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AsthmaPhenotypes SIGNED

Understanding asthma phenotypes: going beyond the atopic/non-atopic paradigm

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "AsthmaPhenotypes" data sheet

The following table provides information about the project.

Coordinator
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER 

Organization address
address: KEPPEL STREET
city: LONDON
postcode: WC1E 7HT
website: http://www.lshtm.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.lshtm.ac.uk/research/centres-projects-groups/wasp
 Total cost 2˙348˙803 €
 EC max contribution 2˙348˙803 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER UK (LONDON) coordinator 1˙269˙332.00
2    UNIVERSITY OF BRISTOL UK (BRISTOL) participant 269˙141.00
3    Massey University NZ (Palmerston North) participant 268˙475.00
4    UNIVERSIDADE FEDERAL DA BAHIA BR (SALVADOR) participant 255˙882.00
5    ST GEORGE'S HOSPITAL MEDICAL SCHOOL UK (LONDON) participant 255˙880.00
6    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) participant 30˙093.00
7    MEDICAL RESEARCH COUNCIL UK (SWINDON) participant 0.00

Map

 Project objective

Fifteen years ago it was widely believed that asthma was an allergic/atopic disease caused by allergen exposure in infancy; this produced atopic sensitization and continued exposure resulted in eosinophilic airways inflammation, bronchial hyper-responsiveness and reversible airflow obstruction. It is now clear that this model is at best incomplete. Less than one-half of asthma cases involve allergic (atopic) mechanisms, and most asthma in low-and-middle income countries is non-atopic. Westernization may be contributing to the global increases in asthma prevalence, but this process appears to involve changes in asthma susceptibility rather than increased exposure to “established” asthma risk factors. Understanding why these changes are occurring is essential in order to halt the growing global asthma epidemic.This will require a combination of epidemiological, clinical and basic science studies in a variety of environments.

A key task is to reclassify asthma phenotypes. These are important to: (i) better understand the aetiological mechanisms of asthma; (ii) identify new causes; and (iii) identify new therapeutic measures. There are major opportunities to address these issues using new techniques for sample collection from the airways (sputum induction, nasal lavage), new methods of analysis (microbiome, epigenetics), and new bioinformatics methods for integrating data from multiple sources and levels. There is an unprecedented potential to go beyond the old atopic/non-atopic categorization of phenotypes.

I will therefore conduct analyses to re-examine and reclassify asthma phenotypes. The key features are the inclusion of: (i) both high and low prevalence centres from both high income countries and low-and-middle income countries; (ii) much more detailed biomarker information than has been used for previous studies of asthma phenotypes; and (iii) new bioinformatics methods for integrating data from multiple sources and levels.

 Publications

year authors and title journal last update
List of publications.
2018 Pearce N, Mallol J, El Sony A, Marks G
Asthma as an NCD priority
published pages: 74-76, ISSN: , DOI:
The Global Asthma Report 2018 (Pub: 31/8/18) 2019-07-02
2018 Lucy Pembrey, Mauricio L. Barreto, Jeroen Douwes, Philip Cooper, John Henderson, Harriet Mpairwe, Cristina Ardura-Garcia, Martha Chico, Collin Brooks, Alvaro A. Cruz, Alison M. Elliott, Camila A. Figueiredo, Sinéad M. Langan, Beatrice Nassanga, Susan Ring, Laura Rodrigues, Neil Pearce
Understanding asthma phenotypes: the World Asthma Phenotypes (WASP) international collaboration
published pages: 00013-2018, ISSN: 2312-0541, DOI: 10.1183/23120541.00013-2018
ERJ Open Research 4/3 2019-07-02
2018 Asher I, Billo N, Bissell K, Chen-Yuan C, Ellwood P, El Sony A, Garcia-Marcos L, Marks G, Pearce N, Strachan D
The Global Asthma Network
published pages: 12-13, ISSN: , DOI:
The Global Asthma Report 2018 (Publication date: 31/8/18 2019-07-02
2018 Asher I, Pearce N, Strachan D, Billo N, Chen-Yuang C, Ellwood P, El Sony A, Garcia-Maracos L, Marks G
What is asthma?
published pages: 16-17, ISSN: , DOI:
The Global Asthma Report 2018 (Publication: 31/8/18) 2019-07-02
2016 Neil Pearce, Debbie A Lawlor
Causal inference—so much more than statistics
published pages: 1895-1903, ISSN: 0300-5771, DOI: 10.1093/ije/dyw328
International Journal of Epidemiology 45/6 2019-07-02
2018 Marks G, Pearce N, Strachan D, Asher I, Elwood P
Global burden of disease due to asthma
published pages: 18-21, ISSN: , DOI:
The Global Asthma Report 2018 (Pub: 31/8/18) 2019-07-02
2018 Neil Pearce
Bias in matched case–control studies: DAGs are not enough
published pages: 1-4, ISSN: 0393-2990, DOI: 10.1007/s10654-018-0362-3
European Journal of Epidemiology 33/1 2019-07-02
2018 Strachan D, Limb E, Pearce N, Marks G, Morales E, Perez-Fernandez V
Asthma mortality
published pages: 27-31, ISSN: , DOI:
The Global Asthma Report 2018 (Pub: 31/8/18) 2019-07-02
2018 Garcia-Marcos L, Pearce N, Strachan D, Silverwood R, Rutter C, Elwood E
Factors affecting asthma
published pages: 35-37, ISSN: , DOI:
The Global Asthma Report 2018 (Pub: 31/8/18) 2019-07-02
2017 Lorenzo Richiardi, Francesco Barone-Adesi, Neil Pearce
Cancer subtypes in aetiological research
published pages: 353-361, ISSN: 0393-2990, DOI: 10.1007/s10654-017-0253-z
European Journal of Epidemiology 32/5 2019-07-02
2018 Jan P Vandenbroucke, Neil Pearce
From ideas to studies: how to get ideas and sharpen them into research questions
published pages: 253-264, ISSN: 1179-1349, DOI: 10.2147/CLEP.S142940
Clinical Epidemiology Volume 10 2019-07-02

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