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SCHISTO_PERSIST SIGNED

New approaches to characterise Schistosoma mansoni infections persisting despite mass drug administration

Total Cost €

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EC-Contrib. €

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Partnership

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 SCHISTO_PERSIST project word cloud

Explore the words cloud of the SCHISTO_PERSIST project. It provides you a very rough idea of what is the project "SCHISTO_PERSIST" about.

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Project "SCHISTO_PERSIST" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙490˙270 €
 EC max contribution 1˙490˙270 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 1˙490˙270.00

Map

 Project objective

Neglected tropical diseases affect over 1.4 billion people and cause a greater disease burden than HIV/AIDS. Despite extensive mass drug administration (MDA) schistosomiasis remains a major public health issue, with a socio-economic impact second only to malaria amongst parasites. I will evaluate novel strategies and new technologies to monitor the impact of MDA programmes, to identify threats to MDA effectiveness, and enhance control of schistosomiasis in sub-Saharan Africa.

Specifically I will address five ambitious questions: 1. What is the best way to monitor schistosome infections and drug efficacy? 2. Has drug resistance been selected for? 3. What is the potential for drug resistance to spread? 4. What other factors drive transmission? 5. What other factors affect parasite clearance?

These aims are feasible through innovative interdisciplinary methods including a) state-of-the-art DNA-chip diagnostics, b) novel application of genetic analysis to differentiate surviving worms from juveniles, c) use of drug screening technology to measure in vitro drug susceptibility, providing the first quantifiable in vitro phenotype without using mammals, d) combination of molecular techniques with mathematical models to elucidate the potential spread of phenotypes and e) an unparalleled interdisciplinary approach deducing host effects in non-clearers.

These methods and technologies have not previously been used to assess MDA effectiveness for any helminth infection. My pioneering research will enable a comparative assessment of how transmission is affected by untreated adults and pre-school children, individuals with heavy infections, coinfections, and drug coverage. This will elucidate optimal strategies to reduce transmission hotspots.

My results will improve monitoring protocols and inform policy makers on how best to treat schistosomiasis. I will fill a critical global health knowledge gap, with findings transferable across a range of MDA controlled diseases.

 Publications

year authors and title journal last update
List of publications.
2018 Moses Adriko, Christina Faust, Lauren Carruthers, Arinaitwe Moses, Edridah Tukahebwa, Poppy Lamberton
Low Praziquantel Treatment Coverage for Schistosoma mansoni in Mayuge District, Uganda, Due to the Absence of Treatment Opportunities, Rather Than Systematic Non-Compliance
published pages: 111, ISSN: 2414-6366, DOI: 10.3390/tropicalmed3040111
Tropical Medicine and Infectious Disease 3/4 2019-08-30
2017 Poppy H.L. Lamberton, Christina L. Faust, Joanne P. Webster
Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment: evidence from a laboratory life-history trade-offs selection study
published pages: 110, ISSN: 2049-9957, DOI: 10.1186/s40249-017-0324-0
Infectious Diseases of Poverty 6/1 2019-08-30
2018 Joaquín M. Prada, Panayiota Touloupou, Moses Adriko, Edridah M. Tukahebwa, Poppy H. L. Lamberton, T. Déirdre Hollingsworth
Understanding the relationship between egg- and antigen-based diagnostics of Schistosoma mansoni infection pre- and post-treatment in Uganda
published pages: , ISSN: 1756-3305, DOI: 10.1186/s13071-017-2580-z
Parasites & Vectors 11/1 2019-08-30
2017 Mafalda Viana, Christina L. Faust, Daniel T. Haydon, Joanne P. Webster, Poppy H. L. Lamberton
The effects of subcurative praziquantel treatment on life-history traits and trade-offs in drug-resistant Schistosoma mansoni
published pages: , ISSN: 1752-4571, DOI: 10.1111/eva.12558
Evolutionary Applications 2019-08-30
2018 Joaquín M. Prada, Panayiota Touloupou, Moses Adriko, Edridah M. Tukahebwa, Poppy H. L. Lamberton, T. Déirdre Hollingsworth
Understanding the relationship between egg- and antigen-based diagnostics of Schistosoma mansoni infection pre- and post-treatment in Uganda
published pages: , ISSN: 1756-3305, DOI: 10.1186/s13071-017-2580-z
Parasites & Vectors 11/1 2019-08-30
2019 Stefanie Krauth, Julie Balen, Geoffrey Gobert, Poppy Lamberton
A Call for Systems Epidemiology to Tackle the Complexity of Schistosomiasis, Its Control, and Its Elimination
published pages: 21, ISSN: 2414-6366, DOI: 10.3390/tropicalmed4010021
Tropical Medicine and Infectious Disease 4/1 2019-08-30

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