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Piko SIGNED

Revealing the adaptive internal organization and dynamics of bacteria and mitochondria

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Piko project word cloud

Explore the words cloud of the Piko project. It provides you a very rough idea of what is the project "Piko" about.

observe    resistance    limit    responds    translate    physical    heterogeneous    length    dynamic    virulence    strategy    thousands    organelles    granules    contain    overcome    promotes    resolution    survive    tens    transition    microscopes    interior    endosymbionts    fluorescence    mitochondria    proteins    lie    applicable    motor    quantify    originated    intracellular    proliferating    behavior    dynamics    displays    bacterial    quantitative    entering    micron    below    antibiotic    membrane    fitness    adaptive    size    energy    cells    scales    slow    ancient    transport    microscopy    single    organization    signatures    elucidate    resolved    storage    environment    diffusion    obstacle    super    quiescence    diffraction    appear    throughput    capturing    experiment    mitochondrial    of    poorly    exist    bacteria    survival    cytoplasm    hundreds    tracking    little    quiescent    nature    illumination    colloidal    harsh    microns    starvation    molecular    subcellular    glass    structured    broadly    matrix       nanometers    measured    lack    fluctuations    rely   

Project "Piko" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙366˙835 €
 EC max contribution 2˙366˙835 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 2˙366˙835.00

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 Project objective

Bacteria cells appear to be less complex than our own cells -- yet they are better able to survive harsh conditions. Typically ~1 micron in size, they lack motor proteins; thus, they rely on fluctuations for intracellular transport. Bacteria in the environment often face starvation and exist in a non-proliferating quiescent state, which promotes antibiotic resistance and virulence. Entering quiescence, the bacterial cytoplasm displays signatures of the colloidal glass transition, with increasingly slow and heterogeneous diffusion. Also important for fitness during starvation is the formation of storage granules up to hundreds of nanometers in size. The complex state behavior of the bacterial cytoplasm is therefore important for their survival, but the physical nature of each of these processes is poorly understood. Our own cells are typically tens of microns in size and contain organelles including mitochondria, which originated from ancient bacterial endosymbionts. But little is known about the transport properties of the mitochondrial matrix, or how it responds to changes in mitochondrial membrane potential or energy production. The goal of this project is to elucidate the organization and dynamics of the bacterial cytoplasm and the mitochondrial matrix. A major obstacle to studying the interior of bacteria and mitochondria is the relevant length scales, which lie below the diffraction limit. Furthermore, to observe and quantify their adaptive response, many cells must be measured. Our strategy to overcome both of these technical challenges is to use high-throughput super-resolution fluorescence microscopy. We have developed new microscopes, capable of capturing thousands of super-resolved cells in each experiment. We propose to translate these developments to dynamic structured illumination and long-term molecular tracking. Broadly applicable, this will also enable the quantitative study of the subcellular properties of single bacteria cells or mitochondria.

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The information about "PIKO" are provided by the European Opendata Portal: CORDIS opendata.

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