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SIRENE

Silencing miR-199b to attenuate the progression of heart failure.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SIRENE project word cloud

Explore the words cloud of the SIRENE project. It provides you a very rough idea of what is the project "SIRENE" about.

silencing    rna    data    coding    stage    199b    sustained    shown    generation    ip    mir    strategic    regulate    efficacy    mirnas    market    signalling    functional    found    feasibility    mice    valuable    adult    erc    commercial    business    preclinical    marks    demonstrates    model    models    leads    counteracting    overload    pressure    micrornas    class    affinity    sirene    clinical    clinically    therapeutics    web    promise    vivo    hypertrophic    venture    newly    larger    calmirs    molecules    powerful    pathological    capitalists    rats    morphological    abnormalities    knockdown    longer    animal    species    therapeutic    dose    lethal    protective    holds    specificity    principal    interconnected    molecular    histological    cardiac    risk    implicated    profound    mouse    heart    rescue    strategy    strength    proposition    commercialisation    simultaneously    antagonists    symptoms    presenting    mirna    recognition    consolidate    endogenous    arrhythmias    hypertrophy   

Project "SIRENE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT MAASTRICHT 

Organization address
address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD
website: http://www.maastrichtuniversity.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 150˙000.00

Map

 Project objective

Cardiac hypertrophy is the principal risk factor for the development of heart failure and lethal arrhythmias. A complex web of interconnected signalling pathways has been implicated in hypertrophy and species of non-coding RNA molecules, microRNAs, have been shown to regulate these pathways. The recognition of microRNAs as potential therapeutic targets marks the principal step towards new therapeutic concepts. The SIRENE project represents the advancement of the therapeutic strength of miRNA silencing in clinically relevant heart failure models towards a valuable proposition for counteracting pathological hypertrophic signalling and heart failure development. In specific, during the related ERC CALMIRS project, it was found that sustained knockdown of endogenous miR-199b in the adult mouse heart in vivo leads to profound protective effects against symptoms of heart failure. Therefore, a new class of RNA antagonists, targeting miRNAs is powerful and holds great promise to become the next generation therapeutics. At this stage the newly developed antagonists are unique in their affinity and specificity for miR-199b and current data demonstrates a profound rescue by miR-199b antagonists on heart failure symptoms such as pressure overload induced cardiac morphological, histological, functional and molecular abnormalities in mice. The challenge of the SIRENE project is to identify immediate and longer term opportunities for commercialisation with high clinical and commercial feasibility. Therefore different business models will be studied in terms of market research, IP strategy and business development to eventually consolidate a commercial strategy and business case for presenting our business proposition to strategic partners or venture capitalists. Simultaneously, dose-range finding and efficacy studies will be conducted in rats, a clinically relevant and larger animal model of heart failure, for further preclinical development.

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The information about "SIRENE" are provided by the European Opendata Portal: CORDIS opendata.

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