Opendata, web and dolomites

Neuronetmir

Role of miR-129-5p and Rbfox1 crosstalk in neural network homeostasis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Neuronetmir project word cloud

Explore the words cloud of the Neuronetmir project. It provides you a very rough idea of what is the project "Neuronetmir" about.

alongside    epilepsy    responsible    disorders    edge    rna    explore    human    binding    electrode    synaptic    critical    molecule    building    brain    gene    generate    none    until    skills    imaging    arrays    models    mediators    exert    interdisciplinary    structure    neural    systematic    translation    cells    breakthrough    act    acquire    disease    therapies    mirna    seizures    therapeutic    mir    levels    first    regulate    organotypic    networks    animal    actions    potent    stability    mirnas    mrna    functionally    proteomic    homeostasis    proteins    clinical    tune    rbfox1    molecular    single    fine    rbp    function    modifying    noncoding    multiple    imbalances    inhibitory    pathogenesis    proper    showing    patients    excitatory    efficacy    genetic    vivo    expertise    mechanisms    cultures    techniques    epileptogenic    vitro    micrornas    hallmark    rbps    crosstalk    context    129    drug    rnas    regulated    5p    ineffective    interrogate    cutting    small    network    understand   

Project "Neuronetmir" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 187˙866.00

Map

 Project objective

Imbalances between excitatory and inhibitory neural networks are a hallmark of several brain disorders including epilepsy. Current drug therapies for epilepsy are ineffective in a third of patients and none have disease-modifying effects. It is of high priority, therefore, to understand molecular/ genetic mechanisms responsible for epilepsy development and identify novel targets. The control of mRNA stability and translation is critical for proper neural network function. Here, RNA binding proteins (RBPs) and small noncoding RNAs called microRNAs (miRNA) act together to fine-tune levels of proteins critical for synaptic structure and function. These may represent important therapeutic targets since they regulate gene networks and exert broader actions that can generate more potent effects against seizures. Until now there has been no systematic analysis of miRNA, RBP crosstalk in the context of neural network stability in epilepsy. Building on my recent breakthrough studies showing miR-129-5p/Rbfox1 crosstalk in neural network homeostasis my project will explore the following objectives: First, identify targets regulated by miR-129-5p/Rbfox1 crosstalk in vivo; Second, functionally interrogate miR-129-5p/Rbfox1 crosstalk in neural network stability in vitro and in vivo; Third, investigate miR-129-5p and Rbfox1 function in human neural networks. To achieve these objectives I will apply my existing expertise as well as acquire new skills in a range of state-of-the-art interdisciplinary and cutting-edge techniques including single molecule imaging, proteomic analyses, multiple electrode arrays, human brain organotypic cultures and pre-clinical animal models. The results will establish RBPs, alongside miRNAs, as new mediators of epileptogenic network pathogenesis. Findings will also generate new targets for pre-clinical development and evidence of efficacy in human cells for disease-modifying therapies for epilepsy and disorders of neural network homeostasis.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NEURONETMIR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NEURONETMIR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

COLEX (2019)

Coopetition and Legislation in the Spanish Netherlands (1598-1665)

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More