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DrugsInPregnancy SIGNED

Effects of Medication Use in Pregnancy on Infant Neurodevelopment

Total Cost €


EC-Contrib. €






 DrugsInPregnancy project word cloud

Explore the words cloud of the DrugsInPregnancy project. It provides you a very rough idea of what is the project "DrugsInPregnancy" about.

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Project "DrugsInPregnancy" data sheet

The following table provides information about the project.


Organization address
address: PROBLEMVEIEN 5-7
city: OSLO
postcode: 313

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Project website
 Total cost 1˙499˙439 €
 EC max contribution 1˙499˙439 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I OSLO NO (OSLO) coordinator 1˙499˙439.00


 Project objective

Currently, thousands of pregnant women in the EU and worldwide are being increasingly prescribed medications for which we do not have sufficient information on fetal safety. I hypothesize that our current understanding of safety pharmacology is oversimplified and that medication prescribed during pregnancy may play an unrecognized role in the development of neurodevelopmental disorders. In this research proposal we have the unique opportunity to use a large population-based birth cohort including over 100 000 mother-child pairs and biological data to study how medications may act on the offspring. This offers novel and innovative pharmaceutical insight into the safety of medications. By linking several nationwide registries (National Prescription Data Base, Norwegian Patient Registry, Medical Birth Registry) to a population-based birth cohort (n=108 000) we specifically aim to 1) estimate the effect of prenatal exposure to psychotropics and analgesics on neurodevelopment in young children using a range of methodological approaches to strengthen causal inference. With these data made available, we will 2) determine whether fetal exposure to specific medications results in epigenetic events (i.e. changes in DNA methylation) in the child, and 3) determine whether such changes increase the risks of neurodevelopmental disorders in childhood. The recent availability of large scale human data, possibility of register linkages and genome-wide mapping of DNA methylation at affordable costs makes this research proposal now possible. The size and richness of data including over hundred thousand pregnancies and existence of biological material makes this project unique. The final outcome will be fundamentally new knowledge about how medications affect the developing unborn child and will open up new horizons and opportunities for future research in a new field of “pharmaco-epigenetics” and enhance our understanding of origins of neurodevelopmental disorders.


