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RUBICON SIGNED

Training network for Research on molecUlar and Biomechanical Interactions in CONnective tissue disorders

Total Cost €

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EC-Contrib. €

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Partnership

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 RUBICON project word cloud

Explore the words cloud of the RUBICON project. It provides you a very rough idea of what is the project "RUBICON" about.

participating    staff    laboratories    molecular    human    clock    pathogenesis    class    biologists    webinars    secondments    laboratory    biochemical    focussed    tissue    tendons    disorders    reinforce    extracellular    courses    young    respective    commonalities    core    components    cartilage    stress    network    soluble    training    matrix    technologies    underlying    mechanisms    skills    bone    basis    networking    meetings    global    multidisciplinary    ethics    homeostasis    cross    equipped    targetable    diverse    excellent    instruments    create    geneticists    connective    biomechanical    determinants    intracellular    morphologists    communication    innovation    pathophysiology    interdisciplinary    fundamental    er    secure    groups    exchange    countries    internationally    additional    data    clinicians    rubicon    tissues    signalling    facilities    scientific    fertilise    attractive    extensive    scientists    oxidative    circadian    animal    recognised    consolidate    biochemists    solid    arena    external    genetic    cell   

Project "RUBICON" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DELL'AQUILA 

Organization address
address: PIAZZA SANTA MARGHERITA 2
city: L AQUILA
postcode: 67100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://rubicon-network.org/
 Total cost 877˙500 €
 EC max contribution 607˙500 € (69%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2015
 Funding Scheme MSCA-RISE
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DELL'AQUILA IT (L AQUILA) coordinator 171˙000.00
2    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 144˙000.00
3    REGION HOVEDSTADEN DK (HILLEROD) participant 108˙000.00
4    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 94˙500.00
5    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) participant 90˙000.00
6    ANNA UNIVERSITY CHENNAI IN (CHENNAI) partner 0.00
7    ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI US (NEW YORK) partner 0.00
8    MURDOCH CHILDRENS RESEARCH INSTITUTE AU (PARKVILLE) partner 0.00
9    THE UNIVERSITY OF HONG KONG HK (Pokfulam) partner 0.00
10    UNIVERSITY OF CAPE TOWN ZA (RONDEBOSCH) partner 0.00

Map

 Project objective

RUBICON will establish a global network for staff exchange of scientists and for research training focussed on connective tissue disorders. It will bring together leading scientific groups from 5 European and 5 non-European countries who will study the molecular and biomechanical factors involved in the pathophysiology of connective tissues, including tendons, cartilage and bone. The ambitious objectives of RUBICON are to increase our knowledge of the mechanisms underlying diverse connective tissue disorders, identify commonalities and targetable pathways, and reinforce multidisciplinary awareness in this fundamental research field. Researchers involved in secondments between RUBICON participants will investigate genetic determinants, circadian clock, extracellular matrix components, soluble biochemical factors and intracellular signalling pathways, ER stress and oxidative components involved in connective tissue homeostasis and pathogenesis. Extensive training during secondments will include new technologies and innovation, study design, interdisciplinary laboratory research, data analysis, research management, ethics in animal and human studies, and development of scientific and communication skills. All participating laboratories will ensure attractive working conditions in excellent and internationally recognised institutions, equipped with state-of-the-art instruments and excellent core facilities. Webinars, courses and meetings will provide additional opportunities for training and networking, also be open to external participants. RUBICON is a unique interdisciplinary network including cell biologists, molecular biologists, animal biologists, morphologists, geneticists, biochemists and clinicians who will cross-fertilise their respective research fields. The long-term goal of RUBICON is to consolidate a class of young scientists to secure future developments in the connective tissue arena and create a solid basis for further collaboration in this field.

