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VESCEL SIGNED

Vascular Engineering on chip using differentiated Stem Cells

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EC-Contrib. €

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Project "VESCEL" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT TWENTE 

Organization address
address: DRIENERLOLAAN 5
city: ENSCHEDE
postcode: 7522 NB
website: www.utwente.nl

contact info
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Netherlands [NL]
 Project website https://www.utwente.nl/en/eemcs/bios/research/
 Total cost 2˙250˙000 €
 EC max contribution 2˙250˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT TWENTE NL (ENSCHEDE) coordinator 2˙250˙000.00

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 Project objective

Organs-on-chip hold great promise for the creation of complex and realistic disease models while having the potential to refine, reduce and (partly) replace existing animal models (3R principle). Of all organs, vasculature is extremely well-suited to realize on-chip since it pervades the whole organism, is present in all other organs, its malfunctioning plays a role in many diseases and finally is ideally suited to approach with microfabrication and microfluidic technologies. In the VESCEL program we propose the development of innovative technologies enabling the use of differentiated human induced pluripotent stem cells (hiPSC) to engineer blood vessels on chip that constitute realistic disease models for thrombosis and neurodegenerative (ND) diseases. The use of differentiated hiPSC allows the realization of blood vessels based upon patient-specific material, without the need for biopsies, while development of integrated microsensors for small molecules (pH, O2, NO) offers the possibility of on-line monitoring. To optimize the hiPSC differentiation conditions we propose the use of a microdroplet platform, that combines high-throughput capability (up to 1000 cells/s) with control of single cell microenvironment. We will also develop a new flexible technology for real 3D vasculature realization using advanced 3D printing technologies. These four innovative technology developments will be integrated in two biomedical applications to study two important classes of diseases, thrombosis and neurodegenerative (ND) diseases. For thrombosis we focus on the study of parameters such as blood pressure and stenosis as well as effects of drugs on thrombus formation, while for ND diseases study we will use a blood brain barrier (BBB) model to investigate nanoparticle and peptide transport across the BBB for a form of Alzheimer’s disease, as well as leukocyte extravasation for multiple sclerosis (MS).

 Publications

year authors and title journal last update
List of publications.
2019 Joshua Loessberg-Zahl, Andries D. van der Meer, Albert van den Berg, Jan C. T. Eijkel
Flow focusing through gels as a tool to generate 3D concentration profiles in hydrogel-filled microfluidic chips
published pages: 206-213, ISSN: 1473-0197, DOI: 10.1039/c8lc01140k
Lab on a Chip 19/2 2019-03-11
2018 Amy Cochrane, Hugo J. Albers, Robert Passier, Christine L. Mummery, Albert van den Berg, Valeria V. Orlova, Andries D. van der Meer
Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology
published pages: , ISSN: 0169-409X, DOI: 10.1016/j.addr.2018.06.007
Advanced Drug Delivery Reviews 2019-03-11
2017 Pedro F. Costa, Hugo J. Albers, John E. A. Linssen, Heleen H. T. Middelkamp, Linda van der Hout, Robert Passier, Albert van den Berg, Jos Malda, Andries D. van der Meer
Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data
published pages: 2785-2792, ISSN: 1473-0197, DOI: 10.1039/c7lc00202e
Lab on a Chip 17/16 2019-02-26
2017 Marinke W. van der Helm, Mathieu Odijk, Jean-Philippe Frimat, Andries D. van der Meer, Jan C.T. Eijkel, Albert van den Berg, Loes I. Segerink
Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance
published pages: , ISSN: 1940-087X, DOI: 10.3791/56334
Journal of Visualized Experiments 127 2019-02-26
2018 Martijn P. Tibbe, Anne M. Leferink, Albert van den Berg, Jan C. T. Eijkel, Loes I. Segerink
Microfluidic Gel Patterning Method by Use of a Temporary Membrane for Organ-On-Chip Applications
published pages: 1700200, ISSN: 2365-709X, DOI: 10.1002/admt.201700200
Advanced Materials Technologies 3/3 2019-02-26
2018 Esther Tanumihardja, Wouter Olthuis, Albert van den Berg
Ruthenium Oxide Nanorods as Potentiometric pH Sensor for Organs-On-Chip Purposes
published pages: 2901, ISSN: 1424-8220, DOI: 10.3390/s18092901
Sensors 18/9 2019-02-26
2016 Marinke W. van der Helm, Mathieu Odijk, Jean-Philippe Frimat, Andries D. van der Meer, Jan C.T. Eijkel, Albert van den Berg, Loes I. Segerink
Direct quantification of transendothelial electrical resistance in organs-on-chips
published pages: 924-929, ISSN: 0956-5663, DOI: 10.1016/j.bios.2016.06.014
Biosensors and Bioelectronics 85 2019-02-26

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