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HaemMetabolome SIGNED

Deciphering the Metabolism of Haematological Cancers

Total Cost €

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EC-Contrib. €

0

Partnership

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Project "HaemMetabolome" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://haemmetabolome-itn.eu
 Total cost 2˙572˙664 €
 EC max contribution 2˙572˙664 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-EJD
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2019-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 819˙863.00
2    UNIVERSITAT DE BARCELONA ES (BARCELONA) participant 743˙618.00
3    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) participant 510˙748.00
4    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 498˙432.00
5    BRUKER BIOSPIN GMBH DE (RHEINSTETTEN) partner 0.00
6    LIFEGLIMMER GMBH DE (BERLIN) partner 0.00
7    TavarGenix DE (Heidelberg) partner 0.00

Map

 Project objective

It has long been realised that metabolism is central to cellular development, proliferation and homeostasis. Collectively, aberrations in metabolism are now recognised as a major hallmark of cancer, opening new avenues for personalised medicine. As haematological malignancies are multi-factorial diseases, our main emphasis will be on the integration of biomedical multi-omics data and computational systems modelling with the ultimate aim to understand metabolic regulation in haematological cancers. HaemMetabolism is design to unravel the regulatory mechanisms that link cell cycle control and metabolism. For this we will screen a panel of haematological cancer cell lines for the metabolic phenotypes and against a library of inhibitors. Gene-function analyses will be performed using shRNA libraries directed against key metabolome regulators. Validation will occur in primary patient samples in vitro and in vivo in preclinical humanized niche xenograft mouse models. A systems biomedicine approach will be integrated build genome-scale transcriptional models that explain deregulated metabolic pathways relevant for the development of haematological malignancies. This work will not only open new avenues for drug discovery but will also provide a multi-disciplinary framework for student training in biomedical technologies.

 Deliverables

List of deliverables.
Organization of WS1 Documents, reports 2019-07-09 17:07:47
Recruitment ESR Documents, reports 2019-07-09 17:07:48
Report on contribution towards conferences and scientific publications Websites, patent fillings, videos etc. 2019-07-09 17:07:48
Organization of ATC1 Documents, reports 2019-07-09 17:07:47
Newsletters 1 Websites, patent fillings, videos etc. 2019-07-09 17:07:48
Newsletters 2 Websites, patent fillings, videos etc. 2019-07-09 17:07:48
Website set-up Websites, patent fillings, videos etc. 2019-07-09 17:07:47

Take a look to the deliverables list in detail:  detailed list of HaemMetabolome deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Raquel Saborano, Zuhal Eraslan, Jennie Roberts, Farhat L. Khanim, Patricia F. Lalor, Michelle A. C. Reed, Ulrich L. Günther
A framework for tracer-based metabolism in mammalian cells by NMR
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37525-3
Scientific Reports 9/1 2020-03-24
2020 Islam Alshamleh, Nina Krause, Christian Richter, Nina Kurrle, Hubert Serve, Ulrich L. Günther, Harald Schwalbe
Real-Time NMR Spectroscopy for Studying Metabolism
published pages: 2304-2308, ISSN: 1433-7851, DOI: 10.1002/anie.201912919
Angewandte Chemie International Edition 59/6 2020-03-24
2019 Kreitz, Schönfeld, Seibert, Stolp, Alshamleh, Oellerich, Steffen, Schwalbe, Schnütgen, Kurrle, Serve
Metabolic Plasticity of Acute Myeloid Leukemia
published pages: 805, ISSN: 2073-4409, DOI: 10.3390/cells8080805
Cells 8/8 2019-10-28

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The information about "HAEMMETABOLOME" are provided by the European Opendata Portal: CORDIS opendata.

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