BLUEPRINT

A BLUEPRINT of Haematopoietic Epigenomes

 Coordinatore STICHTING KATHOLIEKE UNIVERSITEIT 

 Organization address address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ

contact info
Titolo: Dr.
Nome: Marion
Cognome: Bussemakers
Email: send email
Telefono: 31243615757
Fax: 31243610520

 Nazionalità Coordinatore Netherlands [NL]
 Totale costo 39˙635˙628 €
 EC contributo 29˙996˙664 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2011-single-stage
 Funding Scheme CP-IP
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-10-01   -   2016-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT

 Organization address address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ

contact info
Titolo: Dr.
Nome: Marion
Cognome: Bussemakers
Email: send email
Telefono: 31243615757
Fax: 31243610520

NL (NIJMEGEN) coordinator 5˙435˙138.73
2    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Ms.
Nome: Renata
Cognome: Schaeffer
Email: send email
Telefono: +44 1223 333543
Fax: +44 1223 332988

UK (CAMBRIDGE) participant 3˙681˙477.00
3    FUNDACIO PRIVADA PARC CIENTIFIC DE BARCELONA

 Organization address address: Baldiri i Reixac, 10-12
city: BARCELONA
postcode: 8028

contact info
Titolo: Mr.
Nome: Moises
Cognome: Tarté
Email: send email
Telefono: +34 93 4037036
Fax: +34 93 4029063

ES (BARCELONA) participant 1˙880˙000.00
4    EUROPEAN MOLECULAR BIOLOGY LABORATORY

 Organization address address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Mr.
Nome: Tom
Cognome: Ratcliff
Email: send email
Telefono: +44 1223 492 528
Fax: +44 1223 494 468

DE (HEIDELBERG) participant 1˙630˙189.60
5    FUNDACIO CENTRE DE REGULACIO GENOMICA

 Organization address address: CARRER DOCTOR AIGUADER 88
city: BARCELONA
postcode: 8003

contact info
Titolo: Ms.
Nome: Mariana
Cognome: Morlans
Email: send email
Telefono: +34 93 3160108
Fax: +34 93 3969983

ES (BARCELONA) participant 1˙536˙800.00
6    CELLZOME AG

 Organization address address: MEYERHOFSTRASSE 1
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Mr.
Nome: Reinhard
Cognome: Markus
Email: send email
Telefono: +49 6221 13757 107
Fax: +49 6221 13757 204

DE (HEIDELBERG) participant 1˙214˙400.00
7    QUEEN MARY UNIVERSITY OF LONDON

 Organization address address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS

contact info
Titolo: Ms.
Nome: Szendeffy
Cognome: Tanya
Email: send email
Telefono: 442079000000

UK (LONDON) participant 1˙165˙846.00
8    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Martin
Cognome: Vingron
Email: send email
Telefono: +49 30 8413 1150
Fax: +49 30 8413 1152

DE (MUENCHEN) participant 984˙200.00
9    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Ms.
Nome: Greta
Cognome: Borg-Carbott
Email: send email
Telefono: 442031000000
Fax: 442078000000

UK (LONDON) participant 929˙916.40
10    Genomatix Software GmbH

 Organization address address: Bayerstrasse 85a
city: Muenchen
postcode: 80335

contact info
Titolo: Dr.
Nome: Martin
Cognome: Seifert
Email: send email
Telefono: +49 89 5997660
Fax: +49 89 599766 55

DE (Muenchen) participant 897˙600.00
11    CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

 Organization address address: CALLE ROSSELLO 149 PUERTA BJS
city: BARCELONA
postcode: 8036

contact info
Titolo: Ms.
Nome: Nathalie
Cognome: Villahoz
Email: send email
Telefono: +34 932275400
Fax: +34 932275717

ES (BARCELONA) participant 888˙176.80
12    FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

 Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029

contact info
Titolo: Ms.
Nome: Laura
Cognome: Bertolini
Email: send email
Telefono: +34 917 328 000
Fax: +34 912 246 980

ES (MADRID) participant 710˙600.00
13    ISTITUTO EUROPEO DI ONCOLOGIA SRL

 Organization address address: Via Filodrammatici 10
city: MILANO
postcode: 20121

contact info
Titolo: Ms.
Nome: Ilaria
Cognome: Foti
Email: send email
Telefono: +39 0257 489295
Fax: +39 0257 489246

IT (MILANO) participant 631˙400.00
14    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH

 Organization address address: Dr. Ignaz Seipel-Platz 2
city: WIEN
postcode: 1010

contact info
Titolo: Ms.
Nome: Angelika
Cognome: Eisner
Email: send email
Telefono: +43 1 40160 70028
Fax: +43 1 40160 970000

AT (WIEN) participant 614˙265.10
15 KOBENHAVNS UNIVERSITET DK participant 600˙000.00
16    Nome Ente NON disponibile

 Organization address address: VIALE BENEDUCE 10
city: CASERTA
postcode: 81100

contact info
Titolo: Dr.
Nome: Annunziata
Cognome: Valente
Email: send email
Telefono: 390816000000
Fax: 39081450169

IT (CASERTA) participant 584˙988.00
17    GENOME RESEARCH LIMITED

 Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215
city: LONDON
postcode: NW1 2BE

contact info
Titolo: Mr.
Nome: David
Cognome: Davison
Email: send email
Telefono: +44 1223 49 4937
Fax: +44 1223 49 4883

UK (LONDON) participant 573˙766.60
18    CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL

 Organization address address: OLSHAUSENSTRASSE 40
city: KIEL
postcode: 24118

contact info
Titolo: Ms.
Nome: Susanne
Cognome: Neufeldt
Email: send email
Telefono: +49 431 880 7246
Fax: +49 431 880 1560

DE (KIEL) participant 557˙840.00
19    DIAGENODE

 Organization address address: RUE DU BOIS SAINT JEAN 3 LIEGE PARK SCIENCE
city: SERAING
postcode: 4102

contact info
Titolo: Mr.
Nome: Léon
Cognome: Etienne
Email: send email
Telefono: +32 4 364 2050
Fax: +32 4 364 2051

BE (SERAING) participant 557˙520.00
20    THE BABRAHAM INSTITUTE

 Organization address address: Babraham Hall
city: CAMBRIDGE
postcode: CB22 3AT

contact info
Titolo: Dr.
Nome: Caroline
Cognome: Edmonds
Email: send email
Telefono: +44 1223 496000
Fax: +44 1223 496000

UK (CAMBRIDGE) participant 459˙932.50
21    EUROPEAN RESEARCH AND PROJECT OFFICE GMBH

 Organization address address: Science Park 1, Stuhlsatzenhausweg 69
city: SAARBRUECKEN
postcode: 66123

contact info
Titolo: Ms.
Nome: Melanie
Cognome: Paulus
Email: send email
Telefono: +49 681 9592 3375
Fax: +49 681 9592 3370

DE (SAARBRUECKEN) participant 431˙300.00
22    WEIZMANN INSTITUTE OF SCIENCE

 Organization address address: HERZL STREET 234
city: REHOVOT
postcode: 7610001

contact info
Titolo: Ms.
Nome: Talia
Cognome: Tzahor
Email: send email
Telefono: +972 8 934 4026
Fax: +972 8 934 4165

IL (REHOVOT) participant 360˙640.80
23    FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE

 Organization address address: AVENIDA GRAN VIA HOSPITALET 199-203
city: L'HOSPITALET DE LLOBREGAT
postcode: 8908

contact info
Titolo: Ms.
Nome: Anaïs
Cognome: Desclos
Email: send email
Telefono: +34 93 260 7245
Fax: +34 93 260 7219