year authors and title journal last update
List of publications.
2019 Jacqueline M Cohen, Mollie E Wood, Sonia Hernández-Díaz, Eivind Ystrom, Hedvig Nordeng
Paternal antidepressant use as a negative control for maternal use: assessing familial confounding on gestational length and anxiety traits in offspring
published pages: 1665-1672, ISSN: 0300-5771, DOI: 10.1093/ije/dyz170
International Journal of Epidemiology 48/5 2020-04-15
2019 Michael Ceulemans, Angela Lupattelli, Hedvig Nordeng, Marina Odalovic, Michael Twigg, Veerle Foulon
Women’s Beliefs About Medicines and Adherence to Pharmacotherapy in Pregnancy: Opportunities for Community Pharmacists
published pages: 469-482, ISSN: 1381-6128, DOI: 10.2174/1381612825666190321110420
Current Pharmaceutical Design 25/5 2020-04-15
2019 Frank, Anna-Simone Josefine
Thyroid hormone replacement therapy during pregnancy – Quantifying medication patterns and associated outcomes in the offspring
published pages: , ISSN: , DOI:
2019 Angela Lupattelli, Mollie E. Wood, Hedvig Nordeng
Analyzing Missing Data in Perinatal Pharmacoepidemiology Research: Methodological Considerations to Limit the Risk of Bias
published pages: 2477-2487, ISSN: 0149-2918, DOI: 10.1016/j.clinthera.2019.11.003
Clinical Therapeutics 41/12 2020-03-31
2019 Johanne N. Trønnes, Mollie Wood, Angela Lupattelli, Eivind Ystrom, Hedvig Nordeng
Prenatal paracetamol exposure and neurodevelopmental outcomes in preschool‐aged children
published pages: , ISSN: 0269-5022, DOI: 10.1111/ppe.12568
Paediatric and Perinatal Epidemiology 2020-03-31
2019 Anna S. Frank, Angela Lupattelli, Ragnhild E. Brandlistuen, Hedvig Nordeng
Maternal Thyroid Hormone Replacement Therapy Exposure and Language and Communication Skills of Offspring at 8 Years of Age
published pages: e1912424, ISSN: 2574-3805, DOI: 10.1001/jamanetworkopen.2019.12424
JAMA Network Open 2/10 2020-03-31
2018 Anna S. Frank, Angela Lupattelli, David S. Matteson, Hedvig Nordeng
Maternal use of thyroid hormone replacement therapy before, during, and after pregnancy: agreement between self-report and prescription records and group-based trajectory modeling of prescription patterns
published pages: 1801-1816, ISSN: 1179-1349, DOI: 10.2147/clep.s175616
Clinical Epidemiology Volume 10 2020-03-31
2019 Anna S. Frank, Angela Lupattelli, David S. Matteson, Helle Margrete Meltzer, Hedvig Nordeng
Thyroid hormone replacement therapy patterns in pregnant women and perinatal outcomes in the offspring
published pages: 111-121, ISSN: 1053-8569, DOI: 10.1002/pds.4927
Pharmacoepidemiology and Drug Safety 29/1 2020-03-31
2019 Sarah Hjorth, Rebecca Bromley, Eivind Ystrom, Angela Lupattelli, Olav Spigset, Hedvig Nordeng
Use and validity of child neurodevelopment outcome measures in studies on prenatal exposure to psychotropic and analgesic medications – A systematic review
published pages: e0219778, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0219778
PLOS ONE 14/7 2020-03-31
2019 Angela Lupattelli, Christina D. Chambers, Gretchen Bandoli, Marte Handal, Svetlana Skurtveit, Hedvig Nordeng
Association of Maternal Use of Benzodiazepines and Z-Hypnotics During Pregnancy With Motor and Communication Skills and Attention-Deficit/Hyperactivity Disorder Symptoms in Preschoolers
published pages: e191435, ISSN: 2574-3805, DOI: 10.1001/jamanetworkopen.2019.1435
JAMA Network Open 2/4 2020-03-31
2019 Kristina Gervin, Lucas A. Salas, Kelly M. Bakulski, Menno C. van Zelm, Devin C. Koestler, John K. Wiencke, Liesbeth Duijts, Henriëtte A. Moll, Karl T. Kelsey, Michael S. Kobor, Robert Lyle, Brock C. Christensen, Janine F. Felix, Meaghan J. Jones
Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data
published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-019-0717-y
