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HOTSPOT SIGNED

Genomic hotspots of adaptation to whole genome duplication

Total Cost €

0

EC-Contrib. €

0

Partnership

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 HOTSPOT project word cloud

Explore the words cloud of the HOTSPOT project. It provides you a very rough idea of what is the project "HOTSPOT" about.

plant    attending    crops    organisms    clear    conserved    mysterious    genome    variation    causal    quality    adapt    roles    revealed    altered    extant    repeatability    basis    diploid    divergence    species    gene    nature    polyploid    duplication    occurs    reference    meiosis    populations    difficulties    diverse    lyrata    implicated    ploidy    least    cytological    functional    organismal    nonetheless    mimulus    poses    arenosa    sweeps    guttatus    utilize    kingdoms    speciation    eukaryotic    autotetraploid    molecular    independently    genes    natural    cellular    sudden    ongoing    overcome    amara    solutions    reveals    despite    evolutionary    mechanisms    segregation    understand    wgds    independent    wgd    intraspecific    date    selective    contributes    domestication    environment    nevertheless    effect    assemblies    pumila    genetic    force    constraint    chromosome    arabidopsis    intense    regulation    context    whole    complexity    evolution    scanning    pairing    causes    cloned    cardamine    chromosomes    harbor    genomic    crossover    globally    dramatic    meiotic    arabis    prevalent   

Project "HOTSPOT" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF NOTTINGHAM 

Organization address
address: University Park
city: NOTTINGHAM
postcode: NG7 2RD
website: www.nottingham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website http://yant.jic.ac.uk/
 Total cost 1˙490˙329 €
 EC max contribution 1˙490˙329 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF NOTTINGHAM UK (NOTTINGHAM) coordinator 672˙894.00
2    JOHN INNES CENTRE UK (NORWICH) participant 817˙434.00

Map

 Project objective

Whole genome duplication (WGD) occurs in all eukaryotic kingdoms and is implicated in organismal complexity, adaptation and speciation. WGD is an especially important force in plant evolution and domestication. Nevertheless, despite the evolutionary potential of WGD, a sudden duplication of all chromosomes poses challenges to key processes, especially the reliable segregation of chromosomes at meiosis. Nonetheless, nature reveals solutions: the many polyploid species with diploid-like meiosis show that difficulties can be overcome. However, the molecular basis of this is mysterious: only one causal gene has been cloned to date. Our work in autotetraploid Arabidopsis arenosa revealed clear WGD-associated selective sweeps on meiosis genes with roles in crossover regulation. Natural variation in at least one of these genes has a dramatic effect on meiotic chromosome pairing. Here we assess whether species that independently adapted to the challenges attending WGD evolved similar solutions, whether crossover regulation is a common target of WGD-associated adaptation and whether standing variation in diploid populations contributes to adaptation to WGD. Aims of this programme are to: 1) produce quality reference genome assemblies for Cardamine amara and Arabis pumila, both of which harbor extant intraspecific ploidy variation; 2) test for the repeatability of adaptation mechanisms to WGD by genome scanning both species as well as three other independent WGDs in Arabidopsis lyrata and Mimulus guttatus; and 3) determine the causes and consequences of divergence of meiosis genes using functional analyses. We will utilize diverse genetic, genomic, and cytological approaches to understand repeatability and constraint in the context of intense selection on a conserved process. Further, this will provide insight into how organisms adapt to the altered cellular environment following WGD, a prevalent ongoing force in evolution and in the domestication of globally important crops.

 Publications

year authors and title journal last update
List of publications.
2016 Brian J. Arnold, Brett Lahner, Jeffrey M. DaCosta, Caroline M. Weisman, Jesse D. Hollister, David E. Salt, Kirsten Bomblies, Levi Yant
Borrowed alleles and convergence in serpentine adaptation
published pages: 8320-8325, ISSN: 0027-8424, DOI: 10.1073/pnas.1600405113
Proceedings of the National Academy of Sciences 113/29 2020-01-28

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