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Phd SIGNED

Deciphering PI3K biology in health and disease

Total Cost €

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EC-Contrib. €

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Partnership

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Project "Phd" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE 

Organization address
address: AVENIDA GRAN VIA HOSPITALET 199-203
city: L'HOSPITALET DE LLOBREGAT
postcode: 8908
website: www.idibell.cat

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://pi3k-phdproject.eu/
 Total cost 3˙896˙148 €
 EC max contribution 3˙896˙148 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2019-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE ES (L'HOSPITALET DE LLOBREGAT) coordinator 530˙172.00
2    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 546˙575.00
3    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 525˙751.00
4    FORSCHUNGSVERBUND BERLIN EV DE (BERLIN) participant 498˙432.00
5    THE BABRAHAM INSTITUTE UK (CAMBRIDGE) participant 440˙297.00
6    UNIVERSITAT BASEL CH (BASEL) participant 265˙226.00
7    CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE FR (ILLKIRCH GRAFFENSTADEN) participant 262˙875.00
8    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) participant 258˙061.00
9    FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON ES (BARCELONA) participant 247˙872.00
10    ARIVIS AG DE (UNTERSCHLEISSHEIM) participant 214˙603.00
11    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 106˙278.00
12    Institut Clinique de la Souris FR (Illkirch-Graffenstaden) partner 0.00
13    UbiK media S.L. ES (Barcelona) partner 0.00

Map

 Project objective

The Phosphoinositide 3-kinase (PI3K) pathway is at the core of multiple fundamental biological processes controlling metabolism, protein synthesis, cell growth, survival, and migration. This inevitably leads to the involvement of the PI3K signalling pathway in a number of different diseases, ranging from inflammation and diabetes to cancer, with PI3K pathway alterations present in almost 80% of human cancers. Therefore, PI3Ks have emerged as important targets for drug discovery and, during 2014, the first PI3K inhibitor was approved by FDA in the US for the treatment of a lymphocytic leukaemia. Nonetheless, our understanding of PI3K-mediated signalling is still poor and only a fraction of the potential therapeutic applications have been addressed so far, leaving a large amount of translational work unexplored. Europe features a set of top quality research institutions and pharmaceutical companies focused on PI3K studies but their activities have been so far scattered. This proposal fills this gap by providing a multidisciplinary network (biochemistry, mouse studies, disease models, drug development, software development) and an unprecedented training opportunity from the bench to the bedside (from pre-clinical discoveries to clinical trials), through cutting edge molecular biology, drug discovery and clinical trial organization. The proposal is aimed at training young investigators in deep understanding of the different PI3K isoforms in distinct tissues and to translate this knowledge into a new generation of PI3K inhibitors, treatment modalities and into identify new uses for existing PI3K inhibitors.

 Deliverables

List of deliverables.
Research Training Workshop 3 Other 2020-03-24 11:01:37
Research Training Workshop 4 Other 2020-03-24 11:01:50
PhD Completion Other 2020-03-24 11:01:56
Dissemination and Outreach Plan 4 Documents, reports 2020-03-24 11:01:58
Network Website Websites, patent fillings, videos etc. 2019-07-09 18:03:37
Mid-term review meeting Documents, reports 2019-07-09 18:03:37
Research Training Workshop 2 Other 2019-07-09 18:03:36
Dissemination and Outreach Plan 3 Documents, reports 2019-07-09 18:03:37
Dissemination and Outreach Plan 2 Documents, reports 2019-07-09 18:03:37
Dissemination and Outreach Plan 1 Documents, reports 2019-07-09 18:03:36
Promotional Video Websites, patent fillings, videos etc. 2019-07-09 18:03:36
Research Training Workshop 1 Other 2019-07-09 18:03:36
Recruitment Other 2019-07-09 18:03:36

Take a look to the deliverables list in detail:  detailed list of Phd deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Nicole Therville, Silvia Arcucci, Aurélie Vertut, Fernanda Ramos-Delgado, Dina Ferreira Da Mota, Marlène Dufresne, Céline Basset, Julie Guillermet-Guibert
Experimental pancreatic cancer develops in soft pancreas: novel leads for an individualized diagnosis by ultrafast elasticity imaging
published pages: 6369-6379, ISSN: 1838-7640, DOI: 10.7150/thno.34066
Theranostics 9/22 2019-12-16
2017 Florent Beaufils, Natasa Cmiljanovic, Vladimir Cmiljanovic, Thomas Bohnacker, Anna Melone, Romina Marone, Eileen Jackson, Xuxiao Zhang, Alexander Sele, Chiara Borsari, Jürgen Mestan, Paul Hebeisen, Petra Hillmann, Bernd Giese, Marketa Zvelebil, Doriano Fabbro, Roger L. Williams, Denise Rageot, Matthias P. Wymann
5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology
published pages: 7524-7538, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b00930
Journal of Medicinal Chemistry 60/17 2019-10-14
2018 Célia Cintas, Thibaut Douché, Nicole Therville, Silvia Arcucci, Fernanda Ramos-Delgado, Céline Basset, Benoît Thibault, Julie Guillermet-Guibert
Signal-Targeted Therapies and Resistance Mechanisms in Pancreatic Cancer: Future Developments Reside in Proteomics
published pages: 174, ISSN: 2072-6694, DOI: 10.3390/cancers10060174
Cancers 10/6 2019-10-14
2018 Abhishek Derle, Maria Chiara De Santis, Luca Gozzelino, Edoardo Ratto, Miriam Martini
The role of metabolic adaptation to nutrient stress in pancreatic cancer
published pages: 332-339, ISSN: 2523-0204, DOI: 10.15698/cst2018.12.166
Cell Stress 2/12 2019-10-14
2018 Ana Angulo-Urarte, Pedro Casado, Sandra D. Castillo, Piotr Kobialka, Maria Paraskevi Kotini, Ana M. Figueiredo, Pau Castel, Vinothini Rajeeve, Maria Milà-Guasch, Jaime Millan, Cora Wiesner, Helena Serra, Laia Muixi, Oriol Casanovas, Francesc Viñals, Markus Affolter, Holger Gerhardt, Stephan Huveneers, Heinz-Georg Belting, Pedro R. Cutillas, Mariona Graupera
Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07172-3
Nature Communications 9/1 2019-10-14

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