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Neuronetmir

Role of miR-129-5p and Rbfox1 crosstalk in neural network homeostasis

Total Cost €

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EC-Contrib. €

0

Partnership

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 Neuronetmir project word cloud

Explore the words cloud of the Neuronetmir project. It provides you a very rough idea of what is the project "Neuronetmir" about.

critical    context    none    techniques    organotypic    human    mediators    regulated    responsible    structure    therapies    building    first    micrornas    homeostasis    disorders    epileptogenic    arrays    synaptic    network    fine    imbalances    proteins    interrogate    proper    generate    rbps    showing    breakthrough    networks    levels    interdisciplinary    imaging    function    until    acquire    proteomic    molecule    disease    models    cutting    tune    vitro    understand    noncoding    mirnas    hallmark    genetic    modifying    small    mirna    efficacy    crosstalk    neural    edge    vivo    rbp    ineffective    seizures    explore    epilepsy    alongside    exert    functionally    rbfox1    potent    cells    inhibitory    systematic    129    binding    excitatory    act    animal    mechanisms    single    patients    rnas    cultures    pathogenesis    5p    electrode    rna    brain    molecular    regulate    mir    stability    gene    drug    skills    therapeutic    mrna    clinical    actions    translation    expertise    multiple   

Project "Neuronetmir" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 187˙866.00

Map

 Project objective

Imbalances between excitatory and inhibitory neural networks are a hallmark of several brain disorders including epilepsy. Current drug therapies for epilepsy are ineffective in a third of patients and none have disease-modifying effects. It is of high priority, therefore, to understand molecular/ genetic mechanisms responsible for epilepsy development and identify novel targets. The control of mRNA stability and translation is critical for proper neural network function. Here, RNA binding proteins (RBPs) and small noncoding RNAs called microRNAs (miRNA) act together to fine-tune levels of proteins critical for synaptic structure and function. These may represent important therapeutic targets since they regulate gene networks and exert broader actions that can generate more potent effects against seizures. Until now there has been no systematic analysis of miRNA, RBP crosstalk in the context of neural network stability in epilepsy. Building on my recent breakthrough studies showing miR-129-5p/Rbfox1 crosstalk in neural network homeostasis my project will explore the following objectives: First, identify targets regulated by miR-129-5p/Rbfox1 crosstalk in vivo; Second, functionally interrogate miR-129-5p/Rbfox1 crosstalk in neural network stability in vitro and in vivo; Third, investigate miR-129-5p and Rbfox1 function in human neural networks. To achieve these objectives I will apply my existing expertise as well as acquire new skills in a range of state-of-the-art interdisciplinary and cutting-edge techniques including single molecule imaging, proteomic analyses, multiple electrode arrays, human brain organotypic cultures and pre-clinical animal models. The results will establish RBPs, alongside miRNAs, as new mediators of epileptogenic network pathogenesis. Findings will also generate new targets for pre-clinical development and evidence of efficacy in human cells for disease-modifying therapies for epilepsy and disorders of neural network homeostasis.

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The information about "NEURONETMIR" are provided by the European Opendata Portal: CORDIS opendata.

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