 Deliverables

List of deliverables.
Press releases Websites, patent fillings, videos etc. 2020-02-20 16:54:37
Reports on RUBICON training events and webinars Documents, reports 2020-02-20 16:54:37
Info-packs describing arrangements for receiving staff exchanges Documents, reports 2020-02-20 16:54:37
Project website Websites, patent fillings, videos etc. 2020-02-20 16:54:37
Communication and media protocol Other 2020-02-20 16:54:37

Take a look to the deliverables list in detail:  detailed list of RUBICON deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Antonio Maurizi, Mattia Capulli, Annabel Curle, Rajvi Patel, Argia Ucci, Juliana Alves Côrtes, Harriet Oxford, Shireen R. Lamandé, John F. Bateman, Nadia Rucci, Anna Teti
Extra-skeletal manifestations in mice affected by Clcn7-dependent autosomal dominant osteopetrosis type 2 clinical and therapeutic implications
published pages: , ISSN: 2095-6231, DOI: 10.1038/s41413-019-0055-x
Bone Research 7/1 2020-03-11
2019 Peter Hung Thanh Tran
The mechanisms behind the development of tendinopathy: Early structural, inflammatory, nociceptive and clinical changes
published pages: , ISSN: , DOI:
2020-02-20
2017 Maurizi A, Capulli M, Patel R, Rucci N, Teti.
CLCN7-dependent Autosomal Dominant Osteopetrosis type 2 (ADO2): more than a bone disease.
published pages: , ISSN: 0884-0431, DOI: 10.1002/jbmr.v32.S1
Journal of Bone and Mineral Research 32/S1 2020-02-20
2017 Vimal Veeriah, University of L\'Aquila, Mattia Capulli, University of L\'Aquila, Angelo Zanniti
Interleukin 1β (IL1β), Nitric Oxide Synthase 2 (NOS2), Lipocalin 2 (LCN2) and Vascular Endothelial Growth Factor (VEGF) Orchestrate the Coupled Mechanoresponse of Skeletal Angiogenesis and Osteogenesis
published pages: , ISSN: 0884-0431, DOI: 10.1002/jbmr.v31.S1
Journal of Bone and Mineral Research 31/S1 2020-02-20
2017 Antonio Maurizi, Nadia Rucci, Tina Schleicher, Yadhu Kumar, Anna Teti, Mattia Capulli,.
Transcriptomic Analysis of Osteoclasts from Autosomal Dominant Osteopetrosis type2 (ADO2) Mice harboring the G213R Mutation of the Chloride-Proton Antiporter type 7 (ClC7)
published pages: , ISSN: 1523-4681, DOI: 10.1002/jbmr.v32.S1/issuetoc
Journal of Bone and Mineral Research 32/S1 2020-02-20
2017 Maurizi A, Capulli M, Patel R, Rucci N, Teti.
A deep phenotyping of autosomal dominant osteopetrosis type 2 (ADO2) mouse model revealed multiorgan dysfunctions.
published pages: , ISSN: , DOI:
International Conference on Children Bone Health held in Würzburg, Germany, on June 10-13, 2017. 2020-02-20
2018 Vimal Veeriah, Riccardo Paone, Suvro Chatterjee, Anna Teti, Mattia Capulli
Osteoblasts Regulate Angiogenesis in Response to Mechanical Unloading
published pages: , ISSN: 0171-967X, DOI: 10.1007/s00223-018-0496-z
Calcified Tissue International Nov 21 2020-02-20
2016 Vimal Veeriah, Angelo Zanniti, Riccardo Paone, Suvro Chatterjee, Nadia Rucci, Anna Teti, Mattia Capulli
Interleukin-1β, lipocalin 2 and nitric oxide synthase 2 are mechano-responsive mediators of mouse and human endothelial cell-osteoblast crosstalk
published pages: 6:29880, ISSN: 2045-2322, DOI: 10.1038/srep29880
Scientific Reports 6/1 2020-02-20
2017 Anna Teti, Michael J. Econs
Osteopetroses, emphasizing potential approaches to treatment
published pages: pii: S8756-3282(, ISSN: 8756-3282, DOI: 10.1016/j.bone.2017.02.002
Bone 102 2020-02-20
2018 John F. Bateman, Lisa Sampurno, Antonio Maurizi, Shireen R. Lamandé, Natalie A. Sims, Tegan L. Cheng, Aaron Schindeler, David G. Little
Effect of rapamycin on bone mass and strength in the α2(I)-G610C mouse model of osteogenesis imperfecta
published pages: , ISSN: 1582-1838, DOI: 10.1111/jcmm.14072
Journal of Cellular and Molecular Medicine 2018;00:1‐11 2020-02-20

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