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SCENT SIGNED

SCENT: Hybrid Gels for Rapid Microbial Detection

Total Cost €

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EC-Contrib. €

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Partnership

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 SCENT project word cloud

Explore the words cloud of the SCENT project. It provides you a very rough idea of what is the project "SCENT" about.

global    infections    forefront    24    spreading    economic    alarming    antimicrobial    hybrid    tackle    signal    employing    class    aggressive    acquired    group    receptors    selectivity    threat    clinical    characterise    artificial    36    confinement    resistant    tools    community    burden    databases    fast    stimulus    signatures    causing    settings    peptides    chemical    selective    operation    sensors    pathogenic    explore    bacterial    organism    semi    scientific    metabolites    olfactory    slow    detection    billion    mimicking    odour    limitation    create    noses    odorant    tuberculosis    area    rapid    bioinspired    week    ways    intend    deaths    volatile    biological    resistances    libraries    gels    microbial    25    limited    works    environmental    footprint    customisable    pace    infected    infectious    infection    nose    generate    place    individuals    assemble    spread    annual    disease    discovered    stability    bacteria    complexity    usually    unfortunately    identification    alternative    exceeding    responsive    therapy    diagnostics    volatiles   

Project "SCENT" data sheet

The following table provides information about the project.

Coordinator
NOVA ID FCT - ASSOCIACAO PARA A INOVACAO E DESENVOLVIMENTO DA FCT 

Organization address
address: CAMPUS DE CAPARICA FACULDADE DE CIENCIAS E TECNOLOGIA DA UNIVERSIDADE NOVA DE LISBOA
city: CAPARICA
postcode: 2829 516
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website https://sites.fct.unl.pt/biomolecular_eng/pages/scent
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-12-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NOVA ID FCT - ASSOCIACAO PARA A INOVACAO E DESENVOLVIMENTO DA FCT PT (CAPARICA) coordinator 1˙500˙000.00

Map

 Project objective

Antimicrobial resistant bacteria are a global threat spreading at an alarming pace. They cause over 25,000 annual deaths in the EU, and represent an economic burden exceeding €1.5 billion a year. Current methods for microbial detection in clinical settings take about 24-36 h, but for slow-growing bacteria, as those causing tuberculosis, it can take more than a week. Early-detection and confinement of the infected individuals are the only ways to provide adequate therapy and control infection spread. Thus, tools for rapid identification of bacterial infections are greatly needed. The analysis of microbial volatile metabolites is an area of increasing interest in diagnostics. Recent works demonstrate that fast microbial identification is possible with chemical nose sensors. These sensors usually present limited stability and selectivity, and require aggressive conditions during processing and operation. Bioinspired nose sensors employing biological olfactory receptors are an alternative. Unfortunately, their complexity and low stability are a limitation. My group recently discovered a new class of stimulus-responsive gels which tackle these key challenges. Our gels are customisable and have a low environmental footprint associated. I intend to further explore their potential to advance the field of odour detection, while providing new tools for the scientific community. I will focus specifically in fast microbial detection. To accomplish this, I propose to 1) build libraries of hybrid gels with semi-selective and selective properties, 2) generate odorant specific peptides mimicking olfactory receptors, 3) fully characterise the gels, 4) assemble artificial noses for analysis of microbial volatiles, 5) create databases with organism-specific signal signatures, 6) identify pathogenic bacteria, including those with acquired antimicrobial-resistances. This project is a timely approach which will place Europe in the forefront of infectious disease control.

 Publications

year authors and title journal last update
List of publications.
2019 Gaetano Maugeri, Iana Lychko, Rita Sobral, Ana C. A. Roque
Identification and Antibiotic-Susceptibility Profiling of Infectious Bacterial Agents: A Review of Current and Future Trends
published pages: 1700750, ISSN: 1860-6768, DOI: 10.1002/biot.201700750
Biotechnology Journal 14/1 2019-11-08
2019 Carina Esteves, Gonçalo M.C. Santos, Cláudia Alves, Susana I.C.J. Palma, Ana R. Porteira, João Filho, Henrique M.A. Costa, Vitor D. Alves, Bruno M. Morais Faustino, Isabel Ferreira, Hugo Gamboa, Ana C.A. Roque
Effect of film thickness in gelatin hybrid gels for artificial olfaction
published pages: 100002, ISSN: 2590-0064, DOI: 10.1016/j.mtbio.2019.100002
Materials Today Bio 1 2019-11-08
2017 Abid Hussain, Ana T. S. Semeano, Susana I. C. J. Palma, Ana S. Pina, José Almeida, Bárbara F. Medrado, Ana C. C. S. Pádua, Ana L. Carvalho, Madalena Dionísio, Rosamaria W. C. Li, Hugo Gamboa, Rein V. Ulijn, Jonas Gruber, Ana C. A. Roque
Tunable Gas Sensing Gels by Cooperative Assembly
published pages: 1700803, ISSN: 1616-301X, DOI: 10.1002/adfm.201700803
Advanced Functional Materials 27/27 2019-05-29
2017 Marta Sofia Banza Gonçalves
Extraction of plant biopolymers and their use in gas sensitive hybrid materials
published pages: , ISSN: , DOI:
2019-05-20
2018 Susana I. C. J. Palma, Ana P. Traguedo, Ana R. Porteira, Maria J. Frias, Hugo Gamboa, Ana C. A. Roque
Machine learning for the meta-analyses of microbial pathogens’ volatile signatures
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-21544-1
Scientific Reports 8/1 2019-05-20
2018 Ana T.S. Semeano, Daniele F. Maffei, Susana Palma, Rosamaria W.C. Li, Bernadette D.G.M. Franco, Ana C.A. Roque, Jonas Gruber
Tilapia fish microbial spoilage monitored by a single optical gas sensor
published pages: 72-76, ISSN: 0956-7135, DOI: 10.1016/j.foodcont.2018.01.025
Food Control 89 2019-05-20
2016 Ana Patrícia Imaginário Traguedo
Theoretical and experimental approaches towards the non-invasive and selective detection of microbial pathogens
published pages: , ISSN: , DOI:
2019-05-20

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