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Piko SIGNED

Revealing the adaptive internal organization and dynamics of bacteria and mitochondria

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Piko project word cloud

Explore the words cloud of the Piko project. It provides you a very rough idea of what is the project "Piko" about.

micron    displays    of    quiescent    glass    elucidate    fluctuations    bacterial    fitness    experiment    colloidal    resistance    appear    physical    diffraction    structured    cells    membrane    dynamics    limit    adaptive    resolved    responds    motor    length    resolution    tens    environment    dynamic    contain    rely    quiescence    illumination    throughput    promotes    strategy    thousands    size    super    exist    granules    observe    proliferating    heterogeneous    bacteria    microscopy    below    nature    transport    intracellular    poorly    overcome    broadly    organization    starvation    single    matrix    hundreds    antibiotic    scales    virulence    survival    behavior    microscopes    tracking    capturing    cytoplasm    translate    little    originated    ancient    interior    fluorescence    proteins    endosymbionts    nanometers    survive    lie    entering    energy    transition    molecular    diffusion    microns    mitochondrial    quantify    obstacle    quantitative    applicable    subcellular    lack    organelles    slow    measured    harsh    storage    mitochondria    signatures      

Project "Piko" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙366˙835 €
 EC max contribution 2˙366˙835 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 2˙366˙835.00

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 Project objective

Bacteria cells appear to be less complex than our own cells -- yet they are better able to survive harsh conditions. Typically ~1 micron in size, they lack motor proteins; thus, they rely on fluctuations for intracellular transport. Bacteria in the environment often face starvation and exist in a non-proliferating quiescent state, which promotes antibiotic resistance and virulence. Entering quiescence, the bacterial cytoplasm displays signatures of the colloidal glass transition, with increasingly slow and heterogeneous diffusion. Also important for fitness during starvation is the formation of storage granules up to hundreds of nanometers in size. The complex state behavior of the bacterial cytoplasm is therefore important for their survival, but the physical nature of each of these processes is poorly understood. Our own cells are typically tens of microns in size and contain organelles including mitochondria, which originated from ancient bacterial endosymbionts. But little is known about the transport properties of the mitochondrial matrix, or how it responds to changes in mitochondrial membrane potential or energy production. The goal of this project is to elucidate the organization and dynamics of the bacterial cytoplasm and the mitochondrial matrix. A major obstacle to studying the interior of bacteria and mitochondria is the relevant length scales, which lie below the diffraction limit. Furthermore, to observe and quantify their adaptive response, many cells must be measured. Our strategy to overcome both of these technical challenges is to use high-throughput super-resolution fluorescence microscopy. We have developed new microscopes, capable of capturing thousands of super-resolved cells in each experiment. We propose to translate these developments to dynamic structured illumination and long-term molecular tracking. Broadly applicable, this will also enable the quantitative study of the subcellular properties of single bacteria cells or mitochondria.

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The information about "PIKO" are provided by the European Opendata Portal: CORDIS opendata.

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