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P450RESIST SIGNED

Understanding and exploiting the insect P450 resistome

Total Cost €

0

EC-Contrib. €

0

Partnership

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 P450RESIST project word cloud

Explore the words cloud of the P450RESIST project. It provides you a very rough idea of what is the project "P450RESIST" about.

shown    ongoing    adaptive    drivers    molecular    evolve    determinants    resistant    pest    insects    vitro    expression    toolkit    modulate    wp    metabolism    family    characterise    insect    overcome    regulatory    critical    superfamily    structure    nature    qualitative    mediating    ubiquitous    defend    cutting    protection    sustainable    transgenics    alter    summary    herbivore    enzyme    opportunity    conferring    synthetic    slow    strategies    breaking    resistance    p450    exceptional    model    epigenetics    despite    enzymes    insecticides    prevent    vivo    insights    crop    workpackages    edge    p450s    metabolic    diagnostics    screening    evolution    toxin    throughput    binding    explore    consisting    variety    gained    xenobiotics    cytochrome    frequency    relative    relatively    themselves    families    defence    quantitative    wp1    function    chemicals    rare    interaction    plants    anti    genomics    natural    chemistry    insecticide    tools    resistome   

Project "P450RESIST" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EXETER 

Organization address
address: THE QUEEN'S DRIVE NORTHCOTE HOUSE
city: EXETER
postcode: EX4 4QJ
website: www.ex.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙975˙512 €
 EC max contribution 1˙975˙512 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EXETER UK (EXETER) coordinator 1˙949˙494.00
2    ROTHAMSTED RESEARCH LIMITED UK (HARPENDEN) participant 26˙017.00

Map

 Project objective

Insect resistance to synthetic insecticides and the anti-herbivore defence chemicals produced by many plants is an ongoing challenge to sustainable pest management while also an exceptional model system to study adaptive evolution. The cytochrome P450s are a superfamily of enzymes that are ubiquitous in nature, and one of the most important enzyme families used by insects to defend themselves against natural and synthetic xenobiotics. Insects have been shown to evolve resistance through quantitative changes in P450 expression or via qualitative changes in P450s that alter metabolic activity. Despite their importance in conferring resistance the variety of regulatory changes that modulate P450 expression in resistant insects and their relative frequency/impact is not fully understood. Furthermore, although qualitative changes in insect P450s associated with resistance are relatively rare they represent a unique opportunity to characterise insecticide/toxin binding and identify the critical structure/function determinants of the P450/insect toxin interaction.

In this project I will exploit cutting-edge advances in genomics, epigenetics and transgenics to study the insect P450 resistome in three main workpackages:

WP-1: Will identify the molecular drivers of quantitative changes to insect P450s. WP-2: Will explore the role of qualitative changes in insect P450s in mediating resistance and identify structure/function determinants of insecticide metabolism. WP-3: Will exploit the knowledge gained in WP1/2 and from previous research to deliver a ‘P450 toolkit’ consisting of in vitro and in vivo screening tools, with which to identify resistance breaking chemistry, and high-throughput diagnostics for use in resistance management.

In summary this project will provide novel insights into this important enzyme family and provide tools that can be used to develop new products and strategies that slow, prevent, or overcome resistance and so ensure sustainable crop protection

 Publications

year authors and title journal last update
List of publications.
2018 Christoph T. Zimmer, William T. Garrood, Kumar Saurabh Singh, Emma Randall, Bettina Lueke, Oliver Gutbrod, Svend Matthiesen, Maxie Kohler, Ralf Nauen, T.G. Emyr Davies, Chris Bass
Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the Brown Planthopper
published pages: 268-274.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.11.060
Current Biology 28/2 2019-05-30
2018 Cristina Manjon, Bartlomiej J. Troczka, Marion Zaworra, Katherine Beadle, Emma Randall, Gillian Hertlein, Kumar Saurabh Singh, Christoph T. Zimmer, Rafael A. Homem, Bettina Lueke, Rebecca Reid, Laura Kor, Maxie Kohler, Jürgen Benting, Martin S. Williamson, T.G. Emyr Davies, Linda M. Field, Chris Bass, Ralf Nauen
Unravelling the Molecular Determinants of Bee Sensitivity to Neonicotinoid Insecticides
published pages: 1137-1143.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.02.045
Current Biology 28/7 2019-05-30

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