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TraumiR SIGNED

microRNAs in susceptibility to traumatic stress

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

TraumiR project word cloud

Explore the words cloud of the TraumiR project. It provides you a very rough idea of what is the project "TraumiR" about.

prediction disorders interventions brain trauma psychiatric cohorts ptsd exact players underlying career host disorder group manipulation schemes usable network exposure alters ultimately researcher differ multidisciplinary mirna distinguish mirnas yielding launch prospects stress war profiles biological function preventive unknown identification underlie levels demonstrated biomarkers tapping clinically regulate post correlation reinforce risk epidemiological traumatic relationship prevalent tested professional possibility skills gene experimental persons people laboratory broadening strikingly blood prospective dna sampling animal translational profiling differential foundation epigenetic hypotheses susceptibility stressors longitudinal mechanisms methylation animals military excellent expression hypothesize soldiers strategies

Project "TraumiR" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://www.ecnp.eu/presentationpdfs/71/P.4.a.009.pdf
Total cost	177˙598 €
EC max contribution	177˙598 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-06-01 to 2018-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	coordinator	177˙598.00

Map

Project objective

Traumatic stressors are important and prevalent risk factors for psychiatric disorders, such as post-traumatic stress disorder (PTSD). People differ strikingly in their susceptibility to develop PTSD after traumatic stress, however the exact underlying biological mechanisms of differential susceptibility are unknown. The identification of biomarkers that distinguish between persons at high and low risk of developing PTSD following trauma exposure would enable more effective preventive strategies and early interventions. Epigenetic mechanisms have been proposed to underlie the relationship between exposure to traumatic stress and the susceptibility to develop PTSD. Recent work carried out by the host laboratory demonstrated that DNA methylation might regulate the impact of traumatic stress on gene expression and ultimately brain function. Based on this and the emerging role of miRNA as key epigenetic players in psychiatric disorders, I hypothesize that (i) susceptibility to traumatic stress exposure is associated with distinct miRNAs expression profiles with blood-brain correlation, (ii) experimental manipulation of miRNA expression levels in animals alters their susceptibility to traumatic stress. These hypotheses will be tested by a unique set of epigenetic epidemiological studies using prospective cohorts with longitudinal sampling schemes of military soldiers deployed to war, next to experimental animal studies. The proposed multidisciplinary and translational project will open the possibility of tapping into the mechanisms underlying differential susceptibility to traumatic stress through blood profiling. It has excellent prospects for yielding clinically relevant and usable biomarkers for the prediction of susceptibility to traumatic stressors. Moreover, the project will reinforce my foundation as a highly promising early career researcher by broadening my knowledge, skills, professional experience and network necessary to launch my own research group.

Publications

List of publications.
year	authors and title	journal	last update
2017	Clara Snijders, Laurence de Nijs, Dewleen G. Baker, Richard L. Hauger, Daniel van den Hove, Gunter Kenis, Caroline M. Nievergelt, Marco P. Boks, Eric Vermetten, Fred H. Gage, Bart P.F. Rutten MicroRNAs in Post-traumatic Stress Disorder published pages: , ISSN: , DOI: 10.1007/7854_2017_32	Current Topics in Behavioral Neurosciences	2019-06-13
2018	Sillivan, S.E. Jamieson, S. de Nijs, L. Jones, M. Snijders, C. Klengel, T. Joseph, N.F. Krauskopf, J. Kleinjans, J. Vinkers, C.H. Boks, M.P.M. Geuze, E. Vermetten, E. Ressler, K.J. Rutten, B.P.F. Rumbaugh, G. Miller C.A. microRNA regulation of persistent stress-enhanced memory published pages: , ISSN: 1095-9203, DOI:	Science	2019-06-13
2017	L. De Nijs, J. Krauskopf, C. Snijders, J. Kleinjans, B. Machiels, B. Smeets, G. Kenis, D. Van den Hove, C. Vinkers, E. Geuze, M. Boks, E. Vermetten, B. Rutten Alterations in Blood-based miRNA in Veterans Affected with Combat-related PTSD published pages: , ISSN: , DOI:		2019-06-13
2017	L. De Nijs, J. Krauskopf, C. Snijders, J. Kleinjans, B. Machiels, B. Smeets, G. Kenis, D. Van den Hove, C. Vinkers, E. Geuze, M. Boks, E. Vermetten, B. Rutten Circulating microRNAs as potential biomarkers of differential susceptibility to traumatic stress published pages: S986-S987, ISSN: 0924-977X, DOI: 10.1016/S0924-977X(17)31736-4	European Neuropsychopharmacology 27	2019-06-13
2017	Laurence de Nijs, Julian Krauskopf, Jos Kleinjans, Barbie Machiels, Clara Snijders, Bert Smeets, Gunter Kenis, Daniel van den Hove, Christiaan Vinkers, Elbert Geuze, Marco Boks, Eric Vermetten, Bart Rutten 503. Circulating microRNAs as Potential Biomarkers of Differential Susceptibility to Traumatic Stress published pages: S204-S205, ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2017.02.1111	Biological Psychiatry 81/10	2019-06-13

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The information about "TRAUMIR" are provided by the European Opendata Portal: CORDIS opendata.