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IonoChem

IonoChem: A new and highly efficient cross membrane drug delivery strategy

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

IonoChem project word cloud

Explore the words cloud of the IonoChem project. It provides you a very rough idea of what is the project "IonoChem" about.

refinement amounts fee turn systemic gmp customers plan vioxx administered customer techniques drug lipophilization eg model lipohilic elaboration us hydrophobic quantities market ionochem perform proprietary intracellular membrane tails global initial manufacturers licensing search qualification suitable technologies 2013 adding establishment segments rnai service ups contact annual times designed company sufficient sales types easily withdrawn ionovation dna biological solution inside introduction 11 therapeutics enter one toxic manufacturer line preclinical valued head clients billion membranes classes vs ratio platform quarters business facilities rna pricing many patient experimental contract worth pass drugs cells upscaling molecules molecule tail cell 151 nature setting

Project "IonoChem" data sheet

The following table provides information about the project.

Coordinator	IONOVATION GMBH Organization address address: WESTERBREITE 7 city: OSNABRUCK postcode: 49084 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.ionovation.com/index.php/ionochem
Total cost	71˙429 €
EC max contribution	50˙000 € (70%)
Programme	1. H2020-EU.2.3.1. (Mainstreaming SME support, especially through a dedicated instrument) 2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
Code Call	H2020-SMEINST-1-2015
Funding Scheme	SME-1
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2016-02-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IONOVATION GMBH IONOVATION GMBH Organization address address: WESTERBREITE 7 city: OSNABRUCK postcode: 49084 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (OSNABRUCK)	coordinator	50˙000.00

Map

Project objective

Many drugs are designed to target molecules inside cells. Due to the hydrophobic nature of the cell membranes however not all types of drugs can enter the cells in sufficient quantities. Thus large amounts of drug need to be administered which can lead to highly toxic systemic effects for the patient. Furthermore, new classes of therapeutics such as RNA- and DNA-based drugs require advanced delivery techniques to reach their intracellular targets. Ionovation’s proprietary IonoChem technology will provide a novel and highly effective solution to this problem by adding lipohilic “tails” directly to drug molecules at a one-on-one ratio. These “tails” allow drugs to easily pass through the cell membrane. As part of a service offer Ionovation will work with clients to identify the most effective tail for a particular molecule, and will also perform the lipophilization. The IonoChem platform will enable Ionovation GmbH (a manufacturer of experimental set-ups for the analysis of biological membranes) to enter the market for drug delivery technologies, thus creating a new line of business for the company. IonoChem will target the market for drug delivery systems, which was valued at US$151 billion in 2013. Market segments for initial introduction of the technology include RNAi drug delivery (a market worth US $11,7 billion in 2013) and drugs withdrawn from the market (eg Vioxx with 2.5 billion US $ annual global sales). Objectives of the phase I project include analysis of customer needs (pricing, expected turn-around times etc.), refinement of business model (licensing/fee for use model for contract manufacturers vs. service offer with production facilities at Ionovation’s head quarters); search for a suitable contract manufacturer for the phase II activities and the elaboration of a business plan. Phase II objectives include upscaling of the production under GMP conditions, establishment of contact to customers and the qualification of IonoChem in a preclinical setting.

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The information about "IONOCHEM" are provided by the European Opendata Portal: CORDIS opendata.

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