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Reactions That Translate mRNA into Drug-like Molecules

Total Cost €


EC-Contrib. €






 TRIGGDRUG project word cloud

Explore the words cloud of the TRIGGDRUG project. It provides you a very rough idea of what is the project "TRIGGDRUG" about.

synthesis    drug    advantage    how    active    translate    small    couple    cancer    chemistry    synergy    sequencing    personalized    reaction    idea    eliminate    cope    harnessed    inside    caused    validated    cells    kinase    rna    inhibitors    expressed    molecules    reactions    look    translocation    healthy    transcriptome    opportunity    patient    molecule    promoted    triggers    accordingly    aberrantly    mrna    single    molecular    perturbation    form    tool    nutshell    2040    peptidomimetics    express    read    generation    nucleic    recognition    turnover    provides    amplification    apoptosis    worlds    protein    expression    formed    identity    therapy    instructors    triggered    deregulated    output    mutation    death    reactivity    alkylidene    copy    disease    sequence    data    cell    chemical    induce    transfer    rewire    acyl    activated    reactive    inhibition    template    genes    cure    peptides    cellular    hijack    photodynamic    acid    gene   

Project "TRIGGDRUG" data sheet

The following table provides information about the project.


Organization address
city: BERLIN
postcode: 10117

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙470˙400 €
 EC max contribution 2˙470˙400 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HUMBOLDT-UNIVERSITAET ZU BERLIN DE (BERLIN) coordinator 2˙470˙400.00


 Project objective

How could a molecular cancer therapy look like in 2040? In cancer, gene expression is deregulated due to amplification, mutation and translocation of genes. Next generation RNA sequencing provides us with the opportunity to identify the number and identity of the gene products aberrantly expressed in a patient. But do we have methods that take advantage of the personalized sequence data? In this research project we propose the idea to use the RNA molecules expressed upon disease-type gene expression as instructors for the chemical synthesis of drug-like molecules that cure the disease. Accordingly, drug-like molecules would only be formed in those cells that express the disease-specific RNA molecules. Such a personalized molecular therapy would eliminate side effects caused by unwanted perturbation of healthy cells. The idea to use cellular RNA molecules as triggers for drug synthesis requires methods that couple RNA recognition with a change of chemical reactivity. Reactive molecules must be able to “read” and “translate” the sequence of a RNA molecule into a drug-like output. We will develop mRNA-triggered reactions that i) proceed with turnover in template to cope with low mRNA copy numbers and ii) allow the single-step synthesis of highly active drug-like molecules to address deregulated protein targets inside cancer cells. To achieve this aim, we will advance chemical acyl transfer and alkylidene transfer reactions. The reactions on disease-specific mRNA will form peptides/peptidomimetics/small molecule-based kinase inhibitors which will induce apoptosis in cancer cells. We will target validated drug targets. Synergy between the nucleic acid and protein worlds will be harnessed. Furthermore, we will develop a RNA-promoted reaction with turnover beyond product inhibition. This will enable a transcriptome-activated photodynamic therapy. In a nutshell, we will develop a chemistry-based tool to hijack disease mRNA and rewire the cell death program.


year authors and title journal last update
List of publications.
2018 Jasmine Chamiolo, Ge‐min Fang, Felix Hövelmann, Dhana Friedrich, Andrea Knoll, Alexander Loewer, Oliver Seitz
Comparing Agent‐Based Delivery of DNA and PNA Forced Intercalation (FIT) Probes for Multicolor mRNA Imaging
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201800526
ChemBioChem 2019-04-18

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