Clinical Epigenetics 11/1 2020-03-31
2019 Gro C. Havnen, Maria Bich-Thuy Truong, Mai-Linh H. Do, Kristine Heitmann, Lone Holst, Hedvig Nordeng
Women’s perspectives on the management and consequences of hyperemesis gravidarum – a descriptive interview study
published pages: 30-40, ISSN: 0281-3432, DOI: 10.1080/02813432.2019.1569424
Scandinavian Journal of Primary Health Care 37/1 2020-03-31
2020 Emil A Stoltenberg, Hedvig ME Nordeng, Eivind Ystrom, Sven O Samuelsen
The cure model in perinatal epidemiology
published pages: 96228022090409, ISSN: 0962-2802, DOI: 10.1177/0962280220904092
Statistical Methods in Medical Research 2020-03-31
2016 Kristina Gervin, Christian Magnus Page, Hans Christian D. Aass, Michelle A. Jansen, Heidi Elisabeth Fjeldstad, Bettina Kulle Andreassen, Liesbeth Duijts, Joyce B. van Meurs, Menno C. van Zelm, Vincent W. Jaddoe, Hedvig Nordeng, Gunn Peggy Knudsen, Per Magnus, Wenche Nystad, Anne Cathrine Staff, Janine F. Felix, Robert Lyle
Cell type specific DNA methylation in cord blood: A 450K-reference data set and cell count-based validation of estimated cell type composition
published pages: 690-698, ISSN: 1559-2294, DOI: 10.1080/15592294.2016.1214782
Epigenetics 11/9 2019-05-29
2017 Stefania Salvatore, Diana Domanska, Mollie Wood, Hedvig Nordeng, Geir Kjetil Sandve
Complex patterns of concomitant medication use: A study among Norwegian women using paracetamol during pregnancy
published pages: e0190101, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0190101
PLOS ONE 12/12 2019-05-29
2016 Hedvig Nordeng
Drug utilization in pregnant women
published pages: 240-247, ISSN: , DOI: 10.1002/9781118949740.ch23
Drug Utilization Research: Methods and Applications 2019-05-29
2017 Hedvig Nordeng, Angela Lupattelli, Mollie Wood
Prenatal exposure to antidepressants and increased risk of psychiatric disorders
published pages: j3950, ISSN: 0959-8138, DOI: 10.1136/bmj.j3950
BMJ 2019-05-29
2018 Mollie E. Wood, Stavroula Chrysanthopoulou, Hedvig M.E. Nordeng, Kate L. Lapane
The Impact of Nondifferential Exposure Misclassification on the Performance of Propensity Scores for Continuous and Binary Outcomes
published pages: 1, ISSN: 0025-7079, DOI: 10.1097/MLR.0000000000000800
Medical Care 2019-05-29
2017 Angela Lupattelli, Mollie Wood, Kate Lapane, Olav Spigset, Hedvig Nordeng
Risk of preeclampsia after gestational exposure to selective serotonin reuptake inhibitors and other antidepressants: A study from The Norwegian Mother and Child Cohort Study
published pages: 1266-1276, ISSN: 1053-8569, DOI: 10.1002/pds.4286
Pharmacoepidemiology and Drug Safety 26/10 2019-05-29
2017 Eivind Ystrom, Kristin Gustavson, Ragnhild Eek Brandlistuen, Gun Peggy Knudsen, Per Magnus, Ezra Susser, George Davey Smith, Camilla Stoltenberg, Pål Surén, Siri E. Håberg, Mady Hornig, W. Ian Lipkin, Hedvig Nordeng, Ted Reichborn-Kjennerud
Prenatal Exposure to Acetaminophen and Risk of ADHD
published pages: e20163840, ISSN: 0031-4005, DOI: 10.1542/peds.2016-3840
Pediatrics 140/5 2019-05-29
2018 Anna S. Frank, Angela Lupattelli, Hedvig Nordeng
Risk factors for discontinuation of thyroid hormone replacement therapy in early pregnancy: a study from the Norwegian Mother and Child Cohort Study and the Medical Birth Registry of Norway
published pages: , ISSN: 0001-6349, DOI: 10.1111/aogs.13339
Acta Obstetricia et Gynecologica Scandinavica 2019-05-29
2017 Gerd-Marie Eskerud Harris, Mollie Wood, Malin Eberhard-Gran, Christofer Lundqvist, Hedvig Nordeng
Patterns and predictors of analgesic use in pregnancy: a longitudinal drug utilization study with special focus on women with migraine
published pages: , ISSN: 1471-2393, DOI: 10.1186/s12884-017-1399-0
