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SIRENE

Silencing miR-199b to attenuate the progression of heart failure.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SIRENE project word cloud

Explore the words cloud of the SIRENE project. It provides you a very rough idea of what is the project "SIRENE" about.

animal    therapeutics    strategy    endogenous    venture    pressure    models    commercial    preclinical    newly    pathological    valuable    principal    leads    species    histological    rna    protective    signalling    mice    arrhythmias    symptoms    found    mirnas    data    vivo    clinical    sustained    dose    commercialisation    overload    affinity    regulate    risk    strength    business    implicated    molecules    abnormalities    mirna    simultaneously    199b    micrornas    clinically    mouse    stage    feasibility    rescue    strategic    cardiac    hypertrophy    recognition    marks    functional    presenting    lethal    molecular    interconnected    calmirs    ip    efficacy    sirene    rats    consolidate    erc    powerful    therapeutic    hypertrophic    knockdown    larger    adult    shown    mir    capitalists    specificity    web    counteracting    profound    coding    silencing    longer    morphological    model    promise    antagonists    market    holds    heart    class    proposition    demonstrates    generation   

Project "SIRENE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT MAASTRICHT 

Organization address
address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD
website: http://www.maastrichtuniversity.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 150˙000.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Cardiac hypertrophy is the principal risk factor for the development of heart failure and lethal arrhythmias. A complex web of interconnected signalling pathways has been implicated in hypertrophy and species of non-coding RNA molecules, microRNAs, have been shown to regulate these pathways. The recognition of microRNAs as potential therapeutic targets marks the principal step towards new therapeutic concepts. The SIRENE project represents the advancement of the therapeutic strength of miRNA silencing in clinically relevant heart failure models towards a valuable proposition for counteracting pathological hypertrophic signalling and heart failure development. In specific, during the related ERC CALMIRS project, it was found that sustained knockdown of endogenous miR-199b in the adult mouse heart in vivo leads to profound protective effects against symptoms of heart failure. Therefore, a new class of RNA antagonists, targeting miRNAs is powerful and holds great promise to become the next generation therapeutics. At this stage the newly developed antagonists are unique in their affinity and specificity for miR-199b and current data demonstrates a profound rescue by miR-199b antagonists on heart failure symptoms such as pressure overload induced cardiac morphological, histological, functional and molecular abnormalities in mice. The challenge of the SIRENE project is to identify immediate and longer term opportunities for commercialisation with high clinical and commercial feasibility. Therefore different business models will be studied in terms of market research, IP strategy and business development to eventually consolidate a commercial strategy and business case for presenting our business proposition to strategic partners or venture capitalists. Simultaneously, dose-range finding and efficacy studies will be conducted in rats, a clinically relevant and larger animal model of heart failure, for further preclinical development.

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The information about "SIRENE" are provided by the European Opendata Portal: CORDIS opendata.

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