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PHII SIGNED

PTX3 in Humoral Innate Immunity

Total Cost €

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EC-Contrib. €

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Partnership

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Project "PHII" data sheet

The following table provides information about the project.

Coordinator
HUMANITAS MIRASOLE SPA 

Organization address
address: VIA MANZONI 56
city: ROZZANO (MI)
postcode: 20100
website: www.humanitas.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙497˙081 €
 EC max contribution 2˙497˙081 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HUMANITAS MIRASOLE SPA IT (ROZZANO (MI)) coordinator 2˙497˙081.00

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 Project objective

The innate immune system includes a cellular and a humoral arm. Structural diversity is a characteristic of humoral fluid phase pattern recognition molecules. These include complement components, collectins, ficolins, and pentraxins. We have used the long pentraxin PTX3, identified by the applicant (cDNA and genomic, mouse and human), as a prototypic fluid phase pattern recognition molecule to dissect its function, as well as to define general properties of humoral innate immunity and its interplay with the cellular arm. The general objective of this application is to explore unexpected vistas on humoral innate immunity, using PTX3 as a molecular tool. Specifically two hypothesis will be tested based on preliminary data. First the applicant will test the hypothesis that matrix and microbe recognition are related functions of PTX3 and that a microenvironmental signal (acidic pH) sets PTX3 in a matrix recognition, tissue repair mode. A second related line of work will focus on inflammation as a key component of the tumor microenvironment. The applicant will test the hypothesis that PTX3 and elements of the humoral innate immune system are essential components of cancer related inflammation. In particular, based on preliminary data, the hypothesis will be tested that PTX3 acts as an extrinsic oncosuppressor in murine carcinogenesis and in selected human cancers by suppressing the recruitment of tumor-promoting inflammatory cells. These studies are expected to provide new unexpected vistas on the humoral arm of the innate immune system.

