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NSETHIO SIGNED

Nodding Syndrome: a trans-disciplinary approach to identify the cause and decrease the incidence of river epilepsy

Total Cost €

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EC-Contrib. €

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Partnership

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 NSETHIO project word cloud

Explore the words cloud of the NSETHIO project. It provides you a very rough idea of what is the project "NSETHIO" about.

sudan    worm    vector    faltering    seizures    15    country    hypotheses    valley    syndrome    transmit    neurotropic    epilepsy    detect    onchocerciasis    hope    mystery    orientale    health    hypothesise    mbam    independently    retardation    regions    public    postulate    tanzania    neurological    causes    clonic    drc    symbiont    remained    river    hyper    ivermectin    trans    parasitic    1950    nodding    blackflies    children    visits    decrease    clinical    followed    transmitted    never    sectional    post    plan    developmental    strategies    mortem    tonic    severe    atonic    incurable    metagenomic    republic    exploratory    epidemiological    forms    province    endemic    pathogen    age    entomological    vectors    democratic    effect    cameroon    eco    nearly    epidemic    socio    disciplinary    hypothesis    uganda    head    economic    disease    incidence    caused    south    missions    first    ns    supports    either    mainly    congo    form    gathered    unknown    cross    discover    virus   

Project "NSETHIO" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT ANTWERPEN 

Organization address
address: PRINSSTRAAT 13
city: ANTWERPEN
postcode: 2000
website: www.ua.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website https://www.uantwerpen.be/en/rg/global-health-institute/research/research-projects/nsethio-project/
 Total cost 2˙417˙000 €
 EC max contribution 2˙417˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT ANTWERPEN BE (ANTWERPEN) coordinator 2˙199˙931.00
2    SAN DIEGO STATE UNIVERSITY FOUNDATION US (SAN DIEGO) participant 97˙500.00
3    UNIVERSITATSKLINIKUM BONN DE (BONN) participant 61˙000.00
4    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 58˙568.00

Map

 Project objective

Nodding syndrome (NS) is a neurological, incurable syndrome, currently affecting mainly children between 5 and 15 years of age in South Sudan, Uganda and Tanzania. Since 1950, when NS was first described, its cause has remained a mystery. NS is characterized by head-nodding (an atonic form of epilepsy), often followed by clonic - tonic seizures, developmental retardation and faltering growth. In the affected regions, NS is a major public health problem associated with severe socio-economic consequences. After exploratory missions to South Sudan, Uganda and the Democratic Republic of the Congo (DRC), we gathered epidemiological evidence that supports the hypothesis that NS is a disease caused by a pathogen transmitted by blackflies, the vectors that transmit the parasitic worm that causes onchocerciasis. This pathogen could be an unknown neurotropic virus or another pathogen that is transmitted either independently or as a symbiont of the worm. We postulate that this pathogen is able to cause typical NS, but also other forms of epidemic epilepsy. We hypothesise that the same disease is also endemic in other onchocerciasis hyper-endemic regions e.g. in the Mbam valley, Cameroon and the Orientale Province, DRC (where it is referred to as “river epilepsy”). In this project we aim to investigate our hypotheses in South Sudan, Uganda, Tanzania, Cameroon and the DRC with a trans-disciplinary approach including clinical-epidemiological, post-mortem, eco-entomological, and metagenomic studies. We will study the effect of vector control methods and ivermectin distribution on the incidence of river epilepsy. So far a multi-country study on NS was never done and nearly all previous studies were cross-sectional, carried out during short country visits. With this long term research plan we hope to finally discover the cause of NS and detect effective control strategies to decrease the incidence of epilepsy in onchocerciasis endemic areas.

