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ANaPSyS SIGNED

Artificial Natural Products System Synthesis

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ANaPSyS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT KONSTANZ 

Organization address
address: UNIVERSITATSSTRASSE 10
city: KONSTANZ
postcode: 78464
website: www.uni-konstanz.de/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.chemie.uni-konstanz.de/gaich/
 Total cost 1˙497˙000 €
 EC max contribution 1˙497˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT KONSTANZ DE (KONSTANZ) coordinator 1˙497˙000.00

Map

 Project objective

'Traditionally, natural products are classified into 'natural product families'. Within a family all congeners display specific structure elements, owing to their common biosynthetic pathway. This suggests a bio-inspired or 'collective synthesis', as has been devised by D: W. MacMillan. However, a biosynthetic pathway is confined to these structure elements, thus limiting synthesis with regard to structure diversification. In this research proposal the applicant exemplarily devises a strategic concept to overcome these limitations, by replacing the dogma of 'retrosynthetic analysis' with 'structure pattern recognition'. This concept is termed 'Artificial Natural Product Systems Synthesis — ANaPSyS', and aims to supersede the current 'logic of chemical synthesis' as a standard practice in this field. ANaPSyS exclusively categorizes natural products based on structural relationships — regardless of biogenetic origin. The structure pattern analysis groups natural products according to their shared core structure, and thereof creates a common precursor called 'privileged intermediate (PI)'. This intermediate is resembled in each of these natural products and is architecturally less complex. As a result every member of this natural product group can originate from a different natural product family and is obtained via this 'privileged intermediate', which serves as basis for the artificial synthetic network. With ANaPSyS a synthetic route is not restricted to a single target structure anymore (as in conventional synthesis). In comparison with bio-inspired synthesis, which is limited to a single natural product family, ANaPSyS enables the synthesis of a whole set of natural product families. With every synthesis accomplished, the network is upgraded — hence diversification leads to a rise in revenue. As a consequence, synthetic efficiency is drastically enhanced, therefore profoundly boosting and facilitating lead structure development. '

 Publications

year authors and title journal last update
List of publications.
2016 Sebastian Krüger, Tanja Gaich
Total Syntheses of Vellosimine, N -Methylvellosimine, and 10-Methoxyvellosimine and Formal Synthesis of 16-Epinormacusine B through a [5+2] Cycloaddition
published pages: 4893-4899, ISSN: 1434-193X, DOI: 10.1002/ejoc.201600870
European Journal of Organic Chemistry 2016/28 2019-06-19
2019 Tanja Gaich, Christa Karoline Gisela Gerlinger
Structure Pattern Based Total Synthesis
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201901308
Chemistry – A European Journal 2019-08-05
2018 Tanja Gaich, Heiko Rebmann, Christa K. G. Gerlinger
Gram‐scale Total Syntheses of Sarpagine Alkaloids and non‐Natural Derivatives
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201805644
Chemistry – A European Journal 2019-08-05
2018 Christa K. G. Gerlinger, Sebastian Krüger, Tanja Gaich
Total Synthesis of Parvineostemonine by Structure Pattern Recognition: A Unified Approach to Stemona and Sarpagine Alkaloids
published pages: 3994-3997, ISSN: 0947-6539, DOI: 10.1002/chem.201800365
Chemistry - A European Journal 24/16 2019-05-09

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