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GlyCoCan SIGNED

Exploiting Glycosylation of Colorectal Cancer for the development of improved diagnostics and therapeutics

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

GlyCoCan project word cloud

Explore the words cloud of the GlyCoCan project. It provides you a very rough idea of what is the project "GlyCoCan" about.

individual immunology reduce incidence generation tackling esr worldwide colleagues treatment successful giving screening disciplinary immense training pave biomarkers principally regard 700 perspective techniques building invasive collaborations relationship gmp regulations sensitivity glycobiology efficient underlying proteomics cancer annual lack ich detection network poorly therapeutic antigens inter function academic crc million biomarker diagnostic oncology substantially iso9001 productive unmet diseases carbohydrate guidelines suggested substantial stages structure nov young internationally population glyco careers esrs approximately teaching colorectal screenings mortality 2012 burden prognostic glycosylation glycans molecular scientific transfer el mechanisms discovery glycocan molecules industrial specificity biopharma

Project "GlyCoCan" data sheet

The following table provides information about the project.

Coordinator	ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://glycocan.eu/
Total cost	3˙297˙697 €
EC max contribution	3˙293˙890 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2019-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	coordinator	628˙470.00
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	525˙751.00
3	NOVA ID FCT - ASSOCIACAO PARA A INOVACAO E DESENVOLVIMENTO DA FCT NOVA ID FCT - ASSOCIACAO PARA A INOVACAO E DESENVOLVIMENTO DA FCT Organization address address: CAMPUS DE CAPARICA FACULDADE DE CIENCIAS E TECNOLOGIA DA UNIVERSIDADE NOVA DE LISBOA city: CAPARICA postcode: 2829 516 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (CAPARICA)	participant	476˙712.00
4	GENOS DOO ZA VJESTACENJE I ANALIZU GENOS DOO ZA VJESTACENJE I ANALIZU Organization address address: VATROGASNA 112 city: OSIJEK postcode: 31000 website: www.genos.hr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HR (OSIJEK)	participant	371˙641.00
5	LUDGER LIMITED LUDGER LIMITED Organization address address: CULHAM SCIENCE CENTRE - BUILDING E1 city: ABINGDON postcode: OX14 3EB website: www.ludger.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (ABINGDON)	participant	273˙287.00
6	ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA Organization address address: VIA ZAMBONI 33 city: BOLOGNA postcode: 40126 website: www.unibo.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BOLOGNA)	participant	258˙061.00
7	STICHTING VU STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	255˙374.00
8	STICHTING VUMC STICHTING VUMC Organization address address: DE BOELELAAN 1117 city: AMSTERDAM postcode: 1081 HV website: www.vumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	255˙374.00
9	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	249˙216.00
10	FACULDADE DE CIENCIAS MEDICAS DA UNIVERSIDADE NOVA DE LISBOA FACULDADE DE CIENCIAS MEDICAS DA UNIVERSIDADE NOVA DE LISBOA Organization address address: CAMPO MARTIRES DA PATRIA 130 city: LISBOA postcode: 1169 056 website: www.fcm.unl.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	participant	0.00
11	DC4U DC4U Organization address address: DE CORRIDOR 21E city: BREUKELEN postcode: 3621 ZA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (BREUKELEN)	partner	0.00
12	INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA Organization address address: AVENIDA DA REPUBLICA QUINTO DO MARQUES city: OEIRAS postcode: 2781 901 website: www.ibet.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (OEIRAS)	partner	0.00
13	INSTITUTO PORTUGUES DE ONCOLOGIA DO PORTO FRANCISCO GENTIL, EPE INSTITUTO PORTUGUES DE ONCOLOGIA DO PORTO FRANCISCO GENTIL, EPE Organization address address: RUA ANTONIO BERNARDINO ALMEIDA city: PORTO postcode: 4200-072 website: http://www.ipoporto.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (PORTO)	partner	0.00
14	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	partner	0.00
15	Postdoc Career Development Forum BV Postdoc Career Development Forum BV Organization address address: Hooghiemstraplein 144 city: Utrecht postcode: 3508SB website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Utrecht)	partner	0.00
16	ROCHE DIAGNOSTICS GMBH ROCHE DIAGNOSTICS GMBH Organization address address: Sandhofer Strasse 116 city: MANNHEIM postcode: 68305 website: www.roche-diagnostics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MANNHEIM)	partner	0.00
17	UNIVERSITATSKLINIKUM SCHLESWIG-HOLSTEIN UNIVERSITATSKLINIKUM SCHLESWIG-HOLSTEIN Organization address address: Ratzeburger Allee 160 city: Lübeck postcode: 23562 website: www.uni-kiel.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Lübeck)	partner	0.00

