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Piko SIGNED

Revealing the adaptive internal organization and dynamics of bacteria and mitochondria

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Piko project word cloud

Explore the words cloud of the Piko project. It provides you a very rough idea of what is the project "Piko" about.

storage    adaptive    resolved    energy    diffraction    entering    transport    originated    displays    quiescence    length    starvation    quantify    cytoplasm    overcome    bacteria    lack    mitochondria    exist    structured    ancient    scales    hundreds    elucidate    behavior    transition    dynamic    survive    nature    endosymbionts    strategy    organelles    quantitative    obstacle    observe    membrane    proteins    signatures    harsh    throughput    tens    lie       thousands    heterogeneous    environment    intracellular    physical    super    fluctuations    motor    of    capturing    promotes    resistance    microscopes    colloidal    limit    cells    rely    glass    matrix    antibiotic    resolution    translate    little    bacterial    subcellular    slow    poorly    granules    measured    below    virulence    diffusion    survival    contain    microns    nanometers    single    fitness    mitochondrial    proliferating    applicable    interior    molecular    broadly    microscopy    experiment    appear    quiescent    illumination    micron    size    dynamics    responds    fluorescence    organization    tracking   

Project "Piko" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙366˙835 €
 EC max contribution 2˙366˙835 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 2˙366˙835.00

Map

 Project objective

Bacteria cells appear to be less complex than our own cells -- yet they are better able to survive harsh conditions. Typically ~1 micron in size, they lack motor proteins; thus, they rely on fluctuations for intracellular transport. Bacteria in the environment often face starvation and exist in a non-proliferating quiescent state, which promotes antibiotic resistance and virulence. Entering quiescence, the bacterial cytoplasm displays signatures of the colloidal glass transition, with increasingly slow and heterogeneous diffusion. Also important for fitness during starvation is the formation of storage granules up to hundreds of nanometers in size. The complex state behavior of the bacterial cytoplasm is therefore important for their survival, but the physical nature of each of these processes is poorly understood. Our own cells are typically tens of microns in size and contain organelles including mitochondria, which originated from ancient bacterial endosymbionts. But little is known about the transport properties of the mitochondrial matrix, or how it responds to changes in mitochondrial membrane potential or energy production. The goal of this project is to elucidate the organization and dynamics of the bacterial cytoplasm and the mitochondrial matrix. A major obstacle to studying the interior of bacteria and mitochondria is the relevant length scales, which lie below the diffraction limit. Furthermore, to observe and quantify their adaptive response, many cells must be measured. Our strategy to overcome both of these technical challenges is to use high-throughput super-resolution fluorescence microscopy. We have developed new microscopes, capable of capturing thousands of super-resolved cells in each experiment. We propose to translate these developments to dynamic structured illumination and long-term molecular tracking. Broadly applicable, this will also enable the quantitative study of the subcellular properties of single bacteria cells or mitochondria.

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The information about "PIKO" are provided by the European Opendata Portal: CORDIS opendata.

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