 Publications

year authors and title journal last update
List of publications.
2018 Martina Molgora, Domenico Supino, Domenico Mavilio, Angela Santoni, Lorenzo Moretta, Alberto Mantovani, Cecilia Garlanda
The yin-yang of the interaction between myelomonocytic cells and NK cells
published pages: e12705, ISSN: 0300-9475, DOI: 10.1111/sji.12705
Scandinavian Journal of Immunology 88/3 2020-04-24
2019 Fabrizia Bonacina, Annalisa Moregola, Rémi Porte, Andrea Baragetti, Eduardo Bonavita, Alice Salatin, Liliana Grigore, Fabio Pellegatta, Martina Molgora, Marina Sironi, Elisa Barbati, Alberto Mantovani, Barbara Bottazzi, Alberico Luigi Catapano, Cecilia Garlanda, Giuseppe Danilo Norata
Pentraxin 3 deficiency protects from the metabolic inflammation associated to diet-induced obesity
published pages: 1861-1872, ISSN: 0008-6363, DOI: 10.1093/cvr/cvz068
Cardiovascular Research 115/13 2020-04-24
2019 Andrea Doni, Matteo Stravalaci, Antonio Inforzato, Elena Magrini, Alberto Mantovani, Cecilia Garlanda, Barbara Bottazzi
The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00712
Frontiers in Immunology 10 2020-04-24
2019 Andrea Ponzetta, Roberta Carriero, Silvia Carnevale, Marialuisa Barbagallo, Martina Molgora, Chiara Perucchini, Elena Magrini, Francesca Gianni, Paolo Kunderfranco, Nadia Polentarutti, Fabio Pasqualini, Sabrina Di Marco, Domenico Supino, Clelia Peano, Ferdinando Cananzi, Piergiuseppe Colombo, Silvana Pilotti, Suliman Yousef Alomar, Eduardo Bonavita, Maria Rosaria Galdiero, Cecilia Garlanda, Albert
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors
published pages: 346-360.e24, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.05.047
Cell 178/2 2020-04-24
2019 Giuseppe A. Ramirez, Patrizia Rovere-Querini, Miriam Blasi, Silvia Sartorelli, Maria Chiara Di Chio, Mattia Baldini, Rebecca De Lorenzo, Enrica P. Bozzolo, Roberto Leone, Alberto Mantovani, Angelo A. Manfredi, Enrico Tombetti
PTX3 Intercepts Vascular Inflammation in Systemic Immune-Mediated Diseases
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01135
Frontiers in Immunology 10 2020-04-24
2019 Giuseppe Ristagno, Francesca Fumagalli, Barbara Bottazzi, Alberto Mantovani, Davide Olivari, Deborah Novelli, Roberto Latini
Pentraxin 3 in Cardiovascular Disease
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00823
Frontiers in Immunology 10 2020-04-24
2017 Alberto Mantovani
Wandering pathways in the regulation of innate immunity and inflammation
published pages: 1-5, ISSN: 0896-8411, DOI: 10.1016/j.jaut.2017.10.007
Journal of Autoimmunity 85 2020-02-12
2018 Danka Grčević, Marina Sironi, Sonia Valentino, Livija Deban, Hrvoje Cvija, Antonio Inforzato, Nataša Kovačić, Vedran Katavić, Tomislav Kelava, Ivo Kalajzić, Alberto Mantovani, Barbara Bottazzi
The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair
published pages: 1-18, ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00417
Frontiers in Immunology 9 2020-02-12
2017 Mihai G Netea, Frances Balkwill, Michel Chonchol, Fabio Cominelli, Marc Y Donath, Evangelos J Giamarellos-Bourboulis, Douglas Golenbock, Mark S Gresnigt, Michael T Heneka, Hal M Hoffman, Richard Hotchkiss, Leo A B Joosten, Daniel L Kastner, Martin Korte, Eicke Latz, Peter Libby, Thomas Mandrup-Poulsen, Alberto Mantovani, Kingston H G Mills, Kristen L Nowak, Luke A O\'Neill, Peter Pickkers, Tom van
A guiding map for inflammation
published pages: 826-831, ISSN: 1529-2908, DOI: 10.1038/NI.3790
Nature Immunology 18/8 2020-02-12
2018 Cecilia Garlanda, Barbara Bottazzi, Elena Magrini, Antonio Inforzato, Alberto Mantovani
PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer
published pages: 623-639, ISSN: 0031-9333, DOI: 10.1152/physrev.00016.2017
Physiological Reviews 98/2 2020-02-12
2017 Martina Molgora, Eduardo Bonavita, Andrea Ponzetta, Federica Riva, Marialuisa Barbagallo, Sébastien Jaillon, Branka Popović, Giovanni Bernardini, Elena Magrini, Francesca Gianni, Santiago Zelenay, Stipan Jonjić, Angela Santoni, Cecilia Garlanda, Alberto Mantovani
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity
published pages: 110-114, ISSN: 0028-0836, DOI: 10.1038/NATURE24293
Nature 551/7678 2020-02-12
2017 Marcello Rubino, Paolo Kunderfranco, Gianluca Basso, Carolina Magdalen Greco, Fabio Pasqualini, Simone Serio, Massimo Roncalli, Luigi Laghi, Alberto Mantovani, Roberto Papait, Cecilia Garlanda
Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer
published pages: e1333215, ISSN: 2162-402X, DOI: 10.1080/2162402X.2017.1333215
OncoImmunology 2020-02-12
2018 Martina Molgora, Domenico Supino, Alberto Mantovani, Cecilia Garlanda
Tuning inflammation and immunity by the negative regulators IL-1R2 and IL-1R8
published pages: 233-247, ISSN: 0105-2896, DOI: 10.1111/imr.12609
Immunological Reviews 281/1 2020-02-12
2018 Alberto Mantovani, Isabella Barajon, Cecilia Garlanda
IL-1 and IL-1 regulatory pathways in cancer progression and therapy
published pages: 57-61, ISSN: 0105-2896, DOI: 10.1111/imr.12614
Immunological Reviews 281/1 2020-02-12
2018 Alberto Mantovani
Redundancy and robustness versus division of labour and specialization in innate immunity
published pages: 28-30, ISSN: 1044-5323, DOI: 10.1016/j.smim.2017.12.006
Seminars in Immunology 36 2020-02-12
2017 Andrea Doni, Giovanna D\'Amico, Diego Morone, Alberto Mantovani, Cecilia Garlanda
Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage
published pages: 31-40, ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2016.07.026
Seminars in Cell & Developmental Biology 61 2020-02-12
2017 Annalisa Del Prete, Laura Martínez-Muñoz, Cristina Mazzon, Lara Toffali, Francesca Sozio, Lorena Za, Daniela Bosisio, Luisa Gazzurelli, Valentina Salvi, Laura Tiberio, Chiara Liberati, Eugenio Scanziani, Annunciata Vecchi, Carlo Laudanna, Mario Mellado, Alberto Mantovani, Silvano Sozzani
The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage
published pages: 1223-1234, ISSN: 0006-4971, DOI: 10.1182/blood-2017-04-777680
Blood 130/10 2020-02-12
2018 Giulia Marelli, Roberta Avigni, Paola Allavena, Cecilia Garlanda, Alberto Mantovani, Andrea Doni, Marco Erreni
\"Optical in vivo imaging detection of preclinical models of gut tumors through the expression of Integrin αVβ3\"
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.25826
Oncotarget 9/59 2020-02-12

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