Phd SIGNED
Deciphering PI3K biology in health and disease
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the Phd project. It provides you a very rough idea of what is the project "Phd" about.
Project "Phd" data sheet
The following table provides information about the project.
| Coordinator |
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Organization address contact info |
| Coordinator Country | Spain [ES] |
| Project website | http://pi3k-phdproject.eu/ |
| Total cost | 3˙896˙148 € |
| EC max contribution | 3˙896˙148 € (100%) |
| Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
| Code Call | H2020-MSCA-ITN-2015 |
| Funding Scheme | MSCA-ITN-ETN |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-11-01 to 2019-10-31 |
Partnership
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Project objective
The Phosphoinositide 3-kinase (PI3K) pathway is at the core of multiple fundamental biological processes controlling metabolism, protein synthesis, cell growth, survival, and migration. This inevitably leads to the involvement of the PI3K signalling pathway in a number of different diseases, ranging from inflammation and diabetes to cancer, with PI3K pathway alterations present in almost 80% of human cancers. Therefore, PI3Ks have emerged as important targets for drug discovery and, during 2014, the first PI3K inhibitor was approved by FDA in the US for the treatment of a lymphocytic leukaemia. Nonetheless, our understanding of PI3K-mediated signalling is still poor and only a fraction of the potential therapeutic applications have been addressed so far, leaving a large amount of translational work unexplored. Europe features a set of top quality research institutions and pharmaceutical companies focused on PI3K studies but their activities have been so far scattered. This proposal fills this gap by providing a multidisciplinary network (biochemistry, mouse studies, disease models, drug development, software development) and an unprecedented training opportunity from the bench to the bedside (from pre-clinical discoveries to clinical trials), through cutting edge molecular biology, drug discovery and clinical trial organization. The proposal is aimed at training young investigators in deep understanding of the different PI3K isoforms in distinct tissues and to translate this knowledge into a new generation of PI3K inhibitors, treatment modalities and into identify new uses for existing PI3K inhibitors.
Deliverables
| Research Training Workshop 3 | Other | 2020-03-24 11:01:37 |
| Research Training Workshop 4 | Other | 2020-03-24 11:01:50 |
| PhD Completion | Other | 2020-03-24 11:01:56 |
| Dissemination and Outreach Plan 4 | Documents, reports | 2020-03-24 11:01:58 |
| Network Website | Websites, patent fillings, videos etc. | 2019-07-09 18:03:37 |
| Mid-term review meeting | Documents, reports | 2019-07-09 18:03:37 |
| Research Training Workshop 2 | Other | 2019-07-09 18:03:36 |
| Dissemination and Outreach Plan 3 | Documents, reports | 2019-07-09 18:03:37 |
| Dissemination and Outreach Plan 2 | Documents, reports | 2019-07-09 18:03:37 |
| Dissemination and Outreach Plan 1 | Documents, reports | 2019-07-09 18:03:36 |
| Promotional Video | Websites, patent fillings, videos etc. | 2019-07-09 18:03:36 |
| Research Training Workshop 1 | Other | 2019-07-09 18:03:36 |
| Recruitment | Other | 2019-07-09 18:03:36 |
Take a look to the deliverables list in detail: detailed list of Phd deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Nicole Therville, Silvia Arcucci, Aurélie Vertut, Fernanda Ramos-Delgado, Dina Ferreira Da Mota, Marlène Dufresne, Céline Basset, Julie Guillermet-Guibert Experimental pancreatic cancer develops in soft pancreas: novel leads for an individualized diagnosis by ultrafast elasticity imaging published pages: 6369-6379, ISSN: 1838-7640, DOI: 10.7150/thno.34066 |
Theranostics 9/22 | 2019-12-16 |
| 2017 |
Florent Beaufils, Natasa Cmiljanovic, Vladimir Cmiljanovic, Thomas Bohnacker, Anna Melone, Romina Marone, Eileen Jackson, Xuxiao Zhang, Alexander Sele, Chiara Borsari, Jürgen Mestan, Paul Hebeisen, Petra Hillmann, Bernd Giese, Marketa Zvelebil, Doriano Fabbro, Roger L. Williams, Denise Rageot, Matthias P. Wymann 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology published pages: 7524-7538, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b00930 |
Journal of Medicinal Chemistry 60/17 | 2019-10-14 |
| 2018 |
Célia Cintas, Thibaut Douché, Nicole Therville, Silvia Arcucci, Fernanda Ramos-Delgado, Céline Basset, Benoît Thibault, Julie Guillermet-Guibert Signal-Targeted Therapies and Resistance Mechanisms in Pancreatic Cancer: Future Developments Reside in Proteomics published pages: 174, ISSN: 2072-6694, DOI: 10.3390/cancers10060174 |
Cancers 10/6 | 2019-10-14 |
| 2018 |
Abhishek Derle, Maria Chiara De Santis, Luca Gozzelino, Edoardo Ratto, Miriam Martini The role of metabolic adaptation to nutrient stress in pancreatic cancer published pages: 332-339, ISSN: 2523-0204, DOI: 10.15698/cst2018.12.166 |
Cell Stress 2/12 | 2019-10-14 |
| 2018 |
Ana Angulo-Urarte, Pedro Casado, Sandra D. Castillo, Piotr Kobialka, Maria Paraskevi Kotini, Ana M. Figueiredo, Pau Castel, Vinothini Rajeeve, Maria Milà -Guasch, Jaime Millan, Cora Wiesner, Helena Serra, Laia Muixi, Oriol Casanovas, Francesc Viñals, Markus Affolter, Holger Gerhardt, Stephan Huveneers, Heinz-Georg Belting, Pedro R. Cutillas, Mariona Graupera Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07172-3 |
Nature Communications 9/1 | 2019-10-14 |
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