GlyCoCan SIGNED
Exploiting Glycosylation of Colorectal Cancer for the development of improved diagnostics and therapeutics
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the GlyCoCan project. It provides you a very rough idea of what is the project "GlyCoCan" about.
Project "GlyCoCan" data sheet
The following table provides information about the project.
| Coordinator |
ACADEMISCH ZIEKENHUIS LEIDEN
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Project website | https://glycocan.eu/ |
| Total cost | 3˙297˙697 € |
| EC max contribution | 3˙293˙890 € (100%) |
| Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
| Code Call | H2020-MSCA-ITN-2015 |
| Funding Scheme | MSCA-ITN-ETN |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-09-01 to 2019-08-31 |
Partnership
Take a look of project's partnership.
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Project objective
Colorectal cancer (CRC) is a major worldwide cancer burden with about 1.4 million cases in 2012 and an annual mortality of approximately 700,000. Early detection is crucial as treatment is most efficient in early stages where population based screenings could substantially reduce incidence and mortality. Current screening techniques are invasive or lack sensitivity and specificity. Moreover, the molecular mechanisms leading to the formation of different antigens suggested as CRC biomarkers and potential therapeutic targets are poorly understood, especially with regard to carbohydrate-based molecules, such as glycans. Enhancing our understanding of the structure-function relationship of glycosylation in CRC could lead to the discovery of improved diagnostic and prognostic biomarkers and pave the way for nov-el therapeutic targets. Building on an established network of analysts with many years of experience in (glyco)proteomics and biomarker research, in collaboration with colleagues in the field of glycobiology and glyco-immunology, GlyCoCan will develop new methods, and use current state of the art methods, to investigate the role of glycosylation in many different aspects of CRC. The GlyCoCan multi-disciplinary network will principally be a training programme with a substantial industrial focus on technology transfer and teaching of internationally adopted biopharma regulations (GMP, ISO9001, ICH guidelines). The underlying specific research objectives will be addressed within individual ESR projects, giving rise to a generation of ESRs whose main focus is investigating and tackling the challenges of the role of glycosylation within CRC and other diseases. The network will address the currently unmet need for glycosylation researchers with an inter-disciplinary perspective to fully exploit the immense potential of the young scientific field of glyco-oncology and to set them on a path to successful and productive careers in academic and industrial collaborations.
Deliverables
| Completion of theses | Websites, patent fillings, videos etc. | 2020-04-06 09:29:28 |
| Website established | Websites, patent fillings, videos etc. | 2020-04-06 09:29:27 |
Take a look to the deliverables list in detail: detailed list of GlyCoCan deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Zejian Zhang, Manfred Wuhrer, Stephanie Holst Serum sialylation changes in cancer published pages: 139-160, ISSN: 0282-0080, DOI: 10.1007/s10719-018-9820-0 |
Glycoconjugate Journal 35/2 | 2020-04-06 |
| 2018 |
Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto RodrÃguez, Yvette van Kooyk, Sandra J. van Vliet Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2018.00039 |
Frontiers in Oncology 8 | 2020-04-06 |
| 2018 |
Mylène A. Carrascal, Catarina Talina, Paula Borralho, A. Gonçalo Mineiro, Ana Raquel Henriques, Cláudia Pen, Manuela Martins, Sofia Braga, Robert Sackstein, Paula A. Videira Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue published pages: , ISSN: 1471-2407, DOI: 10.1186/s12885-018-4410-x |
BMC Cancer 18/1 | 2020-04-06 |
| 2018 |
Inês Gomes Ferreira, Michela Pucci, Giulia Venturi, Nadia Malagolini, Mariella Chiricolo and Fabio Dall’Olio Glycosylation as a Main Regulator of Growth and Death Factor Receptors Signaling published pages: 580, ISSN: 1422-0067, DOI: 10.3390/ijms19020580 |
International Journal of Molecular Sciences 19/2 | 2020-04-06 |
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