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VADEMA SIGNED

Doctoral Industrial School for Vaccine Design through Structural Mass Spectrometry

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

VADEMA project word cloud

Explore the words cloud of the VADEMA project. It provides you a very rough idea of what is the project "VADEMA" about.

applicative experimental observation antigens infections industrial immune glycoconjugation students threatening parts respective structural portions live host antigen form microorganisms opportunity recombinant led trained courses opened rational basic broadly phd consisting leaders mass powerful decades good diseases immunity components reverse accessible soluble academic technologies native training immunology bearing innovative human life designing raised despite occasion multiple dna vaccinology spread alternative group attenuated membrane efficacious empirical discovered complemented science killed grow epitopes purified forms impossible receive vaccines previously platform spectrometry devastating humoral efforts efficient compare degree outcome successful dynamics conformation protective combined strategy possibility

Project "VADEMA" data sheet

The following table provides information about the project.

Coordinator	GLAXOSMITHKLINE VACCINES SRL Organization address address: VIA FIORENTINA 1 city: SIENA postcode: 53100 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.vadema.eu/
Total cost	1˙096˙286 €
EC max contribution	1˙096˙286 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-EID
Starting year	2016
Duration (year-month-day)	from 2016-11-01 to 2020-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	GLAXOSMITHKLINE VACCINES SRL GLAXOSMITHKLINE VACCINES SRL Organization address address: VIA FIORENTINA 1 city: SIENA postcode: 53100 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SIENA)	coordinator	516˙122.00
2	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	580˙163.00

Map

Project objective

Vaccines discovered from empirical approaches and consisting in killed, live-attenuated microorganisms or purified components have led to the successful control of many devastating diseases. Several novel technologies, such as recombinant DNA technology, glycoconjugation, reverse vaccinology have opened the possibility of designing vaccines previously considered impossible to make. Despite decades of efforts, vaccines have not yet been developed against several of the most life-threatening infections. Based on the observation that an efficacious immune response only require protective epitopes, structural vaccinology combined with human immunology are therefore rapidly emerging as a powerful alternative strategy for the rational design of vaccines bearing multiple protective epitopes and offering the opportunity of developing broadly effective immunity. The proposal is focused on the development of a Structural Mass Spectrometry platform and its application to compare conformation and dynamics of antigens in their native states (membrane) with their recombinant soluble forms (vaccines) and to get a better understanding of the humoral response raised against the two forms. The outcome of such studies will be to identify antigen portions accessible to the host immune system and those epitopes that can be recognized in the native form of the antigens to design efficient vaccines. Structural Mass Spectrometry is a very new science in Europe and the proposal represents the unique opportunity for 4 PhD students to be trained by an academic and an industrial group, leaders in respective parts of the field. The program will be complemented with a number of training courses. The students will receive a PhD degree in structural mass spectrometry applied to vaccinology. It represents a good occasion to spread this technology in Europe and good opportunities for students that are willing to grow both in basic science as well as innovative and applicative experimental research.

Deliverables

List of deliverables.
Recruitment	Other	2019-03-20 15:38:37
Supervisory Board	Other	2019-03-25 10:34:34

Take a look to the deliverables list in detail: detailed list of VADEMA deliverables.

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The information about "VADEMA" are provided by the European Opendata Portal: CORDIS opendata.