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ERAofART

Epigenetic Risk Assesment of Assisted Reproductive Technologies

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ERAofART" data sheet

The following table provides information about the project.

Coordinator
INSTYTUT GENETYKI I HODOWLI ZWIERZAT POLSKIEJ AKADEMII NAUK 

Organization address
address: POSTEPU 36A
city: MAGDALENKA
postcode: 05 552
website: www.ighz.edu.pl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Poland [PL]
 Project website http://www.eraofart.ighz.edu.pl/en/
 Total cost 1˙176˙700 €
 EC max contribution 1˙176˙700 € (100%)
 Programme 1. H2020-EU.4.b. (Twinning of research institutions)
 Code Call H2020-TWINN-2015
 Funding Scheme CSA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTYTUT GENETYKI I HODOWLI ZWIERZAT POLSKIEJ AKADEMII NAUK PL (MAGDALENKA) coordinator 471˙685.00
2    UNIVERSITA DEGLI STUDI DI TERAMO IT (TERAMO) participant 271˙500.00
3    UNIWERSYTET JAGIELLONSKI PL (KRAKOW) participant 221˙015.00
4    JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG DE (WUERZBURG) participant 212˙500.00

Map

 Project objective

Assisted Reproduction Technologies (ART) are developing rapidly to provide response to infertility and to the cultural shift to postpone parenthood. Later childbearing and ART has been associated with an increased risk of the epigenetic disorders in offspring. Thus, in order to guarantee better and safer healthcare for EU citizens, risks and benefits of the use of various ART procedures needs to be thoughtfully tested. The project aims at overcoming the existing gaps and strengthening our capacity in Epigenetic Risk Assessment of Assisted Reproduction Technologies (ERA of ART). Long term GOAL of our project is to become the European Centre of Excellence and Innovation for Epigenetic Risk Assessment of ART. To do this, we will create link between IGAB PAS, providing high quality know-how in mouse embryology with University of Wuerzburg (leader in epigenetic assessment of ART embryos), with University of Teramo (having long-standing expertise in wide range of ART procedures in large animals) and with Uniwersytet Jagiellonski (having long-standing expertise in human genetics). This twinning project will provide technological platform and expertise for epigenetic analyses and ART in large and small animal models. The specific aims of our project based on SWOT analysis are: 1) to enhance the scientific and technical skills of our staff; 2) stimulate preparation of joint research projects; 3) produce high impact factor publications and; 4) establish the cooperation with infertility clinics. The expected impact of this project is the creation of European Reference Network for ART safety evaluation, which is within the priorities of The Third Health Programme 2014-2020 of EC as well as within thematic area: HEALTHY SOCIETY of National Smart Specializations. This will have positive impact on the research in reproductive medicine and ART sector in general and will create a unique opportunity for Polish institution to become the reference Centre for knowledge-based decision making while preparing ART legislation.

 Deliverables

List of deliverables.
Operational website of the project Websites, patent fillings, videos etc. 2019-10-10 13:28:16
Statement that the report has been completed Documents, reports 2019-10-10 13:28:16
Promotional leaflet of the project Websites, patent fillings, videos etc. 2019-10-10 13:28:16
Report of the Conference: What is known about offspring obtained by Assisted Reproduction Technologies with agenda, proceedings, conclusions, lists of participants, further actions and implications for IGHZ PAN and partners involved Documents, reports 2019-10-10 13:28:16
Report of the workshop on oocytes and embryo manipulations with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and partners involved Documents, reports 2019-10-10 13:28:16
Promotional brochure of the project Websites, patent fillings, videos etc. 2019-10-10 13:28:16
First reports. Reports on the participation in promotional and information events and focus meeting with agenda of events and analysis of added value for potential increase of research in IGHZ PAN Documents, reports 2019-10-10 13:28:16
Report of the workshop on oocyte maturation and fertilization and embryo culture methods in large animal models with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and partners involved Documents, reports 2019-10-10 13:28:16
Joint report on summer school together with UJ Documents, reports 2019-10-10 13:28:15
Report with the copies of scientific papers and proceedings published in connection to the Twinning Research Group activities Documents, reports 2019-10-10 13:28:15
Report of the conference on ART: Long-Term Perspectives, with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN Documents, reports 2019-10-10 13:28:15
Report of the workshop on comparative experimental embryology methods with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and involved participants Documents, reports 2019-10-10 13:28:15
Cooperation agreements with partners Documents, reports 2019-10-10 13:28:15
Second reports. Reports on the participation in promotional and information events and focus meeting with agenda of events and analysis of added value for potential increase of research in IGHZ PAN Documents, reports 2019-10-10 13:28:15
Report from visits to the international conferences Documents, reports 2019-10-10 13:28:15
Report of the seminar for SME with agenda, proceedings, conclusions, lists of participants, further actions /implications for IGHZ PAN Documents, reports 2019-10-10 13:28:15
Joint report (with WP 2 task 2.2) on summer school in Embryo valuation and Molecular Biology Tools in ART with agenda, proceedings, conclusions, lists of participants, further actions/implications for IGHZ PAN and partners involved Documents, reports 2019-10-10 13:28:15

