pages: , ISSN: , DOI:
ASHG congress 2015 Baltimore, MD 2019-06-18
2017 Niek Verweij, Ruben N. Eppinga, Yanick Hagemeijer, Pim van der Harst
Identification of 15 novel risk loci for coronary artery disease and genetic risk of recurrent events, atrial fibrillation and heart failure
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-03062-8
Scientific Reports 7/1 2019-06-18
2017 Helen R Warren, Evangelos Evangelou, Claudia P Cabrera, He Gao, Meixia Ren, Borbala Mifsud, Ioanna Ntalla, Praveen Surendran, Chunyu Liu, James P Cook, Aldi T Kraja, Fotios Drenos, Marie Loh, Niek Verweij, Jonathan Marten, Ibrahim Karaman, Marcelo P Segura Lepe, Paul F O\'Reilly, Joanne Knight, Harold Snieder, Norihiro Kato, Jiang He, E Shyong Tai, M Abdullah Said, David Porteous, Maris Alver, Neil Poulter, Martin Farrall, Ron T Gansevoort, Sandosh Padmanabhan, Reedik Mägi, Alice Stanton, John Connell, Stephan J L Bakker, Andres Metspalu, Denis C Shields, Simon Thom, Morris Brown, Peter Sever, Tõnu Esko, Caroline Hayward, Pim van der Harst, Danish Saleheen, Rajiv Chowdhury, John C Chambers, Daniel I Chasman, Aravinda Chakravarti, Christopher Newton-Cheh, Cecilia M Lindgren, Daniel Levy, Jaspal S Kooner, Bernard Keavney, Maciej Tomaszewski, Nilesh J Samani, Joanna M M Howson, Martin D Tobin, Patricia B Munroe, Georg B Ehret, Louise V Wain, Louise V Wain, Ahmad Vaez, Rick Jansen, Roby Joehanes, Peter J van der Most, A Mesut Erzurumluoglu, Paul O\'Reilly, Claudia P Cabrera, Helen R Warren, Lynda M Rose, Germaine C Verwoert, Jouke-Jan Hottenga, Rona J Strawbridge, Tonu Esko, Dan E Arking, Shih-Jen Hwang, Xiuqing Guo, Zoltan Kutalik, Stella Trompet, Nick Shrine, Alexander Teumer, Janina S Ried, Joshua C Bis, Albert V Smith, Najaf Amin, Ilja M Nolte, Leo-Pekka Lyytikäinen, Anubha Mahajan, Nicholas J Wareham, Edith Hofer, Peter K Joshi, Kati Kristiansson, Michela Traglia, Aki S Havulinna, Anuj Goel, Mike A Nalls, Siim Sõber, Dragana Vuckovic, Jian\'an Luan, Fabiola Del Greco M, Kristin L Ayers, Jaume Marrugat, Daniela Ruggiero, Lorna M Lopez, Teemu Niiranen, Stefan Enroth, Anne U Jackson, Christopher P Nelson, Jennifer E Huffman, Weihua Zhang, Jonathan Marten, Ilaria Gandin, Sarah E Harris, Tatijana Zemonik, Yingchang Lu, Evangelos Evangelou, Nabi Shah, Martin H de Borst, Massimo Mangino, Bram P Prins, Archie Campbell, Ruifang Li-Gao, Ganesh Chauhan, Christopher Oldmeadow, Gonçalo Abecasis, Maryam Abedi, Caterina M Barbieri, Michael R Barnes, Chiara Batini, Tineka Blake, Michael Boehnke, Erwin P Bottinger, Peter S Braund, Morris Brown, Marco Brumat, Harry Campbell, John C Chambers, Massimiliano Cocca, Francis Collins, John Connell, Heather J Cordell, Jeffrey J Damman, Gail Davies, Eco J de Geus, Renée de Mutsert, Joris Deelen, Yusuf Demirkale, Alex S F Doney, Marcus Dörr, Martin Farrall, Teresa Ferreira, Mattias Frånberg, He Gao, Vilmantas Giedraitis, Christian Gieger, Franco Giulianini, Alan J Gow, Anders Hamsten, Tamara B Harris, Albert Hofman, Elizabeth G Holliday, Marjo-Riitta Jarvelin, Åsa Johansson, Andrew D Johnson, Pekka Jousilahti, Antti Jula, Mika Kähönen, Sekar Kathiresan, Kay-Tee Khaw, Ivana Kolcic, Seppo Koskinen, Claudia Langenberg, Marty Larson, Lenore J Launer, Benjamin Lehne, David C M Liewald, Li Lin, Lars Lind, François Mach, Chrysovalanto Mamasoula, Cristina Menni, Borbala Mifsud, Yuri Milaneschi, Anna Morgan, Andrew D Morris, Alanna C Morrison, Peter J Munson, Priyanka Nandakumar, Quang Tri Nguyen, Teresa Nutile, Albertine J Oldehinkel, Ben A Oostra, Elin Org, Sandosh Padmanabhan, Aarno Palotie, Guillaume Paré, Alison Pattie, Brenda W J H Penninx, Neil Poulter, Peter P Pramstaller, Olli T Raitakari, Meixia Ren, Kenneth Rice, Paul M Ridker, Harriëtte Riese, Samuli Ripatti, Antonietta Robino, Jerome I Rotter, Igor Rudan, Yasaman Saba, Aude Saint Pierre, Cinzia F Sala, Antti-Pekka Sarin, Reinhold Schmidt, Rodney Scott, Marc A Seelen, Denis C Shields, David Siscovick, Rossella Sorice, Alice Stanton, David J Stott, Johan Sundström, Morris Swertz, Kent D Taylor, Simon Thom, Ioanna Tzoulaki, Christophe Tzourio, André G Uitterlinden, Uwe Völker, Peter Vollenweider, Sarah Wild, Gonneke Willemsen, Alan F Wright, Jie Yao, Sébastien Thériault, David Conen, Attia John, Peter Sever, Stéphanie Debette, Dennis O Mook-Kanamori, Eleftheria Zeggini, Tim D Spector, Pim van der Harst, Colin N A Palmer, Anne-Claire Ve
