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Role of miR-129-5p and Rbfox1 crosstalk in neural network homeostasis

Total Cost €


EC-Contrib. €






 Neuronetmir project word cloud

Explore the words cloud of the Neuronetmir project. It provides you a very rough idea of what is the project "Neuronetmir" about.

electrode    regulated    neural    imaging    micrornas    rna    mrna    therapeutic    epilepsy    molecule    none    mirna    5p    mir    animal    explore    therapies    genetic    drug    models    129    inhibitory    epileptogenic    mirnas    brain    pathogenesis    functionally    rbps    clinical    understand    rbp    context    actions    stability    network    binding    vitro    mediators    levels    regulate    generate    arrays    networks    molecular    cells    first    patients    hallmark    until    systematic    multiple    critical    showing    mechanisms    function    disease    disorders    rnas    human    tune    techniques    excitatory    single    edge    small    responsible    translation    gene    efficacy    act    building    proteomic    interrogate    imbalances    breakthrough    fine    seizures    proper    exert    proteins    vivo    rbfox1    expertise    acquire    cutting    modifying    structure    crosstalk    interdisciplinary    noncoding    skills    synaptic    cultures    ineffective    potent    alongside    homeostasis    organotypic   

Project "Neuronetmir" data sheet

The following table provides information about the project.


Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Imbalances between excitatory and inhibitory neural networks are a hallmark of several brain disorders including epilepsy. Current drug therapies for epilepsy are ineffective in a third of patients and none have disease-modifying effects. It is of high priority, therefore, to understand molecular/ genetic mechanisms responsible for epilepsy development and identify novel targets. The control of mRNA stability and translation is critical for proper neural network function. Here, RNA binding proteins (RBPs) and small noncoding RNAs called microRNAs (miRNA) act together to fine-tune levels of proteins critical for synaptic structure and function. These may represent important therapeutic targets since they regulate gene networks and exert broader actions that can generate more potent effects against seizures. Until now there has been no systematic analysis of miRNA, RBP crosstalk in the context of neural network stability in epilepsy. Building on my recent breakthrough studies showing miR-129-5p/Rbfox1 crosstalk in neural network homeostasis my project will explore the following objectives: First, identify targets regulated by miR-129-5p/Rbfox1 crosstalk in vivo; Second, functionally interrogate miR-129-5p/Rbfox1 crosstalk in neural network stability in vitro and in vivo; Third, investigate miR-129-5p and Rbfox1 function in human neural networks. To achieve these objectives I will apply my existing expertise as well as acquire new skills in a range of state-of-the-art interdisciplinary and cutting-edge techniques including single molecule imaging, proteomic analyses, multiple electrode arrays, human brain organotypic cultures and pre-clinical animal models. The results will establish RBPs, alongside miRNAs, as new mediators of epileptogenic network pathogenesis. Findings will also generate new targets for pre-clinical development and evidence of efficacy in human cells for disease-modifying therapies for epilepsy and disorders of neural network homeostasis.

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The information about "NEURONETMIR" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2023-02-05 17:45:48) correctly updated