Take a look to the deliverables list in detail:  detailed list of ERAofART deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Federica Zacchini, Paola Toschi, Grazyna Ewa Ptak
Cobalamin supplementation during in vitro maturation improves developmental competence of sheep oocytes
published pages: 55-61, ISSN: 0093-691X, DOI: 10.1016/j.theriogenology.2017.01.035
Theriogenology 93 2019-10-10
2017 Roberta Arena, Federica Zacchini, Paola Toschi, Luca Palazzese, Marta Czernik, Grażyna Ewa Ptak
Developmental peculiarities in placentae of ovine uniparental conceptuses
published pages: e0188278, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0188278
PLOS ONE 12/11 2019-10-10
2016 Paola Toschi, Marta Czernik, Federica Zacchini, Antonella Fidanza, Pasqualino Loi, Grażyna Ewa Ptak
Evidence of Placental Autophagy during Early Pregnancy after Transfer of In Vitro Produced (IVP) Sheep Embryos
published pages: e0157594, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0157594
PLOS ONE 11/6 2019-10-10
2017 Nady El Hajj, Larissa Haertle, Marcus Dittrich, Sarah Denk, Harald Lehnen, Thomas Hahn, Martin Schorsch, Thomas Haaf
DNA methylation signatures in cord blood of ICSI children
published pages: 1-9, ISSN: 0268-1161, DOI: 10.1093/humrep/dex209
Human Reproduction 2019-10-10
2016 Stefanie Atsem, Juliane Reichenbach, Ramya Potabattula, Marcus Dittrich, Caroline Nava, Christel Depienne, Lena Böhm, Simone Rost, Thomas Hahn, Martin Schorsch, Thomas Haaf, Nady El Hajj
Paternal age effects on sperm FOXK1 and KCNA7 methylation and transmission into the next generation
published pages: ddw328, ISSN: 0964-6906, DOI: 10.1093/hmg/ddw328
Human Molecular Genetics 2019-10-10
2018 Debora A. Anzalone, Silvestre Sampino, Marta Czernik, Domenico Iuso, Grazyna E. Ptak
Polychlorinated biphenyls (PCBs) alter DNA methylation and genomic integrity of sheep fetal cells in a simplified in vitro model of pregnancy exposure
published pages: 39-46, ISSN: 0887-2333, DOI: 10.1016/j.tiv.2017.09.017
Toxicology in Vitro 46 2019-10-10
2017 Swathi Putta, Ilaria Peluso, Nagendra Sastry Yarla, Eswar Kumar Kilari, Anupam Bishayee, Da-Yong Lu, George E. Barreto, Ghulam Md Ashraf, Luciana Scotti, Marcus T. Scotti, Rajeev K. Singla, Thonos Alexiou, Atanas G. Atanasov, Vadim V. Tarasov, P. Veera Bramhachari, Sarat Babu Imandi, Madhuri Chintala, Bechan Sharma, Marcella Reale, Rosanna Filosa, Gjumrakch Aliev, Mohammad Amjad Kamal
Diabetes Mellitus and Male Aging: Pharmacotherapeutics and Clinical Implications
published pages: , ISSN: 1381-6128, DOI: 10.2174/1381612823666170823103830
Current Pharmaceutical Design 23/30 2019-10-10
2018 Takehiro Yamazaki, Hiroaki Taniguchi, Shoto Tsuji, Shiho Sato, Takahiro Kenmotsu, Kenichi Yoshikawa, Koichiro Sadakane
Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold
published pages: , ISSN: 1940-087X, DOI: 10.3791/57815
Journal of Visualized Experiments 140 2019-10-10
2019 Felix Mattern, Antonia Post, Franziska Solger, Aet O’Leary, David A. Slattery, Andreas Reif, Thomas Haaf
Prenatal and postnatal experiences associated with epigenetic changes in the adult mouse brain
published pages: 143-148, ISSN: 0166-4328, DOI: 10.1016/j.bbr.2018.10.037
Behavioural Brain Research 359 2019-10-10
2017 Megan Mitchell, Reiner Strick, Pamela L. Strissel, Ralf Dittrich, Nicole O. McPherson, Michelle Lane, Galyna Pliushch, Ramya Potabattula, Thomas Haaf, Nady El Hajj
Gene expression and epigenetic aberrations in F1-placentas fathered by obese males
published pages: 316-328, ISSN: 1040-452X, DOI: 10.1002/mrd.22784
Molecular Reproduction and Development 84/4 2019-10-10
2017 Aoi Yoshida, Shoto Tsuji, Hiroaki Taniguchi, Takahiro Kenmotsu, Koichiro Sadakane, Kenichi Yoshikawa
