Opendata, web and dolomites

COSMIC SIGNED

Commitment, maturation and infectivity of sexual stage malaria parasites in natural infections

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "COSMIC" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://www.radboudumc.nl/en/people/teun-bousema
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 1˙345˙000.00
2    UNIVERSITY OF GLASGOW UK (GLASGOW) participant 155˙000.00
3    HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC. US (CAMBRIDGE) participant 0.00

Map

 Project objective

Background: One of the major challenges for malaria control and elimination is the phenomenally efficient spread of malaria through sexual stage malaria parasites (gametocytes). The epidemiology and dynamics of gametocytes are poorly understood: it is presently unknown when commitment to gametocytes first occurs during infections and what intrinsic or extrinsic factors influence gametocyte production and infectivity to mosquitoes. I hypothesize that continuous early commitment to gametocyte production and the preferential sequestration of mature gametocytes in the subdermal vasculature are key to explaining the high efficiency of malaria transmission. Aim: This proposal has three main aims: i) to determine when commitment to gametocyte production first occurs during experimental and natural infections; ii) to delineate environmental triggers that stimulate gametocyte production in the absence and presence of treatment; iii) to quantify the differential distribution of parasite developmental stages in different compartments of the human bloodstream. Approach: We will use novel parasite stage composition assays in combination with epidemiological methods to determine the dynamics of gametocyte commitment and maturation during controlled malaria infections in malaria-naive volunteers and during naturally acquired malaria infections in cohorts exposed to malaria in Burkina Faso. A stage-specific immunohistochemistry assay will, for the first time, directly quantify malaria stage composition in the subdermal vasculature and mosquito bloodmeals and allow comparison with other compartments of the circulation. Importance and Innovation: This is the first study to comprehensively characterize gametocyte commitment, maturation and infectivity in experimental and natural infections. This proposal will provide insight in one of the most important questions for malaria elimination: what processes are responsible for the phenomenally efficient transmission of malaria.