ES (L'HOSPITALET DE LLOBREGAT) participant 359˙999.68
24    UNIVERSITAET DES SAARLANDES

 Organization address address: CAMPUS
city: SAARBRUECKEN
postcode: 66041

contact info
Titolo: Ms.
Nome: Melanie
Cognome: Paulus
Email: send email
Telefono: +49 681 9592 3375
Fax: +49 681 9592 3370

DE (SAARBRUECKEN) participant 351˙600.00
25    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Mr.
Nome: Dominique
Cognome: Nobile
Email: send email
Telefono: +33 4 9182 7000
Fax: +33 4 9174 2067

FR (PARIS) participant 338˙793.80
26    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH

 Organization address address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058

contact info
Titolo: Mrs.
Nome: Dorothy
Cognome: Searles
Email: send email
Telefono: +41 61 6972982
Fax: +41 61 6973976

CH (BASEL) participant 288˙803.24
27    ACADEMISCH ZIEKENHUIS GRONINGEN

 Organization address address: Hanzeplein 1
city: GRONINGEN
postcode: 9713 GZ

contact info
Titolo: Ms.
Nome: Gerda
Cognome: Klooster
Email: send email
Telefono: +31 503614245
Fax: 31503614003

NL (GRONINGEN) participant 286˙800.00
28    HALO GENOMICS AB

 Organization address address: DAG HAMMARSKJOLDS VAG 36B
city: Uppsala
postcode: 75183

contact info
Titolo: Dr.
Nome: Olle
Cognome: Ericsson
Email: send email
Telefono: +46 18 495 3122
Fax: +46 18 495 3121

SE (Uppsala) participant 269˙752.80
29    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Ms.
Nome: Maria
Cognome: Van Zeijl
Email: send email
Telefono: +31 10 7043154
Fax: +31 10 7044743

NL (ROTTERDAM) participant 252˙100.00
30    UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

 Organization address address: Piazzale Aldo Moro 5
city: ROMA
postcode: 185

contact info
Titolo: Prof.
Nome: Antonello
Cognome: Mai
Email: send email
Telefono: +39 3388524607
Fax: +39 649913133

IT (ROMA) participant 224˙880.00
31    BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION

 Organization address address: Calle Jordi Girona 31
city: BARCELONA
postcode: 8034

contact info
Titolo: Ms.
Nome: Guadalupe
Cognome: Moreno Beltrán
Email: send email
Telefono: +34 934137525
Fax: +34 934137721

ES (BARCELONA) participant 212˙486.40
32    UNIVERSITE DE GENEVE

 Organization address address: Rue du General Dufour 24
city: GENEVE
postcode: 1211

contact info
Titolo: Prof.
Nome: Stylianos E.
Cognome: Antonarakis
Email: send email
Telefono: +41 22 3795707
Fax: +41 22 3795706

CH (GENEVE) participant 199˙800.00
33    UNIVERSITAET LEIPZIG

 Organization address address: RITTERSTRASSE 26
city: LEIPZIG
postcode: 4109

contact info
Titolo: Mr.
Nome: Gerhard
Cognome: Fuchs
Email: send email
Telefono: +49 341 97 35012
Fax: +49 341 97 35009

DE (LEIPZIG) participant 158˙400.00
34    UNIVERSITAET ULM

 Organization address address: HELMHOLTZSTRASSE 16
city: ULM
postcode: 89081

contact info
Titolo: Mr.
Nome: Frank
Cognome: Gleixner
Email: send email
Telefono: 4973150000000
Fax: 4973150000000

DE (ULM) participant 117˙600.00
35    UNIVERSITAETSKLINIKUM ESSEN

 Organization address address: HUFELANDSTRASSE 55
city: ESSEN
postcode: 45147

contact info
Titolo: Ms.
Nome: Lita
Cognome: Plaumann
Email: send email
Telefono: +49 201 7233436
Fax: +49 201 7235724

