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HOTSPOT SIGNED

Genomic hotspots of adaptation to whole genome duplication

Total Cost €

0

EC-Contrib. €

0

Partnership

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 HOTSPOT project word cloud

Explore the words cloud of the HOTSPOT project. It provides you a very rough idea of what is the project "HOTSPOT" about.

plant    divergence    cytological    whole    pairing    mimulus    conserved    molecular    domestication    cloned    variation    arabidopsis    understand    natural    evolutionary    duplication    globally    force    roles    solutions    nonetheless    causal    crops    nature    reveals    repeatability    eukaryotic    poses    populations    context    sudden    dramatic    basis    autotetraploid    mysterious    clear    extant    date    speciation    wgd    species    genes    occurs    genomic    overcome    constraint    amara    intense    mechanisms    selective    functional    sweeps    chromosome    genetic    evolution    organismal    diploid    altered    implicated    organisms    harbor    nevertheless    difficulties    environment    intraspecific    reference    meiotic    effect    crossover    genome    gene    quality    diverse    contributes    causes    ploidy    complexity    wgds    arenosa    meiosis    chromosomes    segregation    attending    independently    pumila    cellular    lyrata    guttatus    least    utilize    revealed    assemblies    despite    scanning    arabis    adapt    independent    prevalent    ongoing    kingdoms    cardamine    polyploid    regulation   

Project "HOTSPOT" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF NOTTINGHAM 

Organization address
address: University Park
city: NOTTINGHAM
postcode: NG7 2RD
website: www.nottingham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website http://yant.jic.ac.uk/
 Total cost 1˙490˙329 €
 EC max contribution 1˙490˙329 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF NOTTINGHAM UK (NOTTINGHAM) coordinator 672˙894.00
2    JOHN INNES CENTRE UK (NORWICH) participant 817˙434.00

Map

 Project objective

Whole genome duplication (WGD) occurs in all eukaryotic kingdoms and is implicated in organismal complexity, adaptation and speciation. WGD is an especially important force in plant evolution and domestication. Nevertheless, despite the evolutionary potential of WGD, a sudden duplication of all chromosomes poses challenges to key processes, especially the reliable segregation of chromosomes at meiosis. Nonetheless, nature reveals solutions: the many polyploid species with diploid-like meiosis show that difficulties can be overcome. However, the molecular basis of this is mysterious: only one causal gene has been cloned to date. Our work in autotetraploid Arabidopsis arenosa revealed clear WGD-associated selective sweeps on meiosis genes with roles in crossover regulation. Natural variation in at least one of these genes has a dramatic effect on meiotic chromosome pairing. Here we assess whether species that independently adapted to the challenges attending WGD evolved similar solutions, whether crossover regulation is a common target of WGD-associated adaptation and whether standing variation in diploid populations contributes to adaptation to WGD. Aims of this programme are to: 1) produce quality reference genome assemblies for Cardamine amara and Arabis pumila, both of which harbor extant intraspecific ploidy variation; 2) test for the repeatability of adaptation mechanisms to WGD by genome scanning both species as well as three other independent WGDs in Arabidopsis lyrata and Mimulus guttatus; and 3) determine the causes and consequences of divergence of meiosis genes using functional analyses. We will utilize diverse genetic, genomic, and cytological approaches to understand repeatability and constraint in the context of intense selection on a conserved process. Further, this will provide insight into how organisms adapt to the altered cellular environment following WGD, a prevalent ongoing force in evolution and in the domestication of globally important crops.

 Publications

year authors and title journal last update
List of publications.
2016 Brian J. Arnold, Brett Lahner, Jeffrey M. DaCosta, Caroline M. Weisman, Jesse D. Hollister, David E. Salt, Kirsten Bomblies, Levi Yant
Borrowed alleles and convergence in serpentine adaptation
published pages: 8320-8325, ISSN: 0027-8424, DOI: 10.1073/pnas.1600405113
Proceedings of the National Academy of Sciences 113/29 2020-01-28

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