Map

Project objective

Colorectal cancer (CRC) is a major worldwide cancer burden with about 1.4 million cases in 2012 and an annual mortality of approximately 700,000. Early detection is crucial as treatment is most efficient in early stages where population based screenings could substantially reduce incidence and mortality. Current screening techniques are invasive or lack sensitivity and specificity. Moreover, the molecular mechanisms leading to the formation of different antigens suggested as CRC biomarkers and potential therapeutic targets are poorly understood, especially with regard to carbohydrate-based molecules, such as glycans. Enhancing our understanding of the structure-function relationship of glycosylation in CRC could lead to the discovery of improved diagnostic and prognostic biomarkers and pave the way for nov-el therapeutic targets. Building on an established network of analysts with many years of experience in (glyco)proteomics and biomarker research, in collaboration with colleagues in the field of glycobiology and glyco-immunology, GlyCoCan will develop new methods, and use current state of the art methods, to investigate the role of glycosylation in many different aspects of CRC. The GlyCoCan multi-disciplinary network will principally be a training programme with a substantial industrial focus on technology transfer and teaching of internationally adopted biopharma regulations (GMP, ISO9001, ICH guidelines). The underlying specific research objectives will be addressed within individual ESR projects, giving rise to a generation of ESRs whose main focus is investigating and tackling the challenges of the role of glycosylation within CRC and other diseases. The network will address the currently unmet need for glycosylation researchers with an inter-disciplinary perspective to fully exploit the immense potential of the young scientific field of glyco-oncology and to set them on a path to successful and productive careers in academic and industrial collaborations.

Deliverables

List of deliverables.
Completion of theses	Websites, patent fillings, videos etc.	2020-04-06 09:29:28
Website established	Websites, patent fillings, videos etc.	2020-04-06 09:29:27

Take a look to the deliverables list in detail: detailed list of GlyCoCan deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Zejian Zhang, Manfred Wuhrer, Stephanie Holst Serum sialylation changes in cancer published pages: 139-160, ISSN: 0282-0080, DOI: 10.1007/s10719-018-9820-0	Glycoconjugate Journal 35/2	2020-04-06
2018	Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto RodrÃguez, Yvette van Kooyk, Sandra J. van Vliet Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2018.00039	Frontiers in Oncology 8	2020-04-06
2018	MylÃ¨ne A. Carrascal, Catarina Talina, Paula Borralho, A. GonÃ§alo Mineiro, Ana Raquel Henriques, ClÃ¡udia Pen, Manuela Martins, Sofia Braga, Robert Sackstein, Paula A. Videira Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue published pages: , ISSN: 1471-2407, DOI: 10.1186/s12885-018-4410-x	BMC Cancer 18/1	2020-04-06
2018	InÃªs Gomes Ferreira, Michela Pucci, Giulia Venturi, Nadia Malagolini, Mariella Chiricolo and Fabio Dallâ€™Olio Glycosylation as a Main Regulator of Growth and Death Factor Receptors Signaling published pages: 580, ISSN: 1422-0067, DOI: 10.3390/ijms19020580	International Journal of Molecular Sciences 19/2	2020-04-06

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The information about "GLYCOCAN" are provided by the European Opendata Portal: CORDIS opendata.