BMC Pregnancy and Childbirth 17/1 2019-05-29
2017 Johanne N. Trønnes, Angela Lupattelli, Hedvig Nordeng
Safety profile of medication used during pregnancy: results of a multinational European study
published pages: 802-811, ISSN: 1053-8569, DOI: 10.1002/pds.4213
Pharmacoepidemiology and Drug Safety 26/7 2019-05-29
2018 Mollie E. Wood, Kate L. Lapane, Marleen M.H.J. van Gelder, Dheeraj Rai, Hedvig M.E. Nordeng
Making fair comparisons in pregnancy medication safety studies: An overview of advanced methods for confounding control
published pages: 140-147, ISSN: 1053-8569, DOI: 10.1002/pds.4336
Pharmacoepidemiology and Drug Safety 27/2 2019-05-29
2017 Susan E. Andrade, Anick Bérard, Hedvig M.E. Nordeng, Mollie E. Wood, Marleen M.H.J. van Gelder, Sengwee Toh
Administrative Claims Data Versus Augmented Pregnancy Data for the Study of Pharmaceutical Treatments in Pregnancy
published pages: 106-116, ISSN: 2196-2995, DOI: 10.1007/s40471-017-0104-1
Current Epidemiology Reports 4/2 2019-05-29
2017 Kristina Gervin, Hedvig Nordeng, Eivind Ystrom, Ted Reichborn-Kjennerud, Robert Lyle
Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD
published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-017-0376-9
Clinical Epigenetics 9/1 2019-05-29
2018 Gerd-Marie Eskerud Harris, Mollie Wood, Eivind Ystrom, Hedvig Nordeng
Prenatal triptan exposure and neurodevelopmental outcomes in 5-year-old children: Follow-up from the Norwegian Mother and Child Cohort Study
published pages: , ISSN: 0269-5022, DOI: 10.1111/ppe.12461
Paediatric and Perinatal Epidemiology 2019-05-29
2017 Ragnhild E. Brandlistuen, Eivind Ystrom, Sonia Hernandez-Diaz, Svetlana Skurtveit, Randi Selmer, Marte Handal, Hedvig Nordeng
Association of prenatal exposure to benzodiazepines and child internalizing problems: A sibling-controlled cohort study
published pages: e0181042, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0181042
PLOS ONE 12/7 2019-05-29
2016 Olav Spigset, Hedvig Nordeng
Safety of Psychotropic Drugs in Pregnancy and Breastfeeding
published pages: 299-319, ISSN: , DOI: 10.1007/978-3-319-24741-0_15
Pharmacovigilance in Psychiatry 2019-05-29
2018 Jacqueline M. Cohen, Mollie E. Wood, Sonia Hernandez-Diaz, Hedvig Nordeng
Agreement between paternal self-reported medication use and records from a national prescription database
published pages: 413-421, ISSN: 1053-8569, DOI: 10.1002/pds.4411
Pharmacoepidemiology and Drug Safety 27/4 2019-05-29
2018 Angela Lupattelli, Michael J Twigg, Ksenia Zagorodnikova, Myla E Moretti, Mariola Drozd, Alice Panchaud, Andre Rieutord, Romana Gjergja Juraski, Marina Odalovic, Debra Kennedy, Gorazd Rudolf, Herbert Juch, Hedvig Marie Egeland Nordeng
Self-reported perinatal depressive symptoms and postnatal symptom severity after treatment with antidepressants in pregnancy: a cross-sectional study across 12 European countries using the Edinburgh Postnatal Depression Scale
published pages: 655-669, ISSN: 1179-1349, DOI: 10.2147/CLEP.S156210
Clinical Epidemiology Volume 10 2019-04-03
2018 Angela Lupattelli, Elke Ronningen, Stine Kleppe Krogsrud, Hedvig Nordeng, Eivind Ystrom
Personality and its relation to the use of alcohol and cigarettes during pregnancy: A multinational study
published pages: 135910531877519, ISSN: 1359-1053, DOI: 10.1177/1359105318775194
Journal of Health Psychology 2019-04-03
2018 Angela Lupattelli, Olav Spigset, Hedvig Nordeng
Learning the effects of psychotropic drugs during pregnancy using real-world safety data: a paradigm shift toward modern pharmacovigilance
published pages: 783-786, ISSN: 2210-7703, DOI: 10.1007/s11096-018-0672-2
International Journal of Clinical Pharmacy 40/4 2019-04-02

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