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assymcurv SIGNED

The influence of the cell membrane asymmetry and curvature on the functioning of membrane proteins and the transport of therapeutic compounds

Total Cost €

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EC-Contrib. €

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Partnership

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Project "assymcurv" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF PHYSICS OF NATIONAL ACADEMY OF SCIENCE OF UKRAINE 

Organization address
address: PROSPECT NAUKY 46
city: KYIV
postcode: 3680
website: www.iop.kiev.ua

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ukraine [UA]
 Total cost 202˙500 €
 EC max contribution 202˙500 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2015
 Funding Scheme MSCA-RISE
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF PHYSICS OF NATIONAL ACADEMY OF SCIENCE OF UKRAINE UA (KYIV) coordinator 58˙500.00
2    UNIVERSITE DE FRANCHE-COMTE FR (BESANCON) participant 63˙000.00
3    LATVIJAS UNIVERSITATES CIETVIELU FIZIKAS INSTITUTS LV (RIGA) participant 45˙000.00
4    TARTU ULIKOOL EE (TARTU) participant 27˙000.00
5    MATERIALS RESEARCH CENTER UA (KIEV) participant 9˙000.00
6    THE UNIVERSITY OF TEXAS SYSTEM US (AUSTIN) partner 0.00
7    Universidade Federal de Juiz de Fora BR (Juiz de Fora) partner 0.00

Map

 Project objective

Real cell membranes are essentially asymmetric and non-planar. Outer leaflets of the plasma membranes contain neutral lipids and glycolipids, while the inner leaflets host practically all anionic lipids and phosphoinositides. In addition to asymmetric composition the membranes are usually curved due to spontaneous curvature of the membrane lipids and an influence of membrane proteins and cytoskeleton. There are many cellular phenomena, which are influenced by the asymmetry and the membrane curvature such as formation of synaptic vesicles, blebs and apoptotic bodies, membrane fusion and splitting, budding of enveloped viruses, endo and exocytosis, etc. In this work we propose comprehensive interdisciplinary study of the influence of membrane asymmetry and curvature on the functioning of integral membrane proteins and the transmembrane transport of therapeutic compounds (such as cisplatin and its derivatives). The goal is to reveal major physical factors, which distinguish asymmetric and curved membrane environment and govern interactions, orientation and diffusion of the small molecules (drugs) and large integral proteins. The combination of experimental methods (“wet” biochemistry and molecular biology, enhanced infrared and Raman spectroscopy) and computer simulations (coarse-grained and atomistic molecular dynamics, quantum chemistry) would be used in the project in complimentary manner.

 Deliverables

List of deliverables.
Comparison of experimental and simulation results Other 2020-04-07 20:47:07
Curvature-dependent potentials of mean force for drug translocation through the membrane Other 2020-04-07 20:47:07
Curvature-dependent conformational changes of the membrane proteins Other 2020-04-07 20:47:07
Experimental markers of conformation changes in membrane-protein and membrane-drug complexes. Other 2020-04-07 20:47:07
Progress report 2 Documents, reports 2020-04-07 20:47:07
Publishing and dissemination of results Documents, reports 2020-04-07 20:47:07
Progress Report 1 Documents, reports 2020-04-07 20:47:06
Empirical force fields of the drugs Other 2020-04-07 20:47:06
Coherent view of the project goals, methods and schedules Documents, reports 2020-04-07 20:47:06
Mid-term meeting Other 2020-04-07 20:47:06