 Publications

year authors and title journal last update
List of publications.
2017 Robert Colebunders, Michel Mandro, Deby Mukendi, Housseini Dolo, Patrick Suykerbuyk, Marieke Van Oijen
Ivermectin Treatment in Patients With Onchocerciasis-Associated Epilepsy: Protocol of a Randomized Clinical Trial
published pages: e137, ISSN: 1929-0748, DOI: 10.2196/resprot.7186
JMIR Research Protocols 6/8 2019-09-02
2018 Robert Colebunders, F.J. Nelson Siewe, An Hotterbeekx
Onchocerciasis-Associated Epilepsy, an Additional Reason for Strengthening Onchocerciasis Elimination Programs
published pages: 208-216, ISSN: 1471-4922, DOI: 10.1016/j.pt.2017.11.009
Trends in Parasitology 34/3 2019-09-02
2018 Evy Lenaerts, Michel Mandro, Deby Mukendi, Patrick Suykerbuyk, Housseini Dolo, Deogratias Wonya’Rossi, Françoise Ngave, Chellafe Ensoy-Musoro, Anne Laudisoit, An Hotterbeekx, Robert Colebunders
High prevalence of epilepsy in onchocerciasis endemic health areas in Democratic Republic of the Congo
published pages: , ISSN: 2049-9957, DOI: 10.1186/s40249-018-0452-1
Infectious Diseases of Poverty 7/1 2019-09-02
2017 Robert Colebunders, Alfred K. Njamnshi, Marieke van Oijen, Deby Mukendi, Jean Marie Kashama, Michel Mandro, Nolbert Gumisiriza, Pierre-Marie Preux, Patrick Suykerbuyk, Richard Idro
Onchocerciasis-associated epilepsy: From recent epidemiological and clinical findings to policy implications
published pages: 145-152, ISSN: 2470-9239, DOI: 10.1002/epi4.12054
Epilepsia Open 2/2 2019-09-02
2016 Robert Colebunders, Michel Mandro, John L. Mokili, Gisele Mucinya, Germain Mambandu, Kenneth Pfarr, Ingrid Reiter-Owona, Achim Hoerauf, Floribert Tepage, Bethanie Levick, Michael Begon, Anne Laudisoit
Risk factors for epilepsy in Bas-Uélé Province, Democratic Republic of the Congo: a case–control study
published pages: 1-8, ISSN: 1201-9712, DOI: 10.1016/j.ijid.2016.05.018
International Journal of Infectious Diseases 49 2019-09-02
2016 R. Colebunders, A. Hendy, M. van Oijen
Nodding Syndrome in Onchocerciasis Endemic Areas
published pages: 581-583, ISSN: 1471-4922, DOI: 10.1016/j.pt.2016.05.013
Trends in Parasitology 32/8 2019-09-02
2016 Robert Colebunders, Julia Irani, Rory Post
Nodding syndrome—we can now prevent it
published pages: 61-63, ISSN: 1201-9712, DOI: 10.1016/j.ijid.2016.01.016
International Journal of Infectious Diseases 44 2019-09-02
2017 Robert Colebunders, Maarten J. Titulaer
Nodding syndrome: Preventable and treatable
published pages: eaam8532, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aam8532
Science Translational Medicine 9/377 2019-09-02
2018 Adam Hendy, Andreas Krüger, Kenneth Pfarr, Jacobus De Witte, Addow Kibweja, Upendo Mwingira, Jean-Claude Dujardin, Rory Post, Robert Colebunders, Sarah O’Neill, Akili Kalinga
The blackfly vectors and transmission of Onchocerca volvulus in Mahenge, south eastern Tanzania
published pages: 50-59, ISSN: 0001-706X, DOI: 10.1016/j.actatropica.2018.01.009
Acta Tropica 181 2019-09-02
2017 Bethany Levick, Anne Laudisoit, Floribert Tepage, Chellafe Ensoy-Musoro, Michel Mandro, Caroline Bonareri Osoro, Patrick Suykerbuyk, Jean Marie Kashama, Michel Komba, Alliance Tagoto, Dadi Falay, Michael Begon, Robert Colebunders
High prevalence of epilepsy in onchocerciasis endemic regions in the Democratic Republic of the Congo
published pages: e0005732, ISSN: 1935-2735, DOI: 10.1371/journal.pntd.0005732
