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StemCellHabitat SIGNED

Metabolic and Timed Control of Stem Cell Fate in the Developing Animal

Total Cost €

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EC-Contrib. €

0

Partnership

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 StemCellHabitat project word cloud

Explore the words cloud of the StemCellHabitat project. It provides you a very rough idea of what is the project "StemCellHabitat" about.

oxidative    levels    scs    regulator    transcription    spatial    provides    question    details    3d    eukaryotes    additional    directing    correct    neural    hormones    organism    fixed    drosophila    dynamically    fantastic    omics    cell    evident    metabolism    temporal    integrative    temporally    physiological    contributes    regulated    regulates    stage    neurons    metabolically    combining    first    lineage    metabolite    waves    answer    regulate    occurs    formed    metabolic    generation    brain    unclear    right    live    stereotypical    cues    age    mechanisms    dynamics    stem    previously    proper    multidisciplinary    mechanistic    unlimited    fate    combination    cells    little    nb    positions    types    animal    model    tight    imaging    disappear    integrating    decisions    genetics    cycle    regulation    sorting    found    tumors    neuroblasts    proliferation    sc    nbs    developmental    dissect    exit    progeny    time    melanogaster    phosphorylation    highlighting    complexity   

Project "StemCellHabitat" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE NOVA DE LISBOA 

Organization address
address: CAMPUS DE CAMPOLIDE
city: LISBOA
postcode: 1099 085
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 1˙697˙493 €
 EC max contribution 1˙697˙493 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 1˙017˙858.00
2    INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA PT (OEIRAS) participant 679˙635.00

Map

 Project objective

Stem cell (SC) proliferation during development requires tight spatial and temporal regulation to ensure correct cell number and right cell types are formed at the proper positions. Currently very little is known about how SCs are regulated during development. Specifically, it is unclear how SC waves of proliferation are regulated and how the fate of their progeny changes during development. In addition, it has recently become evident that metabolism provides additional complexity in cell fate regulation, highlighting the need for integrating metabolic information across physiological levels. This project will answer the question of how the combination of metabolic state and temporal cues (animal developmental stage) regulate SC fate. I will use Drosophila melanogaster, an animal complex enough to be similar to higher eukaryotes and yet simple enough to dissect the mechanistic details of cell regulation and its impact on the organism. Drosophila neural stem cells, the neuroblasts (NB), are a fantastic model of temporally and metabolically regulated cells. NB lineage fate changes with time, directing the generation of a stereotypical set of neurons, after which they disappear. I have previously found that metabolism is an important regulator of NB cell cycle exit, which occurs in response to an increase in levels of oxidative phosphorylation. Using a multidisciplinary approach combining genetics, cell type/age sorting, multi-omics analysis, fixed and 3D-live NB imaging and metabolite dynamics, I propose an integrative approach to investigate how NBs are regulated in the developing animal. First I will dissect the mechanisms by which metabolism regulates NB fate. Second, I will investigate how metabolism contributes to NB unlimited proliferation and brain tumors. Finally, we will address how temporal transcription factors and hormones dynamically affect cell fate decisions during development.

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The information about "STEMCELLHABITAT" are provided by the European Opendata Portal: CORDIS opendata.

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