 Publications

year authors and title journal last update
List of publications.
2018 André Lin Ouédraogo, Philip A. Eckhoff, Adrian J. F. Luty, Will Roeffen, Robert W. Sauerwein, Teun Bousema, Edward A. Wenger
Modeling the impact of Plasmodium falciparum sexual stage immunity on the composition and dynamics of the human infectious reservoir for malaria in natural settings
published pages: e1007034, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007034
PLOS Pathogens 14/5 2020-03-11
2019 Elamaran Meibalan, Aissata Barry, Matthew P Gibbins, Shehu Awandu, Lisette Meerstein-Kessel, Fiona Achcar, Selina Bopp, Christopher Moxon, Amidou Diarra, Siaka Debe, Nicolas Ouédraogo, Ines Barry-Some, Emilie S Badoum, Traoré Fagnima, Kjerstin Lanke, Bronner P Gonçalves, John Bradley, Dyann Wirth, Chris Drakeley, Wamdaogo Moussa Guelbeogo, Alfred B Tiono, Matthias Marti, Teun Bousema
Plasmodium falciparum Gametocyte Density and Infectivity in Peripheral Blood and Skin Tissue of Naturally Infected Parasite Carriers in Burkina Faso
published pages: , ISSN: 0022-1899, DOI: 10.1093/infdis/jiz680
The Journal of Infectious Diseases 2020-03-11
2018 Getasew Shitaye, Endalamaw Gadisa, Lynn Grignard, Girma Shumie, Wakweya Chali, Temesgen Menberu, Mulualem Belachew, Getaneh Tegegn, Sagni Challi, Jonathan Curry, Laleta Mahey, Tsegaye Hailu, Hassen Mamo, Menakath Menon, Taye Balcha, Abraham Aseffa, Chris Drakeley, Teun Bousema, Fitsum G. Tadesse
Low and heterogeneous prevalence of glucose-6-phosphate dehydrogenase deficiency in different settings in Ethiopia using phenotyping and genotyping approaches
published pages: , ISSN: 1475-2875, DOI: 10.1186/s12936-018-2437-8
Malaria Journal 17/1 2020-03-11
2019 Roos M. Jong, Surafel K. Tebeje, Lisette Meerstein‐Kessel, Fitsum G. Tadesse, Matthijs M. Jore, Will Stone, Teun Bousema
Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites
published pages: 190-215, ISSN: 0105-2896, DOI: 10.1111/imr.12828
Immunological Reviews 293/1 2020-03-11
2019 Kathleen W. Dantzler, Siyuan Ma, Priscilla Ngotho, Will J. R. Stone, Dingyin Tao, Sanna Rijpma, Mariana De Niz, Sandra K. Nilsson Bark, Matthijs M. Jore, Tonke K. Raaijmakers, Angela M. Early, Ceereena Ubaida-Mohien, Leandro Lemgruber, Joseph J. Campo, Andy A. Teng, Timothy Q. Le, Cassidy L. Walker, Patricia Hermand, Philippe Deterre, D. Huw Davies, Phil Felgner, Isabelle Morlais, Dyann F. Wirth,
Naturally acquired immunity against immature Plasmodium falciparum gametocytes
published pages: eaav3963, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aav3963
Science Translational Medicine 11/495 2020-03-11
2019 Alex K. Musiime, Joseph Okoth, Melissa Conrad, Daniel Ayo, Ismail Onyige, John Rek, Joaniter I. Nankabirwa, Emmanuel Arinaitwe, Moses R. Kamya, Grant Dorsey, Geert-Jan van Gemert, Sarah G. Staedke, Chris Drakeley, Teun Bousema, Chiara Andolina
Is that a real oocyst? Insectary establishment and identification of Plasmodium falciparum oocysts in midguts of Anopheles mosquitoes fed on infected human blood in Tororo, Uganda
published pages: , ISSN: 1475-2875, DOI: 10.1186/s12936-019-2922-8
Malaria Journal 18/1 2020-03-11
2018 Isaie J Reuling, Lisanne A van de Schans, Luc E Coffeng, Kjerstin Lanke, Lisette Meerstein-Kessel, Wouter Graumans, Geert-Jan van Gemert, Karina Teelen, Rianne Siebelink-Stoter, Marga van de Vegte-Bolmer, Quirijn de Mast, André J van der Ven, Karen Ivinson, Cornelus C Hermsen, Sake de Vlas, John Bradley, Katharine A Collins, Christian F Ockenhouse, James McCarthy, Robert W Sauerwein, Teun Bousema
A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.31549
eLife 7 2020-02-21