Manipulating Living Cells to Construct a 3D Single-Cell Assembly without an Artificial Scaffold
published pages: 319, ISSN: 2073-4360, DOI: 10.3390/polym9080319
Polymers 9/12 2019-10-10
2017 Federica Zacchini, Roberta Arena, Adam Abramik, Grazyna E Ptak
Embryo biopsy and development: the known and the unknown
published pages: R143-R148, ISSN: 1470-1626, DOI: 10.1530/rep-17-0431
Reproduction 154/5 2019-10-10
2018 F. Zacchini, M. Ogluska, R. Arena, G. E. Ptak
64 Impaired Post-Implantation Development Following Blastomere Biopsy is Associated with Placental Hypomethylation
published pages: 171, ISSN: 1031-3613, DOI: 10.1071/rdv30n1ab64
Reproduction, Fertility and Development 30/1 2019-10-10
2017 Larissa Haertle, Nady El Hajj, Marcus Dittrich, Tobias Müller, Indrajit Nanda, Harald Lehnen, Thomas Haaf
Epigenetic signatures of gestational diabetes mellitus on cord blood methylation
published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-017-0329-3
Clinical Epigenetics 9/1 2019-10-10
2017 Megumi Tsuchiya, M. Rezaul Karim, Taro Matsumoto, Hidesato Ogawa, Hiroaki Taniguchi
A Protein Preparation Method for the High-throughput Identification of Proteins Interacting with a Nuclear Cofactor Using LC-MS/MS Analysis
published pages: , ISSN: 1940-087X, DOI: 10.3791/55077
Journal of Visualized Experiments 119 2019-10-10
2018 Luca PALAZZESE, Jaime GOSÁLVEZ, Debora A. ANZALONE, Pasqualino LOI, Joseph SARAGUSTY
DNA fragmentation in epididymal freeze-dried ram spermatozoa impairs embryo development
published pages: 393-400, ISSN: 0916-8818, DOI: 10.1262/jrd.2018-033
Journal of Reproduction and Development 64/5 2019-10-10
2018 Thomas B. Hildebrandt, Robert Hermes, Silvia Colleoni, Sebastian Diecke, Susanne Holtze, Marilyn B. Renfree, Jan Stejskal, Katsuhiko Hayashi, Micha Drukker, Pasqualino Loi, Frank Göritz, Giovanna Lazzari, Cesare Galli
Embryos and embryonic stem cells from the white rhinoceros
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04959-2
Nature Communications 9/1 2019-10-10
2018 Pasqualino LOI, Cesare GALLI, Giovanna LAZZARI, Kazutsugu MATSUKAWA, Josef FULKA, Jr, Frank GOERITZ, Thomas B. HILDEBRANDT
Development to term of sheep embryos reconstructed after inner cell mass/trophoblast exchange
published pages: 187-191, ISSN: 0916-8818, DOI: 10.1262/jrd.2017-109
Journal of Reproduction and Development 64/2 2019-10-10
2018 Luca Palazzese, Marta Czernik, Domenico Iuso, Paola Toschi, Pasqualino Loi
Nuclear quiescence and histone hyper-acetylation jointly improve protamine-mediated nuclear remodeling in sheep fibroblasts
published pages: e0193954, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0193954
PLOS ONE 13/3 2019-10-10
2019 Joseph Saragusty, Pasqualino Loi
Exploring dry storage as an alternative biobanking strategy inspired by Nature
published pages: 17-27, ISSN: 0093-691X, DOI: 10.1016/j.theriogenology.2018.11.027
Theriogenology 126 2019-10-10
2016 Marta Czernik, Domenico Iuso, Paola Toschi, Saadi Khochbin, Pasqualino Loi
Remodeling somatic nuclei via exogenous expression of protamine 1 to create spermatid-like structures for somatic nuclear transfer
published pages: 2170-2188, ISSN: 1754-2189, DOI: 10.1038/nprot.2016.130
Nature Protocols 11/11 2019-10-10
2017 Marta Czernik, Paola Toschi, Federica Zacchini, Domenico Iuso, Grażyna Ewa Ptak
Deregulated Expression of Mitochondrial Proteins Mfn2 and Bcnl3L in Placentae from Sheep Somatic Cell Nuclear Transfer (SCNT) Conceptuses
published pages: e0169579, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0169579
PLOS ONE 12/1 2019-10-10

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