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
published pages: 403-415, ISSN: 1061-4036, DOI: 10.1038/ng.3768
Nature Genetics 49/3 2019-06-18
2017 Ruben N. Eppinga, Minke H.T. Hartman, Niek Verweij, J. Joep van der Harst, Michiel Rienstra, Pim van der Harst
Refining Thromboembolic Risk in the General Population
published pages: 403-404, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2017.05.022
Journal of the American College of Cardiology 70/3 2019-06-18
2017 Marten E. van den Berg, Helen R. Warren, Claudia P. Cabrera, Niek Verweij, Borbala Mifsud, Jeffrey Haessler, Nathan A. Bihlmeyer, Yi-Ping Fu, Stefan Weiss, Henry J. Lin, Niels Grarup, Ruifang Li-Gao, Giorgio Pistis, Nabi Shah, Jennifer A. Brody, Martina Müller-Nurasyid, Honghuang Lin, Hao Mei, Albert V. Smith, Leo-Pekka Lyytikäinen, Leanne M. Hall, Jessica van Setten, Stella Trompet, Bram P. Prins, Aaron Isaacs, Farid Radmanesh, Jonathan Marten, Aiman Entwistle, Jan A. Kors, Claudia T. Silva, Alvaro Alonso, Joshua C. Bis, Rudolf de Boer, Hugoline G. de Haan, Renée de Mutsert, George Dedoussis, Anna F. Dominiczak, Alex S. F. Doney, Patrick T. Ellinor, Ruben N. Eppinga, Stephan B. Felix, Xiuqing Guo, Yanick Hagemeijer, Torben Hansen, Tamara B. Harris, Susan R. Heckbert, Paul L. Huang, Shih-Jen Hwang, Mika Kähönen, Jørgen K. Kanters, Ivana Kolcic, Lenore J. Launer, Man Li, Jie Yao, Allan Linneberg, Simin Liu, Peter W. Macfarlane, Massimo Mangino, Andrew D. Morris, Antonella Mulas, Alison D. Murray, Christopher P. Nelson, Marco Orrú, Sandosh Padmanabhan, Annette Peters, David J. Porteous, Neil Poulter, Bruce M. Psaty, Lihong Qi, Olli T. Raitakari, Fernando Rivadeneira, Carolina Roselli, Igor Rudan, Naveed Sattar, Peter Sever, Moritz F. Sinner, Elsayed Z. Soliman, Timothy D. Spector, Alice V. Stanton, Kathleen E. Stirrups, Kent D. Taylor, Martin D. Tobin, André Uitterlinden, Ilonca Vaartjes, Arno W. Hoes, Peter van der Meer, Uwe Völker, Melanie Waldenberger, Zhijun Xie, Magdalena Zoledziewska, Andrew Tinker, Ozren Polasek, Jonathan Rosand, Yalda Jamshidi, Cornelia M. van Duijn, Eleftheria Zeggini, J. Wouter Jukema, Folkert W. Asselbergs, Nilesh J. Samani, Terho Lehtimäki, Vilmundur Gudnason, James Wilson, Steven A. Lubitz, Stefan Kääb, Nona Sotoodehnia, Mark J. Caulfield, Colin N. A. Palmer, Serena Sanna, Dennis O. Mook-Kanamori, Panos Deloukas, Oluf Pedersen, Jerome I. Rotter, Marcus Dörr, Chris J. O\'Donnell, Caroline Hayward, Dan E. Arking, Charles Kooperberg, Pim van der Harst, Mark Eijgelsheim, Bruno H. Stricker, Patricia B. Munroe
Discovery of novel heart rate-associated loci using the Exome Chip
published pages: 2346-2363, ISSN: 0964-6906, DOI: 10.1093/hmg/ddx113
Human Molecular Genetics 26/12 2019-06-18
2018 M. Abdullah Said, Ruben N. Eppinga, Erik Lipsic, Niek Verweij, Pim van der Harst
Relationship of Arterial Stiffness Index and Pulse Pressure With Cardiovascular Disease and Mortality
published pages: e007621, ISSN: 2047-9980, DOI: 10.1161/JAHA.117.007621
Journal of the American Heart Association 7/2 2019-06-18
2017 M. Abdullah Said, Ruben N. Eppinga, Yanick Hagemeijer, Niek Verweij, Pim van der Harst
Telomere Length and Risk of Cardiovascular Disease and Cancer
published pages: 506-507, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2017.05.044
Journal of the American College of Cardiology 70/4 2019-06-18

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