2017 Will Stone, Patrick Sawa, Kjerstin Lanke, Sanna Rijpma, Robin Oriango, Maureen Nyaurah, Paul Osodo, Victor Osoti, Almahamoudou Mahamar, Halimatou Diawara, Rob Woestenenk, Wouter Graumans, Marga van de Vegte-Bolmer, John Bradley, Ingrid Chen, Joelle Brown, Giulia Siciliano, Pietro Alano, Roly Gosling, Alassane Dicko, Chris Drakeley, Teun Bousema
A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance
published pages: 457-467, ISSN: 0022-1899, DOI: 10.1093/infdis/jix237
The Journal of Infectious Diseases 216/4 2020-02-21
2018 Katharine A. Collins, Claire Y.T. Wang, Matthew Adams, Hayley Mitchell, Melanie Rampton, Suzanne Elliott, Isaie J. Reuling, Teun Bousema, Robert Sauerwein, Stephan Chalon, Jörg J. Möhrle, James S. McCarthy
A controlled human malaria infection model enabling evaluation of transmission-blocking interventions
published pages: 1551-1562, ISSN: 0021-9738, DOI: 10.1172/JCI98012
Journal of Clinical Investigation 128/4 2020-02-21
2018 Alassane Dicko, Michelle E Roh, Halimatou Diawara, Almahamoudou Mahamar, Harouna M Soumare, Kjerstin Lanke, John Bradley, Koualy Sanogo, Daouda T Kone, Kalifa Diarra, Sekouba Keita, Djibrilla Issiaka, Sekou F Traore, Charles McCulloch, Will J R Stone, Jimee Hwang, Olaf Müller, Joelle M Brown, Vinay Srinivasan, Chris Drakeley, Roly Gosling, Ingrid Chen, Teun Bousema
Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial
published pages: , ISSN: 1473-3099, DOI: 10.1016/S1473-3099(18)30044-6
The Lancet Infectious Diseases 2020-02-21
2017 Isaie J. Reuling, Will J. R. Stone, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Rianne Siebelink-Stoter, Wouter Graumans, Kjerstin Lanke, Teun Bousema, Robert W. Sauerwein
Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays
published pages: , ISSN: 1475-2875, DOI: 10.1186/s12936-017-1959-9
Malaria Journal 16/1 2020-02-21
2018 Jason P. Mooney, Aissata Barry, Bronner P. Gonçalves, Alfred B. Tiono, Shehu S. Awandu, Lynn Grignard, Chris J. Drakeley, Christian Bottomley, Teun Bousema, Eleanor M. Riley
Haemolysis and haem oxygenase-1 induction during persistent “asymptomatic” malaria infection in Burkinabé children
published pages: , ISSN: 1475-2875, DOI: 10.1186/s12936-018-2402-6
Malaria Journal 17/1 2020-02-21
2017 Fitsum G. Tadesse, Jodie A. Schildkraut, Teun Bousema, Alfred B. Tiono, Kjerstin Lanke, Chris Drakeley, Sanna R. Rijpma, Bronner P. Gonçalves, Robert Sauerwein, Issa Nebie
Molecular Markers for Sensitive Detection of Plasmodium falciparum Asexual Stage Parasites and their Application in a Malaria Clinical Trial
published pages: 188-198, ISSN: 0002-9637, DOI: 10.4269/ajtmh.16-0893
The American Journal of Tropical Medicine and Hygiene 97/1 2020-02-21
2016 Joseph Okebe, Teun Bousema, Muna Affara, Gian Luca Di Tanna, Edgard Dabira, Abdoulaye Gaye, Frank Sanya-Isijola, Henry Badji, Simon Correa, Davis Nwakanma, Jean-Pierre Van Geertruyden, Chris Drakeley, Umberto D\'Alessandro
The Gametocytocidal Efficacy of Different Single Doses of Primaquine with Dihydroartemisinin-piperaquine in Asymptomatic Parasite Carriers in The Gambia: A Randomized Controlled Trial
published pages: 348-355, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2016.10.032
EBioMedicine 13 2020-02-21
2017 Fitsum G. Tadesse, Lotus van den Hoogen, Kjerstin Lanke, Jodie Schildkraut, Kevin Tetteh, Abraham Aseffa, Hassen Mamo, Robert Sauerwein, Ingrid Felger, Chris Drakeley, Endalamaw Gadissa, Teun Bousema
The shape of the iceberg: quantification of submicroscopic Plasmodium falciparum and Plasmodium vivax parasitaemia and gametocytaemia in five low endemic settings in Ethiopia
published pages: , ISSN: 1475-2875, DOI: 10.1186/s12936-017-1749-4
Malaria Journal 16/1 2020-02-21
