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CELLPLASTICITY SIGNED

New Frontiers in Cellular Reprogramming: Exploiting Cellular Plasticity

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CELLPLASTICITY" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) 

Organization address
address: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA
city: BARCELONA
postcode: 8028
website: www.irbbarcelona.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙488˙850 €
 EC max contribution 2˙488˙850 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) ES (BARCELONA) coordinator 2˙024˙047.00
2    FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III ES (MADRID) participant 464˙803.00

Map

 Project objective

'Our research group has worked over the years at the interface between cancer and ageing, with a strong emphasis on mouse models. More recently, we became interested in cellular reprogramming because we hypothesized that understanding cellular plasticity could yield new insights into cancer and ageing. Indeed, during the previous ERC Advanced Grant, we made relevant contributions to the fields of cellular reprogramming (Nature 2013), cellular senescence (Cell 2013), cancer (Cancer Cell 2012), and ageing (Cell Metabolism 2012). Now, we take advantage of our diverse background and integrate the above processes. Our unifying hypothesis is that cellular plasticity lies at the basis of tissue regeneration (“adaptive cellular plasticity”), as well as at the origin of cancer (“maladaptive gain of cellular plasticity”) and ageing (“maladaptive loss of cellular plasticity”). A key experimental system will be our “reprogrammable mice” (with inducible expression of the four Yamanaka factors), which we regard as a tool to induce cellular plasticity in vivo. The project is divided as follows: Objective #1 – Cellular plasticity and cancer: role of tumour suppressors in in vivo de-differentiation and reprogramming / impact of transient de-differentiation on tumour initiation / lineage tracing of Oct4 to determine whether a transient pluripotent-state occurs during cancer. Objective #2 – Cellular plasticity in tissue regeneration and ageing: impact of transient de-differentiation on tissue regeneration / contribution of the damage-induced microenvironment to tissue regeneration / impact of transient de-differentiation on ageing. Objective #3: New frontiers in cellular plasticity: chemical manipulation of cellular plasticity in vivo / new states of pluripotency / characterization of in vivo induced pluripotency and its unique properties. We anticipate that the completion of this project will yield new fundamental insights into cancer, regeneration and ageing.'

 Publications

year authors and title journal last update
List of publications.
2017 Manuel Serrano
Ageing: Tools to eliminate senescent cells
published pages: 294-296, ISSN: 0028-0836, DOI: 10.1038/nature22493
Nature 545/7654 2020-02-12
2017 Izumi Horikawa, Kye-yoon Park, Kazunobu Isogaya, Yukiharu Hiyoshi, Han Li, Katsuhiro Anami, Ana I Robles, Abdul M Mondal, Kaori Fujita, Manuel Serrano, Curtis C Harris
Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells
published pages: 1017-1028, ISSN: 1350-9047, DOI: 10.1038/cdd.2017.48
Cell Death and Differentiation 24/6 2020-02-12
2017 Beatriz Lozano-Torres, Irene Galiana, Miguel Rovira, Eva Garrido, Selim Chaib, Andrea Bernardos, Daniel Muñoz-Espín, Manuel Serrano, Ramón Martínez-Máñez, Félix Sancenón
An OFF–ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo
published pages: 8808-8811, ISSN: 0002-7863, DOI: 10.1021/jacs.7b04985
Journal of the American Chemical Society 139/26 2020-02-12
2017 Konstantinos Evangelou, Nikolaos Lougiakis, Sophia V. Rizou, Athanassios Kotsinas, Dimitris Kletsas, Daniel Muñoz-Espín, Nikolaos G Kastrinakis, Nicole Pouli, Panagiotis Marakos, Paul Townsend, Manuel Serrano, Jiri Bartek, Vassilis G. Gorgoulis
Robust, universal biomarker assay to detect senescent cells in biological specimens
published pages: 192-197, ISSN: 1474-9718, DOI: 10.1111/acel.12545
Aging Cell 16/1 2020-02-12
2016 Shira Knafo, Cristina Sánchez-Puelles, Ernest Palomer, Igotz Delgado, Jonathan E Draffin, Janire Mingo, Tina Wahle, Kanwardeep Kaleka, Liping Mou, Inmaculada Pereda-Perez, Edvin Klosi, Erik B Faber, Heidi M Chapman, Laura Lozano-Montes, Ana Ortega-Molina, Lara Ordóñez-Gutiérrez, Francisco Wandosell, Jose Viña, Carlos G Dotti, Randy A Hall, Rafael Pulido, Nashaat Z Gerges, Andrew M Chan, Mark R Spaller, Manuel Serrano, César Venero, José A Esteban
PTEN recruitment controls synaptic and cognitive function in Alzheimer\'s models
published pages: 443-453, ISSN: 1097-6256, DOI: 10.1038/nn.4225
Nature Neuroscience 19/3 2020-02-12
2017 Manuel Serrano
Understanding Aging
published pages: 1083-1085, ISSN: 0028-4793, DOI: 10.1056/NEJMcibr1615878
New England Journal of Medicine 376/11 2020-02-12
2017 Miguel Ángel Sánchez-Luengo, Miguel Rovira, Manuel Serrano, Pablo Jose Fernandez-Marcos, Lola Martinez
Analysis of the advantages of cis reporters in optimized FACS-Gal
published pages: 721-729, ISSN: 1552-4922, DOI: 10.1002/cyto.a.23086
Cytometry Part A 91/7 2020-02-12
2017 Ramaswamy Kannappan, Alex Matsuda, João Ferreira-Martins, Eric Zhang, Giorgia Palano, Anna Czarna, Mauricio Castro Cabral-Da-Silva, Adriana Bastos-Carvalho, Fumihiro Sanada, Noriko Ide, Marcello Rota, Maria A. Blasco, Manuel Serrano, Piero Anversa, Annarosa Leri
p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo
published pages: 224-237, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2017.01.028
EBioMedicine 16 2020-02-12

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