PLOS Neglected Tropical Diseases 11/7 2019-09-02
2017 R. Colebunders, P. Suykerbuyk, S.T. Jacob, M. van Oijen
Nodding syndrome, other forms of epilepsy, and the Nakalanga syndrome most likely directly or indirectly caused by Onchocerca volvulus
published pages: 439-440, ISSN: 0022-510X, DOI: 10.1016/j.jns.2016.10.008
Journal of the Neurological Sciences 372 2019-09-02
2018 Bruno P. Mmbando, Patrick Suykerbuyk, Mohamed Mnacho, Advocatus Kakorozya, William Matuja, Adam Hendy, Helena Greter, Williams H. Makunde, Robert Colebunders
High prevalence of epilepsy in two rural onchocerciasis endemic villages in the Mahenge area, Tanzania, after 20 years of community directed treatment with ivermectin
published pages: , ISSN: 2049-9957, DOI: 10.1186/s40249-018-0450-3
Infectious Diseases of Poverty 7/1 2019-09-02
2018 Natalie V. S. Vinkeles Melchers, Sarah Mollenkopf, Robert Colebunders, Michael Edlinger, Luc E. Coffeng, Julia Irani, Trésor Zola, Joseph N. Siewe, Sake J. de Vlas, Andrea S. Winkler, Wilma A. Stolk
Burden of onchocerciasis-associated epilepsy: first estimates and research priorities
published pages: , ISSN: 2049-9957, DOI: 10.1186/s40249-018-0481-9
Infectious Diseases of Poverty 7/1 2019-09-02
2018 Gasim Abd-Elfarag, Makoy Yibi Logora, Jane Y. Carter, Morrish Ojok, Jackson Songok, Sonia Menon, Ferdinand Wit, Richard Lako, Robert Colebunders
The effect of bi-annual community-directed treatment with ivermectin on the incidence of epilepsy in onchocerciasis endemic villages in South Sudan: a study protocol
published pages: , ISSN: 2049-9957, DOI: 10.1186/s40249-018-0496-2
Infectious Diseases of Poverty 7/1 2019-09-02
2018 Evy Lenaerts, Michel Mandro, Deby Mukendi, Patrick Suykerbuyk, Housseini Dolo, Deogratias Wonya’Rossi, Françoise Ngave, Chellafe Ensoy-Musoro, Anne Laudisoit, An Hotterbeekx, Robert Colebunders
High prevalence of epilepsy in onchocerciasis endemic health areas in Democratic Republic of the Congo
published pages: , ISSN: 2049-9957, DOI: 10.1186/s40249-018-0452-1
Infectious Diseases of Poverty 7/1 2019-09-02
2018 Natalie V. S. Vinkeles Melchers, Sarah Mollenkopf, Robert Colebunders, Michael Edlinger, Luc E. Coffeng, Julia Irani, Trésor Zola, Joseph N. Siewe, Sake J. de Vlas, Andrea S. Winkler, Wilma A. Stolk
Burden of onchocerciasis-associated epilepsy: first estimates and research priorities
published pages: , ISSN: 2049-9957, DOI: 10.1186/s40249-018-0481-9
Infectious Diseases of Poverty 7/1 2019-09-02
2018 Gasim Abd-Elfarag, Makoy Yibi Logora, Jane Y. Carter, Morrish Ojok, Jackson Songok, Sonia Menon, Ferdinand Wit, Richard Lako, Robert Colebunders
The effect of bi-annual community-directed treatment with ivermectin on the incidence of epilepsy in onchocerciasis endemic villages in South Sudan: a study protocol
published pages: , ISSN: 2049-9957, DOI: 10.1186/s40249-018-0496-2
Infectious Diseases of Poverty 7/1 2019-09-02
2018 Bruno P. Mmbando, Patrick Suykerbuyk, Mohamed Mnacho, Advocatus Kakorozya, William Matuja, Adam Hendy, Helena Greter, Williams H. Makunde, Robert Colebunders
High prevalence of epilepsy in two rural onchocerciasis endemic villages in the Mahenge area, Tanzania, after 20 years of community directed treatment with ivermectin
published pages: , ISSN: 2049-9957, DOI: 10.1186/s40249-018-0450-3
Infectious Diseases of Poverty 7/1 2019-09-02

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