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P450RESIST SIGNED

Understanding and exploiting the insect P450 resistome

Total Cost €

0

EC-Contrib. €

0

Partnership

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 P450RESIST project word cloud

Explore the words cloud of the P450RESIST project. It provides you a very rough idea of what is the project "P450RESIST" about.

edge    cutting    diagnostics    families    natural    variety    crop    evolve    evolution    ubiquitous    critical    relative    metabolic    consisting    opportunity    tools    xenobiotics    relatively    workpackages    overcome    anti    enzymes    family    exceptional    sustainable    synthetic    defence    vitro    metabolism    determinants    strategies    alter    pest    ongoing    vivo    cytochrome    chemistry    throughput    prevent    modulate    insecticide    rare    genomics    despite    nature    mediating    model    explore    frequency    insights    summary    enzyme    plants    shown    superfamily    quantitative    expression    breaking    herbivore    qualitative    characterise    insects    epigenetics    drivers    themselves    structure    adaptive    insect    binding    regulatory    molecular    resistome    slow    wp1    conferring    defend    p450s    resistance    toxin    toolkit    p450    resistant    screening    protection    function    gained    insecticides    interaction    chemicals    transgenics    wp   

Project "P450RESIST" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EXETER 

Organization address
address: THE QUEEN'S DRIVE NORTHCOTE HOUSE
city: EXETER
postcode: EX4 4QJ
website: www.ex.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙975˙512 €
 EC max contribution 1˙975˙512 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EXETER UK (EXETER) coordinator 1˙949˙494.00
2    ROTHAMSTED RESEARCH LIMITED UK (HARPENDEN) participant 26˙017.00

Map

 Project objective

Insect resistance to synthetic insecticides and the anti-herbivore defence chemicals produced by many plants is an ongoing challenge to sustainable pest management while also an exceptional model system to study adaptive evolution. The cytochrome P450s are a superfamily of enzymes that are ubiquitous in nature, and one of the most important enzyme families used by insects to defend themselves against natural and synthetic xenobiotics. Insects have been shown to evolve resistance through quantitative changes in P450 expression or via qualitative changes in P450s that alter metabolic activity. Despite their importance in conferring resistance the variety of regulatory changes that modulate P450 expression in resistant insects and their relative frequency/impact is not fully understood. Furthermore, although qualitative changes in insect P450s associated with resistance are relatively rare they represent a unique opportunity to characterise insecticide/toxin binding and identify the critical structure/function determinants of the P450/insect toxin interaction.

In this project I will exploit cutting-edge advances in genomics, epigenetics and transgenics to study the insect P450 resistome in three main workpackages:

WP-1: Will identify the molecular drivers of quantitative changes to insect P450s. WP-2: Will explore the role of qualitative changes in insect P450s in mediating resistance and identify structure/function determinants of insecticide metabolism. WP-3: Will exploit the knowledge gained in WP1/2 and from previous research to deliver a ‘P450 toolkit’ consisting of in vitro and in vivo screening tools, with which to identify resistance breaking chemistry, and high-throughput diagnostics for use in resistance management.

In summary this project will provide novel insights into this important enzyme family and provide tools that can be used to develop new products and strategies that slow, prevent, or overcome resistance and so ensure sustainable crop protection

 Publications

year authors and title journal last update
List of publications.
2018 Christoph T. Zimmer, William T. Garrood, Kumar Saurabh Singh, Emma Randall, Bettina Lueke, Oliver Gutbrod, Svend Matthiesen, Maxie Kohler, Ralf Nauen, T.G. Emyr Davies, Chris Bass
Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the Brown Planthopper
published pages: 268-274.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.11.060
Current Biology 28/2 2019-05-30
2018 Cristina Manjon, Bartlomiej J. Troczka, Marion Zaworra, Katherine Beadle, Emma Randall, Gillian Hertlein, Kumar Saurabh Singh, Christoph T. Zimmer, Rafael A. Homem, Bettina Lueke, Rebecca Reid, Laura Kor, Maxie Kohler, Jürgen Benting, Martin S. Williamson, T.G. Emyr Davies, Linda M. Field, Chris Bass, Ralf Nauen
Unravelling the Molecular Determinants of Bee Sensitivity to Neonicotinoid Insecticides
published pages: 1137-1143.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.02.045
Current Biology 28/7 2019-05-30

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