EUROCLAST

Exploring Functional and Developmental Osteoclast Heterogeneity in Health and Disease

 Coordinatore STICHTING VU-VUMC 

 Organization address address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Prof.
Nome: Vincent
Cognome: Everts
Email: send email
Telefono: +31 20 5980882
Fax: +31 20 5980333

 Nazionalità Coordinatore Netherlands [NL]
 Totale costo 3˙135˙351 €
 EC contributo 3˙135˙351 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-ITN
 Funding Scheme MC-ITN
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-09-01   -   2017-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    STICHTING VU-VUMC

 Organization address address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Prof.
Nome: Vincent
Cognome: Everts
Email: send email
Telefono: +31 20 5980882
Fax: +31 20 5980333

NL (AMSTERDAM) coordinator 746˙011.44
2    THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN

 Organization address address: KING'S COLLEGE REGENT WALK
city: ABERDEEN
postcode: AB24 3FX

contact info
Titolo: Mrs.
Nome: Kerry
Cognome: Kidd
Email: send email
Telefono: +44 1224 437443
Fax: +44 1224 437458

UK (ABERDEEN) participant 604˙213.25
3    NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S

 Organization address address: Herlev Hovedgade 207
city: Helev
postcode: 2730

contact info
Titolo: Dr.
Nome: Kim
Cognome: Henriksen
Email: send email
Telefono: 4530294242
Fax: +45 44525251

DK (Helev) participant 290˙079.47
4    TURUN YLIOPISTO

 Organization address address: YLIOPISTONMAKI
city: TURUN YLIOPISTO
postcode: 20014

contact info
Titolo: Dr.
Nome: Mari
Cognome: Riipinen
Email: send email
Telefono: 35823336054
Fax: 35823336446

FI (TURUN YLIOPISTO) participant 266˙697.62
5    GOETEBORGS UNIVERSITET

 Organization address address: VASAPARKEN
city: GOETEBORG
postcode: 405 30

contact info
Titolo: Dr.
Nome: Ellen
Cognome: Rydberg
Email: send email
Telefono: +46 31 786 6470
Fax: +46 31 786 4355

SE (GOETEBORG) participant 265˙425.16
6    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Mr.
Nome: Kim
Cognome: Von Schoultz
Email: send email
Telefono: +46 8 524 86071

SE (STOCKHOLM) participant 265˙425.16
7    FUTURE DIAGNOSTICS BV

 Organization address address: NIEUWEWEG 279
city: Wijchen
postcode: 6603 BN

contact info
Titolo: Dr.
Nome: Mike
Cognome: Martens
Email: send email
Telefono: 31246452900
Fax: 31246452899

NL (Wijchen) participant 242˙361.45
8    CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL

 Organization address address: OLSHAUSENSTRASSE 40
city: KIEL
postcode: 24118

contact info
Titolo: Ms.
Nome: Anja
Cognome: Uhlenbrok
Email: send email
Telefono: 494319000000
Fax: 494319000000

DE (KIEL) participant 227˙568.88
9    TECHNISCHE UNIVERSITAET DRESDEN

 Organization address address: HELMHOLTZSTRASSE 10
city: DRESDEN
postcode: 1069

contact info
Titolo: Mr.
Nome: Bertram
Cognome: Skibinski
Email: send email
Telefono: +49 351 463 42191
Fax: +49 351 463 39742

DE (DRESDEN) participant 227˙568.88

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

private    cell    loss    training    biomarkers    diseases    molecular    academic    bone    esrs    euroclast    therapeutics    osteoclast    biology   

 Obiettivo del progetto (Objective)

'Euroclast proposes a research training program on osteoclast biology in the context of osteoclast-driven diseases. Osteoclasts are the complex, multinuclear cells responsible for bone breakdown. Many diseases of osteoclast malfunctioning manifest in bone loss, for example, osteoporosis, cancer-induced bone disease, periodontitis, or rheumatoid arthritis, all conditions set to increase in an ageing EU population. The Euroclast consortium (7 academic, 2 private and 1 ass. partner) focuses on osteoclast heterogeneity, a recent insight that poses new fundamental questions best tackled by a multi-partner consortium capable of assembling the sophisticated molecular, genetic and imaging tools required. We will analyze changes in gene and protein expression during osteoclast (trans)differentiation from different precursor cell pools and in various bone sites and relate this to osteoclast activity and sensitivity to therapeutics. The osteoclast resorptive apparatus will be studied using in depth and will define the key enzymatic and molecular machinery to be translated into novel site-specific drug targets or biomarkers. High throughput screening assays for therapeutics and ELISAs for biomarkers will be developed with our private partners. Our multidisciplinary and cross-sectorial approach will improve understanding and treatment of common disorders associated with osteoclast malfunction and train 11 early stage researchers (ESRs) in modern cell and bone biology. We will provide extensive training in generic skills and all ESRs will spend time with our private partners and be seconded to other academic partners to ensure they are well equipped for employment in research and industrial settings. Euroclast will produce an on-line repository for osteoclast protocols, make methodological and scientific advances in osteoclast and bone biology and create a sustainable network of ESRs and senior academics to tackle diseases of bone loss into the future.'

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