CENTER-TBI
Collaborative European NeuroTrauma Effectiveness Research in TBI
| Coordinatore | UNIVERSITAIR ZIEKENHUIS ANTWERPEN
Organization address
address: WILRIJKSTRAAT 10 contact info |
| Nazionalità Coordinatore | Belgium [BE] |
| Sito del progetto | http://www.center-tbi.eu |
| Totale costo | 39˙560˙968 € |
| EC contributo | 29˙998˙903 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2013-INNOVATION-1 |
| Funding Scheme | CP-IP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-10-01 - 2020-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITAIR ZIEKENHUIS ANTWERPEN
Organization address
address: WILRIJKSTRAAT 10 contact info |
BE (EDEGEM) | coordinator | 11˙750˙694.00 |
| 2 |
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Organization address
address: 's Gravendijkwal 230 contact info |
NL (ROTTERDAM) | participant | 3˙174˙760.00 |
| 3 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | participant | 2˙840˙158.00 |
| 4 |
ICOMETRIX NV
Organization address
address: TERVUURSESTEENWEG 244 contact info |
BE (LEUVEN) | participant | 1˙983˙000.00 |
| 5 |
PECSI TUDOMANYEGYETEM - UNIVERSITY OF PECS
Organization address
address: VASVARI PAL UTCA 4 contact info |
HU (PECS) | participant | 1˙652˙438.00 |
| 6 |
GENOME RESEARCH LIMITED
Organization address
address: THE GIBBS BUILDING, EUSTON ROAD 215 contact info |
UK (LONDON) | participant | 1˙169˙745.00 |
| 7 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | participant | 1˙049˙970.00 |
| 8 |
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Organization address
address: Robert-Koch-Strasse 40 contact info |
DE (GOETTINGEN) | participant | 806˙664.00 |
| 9 |
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O
Organization address
address: Oskar-von-Miller-Ring 29 contact info |
DE (MUENCHEN) | participant | 739˙600.00 |
| 10 |
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
Organization address
address: 3 Avenue Victoria contact info |
FR (PARIS) | participant | 533˙706.00 |
| 11 |
FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO
Organization address
address: VIA FRANCESCO SFORZA 28 contact info |
IT (MILANO) | participant | 404˙000.00 |
| 12 |
THE UNIVERSITY OF SHEFFIELD
Organization address
address: FIRTH COURT WESTERN BANK contact info |
UK (SHEFFIELD) | participant | 401˙775.00 |
| 13 |
Trnavska Univerzita v Trnave
Organization address
address: Hornopotocna 23 contact info |
SK (TRNAVA) | participant | 399˙955.00 |
| 14 |
MONASH UNIVERSITY
Organization address
address: Wellington Road contact info |
AU (VICTORIA) | participant | 279˙499.00 |
| 15 |
Private Universitaet Witten/Herdecke gGmbH
Organization address
address: Alfred-Herrhaussen Strasse 50 contact info |
DE (WITTEN) | participant | 274˙270.00 |
| 16 |
MEDICAL RESEARCH COUNCIL
Organization address
address: NORTH STAR AVENUE POLARIS HOUSE contact info |
UK (SWINDON) | participant | 228˙275.00 |
| 17 |
THE UNIVERSITY OF STIRLING
Organization address
city: STIRLING contact info |
UK (STIRLING) | participant | 224˙684.00 |
| 18 |
Teknologian tutkimuskeskus VTT Oy
Organization address
address: Vuorimiehentie 3 contact info |
FI (Espoo) | participant | 224˙455.00 |
| 19 |
HELSINGIN YLIOPISTO
Organization address
address: YLIOPISTONKATU 4 contact info |
FI (HELSINGIN YLIOPISTO) | participant | 222˙237.00 |
| 20 |
UNIVERSITE DE LIEGE
Organization address
city: LIEGE contact info |
BE (LIEGE) | participant | 202˙374.00 |
| 21 |
OXFORD BROOKES UNIVERSITY
Organization address
address: HEADINGTON CAMPUS GIPSY LANE contact info |
UK (OXFORD) | participant | 197˙230.00 |
| 22 |
AZIENDA OSPEDALIERA SAN GERARDO DI MONZA
Organization address
address: VIA PERGOLESI 33 contact info |
IT (MONZA) | participant | 161˙845.00 |
| 23 |
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD contact info |
UK (LONDON) | participant | 140˙772.00 |
| 24 |
GREATER GLASGOW HEALTH BOARD
Organization address
address: GREAT WESTERN ROAD 1055 J B RUSSELL contact info |
UK (GLASGOW) | participant | 126˙951.00 |
| 25 |
INTERNATIONALE GESELLSCHAFT ZUR ERFORSCHUNG VON HIRNTRAUMATA
Organization address
address: MOLKERGASSE 3/4 contact info |
AT (WIEN) | participant | 112˙400.00 |
| 26 |
OSLO UNIVERSITETSSYKEHUS HF
Organization address
address: FORSKNINGSVEIEN 2B contact info |
NO (OSLO) | participant | 109˙908.00 |
| 27 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Organization address
address: "FRANKLIN STREET 1111, 12 FLOOR" contact info |
US (OAKLAND CA) | participant | 93˙225.00 |
| 28 |
UNIVERSITAETSKLINIKUM HEIDELBERG
Organization address
address: IM NEUENHEIMER FELD 672 contact info |
DE (HEIDELBERG) | participant | 85˙000.00 |
| 29 |
University of Florida
Organization address
address: Grinter Hall 223 contact info |
US (Gainesville) | participant | 79˙999.00 |
| 30 |
REGION HOVEDSTADEN
Organization address
address: KONGENS VAENGE 2 contact info |
DK (HILLEROD) | participant | 52˙000.00 |
| 31 |
RENJI HOSPITAL SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE
Organization address
address: DONGFANG ROAD 1630 contact info |
CN (SHANGHAI) | participant | 50˙000.00 |
| 32 |
VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA
Organization address
address: KIINAMYLLYNKATU 4-8 contact info |
FI (TURKU) | participant | 48˙596.00 |
| 33 |
ACADEMISCH ZIEKENHUIS LEIDEN
Organization address
address: Albinusdreef 2 contact info |
NL (LEIDEN) | participant | 43˙618.00 |
| 34 |
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Organization address