DE (ESSEN) participant 115˙200.00
36    SIGOLIS AB

 Organization address address: DAG HAMMARSKJOLDS VAG 58A
city: UPPSALA
postcode: 752 37

contact info
Titolo: Dr.
Nome: Jonas
Cognome: Jarvius
Email: send email
Telefono: +46 18 444 3600
Fax: +46 18 444 3601

SE (UPPSALA) participant 110˙656.80
37    LUNDS UNIVERSITET

 Organization address address: Paradisgatan 5c
city: LUND
postcode: 22100

contact info
Titolo: Mr.
Nome: Mattias
Cognome: Brattström
Email: send email
Telefono: +46 46 222 7215
Fax: +46 46 222 4540

SE (LUND) participant 92˙250.00
38    Novartis Forschungsstiftung

 Organization address address: Maulbeerstrasse 66
city: BASEL
postcode: 4058

contact info
Titolo: Ms.
Nome: Dorothy
Cognome: Searles
Email: send email
Telefono: 41616972982
Fax: 41616973976

CH (BASEL) participant 85˙763.56
39    VIVIA BIOTECH S.L.

 Organization address address: C SANTIAGO GRISOLIA 2 OFICINA 205
city: TRES CANTOS MADRID
postcode: 28760

contact info
Titolo: Mr.
Nome: Sergio
Cognome: Garcia
Email: send email
Telefono: +34 91 129 3151
Fax: +34 98 344 0787

ES (TRES CANTOS MADRID) participant 76˙411.08
40    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Mr.
Nome: Franck
Cognome: Charron
Email: send email
Telefono: +33 1 49604021
Fax: +33 1 49604146

FR (PARIS) participant 60˙019.20
41    SIENA BIOTECH SPA

 Organization address address: Via Banchi di Sotto 34
city: SIENA
postcode: 53100

contact info
Titolo: Dr.
Nome: Antonio
Cognome: Chiumiento
Email: send email
Telefono: +39 577 381203
Fax: +39 577 381208

IT (SIENA) participant 40˙248.41
42    AGILENT TECHNOLOGIES SWEDEN AB

 Organization address address: KRONBORGSGRAND 23
city: KISTA
postcode: SE16494

contact info
Titolo: Dr.
Nome: Olle
Cognome: Ericsson
Email: send email
Telefono: +46 18 495 3122
Fax: +46 18 495 3121

SE (KISTA) participant 21˙601.50
43    THE UNIVERSITY OF EDINBURGH

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Helen
Cognome: New
Email: send email
Telefono: +44 131 650 9032
Fax: +44 131 650 9023

UK (EDINBURGH) participant 7˙500.00
44    CELLZOME GMBH

 Organization address address: MEYERHOFSTRASSE 1
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Mr.
Nome: Reinhard
Cognome: Markus
Email: send email
Telefono: +49 6221 13757 107
Fax: +49 6221 13757 204

DE (HEIDELBERG) participant 0.00
45    OXFORD NANOPORE TECHNOLOGIES LTD

 Organization address address: ROBERT ROBINSON AVENUE - OXFORD SCIENCE PARK 4
city: OXFORD
postcode: OX4 4GA

contact info
Titolo: Mr.
Nome: Jim
Cognome: Mcdonald
Email: send email
Telefono: +44 845 034 7900
Fax: +44 845 034 7901

UK (OXFORD) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

diagnostic    genetic    compounds    identification    epigenomic    blood    reference    technologies    smart    cell    addition    generating    epigenome    counterparts    blueprint    epigenetic    cancer    haematopoietic    disease    community    types    diseases    data    tests    healthy    genes    pipeline    scientific    malignant    ihec    epigenomes    dna    cells    markers   

 Obiettivo del progetto (Objective)

