Opendata, web and dolomites

Piko SIGNED

Revealing the adaptive internal organization and dynamics of bacteria and mitochondria

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Piko project word cloud

Explore the words cloud of the Piko project. It provides you a very rough idea of what is the project "Piko" about.

limit    fluorescence    cells    mitochondrial    quiescent    diffraction    subcellular    appear    throughput    fitness    survive    applicable    little    starvation    structured    tens    bacteria    adaptive    physical    capturing       diffusion    experiment    transition    obstacle    responds    nature    transport    measured    mitochondria    thousands    storage    observe    granules    heterogeneous    molecular    glass    organization    motor    microscopy    endosymbionts    environment    virulence    single    lie    entering    organelles    fluctuations    resistance    of    hundreds    originated    illumination    bacterial    membrane    quantitative    microns    intracellular    cytoplasm    energy    length    quantify    contain    exist    micron    behavior    elucidate    scales    antibiotic    translate    lack    poorly    dynamics    proliferating    broadly    quiescence    tracking    microscopes    resolved    interior    dynamic    promotes    matrix    overcome    resolution    survival    super    harsh    below    signatures    slow    displays    proteins    nanometers    rely    colloidal    size    strategy    ancient   

Project "Piko" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙366˙835 €
 EC max contribution 2˙366˙835 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 2˙366˙835.00

Map

 Project objective

Bacteria cells appear to be less complex than our own cells -- yet they are better able to survive harsh conditions. Typically ~1 micron in size, they lack motor proteins; thus, they rely on fluctuations for intracellular transport. Bacteria in the environment often face starvation and exist in a non-proliferating quiescent state, which promotes antibiotic resistance and virulence. Entering quiescence, the bacterial cytoplasm displays signatures of the colloidal glass transition, with increasingly slow and heterogeneous diffusion. Also important for fitness during starvation is the formation of storage granules up to hundreds of nanometers in size. The complex state behavior of the bacterial cytoplasm is therefore important for their survival, but the physical nature of each of these processes is poorly understood. Our own cells are typically tens of microns in size and contain organelles including mitochondria, which originated from ancient bacterial endosymbionts. But little is known about the transport properties of the mitochondrial matrix, or how it responds to changes in mitochondrial membrane potential or energy production. The goal of this project is to elucidate the organization and dynamics of the bacterial cytoplasm and the mitochondrial matrix. A major obstacle to studying the interior of bacteria and mitochondria is the relevant length scales, which lie below the diffraction limit. Furthermore, to observe and quantify their adaptive response, many cells must be measured. Our strategy to overcome both of these technical challenges is to use high-throughput super-resolution fluorescence microscopy. We have developed new microscopes, capable of capturing thousands of super-resolved cells in each experiment. We propose to translate these developments to dynamic structured illumination and long-term molecular tracking. Broadly applicable, this will also enable the quantitative study of the subcellular properties of single bacteria cells or mitochondria.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PIKO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PIKO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

TRUST (2018)

Truth and Semantics

Read More  

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More