Take a look to the deliverables list in detail:  detailed list of assymcurv deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Arnaud Peramo, Simona Mura, Semen O. Yesylevskyy, Bruno Cardey, Dunja Sobot, Stephanie Denis, Christophe Ramseyer, Didier Desmaële, Patrick Couvreur
Squalene versus cholesterol: Which is the best nanocarrier for the delivery to cells of the anticancer drug gemcitabine?
published pages: 974-986, ISSN: 1631-0748, DOI: 10.1016/j.crci.2018.02.008
Comptes Rendus Chimie 21/10 2020-04-07
2019 Thibault Minervini, Bruno Cardey, Sarah Foley, Christophe Ramseyer, Mironel Enescu
Fate of cisplatin and its main hydrolysed forms in the presence of thiolates: a comprehensive computational and experimental study
published pages: 833-844, ISSN: 1756-5901, DOI: 10.1039/c8mt00371h
Metallomics 11/4 2020-04-07
2019 Timothée Rivel, Christophe Ramseyer, Semen Yesylevskyy
The asymmetry of plasma membranes and their cholesterol content influence the uptake of cisplatin
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-41903-w
Scientific Reports 9/1 2020-04-07
2019 Julie Mougin, Semen O. Yesylevskyy, Claudie Bourgaux, David Chapron, Jean-Philippe Michel, Franco Dosio, Barbara Stella, Christophe Ramseyer, Patrick Couvreur
Stacking as a Key Property for Creating Nanoparticles with Tunable Shape: The Case of Squalenoyl-Doxorubicin
published pages: 12870-12879, ISSN: 1936-0851, DOI: 10.1021/acsnano.9b05303
ACS Nano 13/11 2020-04-07
2019 Semen Yesylevskyy, Timothée Rivel, Christophe Ramseyer
Curvature increases permeability of the plasma membrane for ions, water and the anti-cancer drugs cisplatin and gemcitabine
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-53952-2
Scientific Reports 9/1 2020-04-07
2019 Kyrylo A. Pyrshev, Semen O. Yesylevskyy, Alexander P. Demchenko
Double-exponential kinetics of binding and redistribution of the fluorescent dyes in cell membranes witness for the existence of lipid microdomains
published pages: 1139-1144, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2018.12.054
Biochemical and Biophysical Research Communications 508/4 2020-04-07
2018 O. P. Gnatyuk, G. I. Dovbeshko, A. Yershov, S. O. Karakhim, O. Ilchenko, O. Yu. Posudievsky
2D-BN nanoparticles as a spectroscopic marker and drug delivery system with protection properties
published pages: 30404-30411, ISSN: 2046-2069, DOI: 10.1039/c8ra05085f
RSC Advances 8/53 2020-04-07
2018 Yibin Lin, Mikhail Bogdanov, Shuo Lu, Ziqiang Guan, William Margolin, Jerrold Weiss, Lei Zheng
The phospholipid-repair system LplT/Aas in Gram-negative bacteria protects the bacterial membrane envelope from host phospholipase A 2 attack
published pages: 3386-3398, ISSN: 0021-9258, DOI: 10.1074/jbc.ra117.001231
Journal of Biological Chemistry 293/9 2020-04-07
2017 Lei Zheng, Yibin Lin, Shuo Lu, Jiazhe Zhang, Mikhail Bogdanov
Biogenesis, transport and remodeling of lysophospholipids in Gram-negative bacteria
published pages: 1404-1413, ISSN: 1388-1981, DOI: 10.1016/j.bbalip.2016.11.015
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1862/11 2020-04-07
2016 Ludmila Davydova, Svetlana Bakholdina, Maria Barkina, Peter Velansky, Mikhail Bogdanov, Nina Sanina
Effects of elevated growth temperature and heat shock on the lipid composition of the inner and outer membranes of Yersinia pseudotuberculosis
published pages: 103-109, ISSN: 0300-9084, DOI: 10.1016/j.biochi.2016.02.004
Biochimie 123 2020-04-07
2017 Liina Kangur, Michael R. Jones, Arvi Freiberg
Hydrogen bonds in the vicinity of the special pair of the bacterial reaction center probed by hydrostatic high-pressure absorption spectroscopy
published pages: , ISSN: 0301-4622, DOI: 10.1016/j.bpc.2017.04.003
Biophysical Chemistry 2020-04-07
2017 Kõu Timpmann, Liina Kangur, Ants Lõhmus, Arvi Freiberg
High-pressure modulation of the structure of the bacterial photochemical reaction center at physiological and cryogenic temperatures
published pages: 144006, ISSN: 0953-4075, DOI: 10.1088/1361-6455/aa77e4
Journal of Physics B: Atomic, Molecular and Optical Physics 50/14 2020-04-07
2016 Manoop Chenchiliyan, Kõu Timpmann, Erko Jalviste, Peter G. Adams, C. Neil Hunter, Arvi Freiberg
Dimerization of core complexes as an efficient strategy for energy trapping in Rhodobacter sphaeroides
published pages: 634-642, ISSN: 0005-2728, DOI: 10.1016/j.bbabio.2016.03.020
Biochimica et Biophysica Acta (BBA) - Bioenergetics 1857/6 2020-04-07
2016 Arvi Freiberg, Manoop Chenchiliyan, Margus Rätsep, Kõu Timpmann
Spectral and kinetic effects accompanying the assembly of core complexes of Rhodobacter sphaeroides
published pages: 1727-1733, ISSN: 0005-2728, DOI: 10.1016/j.bbabio.2016.08.001
Biochimica et Biophysica Acta (BBA) - Bioenergetics 1857/11 2020-04-07
2017 Timothée Rivel, Semen O. Yesylevskyy, Christophe Ramseyer
Structures of single, double and triple layers of lipids adsorbed on graphene: Insights from all-atom molecular dynamics simulations
published pages: 358-369, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2017.03.072
Carbon 118 2020-04-07
2017 Dunja Sobot, Simona Mura, Semen O. Yesylevskyy, Laura Dalbin, Fanny Cayre, Guillaume Bort, Julie Mougin, Didier Desmaële, Sinda Lepetre-Mouelhi, Grégory Pieters, Bohdan Andreiuk, Andrey S. Klymchenko, Jean-Louis Paul, Christophe Ramseyer, Patrick Couvreur
Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery
published pages: 15678, ISSN: 2041-1723, DOI: 10.1038/ncomms15678
Nature Communications 8 2020-04-07

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