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and on their malignant leukaemic counterparts. Reference epigenomes will be generated by state-of-the-art technologies from highly purified cells for a comprehensive set of epigenetic marks in accordance with quality standards set by IHEC. This resource-generating activity will be conducted at dedicated centres to be complemented by confederated hypothesis-driven research into blood-based diseases, including common leukaemias and autoimmune disease (T1D), by epigenetic targets and compound identification, and by discovery and validation of epigenetic markers for diagnostic use. By focussing on 100 samples of known genetic variation BLUEPRINT will complete an epigenome-wide association study, maximizing the biomedical relevance of the reference epigenomes. Key to the success of BLUEPRINT will be the integration with other data sources (i.e. ICGC, 1000 genomes and ENCODE), comprehensive bioinformatic analysis, and user-friendly dissemination to the wider scientific community. The involvement of innovative companies will energize epigenomic research in the private sector by creating new targets for compounds and the development of smart technologies for better diagnostic tests. BLUEPRINT will outreach through a network of associated members and form critical alliances with leading networks in genomics and epigenomics within Europe and worldwide. Through its interdisciplinarity and scientific excellence combined with its strong commitment to networking, training and communication BLUEPRINT strives to become the cornerstone of the EU contribution to IHEC.

Introduzione (Teaser)

A major EU research initiative is collecting data on how genes are activated or repressed in healthy and diseased cells of the blood system. Results of these analysis are expected to provide novel entrypoints for development of therapies for blood related disorders.

Descrizione progetto (Article)

Organism development, disease, damage and a host of environmental factors, including stress and diet, cause changes in packaging of the DNA in the nucleus of a cell. These so called epigenetic alterations are not actual modifications in the genetic code itself but involve the addition of chemical groups to proteins involved in DNA organization. Aberrant placement of these is associated with diseases such as cancer and diabetes.

Forty-one European universities, research institutes and industrial representatives have come together to chart these epigenetic modification in the project 'A blueprint of haematopoietic epigenomes' (http://www.blueprint-epigenome.eu (BLUEPRINT)) . Researchers are generating 100 reference epigenomes of blood cells to identify markers or indicators of changes heralding stages of disease. The scientists have already prepared and released data of 25 full healthy epigenomes from different blood cell types.In addition, another 26 are close to completion and a a further 60 in the pipeline.

To register the genetic basis of disease development, healthy haematopoietic (progenitor) cells are being compared with their malignant cancer counterparts. They include epigenomes from acute myeloid leukaemia and chronic lymphocytic leukemia. Epigenomes are also being generated from cells treated with known and new compounds in order to understand how targeted therapy changes the epigenomic structure.

The work has already led to the identification of several new epigenetic modulators involved in tumour development. Working with two specific compounds that silence the expression of genes that suppress malignancy, the researchers have patented a new approach for inhibitor identification.

BLUEPRINT's Data Coordination Centre is responsible for the storage and distribution of the considerable amounts of data generated. Partners have developed a common data coordination and analysis strategy as well as frameworks for controlled data access. Besides analysing the epigenomic maps within the consortium, BLUEPRINT makes them immediately available to the scientific community to allow optimal usage of the generated datasets.

Apart from utilizing existing methodologies, smart technologies for better diagnostic tests and miniaturisation of the entire analysis pipeline are being developed. They will reduce the need for huge quantities of cells and allow using epigenomic analysis in a clinical setting.

Together, BLUEPRINT deliverables are uncovering key facts in the epigenetics arena for new diagnostics and prognostics. This new area of personalised medicine will transform European healthcare delivery.

Altri progetti dello stesso programma (FP7-HEALTH)

EUROMEDICAT (2011)

EUROmediCAT: Safety of Medication use in Pregnancy in Relation to Risk of Congenital Malformations

Read More  

FEMNAT-CD (2013)

Neurobiology and Treatment of Adolescent Female Conduct Disorder: The Central Role of Emotion Processing

Read More  

NEMO (2009)

Treatment of NEonatal seizures with Medication Off-patent: evaluation of efficacy and safety of bumetanide

Read More