address: Chariteplatz 1 contact info |
DE (BERLIN) | participant | 37˙000.00 |
| 35 |
University of Cincinnati
Organization address
address: "Cincinnati,Ohio" contact info |
US (Cincinnati) | participant | 32˙000.00 |
| 36 |
AUCKLAND UNIVERSITY OF TECHNOLOGY
Organization address
address: QUEEN STREET LEVEL 2 350 contact info |
NZ (Auckland) | participant | 25˙000.00 |
| 37 |
NHS BLOOD AND TRANSPLANT
Organization address
address: OAK HOUSE REEDS CRESCENT contact info |
UK (WATFORD) | participant | 22˙100.00 |
| 38 |
Nome Ente NON disponibile
Organization address
address: Domstrasse 11 contact info |
DE (GREIFSWALD) | participant | 19˙000.00 |
| 39 |
TEKNOLOGIAN TUTKIMUSKESKUS VTT
Organization address
address: TEKNIIKANTIE 4 A contact info |
FI (ESPOO) | participant | 0.00 |
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Obiettivo del progetto (Objective)
'Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical, medical, social and health economic reasons therefore exist for improving treatment. The CENTER-TBI project will collect a prospective, contemporary, highly granular, observational dataset of 5400 patients, which will be used for better characterization of TBI and for Comparative Effectiveness Research (CER). The generalisability of our results will be reinforced by a contemporaneous registry level data collection in 15-25,000 patients. Our conceptual approach is to exploit the heterogeneity in biology, care, and outcome of TBI, to discover novel pathophysiology, refine disease characterization, and identify effective clinical interventions. Key elements are the use of emerging technologies (biomarkers, genomics and advanced MR imaging) in large numbers of patients, across the entire course of TBI (from injury to late outcome) and across all severities of injury (mild to severe). Improved characterization with these tools will aid Precision Medicine, a concept recently advocated by the US National Academy of Science, facilitating targeted management for individual patients. Our consortium includes leading experts and will bring outstanding biostatistical and neuroinformatics expertise to the project. Collaborations with external partners, other FP7 consortia, and international links within InTBIR, will greatly augment scientific resources and broaden the global scope of our research. We anticipate that the project could revolutionize our view of TBI, leading to more effective and efficient therapy, thus improving outcome and reducing costs. These outcomes reflect the goals of CER to assist consumers, clinicians, health care purchasers, and policy makers to make informed decisions, and will improve healthcare at both individual and population levels.'
Descrizione progetto (Article)
TBI is a major cause of death and disability. Both victims and relatives experience suffering, and the associated direct and indirect costs to society are huge.
Currently, up-to-date evidence-based TBI treatment guidelines do not exist. Moreover, recently emerged technologies such as biomarkers, diffusion tensor imaging and genomics have not been considered in older studies.
The http://www.center-tbi.eu (CENTER-TBI) (Collaborative European neurotrauma effectiveness research in TBI) project will employ comparative effectiveness research (CER) to identify the most effective clinical care approach. This 6.5-year project is part of http://ec.europa.eu/research/health/medical-research/brain-research/international-initiative_en.html (The International Initiative for Traumatic Brain Injury Research (InTBIR)).
CENTER-TBI is a large-scale observational study that will attempt to improve TBI classification and characterisation. Using CER, project members will determine between-centre and between-country differences in TBI management and outcome. A total of 78 sites from 21 countries in Europe and Israel will participate.
During the first year of the project, project members laid the foundation for conducting the study and ensuring smooth and harmonised data collection. Over 280 participants attended the training meeting. Already, the study protocol has been registered and accepted for publication in the prestigious Neurosurgery journal. They finalised the case report forms (CRFs), developed a web-based data entry format (e-CRF), finalised outcome instruments and summarised the study procedures in a trial manual.
CENTER-TBI successfully completed the linguistic validation of multiple outcome instruments in many languages. They also established a knowledge commons and obtained an overview of existing knowledge in the literature concerning TBI treatments. The first patients were enrolled in December 2014.
Project members established close collaboration within and outside InTBIR with similar research endeavours such as TRACK-TBI in the United States and ADAPT, a study on severe TBI in children.
Project activities were widely disseminated via presentations at scientific meetings, media publications and interviews. This has attracted global interest, with China and India also setting up similar studies that will be linked to CENTER-TBI.
Transatlantic comparative analysis and meta-analysis of individual patient data in larger numbers will provide a truly global perspective. Identification and implementation of best practices will improve patient outcomes while reducing the immense socioeconomic burden of TBI.
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