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TraumiR SIGNED

microRNAs in susceptibility to traumatic stress

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TraumiR project word cloud

Explore the words cloud of the TraumiR project. It provides you a very rough idea of what is the project "TraumiR" about.

disorders    hypotheses    regulate    people    trauma    preventive    gene    cohorts    stress    military    researcher    expression    function    prediction    skills    exact    host    yielding    longitudinal    group    strategies    hypothesize    schemes    psychiatric    underlying    clinically    unknown    war    multidisciplinary    professional    dna    manipulation    animals    traumatic    strikingly    foundation    experimental    tapping    career    tested    distinguish    exposure    blood    ptsd    identification    differ    epigenetic    profiles    underlie    relationship    biological    correlation    levels    reinforce    interventions    players    profiling    laboratory    possibility    usable    susceptibility    epidemiological    stressors    prevalent    translational    soldiers    excellent    post    launch    prospects    risk    biomarkers    animal    ultimately    demonstrated    mirna    network    mirnas    differential    prospective    sampling    mechanisms    brain    disorder    persons    methylation    broadening    alters   

Project "TraumiR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT MAASTRICHT 

Organization address
address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD
website: http://www.maastrichtuniversity.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://www.ecnp.eu/presentationpdfs/71/P.4.a.009.pdf
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2018-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 177˙598.00

Map

 Project objective

Traumatic stressors are important and prevalent risk factors for psychiatric disorders, such as post-traumatic stress disorder (PTSD). People differ strikingly in their susceptibility to develop PTSD after traumatic stress, however the exact underlying biological mechanisms of differential susceptibility are unknown. The identification of biomarkers that distinguish between persons at high and low risk of developing PTSD following trauma exposure would enable more effective preventive strategies and early interventions. Epigenetic mechanisms have been proposed to underlie the relationship between exposure to traumatic stress and the susceptibility to develop PTSD. Recent work carried out by the host laboratory demonstrated that DNA methylation might regulate the impact of traumatic stress on gene expression and ultimately brain function. Based on this and the emerging role of miRNA as key epigenetic players in psychiatric disorders, I hypothesize that (i) susceptibility to traumatic stress exposure is associated with distinct miRNAs expression profiles with blood-brain correlation, (ii) experimental manipulation of miRNA expression levels in animals alters their susceptibility to traumatic stress. These hypotheses will be tested by a unique set of epigenetic epidemiological studies using prospective cohorts with longitudinal sampling schemes of military soldiers deployed to war, next to experimental animal studies. The proposed multidisciplinary and translational project will open the possibility of tapping into the mechanisms underlying differential susceptibility to traumatic stress through blood profiling. It has excellent prospects for yielding clinically relevant and usable biomarkers for the prediction of susceptibility to traumatic stressors. Moreover, the project will reinforce my foundation as a highly promising early career researcher by broadening my knowledge, skills, professional experience and network necessary to launch my own research group.

 Publications

year authors and title journal last update
List of publications.
2017 Clara Snijders, Laurence de Nijs, Dewleen G. Baker, Richard L. Hauger, Daniel van den Hove, Gunter Kenis, Caroline M. Nievergelt, Marco P. Boks, Eric Vermetten, Fred H. Gage, Bart P.F. Rutten
MicroRNAs in Post-traumatic Stress Disorder
published pages: , ISSN: , DOI: 10.1007/7854_2017_32
Current Topics in Behavioral Neurosciences 2019-06-13
2018 Sillivan, S.E. Jamieson, S. de Nijs, L. Jones, M. Snijders, C. Klengel, T. Joseph, N.F. Krauskopf, J. Kleinjans, J. Vinkers, C.H. Boks, M.P.M. Geuze, E. Vermetten, E. Ressler, K.J. Rutten, B.P.F. Rumbaugh, G. Miller C.A.
microRNA regulation of persistent stress-enhanced memory
published pages: , ISSN: 1095-9203, DOI:
Science 2019-06-13
2017 L. De Nijs, J. Krauskopf, C. Snijders, J. Kleinjans, B. Machiels, B. Smeets, G. Kenis, D. Van den Hove, C. Vinkers, E. Geuze, M. Boks, E. Vermetten, B. Rutten
Alterations in Blood-based miRNA in Veterans Affected with Combat-related PTSD
published pages: , ISSN: , DOI:
2019-06-13
2017 L. De Nijs, J. Krauskopf, C. Snijders, J. Kleinjans, B. Machiels, B. Smeets, G. Kenis, D. Van den Hove, C. Vinkers, E. Geuze, M. Boks, E. Vermetten, B. Rutten
Circulating microRNAs as potential biomarkers of differential susceptibility to traumatic stress
published pages: S986-S987, ISSN: 0924-977X, DOI: 10.1016/S0924-977X(17)31736-4
European Neuropsychopharmacology 27 2019-06-13
2017 Laurence de Nijs, Julian Krauskopf, Jos Kleinjans, Barbie Machiels, Clara Snijders, Bert Smeets, Gunter Kenis, Daniel van den Hove, Christiaan Vinkers, Elbert Geuze, Marco Boks, Eric Vermetten, Bart Rutten
503. Circulating microRNAs as Potential Biomarkers of Differential Susceptibility to Traumatic Stress
published pages: S204-S205, ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2017.02.1111
Biological Psychiatry 81/10 2019-06-13

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The information about "TRAUMIR" are provided by the European Opendata Portal: CORDIS opendata.

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