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SIRENE

Silencing miR-199b to attenuate the progression of heart failure.

Total Cost €

EC-Contrib. €

Partnership

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SIRENE project word cloud

Explore the words cloud of the SIRENE project. It provides you a very rough idea of what is the project "SIRENE" about.

dose regulate pathological mirna rescue functional web signalling affinity overload class protective commercialisation hypertrophy clinical efficacy simultaneously histological mir heart commercial animal mice therapeutics calmirs sirene knockdown lethal marks found powerful preclinical endogenous symptoms holds rats strategic larger mirnas venture molecules morphological data silencing cardiac longer interconnected pressure rna market antagonists coding specificity clinically newly adult hypertrophic erc profound strength ip strategy shown consolidate model capitalists proposition mouse valuable business promise risk feasibility demonstrates arrhythmias generation principal micrornas species stage presenting vivo counteracting sustained abnormalities molecular leads recognition implicated 199b models therapeutic

Project "SIRENE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-PoC
Funding Scheme	ERC-POC
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2017-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	coordinator	150˙000.00

Map

Project objective

Cardiac hypertrophy is the principal risk factor for the development of heart failure and lethal arrhythmias. A complex web of interconnected signalling pathways has been implicated in hypertrophy and species of non-coding RNA molecules, microRNAs, have been shown to regulate these pathways. The recognition of microRNAs as potential therapeutic targets marks the principal step towards new therapeutic concepts. The SIRENE project represents the advancement of the therapeutic strength of miRNA silencing in clinically relevant heart failure models towards a valuable proposition for counteracting pathological hypertrophic signalling and heart failure development. In specific, during the related ERC CALMIRS project, it was found that sustained knockdown of endogenous miR-199b in the adult mouse heart in vivo leads to profound protective effects against symptoms of heart failure. Therefore, a new class of RNA antagonists, targeting miRNAs is powerful and holds great promise to become the next generation therapeutics. At this stage the newly developed antagonists are unique in their affinity and specificity for miR-199b and current data demonstrates a profound rescue by miR-199b antagonists on heart failure symptoms such as pressure overload induced cardiac morphological, histological, functional and molecular abnormalities in mice. The challenge of the SIRENE project is to identify immediate and longer term opportunities for commercialisation with high clinical and commercial feasibility. Therefore different business models will be studied in terms of market research, IP strategy and business development to eventually consolidate a commercial strategy and business case for presenting our business proposition to strategic partners or venture capitalists. Simultaneously, dose-range finding and efficacy studies will be conducted in rats, a clinically relevant and larger animal model of heart failure, for further preclinical development.

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The information about "SIRENE" are provided by the European Opendata Portal: CORDIS opendata.