2017 Bronner P. Gonçalves, Helmi Pett, Alfred B. Tiono, Daryl Murry, Sodiomon B. Sirima, Mikko Niemi, Teun Bousema, Chris Drakeley, Rob ter Heine
Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children
published pages: e02590-16, ISSN: 0066-4804, DOI: 10.1128/AAC.02590-16
Antimicrobial Agents and Chemotherapy 61/5 2020-02-21
2018 Ingrid Chen, Halimatou Diawara, Almahamoudou Mahamar, Koualy Sanogo, Sekouba Keita, Daouda Kone, Kalifa Diarra, Moussa Djimde, Mohamed Keita, Joelle Brown, Michelle E Roh, Jimee Hwang, Helmi Pett, Maxwell Murphy, Mikko Niemi, Bryan Greenhouse, Teun Bousema, Roly Gosling, Alassane Dicko
Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial
published pages: , ISSN: 0022-1899, DOI: 10.1093/infdis/jiy014
The Journal of Infectious Diseases 2020-02-21
2017 Teun Bousema, Chris Drakeley
Determinants of Malaria Transmission at the Population Level
published pages: a025510, ISSN: 2157-1422, DOI: 10.1101/cshperspect.a025510
Cold Spring Harbor Perspectives in Medicine 7/12 2020-02-21
2018 Fitsum G Tadesse, Hannah C Slater, Wakweya Chali, Karina Teelen, Kjerstin Lanke, Mulualem Belachew, Temesgen Menberu, Girma Shumie, Getasew Shitaye, Lucy C Okell, Wouter Graumans, Geert-Jan van Gemert, Soriya Kedir, Addisu Tesfaye, Feleke Belachew, Wake Abebe, Hassen Mamo, Robert Sauerwein, Taye Balcha, Abraham Aseffa, Delenasaw Yewhalaw, Endalamaw Gadisa, Chris Drakeley, Teun Bousema
The relative contribution of symptomatic and asymptomatic Plasmodium vivax and Plasmodium falciparum infections to the infectious reservoir in a low-endemic setting in Ethiopia
published pages: , ISSN: 1058-4838, DOI: 10.1093/cid/cix1123
Clinical Infectious Diseases 2020-02-21
2018 Lynn Grignard, Bronner P. Gonçalves, Angela M. Early, Rachel F. Daniels, Alfred B. Tiono, Wamdaogo M. Guelbéogo, Alphonse Ouédraogo, Elke M. van Veen, Kjerstin Lanke, Amidou Diarra, Issa Nebie, Sodiomon B. Sirima, Geoff A. Targett, Sarah K. Volkman, Daniel E. Neafsey, Dyann F. Wirth, Teun Bousema, Chris Drakeley
Transmission of molecularly undetectable circulating parasite clones leads to high infection complexity in mosquitoes post feeding
published pages: 671-677, ISSN: 0020-7519, DOI: 10.1016/j.ijpara.2018.02.005
International Journal for Parasitology 48/8 2020-02-21
2018 Guido J. H. Bastiaens, Alfred B. Tiono, Joseph Okebe, Helmi E. Pett, Sam A. Coulibaly, Bronner P. Gonçalves, Muna Affara, Alphonse Ouédraogo, Edith C. Bougouma, Guillaume S. Sanou, Issa Nébié, John Bradley, Kjerstin H. W. Lanke, Mikko Niemi, Sodiomon B. Sirima, Umberto d’Alessandro, Teun Bousema, Chris Drakeley
Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: Two open-label, randomized, safety trials
published pages: e0190272, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0190272
PLOS ONE 13/1 2020-02-21
2016 Bronner P. Gonçalves, Chris Drakeley, Teun Bousema
Infectivity of Microscopic and Submicroscopic Malaria Parasite Infections in Areas of Low Malaria Endemicity
published pages: 1516-1517, ISSN: 0022-1899, DOI: 10.1093/infdis/jiw044
Journal of Infectious Diseases 213/9 2020-02-21
2015 Hannah C. Slater, Amanda Ross, André Lin Ouédraogo, Lisa J. White, Chea Nguon, Patrick G.T. Walker, Pengby Ngor, Ricardo Aguas, Sheetal P. Silal, Arjen M. Dondorp, Paul La Barre, Robert Burton, Robert W. Sauerwein, Chris Drakeley, Thomas A. Smith, Teun Bousema, Azra C. Ghani
Assessing the impact of next-generation rapid diagnostic tests on Plasmodium falciparum malaria elimination strategies
published pages: S94-S101, ISSN: 0028-0836, DOI: 10.1038/nature16040
Nature 528/7580 2020-02-21
