Opendata, web and dolomites


microRNAs in susceptibility to traumatic stress

Total Cost €


EC-Contrib. €






 TraumiR project word cloud

Explore the words cloud of the TraumiR project. It provides you a very rough idea of what is the project "TraumiR" about.

yielding    laboratory    sampling    profiles    animal    war    prediction    cohorts    experimental    host    tested    reinforce    foundation    tapping    launch    longitudinal    biomarkers    differential    epigenetic    underlying    gene    levels    alters    underlie    strikingly    stress    function    researcher    possibility    manipulation    blood    distinguish    players    dna    multidisciplinary    clinically    soldiers    risk    interventions    brain    exact    prospects    disorder    regulate    correlation    epidemiological    strategies    persons    ptsd    methylation    profiling    relationship    post    network    group    professional    mechanisms    excellent    traumatic    susceptibility    unknown    demonstrated    differ    people    biological    expression    translational    career    usable    identification    preventive    mirnas    prospective    psychiatric    skills    mirna    schemes    animals    broadening    military    stressors    ultimately    disorders    hypotheses    exposure    trauma    hypothesize    prevalent   

Project "TraumiR" data sheet

The following table provides information about the project.


Organization address
address: Minderbroedersberg 4-6
postcode: 6200 MD

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2018-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Traumatic stressors are important and prevalent risk factors for psychiatric disorders, such as post-traumatic stress disorder (PTSD). People differ strikingly in their susceptibility to develop PTSD after traumatic stress, however the exact underlying biological mechanisms of differential susceptibility are unknown. The identification of biomarkers that distinguish between persons at high and low risk of developing PTSD following trauma exposure would enable more effective preventive strategies and early interventions. Epigenetic mechanisms have been proposed to underlie the relationship between exposure to traumatic stress and the susceptibility to develop PTSD. Recent work carried out by the host laboratory demonstrated that DNA methylation might regulate the impact of traumatic stress on gene expression and ultimately brain function. Based on this and the emerging role of miRNA as key epigenetic players in psychiatric disorders, I hypothesize that (i) susceptibility to traumatic stress exposure is associated with distinct miRNAs expression profiles with blood-brain correlation, (ii) experimental manipulation of miRNA expression levels in animals alters their susceptibility to traumatic stress. These hypotheses will be tested by a unique set of epigenetic epidemiological studies using prospective cohorts with longitudinal sampling schemes of military soldiers deployed to war, next to experimental animal studies. The proposed multidisciplinary and translational project will open the possibility of tapping into the mechanisms underlying differential susceptibility to traumatic stress through blood profiling. It has excellent prospects for yielding clinically relevant and usable biomarkers for the prediction of susceptibility to traumatic stressors. Moreover, the project will reinforce my foundation as a highly promising early career researcher by broadening my knowledge, skills, professional experience and network necessary to launch my own research group.


year authors and title journal last update
List of publications.
2017 Clara Snijders, Laurence de Nijs, Dewleen G. Baker, Richard L. Hauger, Daniel van den Hove, Gunter Kenis, Caroline M. Nievergelt, Marco P. Boks, Eric Vermetten, Fred H. Gage, Bart P.F. Rutten
MicroRNAs in Post-traumatic Stress Disorder
published pages: , ISSN: , DOI: 10.1007/7854_2017_32
Current Topics in Behavioral Neurosciences 2019-06-13
2018 Sillivan, S.E. Jamieson, S. de Nijs, L. Jones, M. Snijders, C. Klengel, T. Joseph, N.F. Krauskopf, J. Kleinjans, J. Vinkers, C.H. Boks, M.P.M. Geuze, E. Vermetten, E. Ressler, K.J. Rutten, B.P.F. Rumbaugh, G. Miller C.A.
microRNA regulation of persistent stress-enhanced memory
published pages: , ISSN: 1095-9203, DOI:
Science 2019-06-13
2017 L. De Nijs, J. Krauskopf, C. Snijders, J. Kleinjans, B. Machiels, B. Smeets, G. Kenis, D. Van den Hove, C. Vinkers, E. Geuze, M. Boks, E. Vermetten, B. Rutten
Alterations in Blood-based miRNA in Veterans Affected with Combat-related PTSD
published pages: , ISSN: , DOI:
2017 L. De Nijs, J. Krauskopf, C. Snijders, J. Kleinjans, B. Machiels, B. Smeets, G. Kenis, D. Van den Hove, C. Vinkers, E. Geuze, M. Boks, E. Vermetten, B. Rutten
Circulating microRNAs as potential biomarkers of differential susceptibility to traumatic stress
published pages: S986-S987, ISSN: 0924-977X, DOI: 10.1016/S0924-977X(17)31736-4
European Neuropsychopharmacology 27 2019-06-13
2017 Laurence de Nijs, Julian Krauskopf, Jos Kleinjans, Barbie Machiels, Clara Snijders, Bert Smeets, Gunter Kenis, Daniel van den Hove, Christiaan Vinkers, Elbert Geuze, Marco Boks, Eric Vermetten, Bart Rutten
503. Circulating microRNAs as Potential Biomarkers of Differential Susceptibility to Traumatic Stress
published pages: S204-S205, ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2017.02.1111
Biological Psychiatry 81/10 2019-06-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TRAUMIR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TRAUMIR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)


An integrated hypothesis for cognitive and positive symptoms in schizophrenia

Read More  


The missing pillar. European social policy and Eurosceptic challenges (SOCIALEU)

Read More  

NeoPur (2019)

New treatments and novel diagnostic tests for neonatal seizures based on purinergic signaling.

Read More