Explore the words cloud of the CELLPLASTICITY project. It provides you a very rough idea of what is the project "CELLPLASTICITY" about.
The following table provides information about the project.
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
|Coordinator Country||Spain [ES]|
|Total cost||2˙488˙850 €|
|EC max contribution||2˙488˙850 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-10-01 to 2021-03-31|
Take a look of project's partnership.
|1||FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)||ES (BARCELONA)||coordinator||2˙024˙047.00|
|2||FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III||ES (MADRID)||participant||464˙803.00|
'Our research group has worked over the years at the interface between cancer and ageing, with a strong emphasis on mouse models. More recently, we became interested in cellular reprogramming because we hypothesized that understanding cellular plasticity could yield new insights into cancer and ageing. Indeed, during the previous ERC Advanced Grant, we made relevant contributions to the fields of cellular reprogramming (Nature 2013), cellular senescence (Cell 2013), cancer (Cancer Cell 2012), and ageing (Cell Metabolism 2012). Now, we take advantage of our diverse background and integrate the above processes. Our unifying hypothesis is that cellular plasticity lies at the basis of tissue regeneration (“adaptive cellular plasticity”), as well as at the origin of cancer (“maladaptive gain of cellular plasticity”) and ageing (“maladaptive loss of cellular plasticity”). A key experimental system will be our “reprogrammable mice” (with inducible expression of the four Yamanaka factors), which we regard as a tool to induce cellular plasticity in vivo. The project is divided as follows: Objective #1 – Cellular plasticity and cancer: role of tumour suppressors in in vivo de-differentiation and reprogramming / impact of transient de-differentiation on tumour initiation / lineage tracing of Oct4 to determine whether a transient pluripotent-state occurs during cancer. Objective #2 – Cellular plasticity in tissue regeneration and ageing: impact of transient de-differentiation on tissue regeneration / contribution of the damage-induced microenvironment to tissue regeneration / impact of transient de-differentiation on ageing. Objective #3: New frontiers in cellular plasticity: chemical manipulation of cellular plasticity in vivo / new states of pluripotency / characterization of in vivo induced pluripotency and its unique properties. We anticipate that the completion of this project will yield new fundamental insights into cancer, regeneration and ageing.'
|year||authors and title||journal||last update|
Ageing: Tools to eliminate senescent cells
published pages: 294-296, ISSN: 0028-0836, DOI: 10.1038/nature22493
Izumi Horikawa, Kye-yoon Park, Kazunobu Isogaya, Yukiharu Hiyoshi, Han Li, Katsuhiro Anami, Ana I Robles, Abdul M Mondal, Kaori Fujita, Manuel Serrano, Curtis C Harris
Î”133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells
published pages: 1017-1028, ISSN: 1350-9047, DOI: 10.1038/cdd.2017.48
|Cell Death and Differentiation 24/6||2020-02-12|
Beatriz Lozano-Torres, Irene Galiana, Miguel Rovira, Eva Garrido, Selim Chaib, Andrea Bernardos, Daniel MuÃ±oz-EspÃn, Manuel Serrano, RamÃ³n MartÃnez-MÃ¡Ã±ez, FÃ©lix SancenÃ³n
An OFFâ€“ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo
published pages: 8808-8811, ISSN: 0002-7863, DOI: 10.1021/jacs.7b04985
|Journal of the American Chemical Society 139/26||2020-02-12|
Konstantinos Evangelou, Nikolaos Lougiakis, Sophia V. Rizou, Athanassios Kotsinas, Dimitris Kletsas, Daniel MuÃ±oz-EspÃn, Nikolaos G Kastrinakis, Nicole Pouli, Panagiotis Marakos, Paul Townsend, Manuel Serrano, Jiri Bartek, Vassilis G. Gorgoulis
Robust, universal biomarker assay to detect senescent cells in biological specimens
published pages: 192-197, ISSN: 1474-9718, DOI: 10.1111/acel.12545
|Aging Cell 16/1||2020-02-12|
Shira Knafo, Cristina SÃ¡nchez-Puelles, Ernest Palomer, Igotz Delgado, Jonathan E Draffin, Janire Mingo, Tina Wahle, Kanwardeep Kaleka, Liping Mou, Inmaculada Pereda-Perez, Edvin Klosi, Erik B Faber, Heidi M Chapman, Laura Lozano-Montes, Ana Ortega-Molina, Lara OrdÃ³Ã±ez-GutiÃ©rrez, Francisco Wandosell, Jose ViÃ±a, Carlos G Dotti, Randy A Hall, Rafael Pulido, Nashaat Z Gerges, Andrew M Chan, Mark R Spaller, Manuel Serrano, CÃ©sar Venero, JosÃ© A Esteban
PTEN recruitment controls synaptic and cognitive function in Alzheimer\'s models
published pages: 443-453, ISSN: 1097-6256, DOI: 10.1038/nn.4225
|Nature Neuroscience 19/3||2020-02-12|
published pages: 1083-1085, ISSN: 0028-4793, DOI: 10.1056/NEJMcibr1615878
|New England Journal of Medicine 376/11||2020-02-12|
Miguel Ãngel SÃ¡nchez-Luengo, Miguel Rovira, Manuel Serrano, Pablo Jose Fernandez-Marcos, Lola Martinez
Analysis of the advantages of cis reporters in optimized FACS-Gal
published pages: 721-729, ISSN: 1552-4922, DOI: 10.1002/cyto.a.23086
|Cytometry Part A 91/7||2020-02-12|
Ramaswamy Kannappan, Alex Matsuda, JoÃ£o Ferreira-Martins, Eric Zhang, Giorgia Palano, Anna Czarna, Mauricio Castro Cabral-Da-Silva, Adriana Bastos-Carvalho, Fumihiro Sanada, Noriko Ide, Marcello Rota, Maria A. Blasco, Manuel Serrano, Piero Anversa, Annarosa Leri
p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo
published pages: 224-237, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2017.01.028
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