2016 Hsiao-Han Chang, Elamaran Meibalan, Justin Zelin, Rachel Daniels, Alice C. Eziefula, Evan C. Meyer, Fitsum Tadesse, Lynn Grignard, Regina C. Joice, Chris Drakeley, Dyann F. Wirth, Sarah K. Volkman, Caroline Buckee, Teun Bousema, Matthias Marti
Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda
published pages: 26330, ISSN: 2045-2322, DOI: 10.1038/srep26330
Scientific Reports 6 2020-02-21
2016 Bronner P. Gonçalves, Alfred B. Tiono, Alphonse Ouédraogo, Wamdaogo M. Guelbéogo, John Bradley, Issa Nebie, Débé Siaka, Kjerstin Lanke, Alice C. Eziefula, Amidou Diarra, Helmi Pett, Edith C. Bougouma, Sodiomon B. Sirima, Chris Drakeley, Teun Bousema
Single low dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission after artemether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trial
published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-016-0581-y
BMC Medicine 14/1 2020-02-21
2016 Alassane Dicko, Joelle M Brown, Halimatou Diawara, Ibrahima Baber, Almahamoudou Mahamar, Harouna M Soumare, Koualy Sanogo, Fanta Koita, Sekouba Keita, Sekou F Traore, Ingrid Chen, Eugenie Poirot, Jimee Hwang, Charles McCulloch, Kjerstin Lanke, Helmi Pett, Mikko Niemi, François Nosten, Teun Bousema, Roly Gosling
Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial
published pages: 674-684, ISSN: 1473-3099, DOI: 10.1016/S1473-3099(15)00479-X
The Lancet Infectious Diseases 16/6 2020-02-21
2016 Abdulla S, Achan J, Adam I, Alemayehu BH, Allan R, Allen EN, Anvikar AR, Arinaitwe E, Ashley EA, Sot M, Asih PB, Awab GR, Barnes KI, Bassat Q, de Manhiça S, Baudin E, Björkman A, Bompart F, Bonnet M, Borrmann S, Bousema T, Carrara VI, Sot M, Cenci F, Tau S, Checchi F, Cot M, Dahal P, D\'Alessandro U, Deloron P, Djimde A, Dondorp A, Dorsey G, Doumbo OK, Drakeley CJ, Duparc S, Espie E, Faiz A, Falade CO, Fanello C, Faye B, Diop UC, Filler S, Fofana B, Fogg C, Gansane A, Faso B, Gaye O, Diop UC, Genton B, Gething PW, Gonzalez R, de Manhiça S, Grandesso F, Greenwood B, Grivoyannis A, Guerin PJ, Hamed K, Hatz C, Hay I, Humphreys GS, Hwang J, Janssens B, Frontières MS, Jima D, Juma E, Kachur SP, Kager P, Kamya MR, Kapulu M, Karema C, Kayentao K, Kiechel JR, Kofoed PE, Lameyre V, Lee SJ, Lell B, Marsh K, Mårtensson A, Massougbodji A, Mayxay M, McGready R, Sot M, Menan H, Menendez C, Meremikwu M, Mockenhaupt FP, Moreira C, Nabasumba C, Nambozi M, Ndiaye JL, Diop UC, Newton PN, Ngasala BE, Nosten F, Sot M, Nsanzabana C, Offianan AT, Oguike M, Ogutu R, Olliaro P, Omar A, Osorio L, Owusu-Agyei S, Penali LK, Pene M, Diop UC, Peshu J, Piola P, Premji Z, Price RN, Ramharter M, Tübingen U, Rombo L, Roper C, Rosenthal PJ, Sagara I, Sawa P, Schallig HD, Schramm B, Shekalaghe SA, Sibley CH, Sirima S, Faso B, Smithuis F, Diop UC, Staedke SG, Stepniewska K, Sutanto I, Sutherland CJ, Swarthout TD, Frontières MS, Syafruddin D, Sylla K, de Parasitologie-Mycologie Médicale S, Diop UC, Talisuna AO, Taylor WR, Temu EA, Kuile FT, Tinto H, Dioulasso B, Faso B, Dioulasso B, Faso B, Tjitra E, Ursing J, Valecha N, van den Broek I, Frontières MS, van Herp M, Frontières MS, van Vugt M, Ward SA, White NJ, Winstanley PA, Woodrow CJ, Yeka A, Zwang J.
Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data
published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-016-0621-7
BMC Medicine 14/1 2020-02-21

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "COSMIC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "COSMIC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

REPLAY_DMN (2019)

A theory of global memory systems

Read More  

DEEPTIME (2020)

Probing the history of matter in deep time

Read More  

TechChild (2019)

Just because we can, should we? An anthropological perspective on the initiation of technology dependence to sustain a child’s life

Read More