Opendata, web and dolomites

LearnAnx_CircAmyg SIGNED

Learning and Anxiety in Amygdala-based Neural Circuits

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 LearnAnx_CircAmyg project word cloud

Explore the words cloud of the LearnAnx_CircAmyg project. It provides you a very rough idea of what is the project "LearnAnx_CircAmyg" about.

protocols    discriminate    dangerous    circuitry    stimuli    extinguish    underlie    posit    functional    computations    maladaptive    exploration    stimulation    post    cortex    prefrontal    major    extinction    gained    logical    arrays    associative    complex    pfc    shed    supplemented    generalization    deep    majority    examine    safe    contact    pioneering    medial    embarked    shock    rule    conditioning    human    simultaneously    mal    animal    behavioural    acquisition    made    emotional    connectivity    primate    enabled    amygdala    anxiety    suggest    aversive    learned    tone    rodents    behaviours    stress    disorders    physiological    unveil    environments    elaborated    neurons    primates    translation    venues    techniques    lab    mechanisms    circuit    circuits    evolutionary    basic    expanded    neural    learning    adaptive    models    form    codes    context    underlying    repertoire    dozens    exploring    cutting    mainly    insights    edge    light    off    powerful    tradeoff    record    traumatic    trade   

Project "LearnAnx_CircAmyg" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙000˙000.00

Map

 Project objective

Major advances were made in understanding circuits that underlie aversive emotional learning. The majority gained by using classical associative models, mainly tone/context-shock conditioning. Failure to extinguish the response or to discriminate from other safe stimuli (generalization), form two main animal models for human anxiety-disorders and post-traumatic-stress. These simple yet powerful approaches enabled cutting-edge techniques in rodents to unveil amygdala circuitry and its connectivity with the medial-prefrontal-cortex. Yet, we have less understanding of the mechanisms that underlie elaborated behavioural models of mal-adaptive behaviour, as well as less understanding of neural codes and computations in the evolutionary-expanded primate amygdala. Our lab recently embarked on exploring these venues by pioneering physiological studies of generalization and extinction protocols in primates. The goal of the current project is to develop behavioural models of complex learning and maladaptive behaviour, and then examine and shed light on the underlying computations in primate amygdala-PFC circuit. We design a novel rule-based learning task, and examine its acquisition, extinction, generalization and exploration-exploitation trade-off in dangerous environments. Specifically, the concepts of rule learning and exploration-exploitation tradeoff form novel insights and aspects of [mal-]adaptive behaviours, and will suggest new animal models of learned anxiety. We record dozens of neurons in the amygdala and prefrontal-cortex simultaneously using deep multi-contact arrays, supplemented by stimulation to address functional connectivity, and development of modelling approaches for the behaviour and neural codes. We posit that the development of more [complex] models is crucial and the next logical step in achieving translation of animal models of anxiety disorders, as well as in understanding basic mechanisms behind the rich repertoire of emotional behaviours.

 Publications

year authors and title journal last update
List of publications.
2019 Raviv Pryluk, Yoav Kfir, Hagar Gelbard-Sagiv, Itzhak Fried, Rony Paz
A Tradeoff in the Neural Code across Regions and Species
published pages: 597-609.e18, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.12.032
Cell 176/3 2019-06-05
2018 Aryeh H. Taub, Yosef Shohat, Rony Paz
Long time-scales in primate amygdala neurons support aversive learning
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07020-4
Nature Communications 9/1 2019-06-05

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LEARNANX_CIRCAMYG" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LEARNANX_CIRCAMYG" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

FunDiT (2019)

Functional Diversity of T cells

Read More