Opendata, web and dolomites

Neuronetmir

Role of miR-129-5p and Rbfox1 crosstalk in neural network homeostasis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Neuronetmir project word cloud

Explore the words cloud of the Neuronetmir project. It provides you a very rough idea of what is the project "Neuronetmir" about.

proteomic    small    hallmark    epilepsy    disease    clinical    techniques    responsible    gene    showing    network    networks    therapies    multiple    electrode    acquire    act    function    explore    understand    mir    human    pathogenesis    proteins    excitatory    brain    arrays    genetic    inhibitory    rbp    rnas    efficacy    mechanisms    therapeutic    imbalances    molecular    levels    organotypic    rbps    generate    first    context    mirna    actions    potent    none    mrna    micrornas    systematic    regulate    binding    structure    proper    modifying    rbfox1    mediators    drug    breakthrough    vivo    interrogate    patients    stability    exert    rna    regulated    noncoding    disorders    vitro    single    ineffective    interdisciplinary    skills    synaptic    crosstalk    cultures    alongside    critical    until    fine    building    tune    epileptogenic    mirnas    cells    models    cutting    129    translation    edge    homeostasis    expertise    molecule    5p    functionally    neural    imaging    animal    seizures   

Project "Neuronetmir" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 187˙866.00

Map

 Project objective

Imbalances between excitatory and inhibitory neural networks are a hallmark of several brain disorders including epilepsy. Current drug therapies for epilepsy are ineffective in a third of patients and none have disease-modifying effects. It is of high priority, therefore, to understand molecular/ genetic mechanisms responsible for epilepsy development and identify novel targets. The control of mRNA stability and translation is critical for proper neural network function. Here, RNA binding proteins (RBPs) and small noncoding RNAs called microRNAs (miRNA) act together to fine-tune levels of proteins critical for synaptic structure and function. These may represent important therapeutic targets since they regulate gene networks and exert broader actions that can generate more potent effects against seizures. Until now there has been no systematic analysis of miRNA, RBP crosstalk in the context of neural network stability in epilepsy. Building on my recent breakthrough studies showing miR-129-5p/Rbfox1 crosstalk in neural network homeostasis my project will explore the following objectives: First, identify targets regulated by miR-129-5p/Rbfox1 crosstalk in vivo; Second, functionally interrogate miR-129-5p/Rbfox1 crosstalk in neural network stability in vitro and in vivo; Third, investigate miR-129-5p and Rbfox1 function in human neural networks. To achieve these objectives I will apply my existing expertise as well as acquire new skills in a range of state-of-the-art interdisciplinary and cutting-edge techniques including single molecule imaging, proteomic analyses, multiple electrode arrays, human brain organotypic cultures and pre-clinical animal models. The results will establish RBPs, alongside miRNAs, as new mediators of epileptogenic network pathogenesis. Findings will also generate new targets for pre-clinical development and evidence of efficacy in human cells for disease-modifying therapies for epilepsy and disorders of neural network homeostasis.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NEURONETMIR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NEURONETMIR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CORRELATION (2020)

Characterization and prediction of service-level traffic for future sliced mobile network

Read More  

Photonic Radar (2019)

Implementation of Long Reach Hybrid Photonic Radar System and convergence over FSO and PON Networks

Read More  

Cartesian Networks (2020)

Cartesian Networks in Early Modern Europe: A Quantitative and Interdisciplinary Approach

Read More