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Piko SIGNED

Revealing the adaptive internal organization and dynamics of bacteria and mitochondria

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Piko project word cloud

Explore the words cloud of the Piko project. It provides you a very rough idea of what is the project "Piko" about.

harsh    little    limit    originated    microscopy    behavior    proteins    starvation    quantify    capturing    organelles    throughput    fluorescence    subcellular    bacterial    size    thousands    transport    glass    diffraction    responds    resolved    endosymbionts    of    length    virulence    displays    exist    antibiotic    tens    survival    storage    mitochondria    matrix    nature    interior    proliferating    cytoplasm    structured    physical    poorly    appear    transition    below    resolution    nanometers    cells    quantitative    adaptive    granules    organization    bacteria    illumination    applicable       lie    molecular    scales    dynamic    single    slow    mitochondrial    entering    broadly    quiescence    experiment    fitness    tracking    hundreds    obstacle    heterogeneous    quiescent    resistance    dynamics    intracellular    diffusion    survive    promotes    elucidate    environment    energy    super    overcome    micron    translate    contain    membrane    signatures    observe    strategy    lack    measured    microscopes    colloidal    ancient    motor    fluctuations    microns    rely   

Project "Piko" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙366˙835 €
 EC max contribution 2˙366˙835 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 2˙366˙835.00

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 Project objective

Bacteria cells appear to be less complex than our own cells -- yet they are better able to survive harsh conditions. Typically ~1 micron in size, they lack motor proteins; thus, they rely on fluctuations for intracellular transport. Bacteria in the environment often face starvation and exist in a non-proliferating quiescent state, which promotes antibiotic resistance and virulence. Entering quiescence, the bacterial cytoplasm displays signatures of the colloidal glass transition, with increasingly slow and heterogeneous diffusion. Also important for fitness during starvation is the formation of storage granules up to hundreds of nanometers in size. The complex state behavior of the bacterial cytoplasm is therefore important for their survival, but the physical nature of each of these processes is poorly understood. Our own cells are typically tens of microns in size and contain organelles including mitochondria, which originated from ancient bacterial endosymbionts. But little is known about the transport properties of the mitochondrial matrix, or how it responds to changes in mitochondrial membrane potential or energy production. The goal of this project is to elucidate the organization and dynamics of the bacterial cytoplasm and the mitochondrial matrix. A major obstacle to studying the interior of bacteria and mitochondria is the relevant length scales, which lie below the diffraction limit. Furthermore, to observe and quantify their adaptive response, many cells must be measured. Our strategy to overcome both of these technical challenges is to use high-throughput super-resolution fluorescence microscopy. We have developed new microscopes, capable of capturing thousands of super-resolved cells in each experiment. We propose to translate these developments to dynamic structured illumination and long-term molecular tracking. Broadly applicable, this will also enable the quantitative study of the subcellular properties of single bacteria cells or mitochondria.

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The information about "PIKO" are provided by the European Opendata Portal: CORDIS opendata.

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