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P450RESIST SIGNED

Understanding and exploiting the insect P450 resistome

Total Cost €

0

EC-Contrib. €

0

Partnership

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 P450RESIST project word cloud

Explore the words cloud of the P450RESIST project. It provides you a very rough idea of what is the project "P450RESIST" about.

molecular    insect    alter    superfamily    summary    plants    screening    critical    insecticide    structure    determinants    ubiquitous    defence    families    quantitative    insects    ongoing    slow    metabolism    shown    protection    cytochrome    chemicals    expression    strategies    p450    transgenics    wp1    themselves    anti    xenobiotics    epigenetics    genomics    prevent    synthetic    defend    relative    exceptional    regulatory    resistome    modulate    gained    qualitative    wp    p450s    mediating    pest    diagnostics    interaction    drivers    evolve    sustainable    rare    resistant    resistance    vivo    toxin    insights    opportunity    despite    characterise    frequency    cutting    relatively    binding    family    metabolic    breaking    overcome    workpackages    vitro    insecticides    chemistry    toolkit    enzymes    adaptive    conferring    herbivore    edge    evolution    function    tools    nature    explore    crop    variety    model    throughput    enzyme    natural    consisting   

Project "P450RESIST" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EXETER 

Organization address
address: THE QUEEN'S DRIVE NORTHCOTE HOUSE
city: EXETER
postcode: EX4 4QJ
website: www.ex.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙975˙512 €
 EC max contribution 1˙975˙512 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EXETER UK (EXETER) coordinator 1˙949˙494.00
2    ROTHAMSTED RESEARCH LIMITED UK (HARPENDEN) participant 26˙017.00

Map

 Project objective

Insect resistance to synthetic insecticides and the anti-herbivore defence chemicals produced by many plants is an ongoing challenge to sustainable pest management while also an exceptional model system to study adaptive evolution. The cytochrome P450s are a superfamily of enzymes that are ubiquitous in nature, and one of the most important enzyme families used by insects to defend themselves against natural and synthetic xenobiotics. Insects have been shown to evolve resistance through quantitative changes in P450 expression or via qualitative changes in P450s that alter metabolic activity. Despite their importance in conferring resistance the variety of regulatory changes that modulate P450 expression in resistant insects and their relative frequency/impact is not fully understood. Furthermore, although qualitative changes in insect P450s associated with resistance are relatively rare they represent a unique opportunity to characterise insecticide/toxin binding and identify the critical structure/function determinants of the P450/insect toxin interaction.

In this project I will exploit cutting-edge advances in genomics, epigenetics and transgenics to study the insect P450 resistome in three main workpackages:

WP-1: Will identify the molecular drivers of quantitative changes to insect P450s. WP-2: Will explore the role of qualitative changes in insect P450s in mediating resistance and identify structure/function determinants of insecticide metabolism. WP-3: Will exploit the knowledge gained in WP1/2 and from previous research to deliver a ‘P450 toolkit’ consisting of in vitro and in vivo screening tools, with which to identify resistance breaking chemistry, and high-throughput diagnostics for use in resistance management.

In summary this project will provide novel insights into this important enzyme family and provide tools that can be used to develop new products and strategies that slow, prevent, or overcome resistance and so ensure sustainable crop protection

 Publications

year authors and title journal last update
List of publications.
2018 Christoph T. Zimmer, William T. Garrood, Kumar Saurabh Singh, Emma Randall, Bettina Lueke, Oliver Gutbrod, Svend Matthiesen, Maxie Kohler, Ralf Nauen, T.G. Emyr Davies, Chris Bass
Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the Brown Planthopper
published pages: 268-274.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.11.060
Current Biology 28/2 2019-05-30
2018 Cristina Manjon, Bartlomiej J. Troczka, Marion Zaworra, Katherine Beadle, Emma Randall, Gillian Hertlein, Kumar Saurabh Singh, Christoph T. Zimmer, Rafael A. Homem, Bettina Lueke, Rebecca Reid, Laura Kor, Maxie Kohler, Jürgen Benting, Martin S. Williamson, T.G. Emyr Davies, Linda M. Field, Chris Bass, Ralf Nauen
Unravelling the Molecular Determinants of Bee Sensitivity to Neonicotinoid Insecticides
published pages: 1137-1143.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.02.045
Current Biology 28/7 2019-05-30

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